Critical Care & Emergencies (all articles)
Study: Changes in End-of-Life Practices in European Intensive Care Units From 1999 to 2016
7 Oct, 2019 | 01:12h | UTCChanges in End-of-Life Practices in European Intensive Care Units From 1999 to 2016 – JAMA (free for a limited period)
Editorial: A Measured Dose of Optimism for the Evolution of ICU-Based Palliative Care (free for a limited period)
[Abstract Only] Study: Similar Outcomes with Medical Management or Mechanical Thrombectomy in Mild Strokes
7 Oct, 2019 | 00:56h | UTCMedical Management vs Mechanical Thrombectomy for Mild Strokes: An International Multicenter Study and Systematic Review and Meta-analysis – JAMA Neurology (link to abstract – $ for full-text)
Commentaries: Medical Therapy Vs Endovascular Therapy: Similar Outcomes for Mild Strokes – Neurology Today (free) AND Similar Benefits for Thrombectomy, Medical Management, in Mild Stroke – Medscape (free)
Related Commentary on Twitter
Mechanical #thrombectomy shows similar efficacy & safety profile compared w/ best medical management for patients with #stroke with mild-deficits emergency large-vessel occlusion. Study details in @JAMANeuro. https://t.co/UIP728yfI6
— Neurology Today (@NeurologyToday) September 25, 2019
[Abstract Only] Randomized Trial: Therapeutic Hypothermia Beneficial for Patients with Cardiac Arrest and Nonshockable Rhythm
3 Oct, 2019 | 08:16h | UTCTargeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Cooling cardiac arrest patients may protect brain function – UPI (free) AND Hypothermia Helps After Cardiac Arrest With Nonshockable Rhythm – MedPage Today (free registration required)
Randomized Trial: Postextubation High-Flow Nasal Oxygen + Noninvasive Ventilation vs. High-Flow Nasal Oxygen Alone to Prevent Reintubation
3 Oct, 2019 | 08:04h | UTCEffect of Postextubation High-Flow Nasal Oxygen With Noninvasive Ventilation vs High-Flow Nasal Oxygen Alone on Reintubation Among Patients at High Risk of Extubation Failure: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Added Benefit of Noninvasive Ventilation to High-Flow Nasal Oxygen to Prevent Reintubation in Higher-Risk Patients (free for a limited period)
In this RCT involving mechanically ventilated patients at high risk of extubation failure, high-flow nasal oxygen with NIV immediately after extubation decreased risk of reintubation compared with high-flow nasal oxygen alone https://t.co/YJD2yOU5Hw #LIVES2019
— JAMA (@JAMA_current) October 3, 2019
ATS/IDSA Guideline: Diagnosis and Treatment of Adults with Community-acquired Pneumonia
2 Oct, 2019 | 02:14h | UTCNews Release: ATS/IDSA publishes clinical guideline on community acquired pneumonia – American Thoracic Society (free)
See also: Executive Summary (free PDF)
Randomized Trial: Conflicting Results in Small Trial Testing Vitamin C for Sepsis and Severe Acute Respiratory Failure, Further Trials are Required
2 Oct, 2019 | 02:04h | UTCEffect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Is High-Dose Vitamin C Beneficial for Patients With Sepsis? (free)
Commentary: ‘Tantalizing’ Results For A Test Of Vitamin C For Sepsis – NPR (free)
In exploratory analyses that did not adjust for multiple comparisons, 3 secondary outcomes (out of 46 examined) were significantly different between groups. At day 28, mortality was 46.3% (38/82) in the placebo group vs 29.8% (25/84) in the vitamin C group (P = .03). The number of ICU-free days to day 28 was 10.7 in the vitamin C group vs 7.7 in the placebo group (P = .03). The number of hospital-free days in the vitamin C group vs the placebo group was 22.6 vs 15.5, respectively (P = .04).
CDC Report: 76.9% of Patients with Vaping-related Lung Illnesses Used a THC-Containing Product
30 Sep, 2019 | 00:56h | UTCCommentaries: Many patients with vaping-related illnesses used THC, CDC reports – STAT (free) AND THC vape products may be the main culprit in the mysterious lung illness outbreak – Vox (free) AND U.S. CDC recommends against using vapes with marijuana ingredient – Reuters (free)
Related: Preliminary Report: Pulmonary Illness Related to E-Cigarette Use (free resources)
Special Issue: Nutrition in Critical Illness
30 Sep, 2019 | 00:50h | UTCHomepage: Nutrition – ICU Management & Practice (free articles)
– Editorial by Prof. Jean-Louis Vincent, MD, PhD
– New ESPEN Guidelines for Nutrition in the Critically Ill: Help, What Happened!?
– Emerging Concepts in Nutritional Therapy for the Critically Ill Child
– Obesity and Nutrition in Critical Illness
– Objective Malnutrition Diagnosis and Personalised Nutrition Delivery in the ICU
– The Role of Speech and Language Therapy Supporting Nutritional Management in ICU
Infographic: An overview of nutrition management in the ICU
[Abstract Only] Randomized Trial: Standard Valsalva vs. Modified Valsalva for Cardioversion of SVT
30 Sep, 2019 | 00:14h | UTCStandard Valsalva vs Modified Valsalva for Cardioversion of SVT? – REBELEM (free)
Original Study: A multicenter randomized controlled trial of a modified Valsalva maneuver for cardioversion of supraventricular tachycardias – The American Journal of Emergency Medicine (link to abstract – $ for full-text)
Related Study: Postural modification to the standard Valsalva manoeuvre for emergency treatment of supraventricular tachycardias (REVERT): a randomised controlled trial – The Lancet (free), Commentaries: Supraventricular tachycardia: back to basics – The Lancet (free) AND The REVERT Trial: A Modified Valsalva Maneuver to Convert SVT – REBELEM (free)
Randomized Trial: Protocolized Non-invasive vs. Invasive Weaning from Mechanical Ventilation for Adults in Intensive Care
30 Sep, 2019 | 00:16h | UTCSource: Critical Care Reviews Newsletter
“A protocolized non-invasive weaning strategy did not reduce time to liberation from ventilation. However, patients who underwent non-invasive weaning had fewer days requiring IMV and required fewer antibiotics for respiratory infections.”
Consensus Statement: Diagnosis and Management of Guillain–Barré Syndrome in Ten Steps
27 Sep, 2019 | 08:35h | UTCDiagnosis and management of Guillain–Barré syndrome in ten steps – Nature Reviews Neurology (free)
Report: State of the Clinical Science of Perioperative Brain Health
26 Sep, 2019 | 08:43h | UTC
Guideline Synopsis: Prevention and Management of Venous Thromboembolism
25 Sep, 2019 | 08:33h | UTCPrevention and Management of Venous Thromboembolism – JAMA (free for a limited period)
Clinical Review Audio: An Update on the Diagnosis and Treatment of Venous Thromboembolic Disease (free)
Original American Society of Hematology 2018 Guidelines: Prophylaxis for hospitalized and nonhospitalized medical patients (free) AND Diagnosis of venous thromboembolism (free) AND Optimal management of anticoagulation therapy (free) AND Treatment of pediatric venous thromboembolism (free) AND Venous thromboembolism in the context of pregnancy (free) AND Heparin-induced thrombocytopenia (free)
Position Paper: Withholding and Withdrawing Life-support in Adults in Emergency Care
25 Sep, 2019 | 08:31h | UTC
Acute Ischemic Stroke: Challenges for the Intensivist
25 Sep, 2019 | 08:14h | UTCAcute ischaemic stroke: challenges for the intensivist – Intensive Care Medicine (free)
Source: Critical Care Reviews Newsletter
Organophosphorus Nerve Agent Poisoning: Managing the Poisoned Patient
25 Sep, 2019 | 07:56h | UTCSource: Critical Care Reviews Newsletter
Metabolic Support in the Critically Ill: A Consensus of 19
20 Sep, 2019 | 08:12h | UTCMetabolic support in the critically ill: a consensus of 19 – Critical Care (free) (via Park M, MD)
Meta-analysis: Preoxygenation Before Intubation in Adult Patients with Acute Hypoxemic Respiratory Failure
20 Sep, 2019 | 08:14h | UTCPreoxygenation before intubation in adult patients with acute hypoxemic respiratory failure: a network meta-analysis of randomized trials – Critical Care (free) (via Park M, MD)
Editorial: How I Wean Patients from Veno-venous Extra-corporeal Membrane Oxygenation
20 Sep, 2019 | 07:43h | UTCHow I wean patients from veno-venous extra-corporeal membrane oxygenation – Critical Care (free) (via Park M, MD)
Less is More in Critical Care is Supported by Evidence-based Medicine
19 Sep, 2019 | 08:15h | UTCLess is more in critical care is supported by evidence-based medicine – Intensive Care Medicine (free for a limited period)
Related: Less is More: Ten Reasons for Considering to Discontinue Unproven Interventions (free commentaries)
Less is More in Nutrition: Critically ill Patients are Starving but not Hungry
19 Sep, 2019 | 08:13h | UTC
[Abstract Only] Study: Blood Culture Results Before and After Antimicrobial Administration in Patients with Severe Manifestations of Sepsis
18 Sep, 2019 | 10:12h | UTCBlood Culture Results Before and After Antimicrobial Administration in Patients with Severe Manifestations of Sepsis: A Diagnostic Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Initiating empirical therapy for sepsis reduces blood culture sensitivity – MedicalXpress (free) AND Study changes guidelines for sepsis management – University of Arizona College of Medicine (free)
What’s New in Airway Management of the Critically ill
18 Sep, 2019 | 02:39h | UTCWhat’s new in airway management of the critically ill – Intensive Care Medicine (free)
New NICE Guidelines: Management of Pneumonia in Adults
17 Sep, 2019 | 08:31h | UTCDiagnosis and Management Pneumonia in Adults – National Institute for Health and Care Excellence (free)
Related NICE Guidelines: Pneumonia (community-acquired): antimicrobial prescribing (free) AND Pneumonia (hospital-acquired): antimicrobial prescribing (free)
See also: NICE Antimicrobial prescribing guidelines (resource covering many common conditions) AND NICE Summary of antimicrobial prescribing guidance – managing common infections (free PDF)
Less is More: Catecholamine-sparing Strategies in Septic Shock
17 Sep, 2019 | 07:38h | UTCLess is more: catecholamine-sparing strategies in septic shock – Intensive Care Medicine (free for a limited period)