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Critical Care & Emergencies (all articles)

Corticosteroids for community acquired pneumonia, influenza and COVID-19: when, how and benefits or harm?

15 Feb, 2021 | 00:47h | UTC

Corticosteroids for CAP, influenza and COVID-19: when, how and benefits or harm? – European Respiratory Review

 

Consensus guidelines on perioperative management of suspected malignant hyperthermia or susceptible patients

15 Feb, 2021 | 00:56h | UTC

Consensus guidelines on perioperative management of malignant hyperthermia suspected or susceptible patients from the European Malignant Hyperthermia Group – British Journal of Anaesthesia

 

Randomized trial: Procalcitonin to reduce long-term infection-associated adverse events in sepsis

15 Feb, 2021 | 00:43h | UTC

Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial – American Journal of Respiratory and Critical Care Medicine

 

Cohort study: Early initiation of prophylactic anticoagulation linked to reduced mortality in patients admitted to hospital with Covid-19

15 Feb, 2021 | 01:18h | UTC

Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study – The BMJ

Commentaries: Preventive blood thinning drugs could reduce COVID hospital deaths – London School of Hygiene & Tropical Medicine AND Preventive blood thinning drugs linked to reduced risk of death in COVID-19 patients – The BMJ AND Expert reaction to a study looking at prophylactic anticoagulants as a treatment for hospitalised patients with COVID-19 – Science Media Centre AND

 

Commentary on Twitter

 

Small RCT: No effect from Zinc and Vitamin C supplementation among ambulatory patients with SARS-CoV-2 infection

15 Feb, 2021 | 01:20h | UTC

Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial – JAMA Network Open

Commentaries: Vitamin C, zinc don’t lessen Covid-19 symptoms, study finds – CNN AND Supplements for the Treatment of Mild COVID-19—Challenging Health Beliefs With Science From A to Z – JAMA Network Open AND Zinc, vitamin C show no effect for COVID-19 in small study – CIDRAP AND Expert reaction to a study looking at prophylactic anticoagulants as a treatment for hospitalised patients with COVID-19 – Science Media Centre

 

Commentary on Twitter

 

Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US

15 Feb, 2021 | 01:13h | UTC

Reports of Anaphylaxis After Receipt of mRNA COVID-19 Vaccines in the US—December 14, 2020-January 18, 2021 – JAMA

Author interview: COVID-19 Vaccine Safety–Anaphylaxis and Allergic Reactions – JAMA

 

Commentary on Twitter

 

RCT: Delayed antibiotic prescription feasible for children with uncomplicated respiratory infections

12 Feb, 2021 | 02:02h | UTC

Delayed Antibiotic Prescription for Children With Respiratory Infections: A Randomized Trial – Pediatrics (link to abstract – $ for full-text)

Commentary: Data support delayed antibiotics in kids with respiratory infections – CIDRAP

 

RCT: Tocilizumab reduces deaths in patients hospitalized with COVID-19

12 Feb, 2021 | 02:25h | UTC

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial – medRxiv

News release: Tocilizumab reduces deaths in patients hospitalised with COVID-19 – University of Oxford

Commentary: Tocilizumab cuts death rate in severe COVID-19, study finds – CIDRAP

 

Commentary on Twitter

 

Guidelines for extracorporeal cardiopulmonary resuscitation in children and adults

11 Feb, 2021 | 01:48h | UTC

Extracorporeal Cardiopulmonary Resuscitation in Adults. Interim Guideline Consensus Statement From the Extracorporeal Life Support Organization – ASAIO Journal

See also: Pediatric Extracorporeal Cardiopulmonary Resuscitation ELSO Guidelines – ASAIO Journal

Commentary: Guidelines for extracorporeal cardiopulmonary resuscitation in children and adults: New ELSO statements in ASAIO Journal – Wolters Kluwer

 

Commentary on Twitter

 

Combination of vancomycin plus piperacillin and risk of acute kidney injury: a worldwide pharmacovigilance database analysis

11 Feb, 2021 | 01:50h | UTC

Combination of vancomycin plus piperacillin and risk of acute kidney injury: a worldwide pharmacovigilance database analysis – Journal of Antimicrobial Chemotherapy

Related: Risk of acute kidney injury and Clostridioides difficile infection with piperacillin/tazobactam, cefepime and meropenem with or without vancomycin – Clinical Infectious Diseases AND Vancomycin Plus Piperacillin-Tazobactam and Acute Kidney Injury in Adults: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text) AND Association of Acute Kidney Injury With Concomitant Vancomycin and Piperacillin/Tazobactam Treatment Among Hospitalized Children – JAMA Pediatrics (link to abstract – $ for full-text) AND Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients – Critical Care

 

Commentary on Twitter

 

Case report: Severe reinfection with South African SARS-CoV-2 variant

11 Feb, 2021 | 02:17h | UTC

Severe reinfection with South African SARS-CoV-2 variant 501Y.V2: A case report – Clinical Infectious Diseases

 

Commentary on Twitter

 

Small RCT: Inhaled budesonide reduces the need for hospitalization in COVID-19 patients

11 Feb, 2021 | 02:18h | UTC

Inhaled budesonide in the treatment of early COVID-19 illness: a randomised controlled trial – medRxiv

Commentaries: Common asthma treatment reduces need for hospitalisation in COVID-19 patients, study suggests – University of Oxford AND Expert reaction to preprint on an RCT of inhaled budesonide in the treatment of early COVID-19 – Science Media Centre

 

ACP: Update on Remdesivir use for hospitalized COVID-19 patients

11 Feb, 2021 | 02:15h | UTC

Should Remdesivir Be Used for the Treatment of Patients With COVID-19? Rapid, Living Practice Points From the American College of Physicians – Annals of Internal Medicine

News Release: Rapid, Living Practice Points from ACP: Update on remdesivir use for hospitalized COVID-19 patients – American College of Physicians

 

RCT: Among patients with acute MI and anemia, a restrictive transfusion strategy resulted in a noninferior rate of major cardiovascular events compared to a liberal transfusion strategy

10 Feb, 2021 | 01:39h | UTC

Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Clinical Trial – JAMA (free for a limited period)

Commentary: Restrictive vs. Liberal Blood Transfusion Strategy for MI and Anemia – American College of Cardiology

 

Commentary on Twitter

 

Cohort study: Adjunctive clindamycin may benefit beta-lactam antibiotic-treated patients with invasive beta-hemolytic streptococcal infections

10 Feb, 2021 | 01:13h | UTC

Effectiveness of adjunctive clindamycin in β-lactam antibiotic-treated patients with invasive β-haemolytic streptococcal infections in US hospitals: a retrospective multicentre cohort study – The Lancet Infectious Diseases (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Put to the test: use of rapid testing technologies for covid-19

10 Feb, 2021 | 01:51h | UTC

Put to the test: use of rapid testing technologies for covid-19 – The BMJ

 

Choosing Wisely for Critical Care: The Next Five

9 Feb, 2021 | 01:07h | UTC

Choosing Wisely For Critical Care: The Next Five – Critical Care Medicine

Related: Critical Care Societies Collaborative – Critical Care: Five Things Physicians and Patients Should Question – Choosing Wisely

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

 

Commentary on Twitter

 

Review: Nosocomial infection in the ICU setting

9 Feb, 2021 | 01:05h | UTC

Nosocomial Infection – Critical Care Medicine

 

Canadians Win Again – Syncope Score Systematic Review

9 Feb, 2021 | 01:03h | UTC

Canadians Win Again – Syncope Score Systematic Review – Journal Feed

Original study: Multivariable risk scores for predicting short‐term outcomes for emergency department patients with unexplained syncope: A systematic review – Academic Emergency Medicine

See calculator: Canadian Syncope Risk Score – MdCalc

 

RCT: Dobutamine-sparing vs. dobutamine-to-all strategy in cardiac surgery

9 Feb, 2021 | 00:57h | UTC

Dobutamine-sparing versus dobutamine-to-all strategy in cardiac surgery: a randomized noninferiority trial – Annals of Intensive Care

 

Thrombosis and COVID-19: Controversies and (Tentative) Conclusions

9 Feb, 2021 | 01:41h | UTC

Thrombosis and COVID-19: Controversies and (Tentative) Conclusions – Clinical Infectious Diseases

 

Commentary on Twitter

 

Small RCT: Peginterferon lambda increases viral clearance in outpatients with COVID-19

9 Feb, 2021 | 01:36h | UTC

Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial – The Lancet Respiratory Medicine

 

Mitigating inequities and saving lives with ICU triage during the COVID-19 pandemic

9 Feb, 2021 | 01:29h | UTC

Mitigating Inequities and Saving Lives with ICU Triage during the COVID-19 Pandemic – American Journal of Respiratory and Critical Care Medicine

Commentary: More on the allocation of scarce medical resources during the pandemic, and a lack of consensus among bioethicists about how to proceed

 

ARDS: Contemporary management and novel approaches during COVID-19

9 Feb, 2021 | 01:31h | UTC

Acute Respiratory Distress Syndrome: Contemporary Management and Novel Approaches during COVID-19 – Anesthesiology

 

Commentary on Twitter

 

RCT: In patients with cirrhosis treated with TIPS, prophylactic rifaximin reduced the risk for Hepatic Encephalopathy

7 Feb, 2021 | 21:10h | UTC

The Use of Rifaximin in the Prevention of Overt Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Rifaximin prevents overt hepatic encephalopathy after TIPS – HealthDay

 

Commentary on Twitter

 

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