Emergency Medicine
M-A | Antiviral drug treatment for nonsevere COVID-19.
27 Jul, 2022 | 12:14h | UTCNews Release: Some antivirals used in nonsevere COVID-19 may reduce hospitalizations and deaths – Canadian Medical Association Journal
Commentary: COVID-19 antivirals may cut risk of hospitalization, death – CIDRAP
M-A | Beneficial and harmful effects of monoclonal antibodies for the treatment and prophylaxis of COVID-19.
27 Jul, 2022 | 12:12h | UTC
NICE Guideline | Pneumonia in adults: diagnosis and management.
26 Jul, 2022 | 13:37h | UTCPneumonia in adults: diagnosis and management – National Institute for Health and Care Excellence
Related Guidelines:
Pneumonia (community-acquired): antimicrobial prescribing
Pneumonia (hospital-acquired): antimicrobial prescribing
Single-center RCT | A procalcitonin-based algorithm to guide antibiotic use in patients with acute pancreatitis.
22 Jul, 2022 | 11:40h | UTCA procalcitonin-based algorithm to guide antibiotic use in patients with acute pancreatitis (PROCAP): a single-centre, patient-blinded, randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Commentary on Twitter
Can procalcitonin safely guide antibiotics in acute pancreatitis? @LancetGastroHep PROCAP study is the answer
Infographics based on the abstract, full paper: https://t.co/PdUla5Fe9Y
Read the Editorial by @lelecapurso and me in https://t.co/k4PVt8tfN8#TheAmylaseSchool @my_ueg pic.twitter.com/cop0DWXmtC— Enrique de-Madaria (@DeMadaria) July 19, 2022
Retrospective cohort study | Impact of ethnicity on the accuracy of measurements of oxygen saturations.
21 Jul, 2022 | 13:15h | UTCRelated:
Racial Bias in Pulse Oximetry Measurement – New England Journal of Medicine
FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias – STAT
Pulse Oximeter Accuracy and Limitations: FDA Safety Communication – U.S. Food & Drug Administration
Review | Therapeutic advances in alcohol-associated hepatitis.
21 Jul, 2022 | 12:36h | UTCTherapeutic advances in alcohol-associated hepatitis – Journal of Hepatology
Commentary on Twitter
Therapeutic advances in #AlcoholAassociatedHepatitis
How to personalise biomarkers & therapies for AH patients❓
By @GSzaboMD, @MarkThursz & @Dr_Vijay_Shah
Full text here?https://t.co/XubWfBCuis
Part of #BreakthroughsInHepatology
➡️https://t.co/QHvXVi5lG8#LiverTwitter pic.twitter.com/dEApFM6JIj— Journal of Hepatology (@JHepatology) June 23, 2022
High-sensitivity cardiac troponin and the 2021 AHA/ACC Guidelines for the evaluation and diagnosis of acute chest pain.
20 Jul, 2022 | 12:29h | UTCHigh-Sensitivity Cardiac Troponin and the 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guidelines for the Evaluation and Diagnosis of Acute Chest Pain – Circulation (free for a limited period)
Commentary on Twitter
#Primer HS Cardiac Troponin & Guidelines for Evaluation and Diagnosis of Acute Check Pain #AHAJournals https://t.co/avcm6LEbgb pic.twitter.com/zs8yRe6u1y
— Circulation (@CircAHA) July 13, 2022
Podcast | Life-threatening conditions during pregnancy.
19 Jul, 2022 | 13:42h | UTCLife-threatening Conditions During Pregnancy – JAMA
EASL Clinical Practice Guidelines on the management of hepatic encephalopathy.
18 Jul, 2022 | 11:49h | UTC
Commentary on Twitter
? @EASLnews Clinical Practice Guidelines on the management of hepatic encephalopathy, in press‼️
Direct link?https://t.co/MvNiPdfQg3@EASLedu @RautouE @mromerogomez @MontagneseSara @DebbieShawcros1#LiverTwitter pic.twitter.com/ebmA7ULGsD
— Journal of Hepatology (@JHepatology) June 17, 2022
RCT | Tixagevimab-cilgavimab for treatment of patients hospitalized with COVID-19.
15 Jul, 2022 | 13:02h | UTCCommentary: The potential of tixagevimab–cilgavimab for treating hospitalized COVID-19 patients – News Medical
Related:
Commentary on Twitter
In pts hospitalised w/ COVID-19 receiving remdesivir and other standard care, tixagevimab–cilgavimab did not improve time to sustained recovery but was safe and mortality was lower vs placebo
From the ACTIV-3–TICO Study Group https://t.co/zaaXBQYl5t pic.twitter.com/xe0tmbFrZ9
— The Lancet Respiratory Medicine (@LancetRespirMed) July 11, 2022
M-A (mostly of observational studies) | Catheter-directed thrombolysis vs. systemic anticoagulation alone for submassive pulmonary embolism.
15 Jul, 2022 | 12:39h | UTC
RCT | Endovascular thrombectomy NOT noninferior to standard bridging thrombolytic with endovascular thrombectomy within 4.5 h of stroke onset.
13 Jul, 2022 | 11:57h | UTCEndovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Related Study: Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
Two new RCTs show we shouldn't skip bridging intravenous thrombolysis in eligible thrombectomy patients: DIRECT-SAFE (n=293) & SWIFT DIRECT (n=408) @TheLancet @SNISinfo@cvsection https://t.co/Tks14TlaVFhttps://t.co/WaTPn34diy pic.twitter.com/Gcddws8oDf
— Babak Jahromi MD PhD FRCSC (@babaksjahromi) July 9, 2022
RCT | Thrombectomy alone NOT noninferior to intravenous alteplase plus thrombectomy in patients with stroke.
13 Jul, 2022 | 11:55h | UTCThrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Related Study: Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
Two new RCTs show we shouldn't skip bridging intravenous thrombolysis in eligible thrombectomy patients: DIRECT-SAFE (n=293) & SWIFT DIRECT (n=408) @TheLancet @SNISinfo@cvsection https://t.co/Tks14TlaVFhttps://t.co/WaTPn34diy pic.twitter.com/Gcddws8oDf
— Babak Jahromi MD PhD FRCSC (@babaksjahromi) July 9, 2022
Fever therapy in febrile adults: systematic review with meta-analyses and trial sequential analyses.
13 Jul, 2022 | 11:51h | UTC
Navigating a Complicated World | Commentary of the new AHA/ACC Chest Pain Guidelines.
12 Jul, 2022 | 12:40h | UTCNews Release: First-Ever Guideline Focused Solely on Chest Pain Evaluation, Diagnosis Released
Guideline Hub: Guideline for the Evaluation and Diagnosis of Chest Pain
Key Points: 2021 AHA/ACC Chest Pain Guideline – American College of Cardiology
Commentary: New Chest Pain Guidelines Out at Last: Most Tests Have a Role – TCTMD
Cochrane review on endovascular thrombectomy and intra-arterial interventions for acute ischemic stroke.
12 Jul, 2022 | 12:29h | UTCCochrane Review on Endovascular Thrombectomy and Intra-Arterial Interventions for Acute Ischemic Stroke – Stroke (free for a limited period)
Review | How to evaluate and care for the suicidal patient in the emergency department.
12 Jul, 2022 | 11:55h | UTCHow to evaluate and care for the suicidal patient in the ED – emDocs
Hypertensive disorders in pregnancy complicated by liver rupture or hematoma: a systematic review of 391 reported cases.
12 Jul, 2022 | 11:48h | UTC
RCT | 20% albumin vs. plasmalyte in patients with cirrhosis and sepsis-induced hypotension.
11 Jul, 2022 | 12:16h | UTC
Review | Understanding and interpreting artificial intelligence, machine learning and deep learning in Emergency Medicine.
11 Jul, 2022 | 12:02h | UTCUnderstanding and interpreting artificial intelligence, machine learning and deep learning in Emergency Medicine – Emergency Medicine Journal (free for a limited period)
M-A | Fluid resuscitation with balanced crystalloids vs. normal saline in critically ill patients.
11 Jul, 2022 | 12:00h | UTCRelated:
Back to BaSICS – Annals of Emergency Medicine
The ongoing saga of normal saline versus balanced fluids – First10EM
Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults – New England Journal of Medicine (link to abstract – $ for full-text)
AHA Scientific Statement | Escalating and de-escalating temporary mechanical circulatory support in cardiogenic shock.
8 Jul, 2022 | 12:05h | UTCTop Things to Know: Escalating and De-escalating Temporary Mechanical Circulatory Support in Cardiogenic Shock– American Heart Association
Commentary: Guiding Cardiogenic Shock Management: Filling in the (Wide) Data Gaps – American Heart Association
RCT | Neutralizing COVID-19 convalescent plasma does not benefit adults hospitalized with COVID-19.
8 Jul, 2022 | 11:59h | UTC
Interim Analysis | Oral Sabizabulin for high-risk, hospitalized adults with Covid-19.
8 Jul, 2022 | 12:02h | UTCOral Sabizabulin for High-Risk, Hospitalized Adults with Covid-19: Interim Analysis – NEJM Evidence
Retrospective Cohort Study | Racial bias and reproducibility in pulse oximetry among medical and surgical inpatients.
7 Jul, 2022 | 12:57h | UTCNews Release: Pulse oximeters missed low oxygen levels in more Black veterans than white veterans – University of Michigan
Related:
Racial Bias in Pulse Oximetry Measurement – New England Journal of Medicine
FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias – STAT
Pulse Oximeter Accuracy and Limitations: FDA Safety Communication – U.S. Food & Drug Administration
Commentary on Twitter
New research found that for individuals in general (medical and surgical) care in hospital, occult hypoxemia was more common for black patients than for white patients https://t.co/DrNlaIE7ho
— The BMJ (@bmj_latest) July 6, 2022