Emergency Medicine
Perspective | Ivermectin is the new Hydroxychorloquine
16 Apr, 2021 | 06:28h | UTCIvermectin is the new Hydroxychorloquine – Science-Based Medicine
Were pregnant women more affected by COVID-19 in the second wave of the pandemic?
16 Apr, 2021 | 06:24h | UTCWere pregnant women more affected by COVID-19 in the second wave of the pandemic? – The Lancet
Pandemic Boosts an Old Idea—Bringing Acute Care to the Patient
15 Apr, 2021 | 06:51h | UTCPandemic Boosts an Old Idea—Bringing Acute Care to the Patient – JAMA
Related studies: Cohort Study: Selected patients with Covid-19 can be safely discharged on home oxygen, with low mortality and readmission rates AND Association of a Bundled Hospital-at-Home and 30-Day Postacute Transitional Care Program With Clinical Outcomes and Patient Experiences – JAMA Internal Medicine
Case Report: Thrombotic Thrombocytopenia after Johnson & Johnson Vaccine
15 Apr, 2021 | 07:02h | UTCThrombotic Thrombocytopenia after Ad26.COV2.S Vaccination – New England Journal of Medicine
Related: U.S. regulators pause Johnson & Johnson vaccine rollout over rare (1 in a million) cases of blood clots AND 4 Things to Know About the J&J Covid Vaccine Pause – Kaiser Health News AND Why Johnson & Johnson shots were paused — and why that’s so confusing – Vox AND Is it the adenovirus vaccine technology, used by AstraZeneca and Johnson & Johnson, causing blood clots? There’s no evidence yet – The Conversation
New studies suggest SARS-CoV-2 variant B.1.1.7 is not more deadly, just more transmissible
14 Apr, 2021 | 02:12h | UTCCommentaries: Expert reaction to two papers looking at the transmissibility and severity of the B.1.1.7 variant – Science Media Centre AND UK coronavirus variant not more deadly, just spreads more easily, studies find – LiveScience
Study: Protocoled time-limited trials among critically ill patients with advanced medical illnesses were associated with reduction of nonbeneficial ICU treatments
13 Apr, 2021 | 05:16h | UTCEvaluation of Time-Limited Trials Among Critically Ill Patients With Advanced Medical Illnesses and Reduction of Nonbeneficial ICU Treatments – JAMA Internal Medicine (free for a limited period)
Commentary: Time-Limited Trials and Potentially Nonbeneficial Treatment in the ICU—Willing to Wait for It – JAMA Internal Medicine AND Time-limited trials may decrease the length of stay of critically ill patients in the intensive care unit – 2 Minute Medicine
Author interview: Time-Limited Trials Among Patients With Advanced Illness to Reduce Nonbeneficial ICU Treatments
Related review: Time-limited trial of intensive care treatment: an overview of current literature – Intensive Care Medicine
RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19
13 Apr, 2021 | 05:30h | UTCOriginal study (preprint): Inhaled budesonide for COVID-19 in people at higher risk of adverse outcomes in the community: interim analyses from the PRINCIPLE trial – medRxiv
Commentary: Covid: Asthma drug ‘speeds up recovery at home’ – BBC
Related study: Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19 (study and commentaries)
Cohort Study: Effects of fluoroquinolones on outcomes of patients with aortic dissection or aneurysm
13 Apr, 2021 | 05:05h | UTCRelated: Another study suggests fluoroquinolone use may increase the risk of development of aortic aneurysms (study and commentaries) AND Link between fluoroquinolones, aorta problems may not be as strong as thought AND Study: Oral Fluoroquinolones and Risk of Mitral and Aortic Regurgitation AND FDA Warns About Increased Risk of Aortic Dissection and Ruptures of Aortic Aneurism with Fluoroquinolones AND Meta-analysis: Fluoroquinolones and the Risk of Aortopathy AND Study: Oral Fluoroquinolone and the Risk of Aortic Dissection AND Research: Fluoroquinolone use and risk of aortic aneurysm and dissection
AHA/ASA Scientific Statement: Perioperative Neurological Evaluation and Management to Lower the Risk of Acute Stroke in Patients Undergoing Noncardiac, Nonneurological Surgery
12 Apr, 2021 | 00:50h | UTC
Commentary on Twitter
NEW GUIDELINE – now codifies what has been discussed for a while "If history of stroke exists, consider delaying elective surgery at least 6 mo
and preferably 9 mo from time of incident stroke." @SPAQIedu @LeeAFleisher @preopconsult @afedwardMD https://t.co/0ewdlPGVlj— Kurt Pfeifer (@KurtPfeifer) April 9, 2021
Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19
13 Apr, 2021 | 05:21h | UTCRelated: Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery AND Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk
[Press release – not published yet] Phase 3 prevention trial showed 81% reduced risk of symptomatic SARS-CoV-2 infections with subcutaneous administration of monoclonal antibodies
13 Apr, 2021 | 05:26h | UTCCommentaries: Regeneron says antibody cocktail prevented Covid when given as simple injection, not an IV – STAT AND Regeneron’s Covid mAb as a prophylactic injection: Reduced risk of symptomatic infection by 81% – Endpoint News
Another study shows intravenous radiocontrast use is not associated with reduced kidney function
12 Apr, 2021 | 00:44h | UTCCommentaries: Radiocontrast Exposure Safe for Kidney Function – HCP Live AND Exposure to contrast on CTPA doesn’t cause long-term kidney injury – AuntMinnie
Related: ACR/NKF Consensus Statement: “The Risk of Acute Kidney Injury Developing in Patients with Reduced Kidney Function Following Exposure to Intravenous Iodinated Contrast Media has Been Overstated” (Guideline and commentaries)
Commentary on Twitter (thread – click for more)
Our new paper in @JAMAInternalMed: is IV contrast nephrotoxic? Lots of studies say no, but have ⬆️risk of confounding: people who get contrast ≠ people who don't get it. We used a natural experiment to try to overcome this bias https://t.co/XWEEohAvK0 1/5
— Robert Goulden (@EMrobg) April 5, 2021
M-A: Treatment for bleeding esophageal varices in people with decompensated liver cirrhosis
12 Apr, 2021 | 00:39h | UTCRelated Cochrane Reviews: M-A: Secondary prevention of variceal bleeding in adults with previous esophageal variceal bleeding due to decompensated liver cirrhosis AND Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network meta‐analysis – Cochrane Library
Comprehensive Review | Pneumonia
9 Apr, 2021 | 03:14h | UTCPneumonia – Nature Reviews Disease Primers (free for a limited period)
Try this link if the above is paywalled.
Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19
12 Apr, 2021 | 01:24h | UTC
Commentary on Twitter
NEW Research— Early administration of inhaled budesonide reduced the likelihood of needing urgent medical care and reduced time to recovery after early #COVID19
RCT from Mona Bafadhel & colleagues https://t.co/6cJogJs7rp pic.twitter.com/C1dhmTcexP
— The Lancet Respiratory Medicine (@LancetRespirMed) April 10, 2021
[Preprint] CoronaVac is 50% effective for reducing symptomatic SARS-CoV-2 infection after the first dose in the setting of high P.1 variant transmission in Brazil
9 Apr, 2021 | 03:36h | UTC
Commentary on Twitter (thread – click for more)
New 50% efficacy study of Brazil-predominant vaccine CoronaVac (by Sinovac) in Manaus ?? among healthcare workers when #P1 ~75% dominant. Not a trial, but the study found a 1st dose >=14-days efficacy of 50% on symptomatic #COVID19, ~32% if +asymptomatic. https://t.co/YMmZ3mmSDI pic.twitter.com/jwx5R627ys
— Eric Feigl-Ding (@DrEricDing) April 8, 2021
Commentary | Distinguishing the real from the hyperglycemia: does COVID-19 induce diabetes?
9 Apr, 2021 | 03:28h | UTC
The NIH COVID-19 Treatment Guidelines Panel’s Statement on the Emergency Use Authorization of Anti-SARS-CoV-2 Monoclonal Antibodies for the Treatment of COVID-19
9 Apr, 2021 | 03:35h | UTC
Study finds low risk of venous thromboembolism in outpatients with Covid-19 – researchers advise against the use of anticoagulants outside clinical trials
8 Apr, 2021 | 08:59h | UTCCommentaries: VTE Related to SARS-CoV-2 Infection Less Of a Problem in Outpatients – TCTMD AND No Increase Seen in Outpatient VTE for SARS-CoV-2-Positive Patients – Physician’s Weekly
Commentary on Twitter (thread – Click for more)
Interesting report on VTE incidence in COVID-19 patients, starting with counting outside of the hospital. See https://t.co/XJvbrfHm6d … 1/n
— Geert-Jan Geersing (@gjgeersing) April 7, 2021
ACP Guidance: Appropriate Use of Short-Course Antibiotics in Common Infections
6 Apr, 2021 | 01:12h | UTCSummary for Patients: Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians
Guidance on syndrome of Thrombosis and Thrombocytopenia occurring after coronavirus Vaccination
7 Apr, 2021 | 01:48h | UTC
Commentary on Twitter
*CLINICIANS*
New guidance for suspected cases of thrombosis-thrombocytopaenia syndrome following COVID-19 vaccination. This is a very rare event but worth bookmarking as it also guides you on what is NOT likely to be a case.MT @Maherjane https://t.co/PHjFlB079y
— Trisha Greenhalgh ? #CovidIsAirborne (@trishgreenhalgh) April 6, 2021
Large study showed no association between blood group types and increased risk of Covid-19
7 Apr, 2021 | 01:41h | UTC
Commentary on Twitter
This case-control study found blood type A was not associated with higher nor type O with lower COVID-19 susceptibility or severity. Blood types were not prognostically useful. https://t.co/P8VpvQWuwE
— JAMA Network Open (@JAMANetworkOpen) April 6, 2021
Diagnostic Test Interpretation: Evaluation of Hypokalemia
6 Apr, 2021 | 01:07h | UTCEvaluation of Hypokalemia – JAMA (free for a limited period)
M-A: Colchicine administration for percutaneous coronary intervention
6 Apr, 2021 | 00:58h | UTCColchicine administration for percutaneous coronary intervention: A meta-analysis of randomized controlled trials – The American Journal of Emergency Medicine (link to abstract – $ for full-text)
Related: Efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomized trials – European Heart Journal (link to abstract – $ for full-text)
Cohort Study: Selected patients with Covid-19 can be safely discharged on home oxygen, with low mortality and readmission rates
5 Apr, 2021 | 01:52h | UTCVideo: Home Oxygen Instructions for Discharged Patients With COVID-19
Commentaries: Covid-19: Ambulatory Management with Home Oxygen Results in Low Mortality, Low Readmissions – Physician’s Weekly AND Mortality, readmission low with COVID-19 discharge on home oxygen – HealthDay
Commentaries on Twitter
Is “HOME O2” safe in #COVID19? @JAMANetworkOpen
N=621 #COVID Pts D/Ced on O2 instead of being kept in hosp. 20% BMI>30, 33% HTN/DM. Only 1.2% 30-d Mort rate & only 8.5% returned for hosp admission. Safe is done right!https://t.co/clZAzEqWwy#medtwitter #CriticalCare #Nurse pic.twitter.com/EInhCdcN6f— WesElyMD (@WesElyMD) April 3, 2021
Cohort study finds #COVID19 patients discharged with home oxygen from the LA safety net public hospital system using an innovative program had similar outcomes to patients not requiring home oxygen. @BradSpellberg @LACUSCMedCenter https://t.co/kZrxVKHB5F
— JAMA Network Open (@JAMANetworkOpen) April 1, 2021