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Chest Medicine

Perspective: Ivermectin for COVID-19 — Breakthrough Treatment or Hydroxychloroquine Redux?

15 Jan, 2021 | 08:51h | UTC

Ivermectin for COVID-19 — Breakthrough Treatment or Hydroxychloroquine Redux? – HIV and ID Observations

Related video: Ivermectin For COVID-19 | A Doctor Explains – ZDoggMD

 

NIH Guideline Statement: “there are insufficient data to recommend either for or against the use of ivermectin for the treatment of COVID-19”

15 Jan, 2021 | 08:53h | UTC

The COVID-19 Treatment Guidelines Panel’s Statement on the Use of Ivermectin for the Treatment of COVID-19 – National Institutes of Health

 

Covid-19 Vaccine — Frequently Asked Questions

15 Jan, 2021 | 08:49h | UTC

Covid-19 Vaccine — Frequently Asked Questions – New England Journal of Medicine

 

Covid-19: When to start invasive ventilation is “the million dollar question”

15 Jan, 2021 | 08:48h | UTC

Covid-19: When to start invasive ventilation is “the million dollar question” – The BMJ

 

Commentary on Twitter

 

Clinical trial finds vitamin D does not ward off colds and flu

15 Jan, 2021 | 08:33h | UTC

Clinical trial finds vitamin D does not ward off colds and flu – QIMR Berghofer Medical Research Institute

Original study: The effect of vitamin D supplementation on acute respiratory tract infection in older Australian adults: an analysis of data from the D-Health Trial – The Lancet Diabetes & Endocrinology

 

Study: Pulmonary embolism detected in 6% of patients with COPD admitted to the hospital with acute worsening of respiratory symptoms

15 Jan, 2021 | 08:37h | UTC

Prevalence of Pulmonary Embolism Among Patients With COPD Hospitalized With Acutely Worsening Respiratory Symptoms – JAMA (link to abstract – $ for full-text)

 

CoronaVac study in Brazil: Is the vaccine 50%, 78%, or 100% effective?

14 Jan, 2021 | 02:11h | UTC

Third time’s the charm? Brazil scales back efficacy claims for COVID-19 vaccine from China – Science

See also: CoronaVac’s Overall Efficacy in Brazil Measured at 50.4% – Bloomberg

 

Meta-analysis: Saliva vs. nasopharyngeal swabs equally sensitive for Covid-19 diagnosis

14 Jan, 2021 | 02:13h | UTC

The Sensitivity and Costs of Testing for SARS-CoV-2 Infection With Saliva Versus Nasopharyngeal Swabs: A Systematic Review and Meta-analysis – Annals of Internal Medicine

Commentary: Saliva, Nasopharyngeal Samples Equally Sensitive for SARS-CoV-2 – Physician’s Weekly

 

Commentary on Twitter

https://twitter.com/EricTopol/status/1348758183846703104

 

Pragmatic Recommendations for the Management of COVID-19 in Low- and Middle-Income Countries

14 Jan, 2021 | 02:04h | UTC

 

Study estimates 50% of new SARS-CoV-2 infections have originated from exposure to asymptomatic or pre-symptomatic individuals

14 Jan, 2021 | 02:08h | UTC

SARS-CoV-2 Transmission From People Without COVID-19 Symptoms – JAMA Network Open

Commentary: At least 50% of COVID-19 cases spread from people without symptoms, a new study found – Business Insider AND More than half of Covid-19 infections acquired from asymptomatic carriers – MedicalResearch

 

Commentary on Twitter

https://twitter.com/TennantRuth/status/1348208811039985665

 

Imaging of Pulmonary Hypertension in Adults: A Position Paper from the Fleischner Society

14 Jan, 2021 | 01:51h | UTC

Imaging of Pulmonary Hypertension in Adults: A Position Paper from the Fleischner Society – Radiology

 

Systematic review: Does behavioral support help people to stop smoking?

14 Jan, 2021 | 01:46h | UTC

Behavioural interventions for smoking cessation: an overview and network meta‐analysis – Cochrane Library

Summary: Does behavioural support help people to stop smoking? – Cochrane Library

 

Systematic review: Immunotherapy vs. chemotherapy for people with advanced non-small cell lung cancer who have not been previously treated

14 Jan, 2021 | 01:30h | UTC

Single or combined immune checkpoint inhibitors compared to first-line platinum-based chemotherapy with or without bevacizumab for people with advanced non-small cell lung cancer – Cochrane Library

Summary: Immunotherapy versus chemotherapy for people with advanced non-small cell lung cancer who have not been not previously been treated – Cochrane Library

 

 

Short review: How Dangerous are new COVID-19 strains?

13 Jan, 2021 | 02:31h | UTC

How Dangerous Are New COVID-19 Strains? – Council on Foreign Relations

 

Commentary on Twitter

 

Confirmed reinfection with SARS-CoV-2 variant VOC-202012/01

13 Jan, 2021 | 02:30h | UTC

Confirmed Reinfection with SARS-CoV-2 Variant VOC-202012/01 – Clinical Infectious Diseases

 

Commentary on Twitter

 

Masks and face coverings for the lay public: A narrative update

13 Jan, 2021 | 02:23h | UTC

Masks and Face Coverings for the Lay Public: A Narrative Update – Annals of Internal Medicine

Related: Update Alert 4: Masks for Prevention of Respiratory Virus Infections, Including SARS-CoV-2, in Health Care and Community Settings – Annals of Internal Medicine

 

Commentary on Twitter (thread – click for more)

 

Six RCTs to answer one question: what is the role of tocilizumab in COVID-19?

13 Jan, 2021 | 02:28h | UTC

Six RCTs to answer one question: what is the role of tocilizumab in COVID-19? – PulmCrit

Related (study and commentaries): Randomized trial: Arthritis drugs improve survival in critically ill patients with Covid-19

 

Video (3 min): Which Covid vaccine is better? Pfizer v Oxford v Moderna

13 Jan, 2021 | 02:21h | UTC

Which Covid vaccine is better? Pfizer v Oxford v Moderna – BBC

 

An evidence review of face masks against COVID-19

13 Jan, 2021 | 02:26h | UTC

An evidence review of face masks against COVID-19 – Proceedings of the National Academy of Sciences

 

Commentary on Twitter

https://mobile.twitter.com/jeremyphoward/status/1348771993949151232

 

Loss of smell in mild Covid-19 cases occurs 86% of the time, study says

13 Jan, 2021 | 02:20h | UTC

Loss of smell in mild Covid-19 cases occurs 86% of the time, study says – CNN

Original study: Prevalence and 6‐month recovery of olfactory dysfunction: a multicentre study of 1363 COVID‐19 patients – Journal of Internal Medicine

 

Blood plasma treatment has limited effect for sickest COVID-19 patients

12 Jan, 2021 | 02:07h | UTC

Blood plasma treatment has limited effect for sickest COVID-19 patients – Imperial College London

See also: Expert reaction to REMAP-CAP recruitment of severely ill COVID-19 patients into convalescent plasma trial being paused after initial analysis suggested it did not improve outcomes – Science Media Centre AND Trial of COVID-19 blood plasma finds no benefit in severely ill patients – Reuters

 

Randomized trial: Plasma therapy administered early is beneficial in high-risk elderly patients

12 Jan, 2021 | 02:05h | UTC

Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults – New England Journal of Medicine

Commentaries: Early convalescent plasma may lower risk of severe COVID in seniors – CIDRAP AND Covid-19: Early Plasma Treatment Improved Outcomes in Older Patients – Physician’s Weekly

 

Commentaries on Twitter

 

Randomized trial: Renin–angiotensin system inhibitors can be safely continued in patients admitted to hospital with COVID-19

12 Jan, 2021 | 01:59h | UTC

Continuation versus discontinuation of renin–angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomised, open-label trial – The Lancet Respiratory Medicine

Commentary: Commonly used blood pressure medications safe for COVID-19 patients, study finds – University of Pennsylvania School of Medicine

 

 

CDC Study: Reducing quarantine to fewer than 14 days might be easier to comply with but carries some risk of spreading the virus

12 Jan, 2021 | 02:03h | UTC

Implications of Shortened Quarantine Among Household Contacts of Index Patients with Confirmed SARS-CoV-2 Infection — Tennessee and Wisconsin, April–September 2020 – CDC Morbidity and Mortality Weekly Report

Commentaries: Shorter Quarantines Can Eliminate Most Contagion. Is Most Enough? New Data – Brief19 AND Some Transmission of SARS-CoV-2 Occurs After Seven, 10 Days – Physician’s Wekly

Related (guideline and commentary): Why the CDC changed its Covid-19 quarantine guidelines

 

Commentary on Twitter

 

CDC Study: Among young, healthy athletes exposed to Covid-19, the probability of receiving positive test results after day 10 of quarantine is low (less than 5%)

12 Jan, 2021 | 02:01h | UTC

Time from Start of Quarantine to SARS-CoV-2 Positive Test Among Quarantined College and University Athletes — 17 States, June–October 2020 – CDC Morbidity and Mortality Weekly Report

 

Commentary on Twitter

 

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