Critical Care
Review | How to use nebulized antibiotics in severe respiratory infections
10 Mar, 2023 | 14:31h | UTCHow to Use Nebulized Antibiotics in Severe Respiratory Infections – Antibiotics
Guideline | Management of severe peri-operative bleeding
8 Mar, 2023 | 14:18h | UTC
M-A | Real-time ultrasound guidance as compared to landmark technique for subclavian central venous cannulation
8 Mar, 2023 | 14:04h | UTCReal-Time Ultrasound Guidance as Compared to Landmark Technique for Subclavian Central Venous Cannulation: A Systematic Review and Meta-Analysis With Trial Sequential Analysis – Critical Care Medicine (link to abstract – $ for full-text)
M-A | Comparison of a short vs. long-course antibiotic therapy for ventilator-associated pneumonia
7 Mar, 2023 | 13:18h | UTCSummary:
This systematic review and meta-analysis of randomized controlled trials aimed to compare the rates of recurrence and relapse of ventilator-associated pneumonia (VAP) between short-course (≤8 days) and long-course (≥10-15 days) antibiotic therapy strategies. Five relevant studies involving 1069 patients were identified.
Compared to long-course therapy, short-course therapy increased the number of antibiotic-free days without any impact on recurrence and relapses of VAP, 28 days mortality, mechanical ventilation duration, number of extra-pulmonary infections, and length of ICU stay.
However, the study’s limitations, such as the small sample size and the lack of standardized definitions of the assessed outcomes, should be considered when interpreting the results.
Commentary: Study finds benefits in short-course antibiotics for ventilator-associated pneumonia – CIDRAP
Review | Acquired disorders of hypomagnesemia
7 Mar, 2023 | 13:09h | UTCAcquired Disorders of Hypomagnesemia – Mayo Clinic Proceedings
Guidelines for the diagnosis, treatment, prevention and control of infections caused by carbapenem-resistant gram-negative bacilli
7 Mar, 2023 | 13:00h | UTCRelated:
RCT | Colistin monotherapy vs. combination therapy for carbapenem-resistant organisms
SR | The effects of flow settings during high-flow nasal cannula support for adult subjects
7 Mar, 2023 | 12:40h | UTC
M-A | Early vs. delayed coronary angiography after out-of-hospital cardiac arrest without ST-segment elevation
6 Mar, 2023 | 14:12h | UTCSummary:
This systematic review and meta-analysis of randomized controlled trials evaluated the efficacy and safety of early vs. delayed coronary angiography following an out-of-hospital cardiac arrest in patients without ST elevation on the ECG.
The review included six trials with 1,590 patients and found that early angiography probably has no effect on mortality, survival with good neurologic outcomes, and ICU length of stay, indicating that the procedure should not be routinely recommended for these patients.
Related:
Emergency vs Delayed Coronary Angiogram in Survivors of Out-of-Hospital Cardiac Arrest: Results of the Randomized, Multicentric EMERGE Trial – JAMA Cardiology (link to abstract – $ for full-text)
Editorial | Helmet trials: resolving the puzzle
6 Mar, 2023 | 14:05h | UTCHelmet trials: resolving the puzzle – Intensive Care Medicine (if the link is paywalled, try this one in PMC)
Nitrous oxide-induced subacute combined degeneration of the cord: diagnosis and treatment
3 Mar, 2023 | 14:01h | UTC
Review | Practical guide for anticoagulant and antiplatelet reversal in clinical practice
3 Mar, 2023 | 13:42h | UTCPractical Guide for Anticoagulant and Antiplatelet Reversal in Clinical Practice – Pharmacy
The European guideline on management of major bleeding and coagulopathy following trauma
2 Mar, 2023 | 13:04h | UTC
Review | The golden grapes of wrath – Staphylococcus aureus bacteremia
1 Mar, 2023 | 13:46h | UTC
M-A | Which adverse events and which drugs are implicated in drug-related hospital admissions
28 Feb, 2023 | 13:59h | UTCSummary: This systematic review and meta-analysis aimed to provide an updated estimation of drug-related hospital admissions, the types and frequency of drug-induced harm, and the drugs involved. The review included 17 studies that examined acute admissions to emergency departments or inpatient wards resulting from drug-induced harm in the general population. These studies were published between January 2012 and December 2021. The estimated rates of admissions resulting from adverse drug reactions* (ADRs) and adverse drug events* (ADEs) were 8.3% and 13.9%, respectively. Almost half of the admissions related to ADRs and over two-thirds of those related to ADEs were possibly preventable. Gastrointestinal disorders, electrolyte disturbances, bleeding events, and renal and urinary disorders were the most frequently involved categories of drug-induced harm. The most frequently involved drug groups were nervous system drugs, followed by cardiovascular and antithrombotic agents.
*Adverse drug events (ADEs) and adverse drug reactions (ADRs) are two terms that are often used interchangeably, but they actually have different meanings. Adverse drug events (ADEs) refer to any negative effect that results from medication exposure and can be caused by a variety of factors, including medication errors, overdose, drug interactions, or allergic reactions. In contrast, adverse drug reactions (ADRs) are a specific type of ADE that occur as unintended effects of medication at normal therapeutic doses.
The adult and pediatric palliative care: differences and shared issues
28 Feb, 2023 | 13:30h | UTC
Review | (Mal)nutrition in critical illness and beyond
28 Feb, 2023 | 13:28h | UTC(Mal)nutrition in critical illness and beyond: a narrative review – Anaesthesia
Cluster RCT | Effectiveness of an intensive care telehealth program to improve process quality
28 Feb, 2023 | 13:31h | UTC
Commentary on Twitter
? A structured, bundled telemedical quality improvement implemented in a local network of?? hospitals improved quality of acute #ICU care vs to standard of care, increasing adherence to evidence-based performance indicators.
Open #FOAMc on @yourICM
? https://t.co/WV56tXoiHM pic.twitter.com/YQQvm2HUO5— Intensive Care Medicine (@yourICM) January 16, 2023
Guideline | Acute mechanical circulatory support
27 Feb, 2023 | 13:04h | UTC
Consensus Report | Sepsis-associated acute kidney injury
27 Feb, 2023 | 13:05h | UTCSepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup – Nature Reviews Nephrology (if the link is paywalled, try this one)
Commentary on Twitter
A Primer in @DiseasePrimers summarizes the epidemiology, mechanisms, diagnosis and treatment of pre-eclampsia, and discusses patient quality of life and open research questions for this condition. https://t.co/IO3uchSl8b pic.twitter.com/Y7Ij6jmy5a
— Nature Portfolio (@NaturePortfolio) February 25, 2023
Sepsis-induced coagulopathy: an update on pathophysiology, biomarkers, and current guidelines
27 Feb, 2023 | 12:36h | UTCSepsis-Induced Coagulopathy: An Update on Pathophysiology, Biomarkers, and Current Guidelines – Life
Related:
Review | How to manage coagulopathies in critically ill patients
Consensus Paper | Early management of isolated severe traumatic brain injury in a hospital without neurosurgical capabilities
24 Feb, 2023 | 13:49h | UTC
Commentary from the author on Twitter
Great to see our consensus published. Early management of isolated severe traumatic brain injury patients in a hospital without neurosurgical capabilities: a consensus and clinical recommendations of the World Society of Emergency Surgery (WSES).https://t.co/k9hwI82dOW pic.twitter.com/pIp5gFRnPa
— Deepak Sharma (@deepak_neuro) January 14, 2023
Review | When and how to use MIC in clinical practice?
24 Feb, 2023 | 13:28h | UTCWhen and How to Use MIC in Clinical Practice? – Antibiotics
Commentary on Twitter
https://twitter.com/ABsteward/status/1616852667124400129
Prevalence of long-term decision regret and associated risk factors in a large cohort of ICU surrogate decision makers
22 Feb, 2023 | 12:22h | UTC
Commentary on Twitter
One in five #ICU surrogate decision makers experience moderate to strong regret about life support decisions in ICU.
Read the full article: https://t.co/epCXB4QHRY@jlvincen @ISICEM #FOAMed #FOAMcc pic.twitter.com/0Q3X2uFYk0
— Critical Care (@Crit_Care) February 20, 2023
Guideline Synopsis | Management of thoracic aortic dissection
21 Feb, 2023 | 11:48h | UTCManagement of Thoracic Aortic Dissection – JAMA (free for a limited period)
Original Guidelines:
Review | How to manage coagulopathies in critically ill patients
21 Feb, 2023 | 11:43h | UTCHow to manage coagulopathies in critically ill patients – Intensive Care Medicine
Commentary on Twitter
Coagulopathies severe/frequent complication in #ICU: how to manage??
? hemorrhagic coagulopathies: non‑malignant & malignant
? thrombotic c.: sepsis‑induced & solid cancer‑associated
? managing hemorrhagic c.
?(preventing &) managing thrombotic c.
?️ https://t.co/CKqzT7dcoH pic.twitter.com/SvpPNf0oGO— Intensive Care Medicine (@yourICM) February 18, 2023