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Critical Care

RCT: Hyperimmune immunoglobulin did not improve outcomes in hospitalized patients with COVID-19.

28 Jan, 2022 | 08:42h | UTC

Hyperimmune immunoglobulin for hospitalised patients with COVID-19 (ITAC): a double-blind, placebo-controlled, phase 3, randomised trial – The Lancet

Commentaries:

High-dose immunoglobulins from convalescent donors for patients hospitalised with COVID-19 – The Lancet

Hyperimmune intravenous immunoglobulin does not improve outcomes for adults hospitalized with COVID-19 – NIH News Releases

 

ELSO Guidelines for anticoagulation in adult and pediatric patients using extracorporeal membrane oxygenation (ECMO).

28 Jan, 2022 | 08:26h | UTC

2021 ELSO Adult and Pediatric Anticoagulation Guidelines – ASAIO Journal

 

Commentary on Twitter

 

RCT: Control of postoperative hypotension using a closed-loop system for norepinephrine infusion in patients after cardiac surgery.

28 Jan, 2022 | 08:22h | UTC

Control of Postoperative Hypotension Using a Closed-Loop System for Norepinephrine Infusion in Patients After Cardiac Surgery: A Randomized Trial – Anesthesia & Analgesia (link to abstract – $ for full-text)

Related: RCT: Computer-assisted individualized hemodynamic management reduces intraoperative hypotension in intermediate- and high-risk surgery – larger trials with patient-relevant outcomes are required.

 

Lab study shows new antiviral pills maintain efficacy against Omicron, but antibody drugs are substantially less effective.

27 Jan, 2022 | 10:03h | UTC

Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant – New England Journal of Medicine

Commentary: Current anti-COVID pills work well against omicron, but antibody drugs are less effective, study finds – University of Wisconsin-Madison

 

Commentary on Twitter

 

Cases of lung transplantation for Covid-19–related respiratory failure in the US were associated with a three-month survival of 95.6%.

27 Jan, 2022 | 10:00h | UTC

Lung Transplantation for Covid-19–Related Respiratory Failure in the United States – New England Journal of Medicine

Commentaries:

New data on COVID-19 lung transplants – Cedars-Sinai Medical Center

~7 Percent of Lung Transplants Due to COVID-19 Respiratory Failure – HealthDay

 

Comprehensive review of chest tube management.

27 Jan, 2022 | 09:40h | UTC

Comprehensive Review of Chest Tube Management – JAMA Surgery (free for a limited period)

 

M-A: Not enough evidence that micronutrient supplementation in addition to standard nutritional support improves clinical outcomes in malnourished medical inpatients.

27 Jan, 2022 | 09:34h | UTC

Effect of micronutrient supplementation in addition to nutritional therapy on clinical outcomes of medical inpatients: results of an updated systematic review and meta-analysis – European Journal of Clinical Nutrition (link to abstract – $ for full-text)

 

Controversies and evidence gaps in the early management of severe traumatic brain injury: back to the ABCs.

27 Jan, 2022 | 09:27h | UTC

Controversies and evidence gaps in the early management of severe traumatic brain injury: back to the ABCs – Trauma Surgery & Acute Care Open

 

Cohort study: Among patients who survived ICU treatment for COVID-19, 75% still reported physical, mental, or cognitive symptoms after 1 year.

26 Jan, 2022 | 02:28h | UTC

Clinical Outcomes Among Patients With 1-Year Survival Following Intensive Care Unit Treatment for COVID-19 – JAMA

Commentaries:

75% of COVID ICU survivors have physical symptoms 1 year on – CIDRAP

Majority of COVID-19 survivors experience health problems one-year post ICU admission – News Medical

 

Guidelines on the management of Type B aortic dissection.

26 Jan, 2022 | 02:06h | UTC

The Society of Thoracic Surgeons/American Association for Thoracic Surgery Clinical Practice Guidelines on the Management of Type B Aortic Dissection – Annals of Thoracic Surgery

News Release: New practice guideline addresses diagnosis, treatment of type B aortic dissection – The Society of Thoracic Surgeons

 

Mass casualty medicine and anesthesia special issue: science and clinical practice.

26 Jan, 2022 | 02:04h | UTC

Editorials:

Mass casualty medicine: time for a 21st century refresh

Exercising for mass casualty preparedness

Massive transfusion and severe blood shortages: establishing and implementing predictors of futility

Transfusion support during mass casualty events

Embracing uncertainty in mass casualty incidents

Pre-hospital critical care at major incidents

Provision of pre-hospital medical care for terrorist attacks

Higher pre-hospital anaesthesia case volumes result in lower mortality rates: implications for mass casualty care

Improving mass casualty planning in low resource settings: Médecins Sans Frontières and International Committee of the Red Cross perspective

Global lessons learned from COVID-19 mass casualty incidents

Reimagining health preparedness in the aftermath of COVID-19

Preparing for mass casualty events despite COVID-19

Paediatric Anaesthesia:

Paediatric patients in mass casualty incidents: a comprehensive review and call to action

Adaptations to practice and resilience in a paediatric major trauma centre during a mass casualty incident

Pre-hospital Care:

Injury scoring systems for blast injuries: a narrative review

Association between case volume and mortality in pre-hospital anaesthesia management: a retrospective observational cohort

Establishing quality indicators for pre-hospital advanced airway management: a modified nominal group technique consensus process

Pre-hospital continuous positive airway pressure after blast lung injury and hypovolaemic shock: a modelling study

Preparedness:

Review of the requirements for effective mass casualty preparedness for trauma systems. A disaster waiting to happen?

Learning from terrorist mass casualty incidents: a global survey

Refining mass casualty plans with simulation-based iterative learning

Specific Incidents:

Mass casualty, intentional vehicular trauma and anaesthesia

Chemical, biological, radiological, and nuclear mass casualty medicine: a review of lessons from the Salisbury and Amesbury Novichok nerve agent incidents

Correspondence:

Pre-hospital oral transmucosal fentanyl citrate for trauma analgesia: preliminary experience and implications for civilian mass casualty response

Implications for trauma system development in a low- and middle-income country: the Sri Lanka 2019 Easter Sunday terrorist attack

Development and evaluation of a mass casualty medicine simulation method using figurines

Influx! A game-based learning tool for in-hospital interprofessional disaster preparedness and response

 

A registry study with 1,581 cases of Stenotrophomonas maltophilia blood and/or lower respiratory infections suggest Levofloxacin is a reasonable alternative to standard therapy with Trimethoprim-sulfamethoxazole.

26 Jan, 2022 | 01:40h | UTC

Trimethoprim-Sulfamethoxazole versus Levofloxacin for Stenotrophomonas maltophilia Infections: A Retrospective Comparative Effectiveness Study of Electronic Health Records from 154 U.S. Hospitals – Open Forum Infectious Diseases

 

Commentary on Twitter

 

Systematic Review: Ultrafiltration for acute heart failure.

26 Jan, 2022 | 01:33h | UTC

Ultrafiltration for acute heart failure – Cochrane Library

Commentary: Fluid removal therapy in acute heart failure – Cochrane Library

 

Review: Point-of-care ultrasound for the trauma anesthesiologist.

26 Jan, 2022 | 01:22h | UTC

Point-of-Care Ultrasound for the Trauma Anesthesiologist – Current Anesthesiology Reports (if the link is paywalled, try this one)

 

RCT: CPAP improved outcomes in patients with acute hypoxemic respiratory failure due to COVID-19, but high-flow nasal oxygen was not better than conventional oxygen therapy.

25 Jan, 2022 | 09:50h | UTC

Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial – JAMA

Editorial: Defining Optimal Respiratory Support for Patients With COVID-19 – JAMA

 

Commentary on Twitter

 

New CPR guidance addresses more contagious COVID-19 variants amidst evolving pandemic.

25 Jan, 2022 | 09:48h | UTC

News release: New CPR guidance addresses more contagious COVID-19 variants amidst evolving pandemic – American Heart Association

See Guidance: 2022 Interim Guidance to Healthcare Providers for Basic and Advanced Cardiac Life Support in Adults, Children, and Neonates with Suspected or Confirmed COVID-19: From the Emergency Cardiovascular Care Committee and Get With the Guidelines®-Resuscitation Adult and Pediatric Task Forces of the American Heart Association in Collaboration with the American Academy of Pediatrics, American Association for Respiratory Care, The Society of Critical Care Anesthesiologists, and American Society of Anesthesiologists

 

RCT: Fentanyl vs. placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department.

25 Jan, 2022 | 09:14h | UTC

Fentanyl versus placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department: the FAKT study – a randomized clinical trial – Academic Emergency Medicine (link to abstract – $ for full-text)

 

Updated Guideline: Recommended drugs and biologics in adult patients with COVID-19.

24 Jan, 2022 | 08:52h | UTC

Clinical Practice Guideline Summary: Recommended Drugs and Biologics in Adult Patients with COVID-19 – Covid-19 Advisory for Ontario

 

Commentary on Twitter (thread – click for more)

https://twitter.com/ASPphysician/status/1484874519252721664

 

A guide to immunotherapy for COVID-19.

24 Jan, 2022 | 08:29h | UTC

A guide to immunotherapy for COVID-19 – Nature Medicine

 

Perioperative guidelines on antiplatelet and anticoagulant agents: 2022 Update.

21 Jan, 2022 | 09:53h | UTC

Perioperative Guidelines on Antiplatelet and Anticoagulant Agents: 2022 Update – Current Anesthesiology Reports

 

M-A: No difference in outcomes with Beta-lactam monotherapy vs. combination therapy for bloodstream infections or pneumonia due to P. aeruginosa.

21 Jan, 2022 | 09:37h | UTC

Beta-lactam monotherapy or combination therapy for bloodstream infections or pneumonia due to P. aeruginosa: a meta-analysis – International Journal of Antimicrobial Agents (link to abstract – $ for full-text)

 

M-A: In comatose survivors of cardiac arrest, targeted hypothermia is not associated with improved survival or better neurological outcomes vs. targeted normothermia.

21 Jan, 2022 | 09:29h | UTC

Targeted Hypothermia Versus Targeted Normothermia In Survivors of Cardiac Arrest: A Systematic Review and Meta-Analysis of Randomized Trials – American Journal of Medicine

Related:

RCT: In comatose survivors of out-of-hospital cardiac arrest, there was no difference in mortality and neurologic outcomes with mild (target temperature of 34 °C) vs. moderate therapeutic hypothermia (target temperature of 31 °C).

M-A: Targeted temperature management following out-of-hospital cardiac arrest – “Routine use of moderate or deep hypothermia in comatose survivors of OHCA may potentially be associated with more harm than benefit”.

RCT: In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not improve outcomes.

 

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.

20 Jan, 2022 | 09:17h | UTC

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis – The Lancet

News Release: An estimated 1.2 million people died in 2019 from antibiotic-resistant bacterial infections, more deaths than HIV/AIDS or malaria – The Lancet

Editorial: Antimicrobial resistance: time to repurpose the Global Fund – The Lancet

Commentary: Antimicrobial resistance now a leading cause of death worldwide, study finds – The Guardian

 

Commentary on Twitter

 

RCT: In critically ill adults, using a balanced multielectrolyte solution did not lower the risk of death or acute kidney injury compared to standard saline.

19 Jan, 2022 | 08:41h | UTC

Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Australian study set to guide the treatment of critically ill patients worldwide – George Institute for Global Health

Related:

BaSICS RCT: Among critically ill patients requiring fluid therapy, treatment with a balanced solution did not lead to reduced mortality compared to a 0.9% saline solution.

BaSICS RCT: Among critically ill patients requiring fluid therapy, there was no difference in mortality with slower (333 mL/h) vs. faster (999 mL/h) intravenous fluid bolus rates.

Cochrane Review: Buffered Solutions Do Not Improve Mortality in Critically Ill Adults and Children Compared to 0,9% Saline

 

Commentary on Twitter

https://twitter.com/NEJM/status/1483540959518281730

 

Clinical practice guidelines for therapeutic drug monitoring of teicoplanin.

19 Jan, 2022 | 08:27h | UTC

Clinical practice guidelines for therapeutic drug monitoring of teicoplanin: a consensus review by the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring – Journal of Antimicrobial Chemotherapy

 

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