Emergency Medicine
Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis
2 Apr, 2021 | 09:23h | UTCCommentaries: Covid-19 led to a global increase in stillbirths, maternal mortality, and depression, review finds – CNN AND COVID-19 pandemic and health-care disruptions: count the most vulnerable – The Lancet Global Health
Commentary on Twitter
NEW—Pregnancy outcomes worsened during the #COVID19 pandemic worldwide, with an increase in maternal deaths, stillbirth, ruptured ectopic pregnancies, and maternal depression.
New review of 40 studies from 17 countries in @LancetGH: https://t.co/GWBohu6b6k pic.twitter.com/4RzgtShYeH
— The Lancet (@TheLancet) April 1, 2021
Rapid point-of-care tests for diagnosing COVID-19 infection: the latest Cochrane evidence
2 Apr, 2021 | 09:21h | UTCOriginal review and commentaries: Systematic review: Rapid, point‐of‐care antigen and molecular‐based tests for diagnosis of SARS‐CoV‐2 infection
Therapeutics and COVID-19 | WHO guideline update advises Ivermectin should only be used to treat COVID-19 within clinical trials
1 Apr, 2021 | 04:02h | UTCSummary and Infographic: Drug treatments for covid-19: living systematic review and network meta-analysis – The BMJ
Original guideline: Therapeutics and COVID-19: living guideline – World Health Organization
News release: WHO advises that ivermectin only be used to treat COVID-19 within clinical trials – World Health Organization
Commentary: WHO joins Europe, Merck in recommending against ivermectin for COVID-19 – Reuters
Commentary on Twitter
?Our updated @WHO #LivingGuidance on #COVID19 now adding recommandation on #ivermectin to previous recs on #steroids #remdesivir #lopinavir #Hydroxychloroquine
?https://t.co/eV7BtVrvAf
?https://t.co/G3Eu18Vg0s#MichaelJacobs @Bram_Rochwerg @PerVandvik @diazjv @bmj_latest https://t.co/qdrBQIZK8e pic.twitter.com/s9TkO1afYs— Thomas Agoritsas, MD PhD (@ThomasAgoritsas) March 31, 2021
ERAS Guidelines for Perioperative Care for Emergency Laparotomy: Part 1—Preoperative: Diagnosis, Rapid Assessment and Optimization
1 Apr, 2021 | 03:35h | UTC
Consensus Document: Management of superficial and deep surgical site infection
1 Apr, 2021 | 03:33h | UTCRelated Guidelines: Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 – JAMA Surgery AND Global guidelines on the prevention of surgical site infection – World Health Organization AND Surgical site infections: prevention and treatment – National Institute for Health and Care Excellence AND APSIC guidelines for the prevention of surgical site infections – Antimicrobial Resistance & Infection Control
Troponin Testing in Patients With Supraventricular Tachycardia—Are We Overtesting? A Teachable Moment
30 Mar, 2021 | 03:07h | UTCTroponin Testing in Patients With Supraventricular Tachycardia—Are We Overtesting? A Teachable Moment – JAMA Internal Medicine (free for a limited period)
Invited Commentary: Updating Our Thinking on Troponin Use and Interpretation (free for a limited period)
Science, Medicine, and the Anesthesiologist – Key Papers from the Most Recent Literature Relevant to Anesthesiologists
30 Mar, 2021 | 02:59h | UTCScience, Medicine, and the Anesthesiologist – Anesthesiology
Analysis of conflicts of interest among authors and researchers of European clinical guidelines in cardiovascular medicine
30 Mar, 2021 | 02:53h | UTC
Commentary on Twitter (thread – click for more)
We've just published in @Clin_Med our analysis of financial conflicts of interest (CoIs) amongst the authors of 5 ESC Guidelines. What we found was quite surprising. We would love to know what you all think!https://t.co/U371ROXGAv
Let's start with a poll ??
— Benoy Shah MD ? (@dr_benoy_n_shah) March 28, 2021
The management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: key points from the ESC 2020 Clinical Practice Guidelines for the general and emergency physician
30 Mar, 2021 | 02:51h | UTC
COVID-19, Personal Protective Equipment, and Human Performance
30 Mar, 2021 | 03:14h | UTCCOVID-19, Personal Protective Equipment, and Human Performance – Anesthesiology
Cochrane Library Editorial: Contested effects and chaotic policies: the 2020 story of (hydroxy) chloroquine for treating COVID‐19
28 Mar, 2021 | 22:55h | UTCCommentary and Infographic: Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus? – Cochrane Library
Original review: Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19 – Cochrane Library
Commentary on Twitter
New #VisualAbstract for the @Cochrane_IDG systematic review on #Chloroquine or #hydroxychloroquine for prevention and treatment of #COVID19 https://t.co/U7TnMzQTil Many thanks to @tylerdau & @cg_coleman from @EmoryMedicine pic.twitter.com/tlFKKa31E8
— The Cochrane Library (@CochraneLibrary) March 25, 2021
Effect of timing of intubation on clinical outcomes of critically ill patients with COVID-19: a systematic review and meta-analysis of non-randomized cohort studies
30 Mar, 2021 | 03:12h | UTC
Commentary on Twitter
Proud to present our meta-analysis of a highly-debated topic! The synthesized evidence of almost 9000 critically ill patients with #COVID_19 suggests that #early_intubation, as suggested by several #guidelines, may not be justified. @crit_care
?https://t.co/eClJlHhYDp pic.twitter.com/DVIop0yGmM
— Vassilis Giannakoulis (@VGiannakoulis) March 27, 2021
RCT: Discontinuing betalactam treatment after 3 days as good as 8 days of treatment for stable patients with community-acquired pneumonia in non-critical care wards
28 Mar, 2021 | 22:25h | UTC
Commentary on Twitter
Less can be more for pneumonia. In 50% CAP patients was possible stop Abx at 3 days and outcomes were the same @TheLancet https://t.co/Hc1AxyndWS pic.twitter.com/Ypk2uXeDQV
— Michael Marks (@dr_michaelmarks) March 26, 2021
Long term outcomes of participants in the PARAMEDIC2 randomized trial of adrenaline in out-of-hospital cardiac arrest – although survival was improved, adrenalin was not associated with favorable neurologic outcomes
28 Mar, 2021 | 22:21h | UTCCommentary: PARAMEDIC2 – Epinephrine vs Placebo OHCA 6-12 Months – Journal Feed
Original study: Randomized Trial: Epinephrine in Out-of-Hospital Cardiac Arrest (study and commentaries) AND Opinion: Epinephrine Harms/Helps in Out of Hospital Cardiac Arrest
Another study indicates SARS-CoV-2 variant B.1.351, but not variant B.1.1.7, has partial resistance to neutralizing antibodies generated by natural infection or mRNA vaccination
28 Mar, 2021 | 22:53h | UTC
Commentaries on Twitter
Now a peer-reviewed pub in a top journal, this elegant study clearly shows that variant B.1.351 isn't stopped by antibodies from prior infection or the Pfizer vax. We'll have revised vaccines, but we don't yet. Please behave accordingly. https://t.co/w8GHPDB7aL
— EQV Analytics (@AnalyticsEqv) March 27, 2021
New @NatureMedicine, further data on immune response after vaccination to 2 variants, B.1.1.7 (UK) and B.1.351 (SA). Reinforcing recent reports, the latter is more of an immune evader, and may pose vulnerability for reinfection post-vaccinehttps://t.co/w8xFc3fkh5 pic.twitter.com/i7DAnjSZwE
— Eric Topol (@EricTopol) March 26, 2021
How COVID-19 Affects the Brain
28 Mar, 2021 | 22:51h | UTCHow COVID-19 Affects the Brain – JAMA Psychiatry
Commentary on Twitter
#COVID19 brain symptoms are a rising concern. Mechanisms of brain damage by the virus include lasting neuroinflammation, thrombotic events and alteration of neurotransmitters release. Consequently, people suffer cognitive, emotional and behavioral symptoms https://t.co/pTzJo6DLV8
— JAMA Psychiatry (@JAMAPsych) March 26, 2021
Interleukin‐6 blocking agents for treating COVID‐19: a living systematic review
28 Mar, 2021 | 22:40h | UTCInterleukin‐6 blocking agents for treating COVID‐19: a living systematic review – Cochrane Library
Commentary on Twitter
JUST PUBLISHED – Interleukin‐6 blocking agents for treating #COVID19 https://t.co/pt8BNfBwa3 New living systematic review from @Cochrane_ACE looks at the evidence from 10 studies in 6896 people with COVID‐19 pic.twitter.com/hjs97lPBEt
— Cochrane UK (@CochraneUK) March 26, 2021
RCT: Metoclopramide + diphenhydramine more efficacious than placebo for acute post-traumatic headache in the ED
26 Mar, 2021 | 08:24h | UTCRandomized Study of Metoclopramide Plus Diphenhydramine for Acute Posttraumatic Headache – Neurology (link to abstract – $ for full-text)
Commentary: Drug Combo Superior to Placebo for Posttraumatic Headache – HealthDay
State of the Art Review | Management of colonic diverticulitis
25 Mar, 2021 | 08:14h | UTCManagement of colonic diverticulitis – The BMJ
Commentary on Twitter
NEW ??State of the Art Clinical Review @bmj_latest
Management of colonic diverticulitis #IDTwitter https://t.co/aUOGYZ8I4n pic.twitter.com/vYjzQ50LY1— Antibiotic Steward??Bassam Ghanem (@ABsteward) March 24, 2021
Covid: The London bus trip that saved maybe a million lives (about the creation of the RECOVERY Trial)
26 Mar, 2021 | 08:53h | UTCCovid: The London bus trip that saved maybe a million lives – BBC
Related: Covid-19: The Inside Story of the RECOVERY Trial
Commentary on Twitter
Very cool story by @JamesTGallagher about a convo on a London bus that led to the creation of the RECOVERY trial, which has been a shining (& too rare) example of how to do critical research in a pandemic. Bravo @PeterHorby & @MartinLandray h/t @hildabast https://t.co/BRSJLSFXdc
— Helen Branswell (@HelenBranswell) March 25, 2021
RCT: Aspirin NOT noninferior to vitamin K antagonists in the treatment of cervical artery dissection
24 Mar, 2021 | 08:09h | UTCAspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial – The Lancet Neurology (link to abstract – $ for full-text)
International study describes peri-intubation incidence of adverse events in critically ill patients
24 Mar, 2021 | 08:08h | UTCIntubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries – JAMA (free for a limited period)
Editorial: International Variation in Intubation and Extubation Practices and Adverse Events Among Critically Ill Patients Receiving Mechanical Ventilation – JAMA (free for a limited period)
Systematic review: Rapid, point‐of‐care antigen and molecular‐based tests for diagnosis of SARS‐CoV‐2 infection
25 Mar, 2021 | 08:38h | UTCCommentaries: Updated Cochrane review assesses how accurate rapid tests are for detecting COVID-19 – Wiley AND Expert reaction to updated Cochrane review of studies on accuracy of rapid tests (including lateral flow and molecular tests) to detect SARS-CoV-2 – Science Media Centre
NICE publishes single guideline for managing COVID-19
24 Mar, 2021 | 08:42h | UTCNews release: COVID-19 rapid guideline: managing COVID-19 – National Institute for Health and Care Excellence
Commentary on Twitter
Today NICE has published a single guideline for managing COVID-19, which brings together content from previous rapid COVID-19 guidance and evidence summaries. Read more: https://t.co/3O5yzpHK9e pic.twitter.com/DyD7lcLX8v
— NICE (@NICEComms) March 23, 2021
Review: Management of Staphylococcus aureus Bloodstream Infections
23 Mar, 2021 | 02:13h | UTCManagement of Staphylococcus aureus Bloodstream Infections – Frontiers in Medicine