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Critical Care & Emergencies (all articles)

RCT: 5 days of high-dose amoxicillin therapy noninferior to 10 days for the treatment of pediatric community-acquired pneumonia

9 Mar, 2021 | 02:29h | UTC

Short-Course Antimicrobial Therapy for Pediatric Community-Acquired Pneumonia: The SAFER Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)

Editorial: Rightsizing Treatment for Pneumonia in Children

Commentary: Five days of antibiotics fine for children with pneumonia – McMaster University

 

Commentary on Twitter (thread – click for more)

 


Report: Risk of death from Covid-19 significantly increased in countries where most are overweight

9 Mar, 2021 | 02:52h | UTC

Report: COVID-19 and Obesity: The 2021 Atlas

Commentaries: Covid-19 death rates 10 times higher in countries where most adults are overweight, report finds – CNN AND Covid-19: Highest death rates seen in countries with most overweight populations – The BMJ AND Covid-19: We must tackle obesity and health inequalities in order to build back better – The BMJ Opinion AND COVID-19 Death Rates 10 Times Higher in Countries Where Most Are Overweight – HealthDay

 


CDC study: Body mass index and risk for COVID-19–related hospitalization, intensive care unit admission, invasive mechanical ventilation, and death

9 Mar, 2021 | 02:54h | UTC

Body Mass Index and Risk for COVID-19–Related Hospitalization, Intensive Care Unit Admission, Invasive Mechanical Ventilation, and Death — United States, March–December 2020 – CDC Morbidity and Mortality Weekly Report

Commentaries: CDC: Obese adults at higher risk for hospitalization, death from COVID-19 – UPI AND Obesity a Big Risk Factor for Severe COVID-19, Study Confirms – HealthDay

 


Colchicine and COVID-19: a Tale of Two Trials

9 Mar, 2021 | 02:51h | UTC

Colchicine and COVID-19: a Tale of Two Trials – CVCT CardioBrief

Study 1: RECOVERY trial: Colchicine arm stopped for lack of efficacy in patients hospitalized with COVID-19

Study 2: [Preprint] Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19

 


[Preprint] Systematic review: Characteristics of SARS-CoV-2 reinfection vs. persistent COVID-19

9 Mar, 2021 | 02:44h | UTC

SARS-CoV-2 Sequence Characteristics of COVID-19 Persistence and Reinfection – medRxiv

Commentary: How can physicians distinguish between COVID-19 persistence and SARS-CoV-2 reinfection? – News Medical

 


Ten things to consider when implementing rationing guidelines during a pandemic

9 Mar, 2021 | 02:46h | UTC

Ten things to consider when implementing rationing guidelines during a pandemic – Intensive Care Medicine

 

Commentary on Twitter

 


Cohort study: Elevated blood pressures are common in the emergency department but are they important?

9 Mar, 2021 | 02:04h | UTC

Yes, Your BP Is Up. No, It Doesn’t Matter. – Journal Feed

Original study: Elevated Blood Pressures Are Common in the Emergency Department but Are They Important? A Retrospective Cohort Study of 30,278 Adults – Annals of Emergency Medicine (link to abstract – $ for full-text)

 


Study: Balanced crystalloids vs. saline in critically ill adults with hyperkalemia or acute kidney injury

9 Mar, 2021 | 02:05h | UTC

Can We Use LR for Hyperkalemia? – Journal Feed

Original study: Balanced Crystalloids versus Saline in Critically Ill Adults with Hyperkalemia or Acute Kidney Injury: Secondary Analysis of a Clinical Trial – American Journal of Respiratory and Critical Care Medicine

 


Systematic review: High‐flow nasal cannula for respiratory support in adult intensive care patients

7 Mar, 2021 | 19:31h | UTC

High‐flow nasal cannula for respiratory support in adult intensive care patients – Cochrane Library

Summary: High-flow nasal cannulae for breathing support in adult intensive care patients – Cochrane Library

 


RECOVERY trial: Colchicine arm stopped for lack of efficacy in patients hospitalized with COVID-19

7 Mar, 2021 | 20:16h | UTC

RECOVERY trial closes recruitment to colchicine treatment for patients hospitalised with COVID-19 – University of Oxford

Commentary: Cochicine does not improve mortality in COVID19 – St Emlyn’s

 

Commentary on Twitter

 


RCT: Azithromycin provides no benefit for community treatment of patients with suspected COVID-19

7 Mar, 2021 | 20:15h | UTC

Azithromycin for community treatment of suspected COVID-19 in people at increased risk of an adverse clinical course in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial – The Lancet

 

Commentary on Twitter

 


[Preprint] Genomics and epidemiology of a novel SARS-CoV-2 lineage P.1 – “P.1 may be 1.4–2.2 times more transmissible and 25-61% more likely to evade protective immunity elicited by previous infection with non-P.1 lineages”

7 Mar, 2021 | 20:05h | UTC

Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil – medRxiv

Commentary: Brazil variant can reinfect virus survivors; COVID-19 vaccine antibodies pass into breast milk – Reuters

 


Diagnosis of non-consensus transient ischemic attacks with focal, negative, and non-progressive symptoms: population-based validation by investigation and prognosis

7 Mar, 2021 | 19:32h | UTC

Diagnosis of non-consensus transient ischaemic attacks with focal, negative, and non-progressive symptoms: population-based validation by investigation and prognosis – The Lancet

 

Commentary on Twitter

 


[Preprint] Increased risk of hospitalization associated with infection with SARS-CoV-2 Lineage B.1.1.7 in Denmark

7 Mar, 2021 | 19:46h | UTC

Increased Risk of Hospitalisation Associated with Infection with SARS-CoV-2 Lineage B.1.1.7 in Denmark – The Lancet

 

Commentary on Twitter (thread – click for more)

 


Therapy options for adrenal insufficiency and recommendations for the management of adrenal crisis

7 Mar, 2021 | 19:00h | UTC

Therapy options for adrenal insufficiency and recommendations for the management of adrenal crisis – Endocrine

 


Prevention of Clostridioides difficile in hospitals: A position paper of the International Society for Infectious Diseases

7 Mar, 2021 | 18:58h | UTC

Prevention of Clostridioides difficile in hospitals: A position paper of the International Society for Infectious Diseases – International Journal of Infectious Diseases

 


RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19

5 Mar, 2021 | 08:53h | UTC

Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial – JAMA

Commentaries: Ivermectin: Yet Another Fad Runs Into The Brick Wall Known As “Actual Science” – Brief-19 AND Ivermectin doesn’t speed recovery from mild COVID-19, study shows – CIDRAP

 


Scientific Statement: Invasive management of acute myocardial infarction complicated by cardiogenic shock

5 Mar, 2021 | 08:33h | UTC

Invasive Management of Acute Myocardial Infarction Complicated by Cardiogenic Shock: A Scientific Statement From the American Heart Association – Circulation

 


Respiratory microbiome in mechanically ventilated patients: a narrative review

5 Mar, 2021 | 08:14h | UTC

Respiratory microbiome in mechanically ventilated patients: a narrative review – Intensive Care Medicine

 

Commentary on Twitter

 


RCT: Mixed findings with Terlipressin plus Albumin for the treatment of Type 1 hepatorenal syndrome

4 Mar, 2021 | 08:35h | UTC

Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)

 


RCT: Albumin provides no benefit to hospitalized patients with decompensated cirrhosis

4 Mar, 2021 | 08:37h | UTC

A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Albumin provides no benefit to hospitalized patients with advanced liver disease – University College London

 


RCT: Inspiratory muscle training with an electronic resistive loading device improves prolonged weaning outcomes

4 Mar, 2021 | 08:10h | UTC

Inspiratory Muscle Training With an Electronic Resistive Loading Device Improves Prolonged Weaning Outcomes in a Randomized Controlled Trial – Critical Care Medicine (link to abstract – $ for full-text)

 

Commentaries on Twitter

 


NIH halts trial of COVID-19 convalescent plasma in emergency department patients with mild symptoms

3 Mar, 2021 | 08:55h | UTC

NIH halts trial of COVID-19 convalescent plasma in emergency department patients with mild symptoms – National Institutes of Health

 


COVID-19 research in critical care: the good, the bad, and the ugly

3 Mar, 2021 | 08:49h | UTC

COVID-19 research in critical care: the good, the bad, and the ugly – Intensive Care Medicine

 

Commentary on Twitter

 


More transmissible and evasive SARS-CoV-2 variant growing rapidly in Brazil

3 Mar, 2021 | 08:53h | UTC

More transmissible and evasive SARS-CoV-2 variant growing rapidly in Brazil – Imperial College London

Original study (preprint): Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil

Commentaries: Covid Brazil variant ‘may spread more easily’ – BBC AND Brazil coronavirus variant: what is it and why is it a concern? An expert explains – The Conversation

 


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