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Emergency Medicine

RCT: Azithromycin provides no benefit for community treatment of patients with suspected COVID-19

7 Mar, 2021 | 20:15h | UTC

Azithromycin for community treatment of suspected COVID-19 in people at increased risk of an adverse clinical course in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial – The Lancet

 

Commentary on Twitter

 


[Preprint] Genomics and epidemiology of a novel SARS-CoV-2 lineage P.1 – “P.1 may be 1.4–2.2 times more transmissible and 25-61% more likely to evade protective immunity elicited by previous infection with non-P.1 lineages”

7 Mar, 2021 | 20:05h | UTC

Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil – medRxiv

Commentary: Brazil variant can reinfect virus survivors; COVID-19 vaccine antibodies pass into breast milk – Reuters

 


[Preprint] Increased risk of hospitalization associated with infection with SARS-CoV-2 Lineage B.1.1.7 in Denmark

7 Mar, 2021 | 19:46h | UTC

Increased Risk of Hospitalisation Associated with Infection with SARS-CoV-2 Lineage B.1.1.7 in Denmark – The Lancet

 

Commentary on Twitter (thread – click for more)

 


Diagnosis of non-consensus transient ischemic attacks with focal, negative, and non-progressive symptoms: population-based validation by investigation and prognosis

7 Mar, 2021 | 19:32h | UTC

Diagnosis of non-consensus transient ischaemic attacks with focal, negative, and non-progressive symptoms: population-based validation by investigation and prognosis – The Lancet

 

Commentary on Twitter

 


Therapy options for adrenal insufficiency and recommendations for the management of adrenal crisis

7 Mar, 2021 | 19:00h | UTC

Therapy options for adrenal insufficiency and recommendations for the management of adrenal crisis – Endocrine

 


Prevention of Clostridioides difficile in hospitals: A position paper of the International Society for Infectious Diseases

7 Mar, 2021 | 18:58h | UTC

Prevention of Clostridioides difficile in hospitals: A position paper of the International Society for Infectious Diseases – International Journal of Infectious Diseases

 


RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19

5 Mar, 2021 | 08:53h | UTC

Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial – JAMA

Commentaries: Ivermectin: Yet Another Fad Runs Into The Brick Wall Known As “Actual Science” – Brief-19 AND Ivermectin doesn’t speed recovery from mild COVID-19, study shows – CIDRAP

 


Scientific Statement: Invasive management of acute myocardial infarction complicated by cardiogenic shock

5 Mar, 2021 | 08:33h | UTC

Invasive Management of Acute Myocardial Infarction Complicated by Cardiogenic Shock: A Scientific Statement From the American Heart Association – Circulation

 


RCT: Albumin provides no benefit to hospitalized patients with decompensated cirrhosis

4 Mar, 2021 | 08:37h | UTC

A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Albumin provides no benefit to hospitalized patients with advanced liver disease – University College London

 


RCT: Mixed findings with Terlipressin plus Albumin for the treatment of Type 1 hepatorenal syndrome

4 Mar, 2021 | 08:35h | UTC

Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)

 


NIH halts trial of COVID-19 convalescent plasma in emergency department patients with mild symptoms

3 Mar, 2021 | 08:55h | UTC

NIH halts trial of COVID-19 convalescent plasma in emergency department patients with mild symptoms – National Institutes of Health

 


More transmissible and evasive SARS-CoV-2 variant growing rapidly in Brazil

3 Mar, 2021 | 08:53h | UTC

More transmissible and evasive SARS-CoV-2 variant growing rapidly in Brazil – Imperial College London

Original study (preprint): Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil

Commentaries: Covid Brazil variant ‘may spread more easily’ – BBC AND Brazil coronavirus variant: what is it and why is it a concern? An expert explains – The Conversation

 


RCT: High flow oxygen does not change the risk of mortality in patients with a suspected acute coronary syndrome

3 Mar, 2021 | 08:37h | UTC

High flow oxygen and risk of mortality in patients with a suspected acute coronary syndrome: pragmatic, cluster randomised, crossover trial – The BMJ

 

Commentary on Twitter

 


M-A: Role of Cilostazol in prevention of vasospasm following aneurysmal subarachnoid hemorrhage

3 Mar, 2021 | 08:16h | UTC

Role of Cilostazol in prevention of vasospasm following aneurysmal subarachnoid hemorrhage – A systematic review, meta-analysis and trial sequential analysis – World Neurosurgery (link to abstract – $ for full-text)

 


Scaling up COVID-19 rapid antigen tests: promises and challenges

2 Mar, 2021 | 02:09h | UTC

Scaling up COVID-19 rapid antigen tests: promises and challenges – The Lancet Infectious Diseases

 


Review: Cardiovascular biomarkers in patients with COVID-19

2 Mar, 2021 | 02:07h | UTC

Cardiovascular biomarkers in patients with COVID-19 – European Heart Journal. Acute Cardiovascular Care

 

Commentary on Twitter

 


Studies: Secondary infections in patients with severe COVID-19

2 Mar, 2021 | 02:05h | UTC

Secondary Infections in Patients with Severe COVID-19 – NEJM Journal Watch

Study 1: Nosocomial infections associated to COVID-19 in the intensive care unit: clinical characteristics and outcome – Intensive Care Medicine

Study 2: COVID-19 increased the risk of ICU-acquired bloodstream infections: a case–cohort study from the multicentric OUTCOMEREA network – Intensive Care Medicine

 


Consensus Document: Venous thromboembolism prophylaxis in the trauma intensive care unit

2 Mar, 2021 | 01:52h | UTC

Venous thromboembolism prophylaxis in the trauma intensive care unit: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document – Trauma Surgery & Acute Care Open

 


Guideline: Treatment of methicillin-resistant Staphylococcus aureus (MRSA)

2 Mar, 2021 | 01:50h | UTC

Treatment of methicillin-resistant Staphylococcus aureus (MRSA): updated guidelines from the UK – JAC-Antimicrobial Resistance

 

Commentary on Twitter

 


Cohort study: Recovery of consciousness and functional outcome in moderate and severe traumatic brain injury

2 Mar, 2021 | 01:34h | UTC

Recovery of Consciousness and Functional Outcome in Moderate and Severe Traumatic Brain Injury – JAMA Neurology (free for a limited period)

Editorial: Holding Out Hope After Traumatic Brain Injury (free for a limited period)

 

Commentary on Twitter

 


Teleneurology-enabled determination of death by neurologic criteria after cardiac arrest or severe neurologic injury

2 Mar, 2021 | 01:32h | UTC

Teleneurology-Enabled Determination of Death by Neurologic Criteria After Cardiac Arrest or Severe Neurologic Injury – Neurology (link to abstract – $ for full-text)

 


RCT: Prescribed light exercise vs. standard management for emergency department patients with acute mild traumatic brain injury

2 Mar, 2021 | 01:30h | UTC

A randomized trial comparing prescribed light exercise to standard management for emergency department patients with acute mild traumatic brain injury – Academic Emergency Medicine (link to abstract – $ for full-text)

Commentary: Exercise After Concussion in Adults? – Journal Feed

 


CDC Study: Suspected SARS-CoV-2 reinfections in a skilled nursing facility

28 Feb, 2021 | 21:55h | UTC

Suspected Recurrent SARS-CoV-2 Infections Among Residents of a Skilled Nursing Facility During a Second COVID-19 Outbreak — Kentucky, July–November 2020 – CDC Morbidity and Mortality Weekly Report

Commentaries: Possible SARS-CoV-2 Reinfection Described at Skilled Nursing Facility – HealthDay AND Reinfections could be more likely among those with a mild first case of COVID-19: case study – CTV News

 

Commentary on Twitter (thread – Click for more)

 


M-A: Treatment with convalescent plasma is not associated with better outcomes in patients with Covid-19

28 Feb, 2021 | 21:51h | UTC

Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19: A Systematic Review and Meta-analysis – JAMA

Editorial: Emerging Lessons From COVID-19 for the US Clinical Research Enterprise

 

Commentary on Twitter

 


Identification of 3 clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19

28 Feb, 2021 | 21:45h | UTC

Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study – The Lancet Infectious Diseases

Invited Commentary: Anticipating outcomes for patients with COVID-19 and identifying prognosis patterns

 

Commentary on Twitter

 


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