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Critical Care

RCT: A Seven-days course of antibiotics for the treatment of bloodstream infections by Enterobacterales was noninferior to a 14-days course.

9 Sep, 2021 | 09:03h | UTC

Seven versus 14-days course of antibiotics for the treatment of bloodstream infections by Enterobacterales. A randomized, controlled trial – Clinical Microbiology and Infection

 

Commentary on Twitter

 

Review: Management of severe traumatic brain injury in regions with limited resources.

9 Sep, 2021 | 08:56h | UTC

Management of severe traumatic brain injury in regions with limited resources – Brain Injury

 

Cochrane review: evidence is insufficient to draw meaningful conclusions if SARS‐CoV‐2-specific monoclonal antibodies are effective in the treatment of COVID-19.

7 Sep, 2021 | 21:51h | UTC

Summary: Are laboratory-made, COVID-19-specific monoclonal antibodies an effective treatment for COVID-19? – Cochrane Library

Original review: SARS‐CoV‐2‐neutralising monoclonal antibodies for treatment of COVID‐19 – Cochrane Library

 

Supplement: Current Issues in Venous Thromboembolism.

7 Sep, 2021 | 21:36h | UTC

Homepage: Current Issues in Venous Thromboembolism – Postgraduate Medicine

Editorial: Current issues in venous thromboembolism

A review of upper extremity deep vein thrombosis

Outpatient treatment of emergency department patients diagnosed with venous thromboembolism

Venous thromboembolism prophylaxis in high-risk orthopedic and cancer surgery

Prophylaxis and treatment of COVID-19 related venous thromboembolism

Challenges in the diagnostic approach of suspected pulmonary embolism in COVID-19 patients

Catheter-directed thrombolysis and mechanical intervention in deep venous thrombosis: what is the status after the ATTRACT trial?

Post-hospital discharge venous thromboembolism prophylaxis in medically ill patients

Radiologic mimics of pulmonary embolism

A comprehensive review of DOACs for cancer associated VTE prophylaxis or treatment

 

Isn’t it time to abandon ARDS? The COVID-19 lesson.

7 Sep, 2021 | 21:34h | UTC

Isn’t it time to abandon ARDS? The COVID-19 lesson – Critical Care

 

Commentary on Twitter

 

Annual Update in Intensive Care and Emergency Medicine 2021 – Covid articles.

7 Sep, 2021 | 10:50h | UTC

Secondary infections in critically ill patients with COVID-19

Tracheostomy for COVID-19: evolving best practice

See also: Non-Covid articles

 

Case series: COVID-19 mRNA vaccination leading to CNS inflammation.

7 Sep, 2021 | 10:49h | UTC

COVID-19 mRNA vaccination leading to CNS inflammation: a case series – Journal of Neurology

 

Medical, ethical, and legal aspects of end-of-life dilemmas in the intensive care unit.

7 Sep, 2021 | 10:37h | UTC

Medical, ethical, and legal aspects of end-of-life dilemmas in the intensive care unit – Cleveland Clinic Journal of Medicine

 

Cohort study: Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest.

7 Sep, 2021 | 10:41h | UTC

Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest – Intensive Care Medicine

 

Commentary on Twitter

 

Annual Update in Intensive Care and Emergency Medicine 2021 – Non-Covid articles.

7 Sep, 2021 | 10:43h | UTC

Advanced management of intermediate-high risk pulmonary embolism

Pathophysiology and clinical implications of the veno-arterial PCO2 gap

To prone or not to prone ARDS patients on ECMO

Management of acute metabolic acidosis in the ICU: sodium bicarbonate and renal replacement therapy

Acute kidney injury in ECMO patients

Monitoring and modifying brain oxygenation in patients at risk of hypoxic ischaemic brain injury after cardiac arrest

Measuring vitamin C in critically ill patients: clinical importance and practical difficulties—Is it time for a surrogate marker?

Still a place for aortic counterpulsation in cardiac surgery and patients with cardiogenic shock?

See also: Covid articles

 

Podcast: The Best of Liver Tests.

7 Sep, 2021 | 10:29h | UTC

#293 The Best of Liver Tests with Dr. Elliot Tapper – The Curbsiders

 

RCT: Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels.

6 Sep, 2021 | 11:11h | UTC

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial – Nature Medicine

 

Commentary on Twitter

 

Study shows cardiac troponin concentrations at presentation are insufficient to distinguish type 1 myocardial infarction from other causes of myocardial injury.

6 Sep, 2021 | 10:42h | UTC

Cardiac Troponin Thresholds and Kinetics to Differentiate Myocardial Injury and Myocardial Infarction – Circulation

 

Commentary on Twitter

 

Musculoskeletal complications following critical illness: A scoping review.

3 Sep, 2021 | 10:07h | UTC

Musculoskeletal complications following critical illness: A scoping review – Journal of Critical Care

 

Commentary on Twitter

 

RCT: Baricitinib reduced mortality in hospitalized adults with COVID-19.

2 Sep, 2021 | 10:17h | UTC

Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial – The Lancet Respiratory Medicine

Commentaries:

Baricitinib: the first immunomodulatory treatment to reduce COVID-19 mortality in a placebo-controlled trial – The Lancet Respiratory Medicine

Rheumatoid Arthritis Drug Combined with Standard of Care May Help Reduce Mortality for Hospitalized COVID-19 Patients – Vanderbilt University Medical Center

 

Commentaries on Twitter

(thread – click for more)

 

Scientific Statement: Coronavirus Disease-2019 and Heart Failure.

2 Sep, 2021 | 10:08h | UTC

Coronavirus Disease-2019 and Heart Failure: A Scientific Statement From the Heart Failure Society of America – Journal of Cardiac Failure

 

Commentary on Twitter

 

RCT: Among critically ill patients, targeting oxygenation to a low-normal range vs. high-normal range did not result in a reduction in organ dysfunction.

2 Sep, 2021 | 08:23h | UTC

Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial – JAMA (free for a limited period)

Related:

M-A of randomized trials: Conservative oxygen therapy for critically ill patients.

Oxygen administration for patients with ARDS – Journal of Intensive Care

Randomized trial: Similar outcomes with lower vs. higher oxygenation targets for acute hypoxemic respiratory failure

Systematic Review: Higher vs. Lower Fraction of Inspired Oxygen or Targets of Arterial Oxygenation for Adults Admitted to the Intensive Care Unit

 

Commentary on Twitter

 

RCT: In patients with acute hypoxemic respiratory failure, a strategy of lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal was not associated with improved outcomes.

2 Sep, 2021 | 08:21h | UTC

Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial – JAMA (free for a limited period)

Related: Randomized Trial: Low vs Intermediate Tidal Volume Strategy in ICU Patients Without ARDS

 

Commentary on Twitter

 

Review: Initial antimicrobial management of sepsis – immediate, empiric, broad-spectrum therapy is key, but it must be accompanied by a commitment to de-escalation and antimicrobial stewardship.

1 Sep, 2021 | 08:59h | UTC

Initial antimicrobial management of sepsis – Critical Care

 

#ESCCongress – RCT: Influenza vaccination early after a myocardial infarction (MI) or in high-risk coronary heart disease resulted in a lower risk of a composite of all-cause death, MI, or stent thrombosis compared with placebo.

31 Aug, 2021 | 08:52h | UTC

Influenza Vaccination after Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial – Circulation

Commentaries:

IAMI: Influenza Vaccine Beneficial for Post-MI Patients – TCTMD

Influenza Vaccination After Myocardial Infarction – IAMI – American College of Cardiology

Flu vaccine after heart attack reduces risk of death – Cardiovascular Business

 

Commentary on Twitter

 

Cohort study: Patients with Covid-19 infected with the Delta variant are twice as likely to need hospital admission or emergency care attendance.

29 Aug, 2021 | 19:02h | UTC

Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study – The Lancet Infectious Diseases

Commentaries:

Importance of epidemiological factors in the evaluation of transmissibility and clinical severity of SARS-CoV-2 variants – The Lancet Infectious Diseases

Covid: Delta variant patients twice as likely to need hospital care – BBC

Covid-19 hospitalization risk doubles with Delta variant, UK study suggests – CNN

Expert reaction to study looking at risk of hospitalisation from the delta variant compared with alpha – Science Media Centre

 

Commentary on Twitter

 

#ESCCongress – RCT: Immediate coronary angiography after out-of-hospital cardiac arrest without ST-segment elevation did not improve outcomes compared to delayed/selective angiography.

29 Aug, 2021 | 18:12h | UTC

Angiography after Out-of-Hospital Cardiac Arrest without ST-Segment Elevation – New England Journal of Medicine

News release: Trial does not support early coronary angiography in cardiac arrest without ST elevation – European Society of Cardiology

Commentaries:

Angiography After Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation – TOMAHAWK – American College of Cardiology

TOMAHAWK: Immediate Coronary Angiography vs. Delayed Angiography in OHCA Patients Without ST-Segment Elevation – American College of Cardiology

 

Commentary on Twitter

 

COVID-19 associated Mucormycosis: risk factors and mechanisms of disease.

27 Aug, 2021 | 10:07h | UTC

COVID-19 associated Mucormycosis (CAM): risk factors and mechanisms of disease – Clinical Infectious Diseases

Related: Clinical Picture: Mucormycosis after COVID-19 in a patient with diabetes. (several articles on the subject)

 

Commentary on Twitter

 

M-A: Physical rehabilitation in the ICU improves physical function and reduces ICU and hospital length of stay.

27 Aug, 2021 | 09:02h | UTC

Physical Rehabilitation in the ICU: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)

 

M-A of randomized trials: Effectiveness of the modified Valsalva maneuver in adults with supraventricular – “The meta-analysis demonstrated a significantly higher success rate for reconversion to sinus rhythm when using the modified VM compared to the standard VM in patients with an SVT (odds ratio = 4.36; 95% confidence interval, 3.30–5.76; P < 0.001)”.

26 Aug, 2021 | 08:51h | UTC

Effectiveness of the modified Valsalva manoeuvre in adults with supraventricular tachycardia: a systematic review and meta-analysis – European Journal of Emergency Medicine (link to abstract – $ for full-text)

Related: Randomized Trial: Standard Valsalva vs. Modified Valsalva for Cardioversion of SVT (studies and commentaries on the subject)

Video: Modified Valsalva manoeuvre for supraventricular tachycardia – The Lancet

 

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