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Emergency Medicine

RCT | 20% albumin vs. plasmalyte in patients with cirrhosis and sepsis-induced hypotension.

11 Jul, 2022 | 12:16h | UTC

A randomized-controlled trial comparing 20% albumin to plasmalyte in patients with cirrhosis and sepsis-induced hypotension [ALPS trial] – Journal of Hepatology

 


Review | Understanding and interpreting artificial intelligence, machine learning and deep learning in Emergency Medicine.

11 Jul, 2022 | 12:02h | UTC

Understanding and interpreting artificial intelligence, machine learning and deep learning in Emergency Medicine – Emergency Medicine Journal (free for a limited period)

 


M-A | Fluid resuscitation with balanced crystalloids vs. normal saline in critically ill patients.

11 Jul, 2022 | 12:00h | UTC

Fluid resuscitation with balanced crystalloids versus normal saline in critically ill patients: a systematic review and meta-analysis – Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Related:

Back to BaSICS – Annals of Emergency Medicine

Effect of Intravenous Fluid Treatment With a Balanced Solution vs 0.9% Saline Solution on Mortality in Critically Ill PatientsThe BaSICS Randomized Clinical Trial – JAMA

Effect of Slower vs Faster Intravenous Fluid Bolus Rates on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial – JAMA

The ongoing saga of normal saline versus balanced fluids – First10EM

Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults – New England Journal of Medicine (link to abstract – $ for full-text)

Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis – NEJM Evidence

Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children – Cochrane Library

 


AHA Scientific Statement | Escalating and de-escalating temporary mechanical circulatory support in cardiogenic shock.

8 Jul, 2022 | 12:05h | UTC

Escalating and De-escalating Temporary Mechanical Circulatory Support in Cardiogenic Shock: A Scientific Statement From the American Heart Association – Circulation

Top Things to Know: Escalating and De-escalating Temporary Mechanical Circulatory Support in Cardiogenic Shock– American Heart Association

Commentary: Guiding Cardiogenic Shock Management: Filling in the (Wide) Data Gaps – American Heart Association

 


RCT | Neutralizing COVID-19 convalescent plasma does not benefit adults hospitalized with COVID-19.

8 Jul, 2022 | 11:59h | UTC

Neutralizing COVID-19 Convalescent Plasma in Adults Hospitalized with COVID-19: A Blinded Randomized Placebo-Controlled Trial – CHEST

Commentary: Study shows convalescent plasma doesn’t benefit severely ill patients hospitalized with COVID-19 – Vanderbilt University Medical Center

 


Interim Analysis | Oral Sabizabulin for high-risk, hospitalized adults with Covid-19.

8 Jul, 2022 | 12:02h | UTC

Oral Sabizabulin for High-Risk, Hospitalized Adults with Covid-19: Interim Analysis – NEJM Evidence

 


Retrospective Cohort Study | Racial bias and reproducibility in pulse oximetry among medical and surgical inpatients.

7 Jul, 2022 | 12:57h | UTC

Racial bias and reproducibility in pulse oximetry among medical and surgical inpatients in general care in the Veterans Health Administration 2013-19: multicenter, retrospective cohort study – The BMJ

News Release: Pulse oximeters missed low oxygen levels in more Black veterans than white veterans – University of Michigan

Related:

Racial and Ethnic Discrepancy in Pulse Oximetry and Delayed Identification of Treatment Eligibility Among Patients With COVID-19 – JAMA Internal Medicine

Racial Bias in Pulse Oximetry Measurement – New England Journal of Medicine

Pulse Oximetry for Monitoring Patients with Covid-19 at Home — A Pragmatic, Randomized Trial – New England Journal of Medicine

Effectiveness and safety of pulse oximetry in remote patient monitoring of patients with COVID-19: a systematic review – The Lancet Digital Health

FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias – STAT

Pulse Oximeter Accuracy and Limitations: FDA Safety Communication – U.S. Food & Drug Administration

 

Commentary on Twitter

 


Coagulation and transfusion updates from 2021.

7 Jul, 2022 | 12:36h | UTC

Coagulation and Transfusion Updates from 2021 – Journal of Cardiothoracic and Vascular Anesthesia

 


M-A | Anticoagulants for thrombosis prophylaxis in acutely ill patients admitted to hospital.

5 Jul, 2022 | 12:19h | UTC

Anticoagulants for thrombosis prophylaxis in acutely ill patients admitted to hospital: systematic review and network meta-analysis – The BMJ


EM Cases | The 7 Ts of massive hemorrhage protocols.

5 Jul, 2022 | 11:35h | UTC

EM Cases: The 7 Ts of Massive Hemorrhage Protocols – emDocs


Guideline Synopsis | Evaluation and diagnosis of chest pain.

4 Jul, 2022 | 12:49h | UTC

Evaluation and Diagnosis of Chest Pain – JAMA (free for a limited period)

Original Guideline:

2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines – Journal of the American College of Cardiology

News Release: First-Ever Guideline Focused Solely on Chest Pain Evaluation, Diagnosis Released

Guideline Hub: Guideline for the Evaluation and Diagnosis of Chest Pain

Key Points: 2021 AHA/ACC Chest Pain Guideline – American College of Cardiology

Commentary: New Chest Pain Guidelines Out at Last: Most Tests Have a Role – TCTMD


RCT: A single immediate dose of intravenous tenecteplase is noninferior to alteplase for the treatment of patients with acute ischemic stroke.

1 Jul, 2022 | 11:44h | UTC

Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

News Release: UCalgary researchers with the Calgary Stroke Program make another breakthrough in the treatment of stroke

 


Consensus Guidelines: Management of hematoma after thyroid surgery.

30 Jun, 2022 | 11:06h | UTC

Management of haematoma after thyroid surgery: systematic review and multidisciplinary consensus guidelines from the Difficult Airway Society, the British Association of Endocrine and Thyroid Surgeons and the British Association of Otorhinolaryngology, Head and Neck Surgery – Anaesthesia

 


RCT: Two-day vs. seven-day course of levofloxacin in acute COPD exacerbation.

28 Jun, 2022 | 11:19h | UTC

Two-day versus seven-day course of levofloxacin in acute COPD exacerbation: a randomized controlled trial – Therapeutic Advances in Respiratory Disease

Commentary: Antibiotics in COPD Exacerbations – 2 days vs 7 days – RebelEM

 


Guideline for the emergency management of anaphylaxis.

28 Jun, 2022 | 10:59h | UTC

A Clinical Practice Guideline for the Emergency Management of Anaphylaxis – Frontiers in Pharmacology

Related:

Wilderness Medical Society Clinical Practice Guidelines on Anaphylaxis – Wilderness and Environmental Medicine

Guideline (S2k) on acute therapy and management of anaphylaxis: 2021 update – Allergo Journal International

EAACI guidelines: Anaphylaxis (2021 update) – European Journal of Allergy and Immunology

 


Systematic Review: Antibiotics for uncomplicated diverticulitis.

27 Jun, 2022 | 11:56h | UTC

Antibiotics for uncomplicated diverticulitis – Cochrane Library

Summary: Antibiotics for uncomplicated diverticulitis – Cochrane Library

Related:

Efficacy and Safety of Non-Antibiotic Outpatient Treatment in Mild Acute Diverticulitis (DINAMO-study): A Multicentre, Randomised, Open-Label, Non-Inferiority Trial – Annals of Surgery (link to abstract – $ for full-text)

The WSES/SICG/ACOI/SICUT/AcEMC/SIFIPAC guidelines for diagnosis and treatment of acute left colonic diverticulitis in the elderly – World Journal of Emergency Surgery

Diagnosis and Management of Acute Left-Sided Colonic Diverticulitis: A Clinical Guideline From the American College of Physicians – Annals of Internal Medicine

Colonoscopy for Diagnostic Evaluation and Interventions to Prevent Recurrence After Acute Left-Sided Colonic Diverticulitis: A Clinical Guideline From the American College of Physicians – Annals of Internal Medicine

Changing Paradigms in the Management of Acute Uncomplicated Diverticulitis – Scandinavian Journal of Surgery

Elective surgical management of diverticulitis – Current Problems in Surgery

Management of Colonic Diverticulitis – Agency for Healthcare Research and Quality

2020 update of the WSES guidelines for the management of acute colonic diverticulitis in the emergency setting – World Journal of Emergency Surgery

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Left-Sided Colonic Diverticulitis – Diseases of the Colon & Rectum

 

Commentary on Twitter

 


Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19.

27 Jun, 2022 | 11:49h | UTC

Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19 – The Lancet Respiratory Medicine

Commentary: Early-phase clinical trials in a pandemic: learning from the response to COVID-19 – The Lancet Respiratory Medicine

 

Commentary on Twitter

 


M-A: Hypothermic vs. normothermic temperature control after cardiac arrest.

24 Jun, 2022 | 11:51h | UTC

Hypothermic versus Normothermic Temperature Control after Cardiac Arrest – NEJM Evidence

Related:

ERC-ESICM guidelines on temperature control after cardiac arrest in adults – Intensive Care Medicine (if the link is paywalled, try this one)

Target temperature management following cardiac arrest: a systematic review and Bayesian meta-analysis – Critical Care

Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets – Intensive Care Medicine

Targeted Temperature Management for Cardiac Arrest Due to Non-shockable Rhythm: A Systematic Review and Meta-Analysis of Randomized Controlled Trials – Frontiers in Medicine

Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial – JAMA

Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest – New England Journal of Medicine

 


Hemorrhagic fever with renal syndrome: literature review, epidemiology, clinical picture and pathogenesis.

24 Jun, 2022 | 11:02h | UTC

Hemorrhagic Fever with Renal Syndrome: Literature Review, Epidemiology, Clinical Picture and Pathogenesis – Infections & Chemotherapy

 


Tips for avoiding common mistakes in out-of-hospital diagnosis of carbon monoxide poisoning.

24 Jun, 2022 | 10:57h | UTC

Tips for avoiding common mistakes in out-of-hospital diagnosis of carbon monoxide poisoning – Journal of Anesthesia, Analgesia and Critical Care

 


Study Commentary | How FAST can you spot a pneumothorax? breaking down a surprising result comparing ultrasound and chest radiograph in traumatic pneumothorax.

24 Jun, 2022 | 10:39h | UTC

How FAST Can You Spot a Pneumothorax? Breaking Down a Surprising Result Comparing Ultrasound and Chest Radiograph in Traumatic Pneumothorax – Annals of Emergency Medicine

Original Study: Not so FAST—Chest ultrasound underdiagnoses traumatic pneumothorax – Journal of Trauma and Acute Care Surgery (link to abstract – $ for full-text)

 


Ivermectin for COVID-19 Cochrane review update: 11 trials and no evidence of benefit shown.

23 Jun, 2022 | 10:38h | UTC

News Release: Ivermectin for COVID-19 review update: 11 trials and no evidence of benefit shown – Liverpool School of Tropical Medicine

Original Article: Ivermectin for preventing and treating COVID‐19 – Cochrane Library

Summary: Ivermectin for preventing and treating COVID-19 – Cochrane Library

 


M-A: Early versus delayed complete revascularization in patients presenting with ST-segment elevation myocardial infarction and multivessel disease.

23 Jun, 2022 | 10:11h | UTC

Early versus delayed complete revascularisation in patients presenting with ST-segment elevation myocardial infarction and multivessel disease: a systematic review and meta-analysis of randomised controlled trials – openheart

 


Consensus Recommendations: Early management of patients with aneurysmal subarachnoid hemorrhage in a hospital with neurosurgical/neuroendovascular facilities.

22 Jun, 2022 | 11:25h | UTC

Part 1: Early management of patients with aneurysmal subarachnoid hemorrhage in a hospital with neurosurgical/neuroendovascular facilities: a consensus and clinical recommendations of the Italian Society of Anesthesia and Intensive Care (SIAARTI)–Part 1 – Journal of Anesthesia, Analgesia and Critical Care

Part 2: Early management of patients with aneurysmal subarachnoid hemorrhage in a hospital with neurosurgical/neuroendovascular facilities: a consensus and clinical recommendations of the Italian Society of Anesthesia and Intensive Care (SIAARTI)—part 2 – Journal of Anesthesia, Analgesia and Critical Care

 


Review: Advanced interventions in the pre-hospital resuscitation of patients with non-compressible hemorrhage after penetrating injuries.

22 Jun, 2022 | 11:21h | UTC

Advanced interventions in the pre-hospital resuscitation of patients with non-compressible haemorrhage after penetrating injuries – Critical Care

 


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