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Critical Care & Emergencies (all articles)

Case series: Vaccine-induced thrombocytopenia with severe headache may precede cerebral venous sinus thrombosis by several days – patients with severe headache 5 to 20 days after adenovirus vector vaccination against Covid-19 should undergo immediate testing for thrombocytopenia and d-dimer levels and, if available, testing for anti–PF4–heparin IgG antibodies.

16 Sep, 2021 | 10:14h | UTC

Vaccine-Induced Thrombocytopenia with Severe Headache – New England Journal of Medicine

 

Commentary on Twitter

 

Review | Acute myocarditis: etiology, diagnosis and management.

17 Sep, 2021 | 09:51h | UTC

Acute myocarditis: aetiology, diagnosis and management – Clinical Medicine Journal

 

RCT: Remdesivir does not improve outcomes in patients admitted to hospital with COVID-19.

15 Sep, 2021 | 09:59h | UTC

Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial – The Lancet Infectious Diseases

Invited commentary: Remdesivir, on the road to DisCoVeRy – The Lancet Infectious Diseases

Related:

Systematic Review: “Remdesivir probably has little or no effect on all‐cause mortality at up to 28 days in hospitalized adults with SARS‐CoV‐2 infection. We are uncertain about the effects of remdesivir on clinical improvement and worsening”.

WHO Solidarity Trial: Remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-19

 

Management of high-risk pulmonary embolism in pregnancy.

15 Sep, 2021 | 08:43h | UTC

Management of high-risk pulmonary embolism in pregnancy – Thrombosis Research

 

Viewpoint | The management of multi-morbidity in elderly patients: Ready yet for precision medicine in intensive care?

14 Sep, 2021 | 08:47h | UTC

The management of multi-morbidity in elderly patients: Ready yet for precision medicine in intensive care? – Critical Care

 

Antifungal Susceptibility Testing: A Primer for Clinicians.

14 Sep, 2021 | 08:46h | UTC

Antifungal Susceptibility Testing: A Primer for Clinicians – Open Forum Infectious Diseases

 

Commentary on Twitter

 

‘Do not resuscitate’ decision recorded for only 1 in 5 very sick hospitalized older patients, study finds

14 Sep, 2021 | 08:40h | UTC

‘Do not resuscitate’ decision recorded for only 1 in 5 very sick older patients, study finds – News Medical

Original study: Do not attempt cardiopulmonary resuscitation (DNACPR) decisions for older medical inpatients: a cohort study – BMJ Supportive & Palliative Care

 

Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications.

12 Sep, 2021 | 21:46h | UTC

Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications – Intensive Care Medicine

 

Commentary on Twitter

 

Study suggests mobile stroke units (ambulances with staff and a CT scanner that may enable faster thrombolysis) may improve outcomes for ischemic stroke patients.

12 Sep, 2021 | 21:41h | UTC

Prospective, Multicenter, Controlled Trial of Mobile Stroke Units – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Patients treated by mobile stroke units had better outcomes, according to study published in NEJM – University of Texas Health Science Center at Houston

 

Commentary on Twitter (video – click to view)

https://twitter.com/NEJM/status/1436690999426748416

 

RCT: Convalescent plasma does not improve outcomes and may be harmful to hospitalized patients with COVID-19.

10 Sep, 2021 | 05:37h | UTC

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial – Nature Medicine

News release: Major study finds convalescent plasma doesn’t help seriously ill COVID-19 patients – McMaster University

Related:

NIH study shows no significant benefit of convalescent plasma for COVID-19 outpatients with early symptoms.

M-A: Convalescent plasma is safe but does not improve outcomes in the treatment of COVID-19.

RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.

 

Commentary on Twitter

 

Ten strategies to optimize early mobilization and rehabilitation in intensive care.

10 Sep, 2021 | 05:14h | UTC

Ten strategies to optimize early mobilization and rehabilitation in intensive care – Critical Care

 

The Lancet Series: Out-of-hospital cardiac arrest 2021.

9 Sep, 2021 | 09:07h | UTC

Homepage: Out-of-hospital cardiac arrest 2021 (free registration required for both articles)

Cardiopulmonary resuscitation in special circumstances

Brain injury after cardiac arrest

 

Commentary on Twitter (thread – click for more)

 

RCT: A Seven-days course of antibiotics for the treatment of bloodstream infections by Enterobacterales was noninferior to a 14-days course.

9 Sep, 2021 | 09:03h | UTC

Seven versus 14-days course of antibiotics for the treatment of bloodstream infections by Enterobacterales. A randomized, controlled trial – Clinical Microbiology and Infection

 

Commentary on Twitter

 

Review: Management of severe traumatic brain injury in regions with limited resources.

9 Sep, 2021 | 08:56h | UTC

Management of severe traumatic brain injury in regions with limited resources – Brain Injury

 

Cochrane review: evidence is insufficient to draw meaningful conclusions if SARS‐CoV‐2-specific monoclonal antibodies are effective in the treatment of COVID-19.

7 Sep, 2021 | 21:51h | UTC

Summary: Are laboratory-made, COVID-19-specific monoclonal antibodies an effective treatment for COVID-19? – Cochrane Library

Original review: SARS‐CoV‐2‐neutralising monoclonal antibodies for treatment of COVID‐19 – Cochrane Library

 

Supplement: Current Issues in Venous Thromboembolism.

7 Sep, 2021 | 21:36h | UTC

Homepage: Current Issues in Venous Thromboembolism – Postgraduate Medicine

Editorial: Current issues in venous thromboembolism

A review of upper extremity deep vein thrombosis

Outpatient treatment of emergency department patients diagnosed with venous thromboembolism

Venous thromboembolism prophylaxis in high-risk orthopedic and cancer surgery

Prophylaxis and treatment of COVID-19 related venous thromboembolism

Challenges in the diagnostic approach of suspected pulmonary embolism in COVID-19 patients

Catheter-directed thrombolysis and mechanical intervention in deep venous thrombosis: what is the status after the ATTRACT trial?

Post-hospital discharge venous thromboembolism prophylaxis in medically ill patients

Radiologic mimics of pulmonary embolism

A comprehensive review of DOACs for cancer associated VTE prophylaxis or treatment

 

Isn’t it time to abandon ARDS? The COVID-19 lesson.

7 Sep, 2021 | 21:34h | UTC

Isn’t it time to abandon ARDS? The COVID-19 lesson – Critical Care

 

Commentary on Twitter

 

Annual Update in Intensive Care and Emergency Medicine 2021 – Covid articles.

7 Sep, 2021 | 10:50h | UTC

Secondary infections in critically ill patients with COVID-19

Tracheostomy for COVID-19: evolving best practice

See also: Non-Covid articles

 

Case series: COVID-19 mRNA vaccination leading to CNS inflammation.

7 Sep, 2021 | 10:49h | UTC

COVID-19 mRNA vaccination leading to CNS inflammation: a case series – Journal of Neurology

 

Medical, ethical, and legal aspects of end-of-life dilemmas in the intensive care unit.

7 Sep, 2021 | 10:37h | UTC

Medical, ethical, and legal aspects of end-of-life dilemmas in the intensive care unit – Cleveland Clinic Journal of Medicine

 

Cohort study: Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest.

7 Sep, 2021 | 10:41h | UTC

Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest – Intensive Care Medicine

 

Commentary on Twitter

 

Annual Update in Intensive Care and Emergency Medicine 2021 – Non-Covid articles.

7 Sep, 2021 | 10:43h | UTC

Advanced management of intermediate-high risk pulmonary embolism

Pathophysiology and clinical implications of the veno-arterial PCO2 gap

To prone or not to prone ARDS patients on ECMO

Management of acute metabolic acidosis in the ICU: sodium bicarbonate and renal replacement therapy

Acute kidney injury in ECMO patients

Monitoring and modifying brain oxygenation in patients at risk of hypoxic ischaemic brain injury after cardiac arrest

Measuring vitamin C in critically ill patients: clinical importance and practical difficulties—Is it time for a surrogate marker?

Still a place for aortic counterpulsation in cardiac surgery and patients with cardiogenic shock?

See also: Covid articles

 

Podcast: The Best of Liver Tests.

7 Sep, 2021 | 10:29h | UTC

#293 The Best of Liver Tests with Dr. Elliot Tapper – The Curbsiders

 

RCT: Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels.

6 Sep, 2021 | 11:11h | UTC

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial – Nature Medicine

 

Commentary on Twitter

 

Study shows cardiac troponin concentrations at presentation are insufficient to distinguish type 1 myocardial infarction from other causes of myocardial injury.

6 Sep, 2021 | 10:42h | UTC

Cardiac Troponin Thresholds and Kinetics to Differentiate Myocardial Injury and Myocardial Infarction – Circulation

 

Commentary on Twitter

 

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