Critical Care
Guideline Synopsis | Management of thoracic aortic dissection
21 Feb, 2023 | 11:48h | UTCManagement of Thoracic Aortic Dissection – JAMA (free for a limited period)
Original Guidelines:
Review | How to manage coagulopathies in critically ill patients
21 Feb, 2023 | 11:43h | UTCHow to manage coagulopathies in critically ill patients – Intensive Care Medicine
Commentary on Twitter
Coagulopathies severe/frequent complication in #ICU: how to manage??
? hemorrhagic coagulopathies: non‑malignant & malignant
? thrombotic c.: sepsis‑induced & solid cancer‑associated
? managing hemorrhagic c.
?(preventing &) managing thrombotic c.
?️ https://t.co/CKqzT7dcoH pic.twitter.com/SvpPNf0oGO— Intensive Care Medicine (@yourICM) February 18, 2023
Review | Neurological complications of sepsis
20 Feb, 2023 | 12:16h | UTCSummary: This article covers the latest developments in the prevention, diagnosis, and treatment of sepsis-associated encephalopathy (SAE) and ICU-acquired weakness (ICUAW). SAE diagnosis is clinical with supporting EEG and neuroimaging. Treatment involves early identification and treatment of infections and organ dysfunction. ICUAW is due to an overlap between critical illness polyneuropathy, critical illness myopathy, and muscle disuse atrophy. It affects all limbs and respiratory muscles and is associated with prolonged hospital stay, increased costs, and both short and long-term mortality. Recovery is typical in weeks or months, but severe cases may result in persistent functional impairments for ICU survivors.
Article: Neurological complications of sepsis – Current Opinion in Critical Care
RCT | Effect of non-invasive ventilation after extubation in critically ill patients with obesity
17 Feb, 2023 | 13:10h | UTCEffect of non-invasive ventilation after extubation in critically ill patients with obesity in France: a multicentre, unblinded, pragmatic randomised clinical trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Commentary on Twitter
NEW Research—Among critically ill adults with obesity undergoing extubation, the use of NIV was effective to reduce treatment-failure within 3 days
Read the RCT from Audrey De Jong & colleagues here: https://t.co/nMB3W8NAYX #SCCM2023 pic.twitter.com/iEHExPEhSN
— The Lancet Respiratory Medicine (@LancetRespirMed) January 21, 2023
RCT | Effect of early mobilization on long-term cognitive impairment in critical illness
17 Feb, 2023 | 13:07h | UTCEffect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial – The Lancet Respiratory Medicine (free registration required)
Related:
M-A | The effect of early active mobilization at 6 months after critical illness
Early Active Mobilization during Mechanical Ventilation in the ICU – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
NEW Research—Early mobilisation might improve long-term cognitive impairment in ICU survivors after MV, but the increased risk of adverse events in the intervention group should be noted
Read the RCT from Bhakti Patel & colleagues here: https://t.co/DeqraodGXq #SCCM2023 pic.twitter.com/RMDhE7UxPM
— The Lancet Respiratory Medicine (@LancetRespirMed) January 21, 2023
M-A | The rate and assessment of muscle wasting during critical illness
17 Feb, 2023 | 12:55h | UTC
Commentary on Twitter
A Review published in @Crit_Care analyzes the data of ICU muscle wasting studies and reports that critically ill patients lose nearly 2% of skeletal muscle per day during the first week of ICU admission.https://t.co/qW5jzbWRSk
— BMC (@BioMedCentral) January 8, 2023
Acute pain management pearls: a focused review for the hospital clinician
17 Feb, 2023 | 12:42h | UTCAcute Pain Management Pearls: A Focused Review for the Hospital Clinician – Healthcare
RCT | Rivaroxaban shows promise compared to Enoxaparin in the acute phase of an acute coronary syndrome
16 Feb, 2023 | 15:20h | UTCInvited Commentary: Rivaroxaban for Patients With Acute Coronary Syndromes—Where Do We Stand? – JAMA Network Open
Commentary on Twitter
The H-REPLACE RCT: short-term rivaroxaban (5mg 2x/day) was noninferior to enoxaparin in safety + efficacy during 6-month follow-up among patients with acute coronary syndrome who missed the primary reperfusion window and before selective revascularization. https://t.co/TIHOwGSWjJ
— JAMA Network Open (@JAMANetworkOpen) February 10, 2023
Guideline | Diagnosis and management of subarachnoid hemorrhage caused by a ruptured aneurysm
16 Feb, 2023 | 15:23h | UTC
Regulations on palliative sedation: an international survey across eight European countries
16 Feb, 2023 | 15:17h | UTC
M-A | Efficacy of endovascular therapy for basilar and vertebral artery occlusion
16 Feb, 2023 | 14:50h | UTCRelated:
M-A | Mechanical thrombectomy in acute basilar artery stroke.
SR | Prognostic models for mortality risk in patients requiring ECMO
15 Feb, 2023 | 15:49h | UTCPrognostic models for mortality risk in patients requiring ECMO – Intensive Care Medicine
Review | Indications, clinical impact, and complications of critical care transesophageal echocardiography
15 Feb, 2023 | 15:45h | UTC
Retrospective Study | Post-cardiac surgery fungal mediastinitis: clinical features, pathogens and outcome
15 Feb, 2023 | 15:40h | UTCPost-cardiac surgery fungal mediastinitis: clinical features, pathogens and outcome – Critical Care
SR | Predisposing and precipitating factors associated with delirium
15 Feb, 2023 | 15:38h | UTC
Consensus Paper | ED management of patients with alcohol intoxication, alcohol withdrawal, and alcohol use disorder
14 Feb, 2023 | 11:05h | UTC
Cohort study | Epidemiology and outcomes of hospital-acquired bloodstream infections in ICU patients
14 Feb, 2023 | 10:44h | UTCEpidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
Hospital‑acquired bloodstream infections in #ICU, @EuroBact2
?mainly due to Gram -, widespread carbapenem resistant, DTR pathogens
?resistance associated w longer delays to adequate ABT therapy
At day-28
?mortality 37%
?16.1% discharged alive from ?
?️https://t.co/0T4FK2mxc5 pic.twitter.com/e0u50hMKqO— Intensive Care Medicine (@yourICM) February 11, 2023
Cohort Study | Global epidemiology of carbapenem-resistant Pseudomonas aeruginosa and associated carbapenemases
14 Feb, 2023 | 10:43h | UTC
M-A | Prevalence of ocular candidiasis and Candida endophthalmitis in patients with candidemia
14 Feb, 2023 | 10:43h | UTC
Commentary on Twitter
Prevalence of ocular candidiasis and Candida endophthalmitis in patients with candidemia: A systematic review and meta-analysis
✅ Just Accepted
? Freely Available
? https://t.co/a8SYDUM8UH pic.twitter.com/L5niNTVIUd— Clinical Infectious Diseases (@CIDJournal) February 9, 2023
Review | Anisocoria in the ED: pathophysiology, evaluation, and management
14 Feb, 2023 | 10:41h | UTCAnisocoria in the ED: Pathophysiology, Evaluation, and Management – emDocs
RCT | Tenecteplase noninferior to alteplase in acute ischemic cerebrovascular events
13 Feb, 2023 | 12:59h | UTCTenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
RCTs | Endovascular therapy improves functional outcomes in large ischemic strokes, but increases bleeding and vascular complications
13 Feb, 2023 | 13:00h | UTCStudy 1: Trial of Endovascular Thrombectomy for Large Ischemic Strokes – New England Journal of Medicine (link to abstract – $ for full-text)
Study 2: Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct – New England Journal of Medicine (link to abstract – $ for full-text)
M-A | Tenecteplase vs. alteplase for treatment of acute ischemic stroke
13 Feb, 2023 | 12:57h | UTCRelated: Tenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Perspective | Five new realities in critical care for patients with cancer
13 Feb, 2023 | 12:53h | UTCFive new realities in critical care for patients with cancer – Intensive Care Medicine
Related:
Consensus Conference: Critically ill cancer patient’s resuscitation.
Raising awareness for time-limited trial discussion upon ICU triage and admission.
Commentary on Twitter
New realities in critical care for pts with cancer
1️⃣ serious illness no longer means end of life
2️⃣ novel cancer therapies: changing outcomes but creating new diseases
3️⃣ take fresh look at ARF
4️⃣ goals of care & time‑limited trial
5️⃣ look beyond #ICU
? https://t.co/ZRNQD6AMIw pic.twitter.com/5QoYVSq5Br— Intensive Care Medicine (@yourICM) February 10, 2023
Extracorporeal treatment for ethylene glycol poisoning: systematic review and recommendations
13 Feb, 2023 | 12:44h | UTC