Chest Medicine
Randomized trial: Similar outcomes with lower vs. higher oxygenation targets for acute hypoxemic respiratory failure
21 Jan, 2021 | 01:16h | UTCLower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Even though supplemental oxygen is used for the treatment of patients with hypoxemic respiratory failure, the most effective oxygenation targets are not known. In this randomized trial, a lower oxygenation target did not result in lower mortality than a higher target.
— NEJM (@NEJM) January 21, 2021
What we know about Covid-19 reinfection so far
20 Jan, 2021 | 01:52h | UTCWhat we know about covid-19 reinfection so far – The BMJ
Commentary on Twitter
https://twitter.com/bmj_latest/status/1351493503675748352
Study: Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity
20 Jan, 2021 | 01:49h | UTC
Commentary on Twitter
A new, very large #SARSCoV2 household transmission study (27K households, 30K cases, 58K contacts)https://t.co/a89uAw3Ohg
—age ≥ 60 and infants most likely to get infected
—<age 20 most likely to infect others (1.6X)@TheLancetInfDis pic.twitter.com/nM044rVEdo— Eric Topol (@EricTopol) January 18, 2021
Systematic review on prophylaxis for COVID-19: Hydroxychloroquine does not work, little evidence regarding other drugs
20 Jan, 2021 | 01:38h | UTCProphylaxis for COVID-19: a systematic review – Clinical Microbiology and Infection
USPSTF Statement: Interventions for tobacco smoking cessation in adults
20 Jan, 2021 | 01:32h | UTCEditorial: A Comprehensive Approach to Increase Adult Tobacco Cessation – JAMA
Author Interview: USPSTF Recommendation: Tobacco Cessation in Adults
JAMA Patient Page: Interventions to Promote Tobacco Cessation
Guideline synopsis: Initiating Pharmacologic Treatment in Tobacco-Dependent Adults
20 Jan, 2021 | 01:31h | UTCInitiating Pharmacologic Treatment in Tobacco-Dependent Adults – JAMA (free for a limited period)
Author Interview: Pharmacologic Management of Tobacco Cessation
Meta-analysis: Corticosteroid use in COVID-19 patients
19 Jan, 2021 | 01:56h | UTCRelated meta-analysis: Corticosteroids for Patients With Coronavirus Disease 2019 (COVID-19) With Different Disease Severity: A Meta-Analysis of Randomized Clinical Trials – Journal of Cardiothoracic and Vascular Anesthesia
Covid-19: What new variants are emerging and how are they being investigated?
19 Jan, 2021 | 01:51h | UTCCovid-19: What new variants are emerging and how are they being investigated? – The BMJ
Evidence summary and clinical decision algorithm to guide clinicians in the care of the hypoxemic, non-intubated patients with suspected Covid-19
19 Jan, 2021 | 01:57h | UTC
IDSA: COVID-19 Diagnostic Guidelines Updates
19 Jan, 2021 | 01:54h | UTCCOVID-19 Diagnostic Guidelines Updates (Jan. 16, 2021) – Infectious Diseases Society of America
New calculator identifies COVID-19 patients at highest risk of deterioration
19 Jan, 2021 | 01:52h | UTCCommentaries: Improving clinical management of COVID-19: the role of prediction models – The Lancet Respiratory Medicine
Tool identifies COVID-19 patients at highest risk of deterioration – UK Research and Innovation
See calculator: 4C Mortality & 4C Deterioration
Commentary on Twitter
This model helps predict clinical deterioration of hospitalized patients with #COVID19 using 11 commonly measured/identifiable variables at the time of hospital contact.
Validated on ~75000 patients from 260 hospitals in the UK.
Nice.
By @Rishi_K_Gupta: https://t.co/OX8vtLtcVY pic.twitter.com/FEs5gZ9M5U
— Isaac Bogoch (@BogochIsaac) January 13, 2021
Meta-analysis: saliva and nasopharyngeal swab nucleic acid amplification have similar diagnostic accuracy for the detection of SARS-CoV-2
19 Jan, 2021 | 01:46h | UTC
RECOVERY trial: No Benefit from convalescent plasma in hospitalized patients with Covid-19
17 Jan, 2021 | 22:26h | UTCCommentary: Covid: ‘Convalescent plasma no benefit to hospital patients’ – BBC
Covid-19: Norway investigates 23 deaths in frail elderly patients after vaccination
17 Jan, 2021 | 22:21h | UTCCovid-19: Norway investigates 23 deaths in frail elderly patients after vaccination – The BMJ
See also: Covid-19 vaccination associated with adverse drug reactions in elderly people who are frail
Herd immunity by infection is not an option
17 Jan, 2021 | 22:16h | UTCHerd immunity by infection is not an option – Science
CDC Study: Performance of an antigen-based test for asymptomatic and symptomatic SARS-CoV-2
17 Jan, 2021 | 22:10h | UTC
Commentary on Twitter
New @CDCMMWR shows COVID-19 antigen tests can be fast and inexpensive but sometimes require a second test to confirm the result. Protect others until your test result is confirmed. Learn more: https://t.co/xu4buZMM0K. pic.twitter.com/GbRfrFscKI
— CDC (@CDCgov) December 31, 2020
Meta-analysis: Prophylactic macrolides beneficial for patients with COPD with frequent exacerbations
17 Jan, 2021 | 22:09h | UTCSummary: Prophylactic antibiotics for people with COPD – Cochrane Library
Position paper: Chest CT diagnosis and clinical management of drug-related pneumonitis in patients receiving molecular targeting agents and immune checkpoint inhibitors
17 Jan, 2021 | 22:07h | UTC
Randomized trial: In patients hospitalized with community-acquired pneumonia, adjunctive oral dexamethasone reduced the length of stay and ICU admissions, with no difference in mortality rates
17 Jan, 2021 | 21:58h | UTCAdjunctive treatment with oral dexamethasone in non-ICU patients hospitalised with community-acquired pneumonia: A randomised clinical trial – European Respiratory Journal (link to abstract – $ for full-text)
Study: Vaping combined with smoking may be as harmful as smoking cigarettes alone
17 Jan, 2021 | 21:53h | UTCCommentaries: Vaping combined with smoking is likely as harmful as smoking cigarettes alone, study finds – American Heart Association AND CVD Biomarker Levels Up for Dual Use of E-Cigarettes, Cigarettes – Physician’s Weekly
Randomized trial: Inhaled Treprostinil in pulmonary hypertension due to interstitial lung disease
17 Jan, 2021 | 21:47h | UTCCommentaries: Inhaled Treprostinil Beneficial in Pulmonary Hypertension – HealthDay
Commentary on Twitter
Patients with pulmonary hypertension due to interstitial lung disease were randomly assigned to inhale treprostinil or placebo. At 16 weeks, there was a significant improvement in exercise capacity with inhaled treprostinil as compared with placebo, assessed by a 6-minute walk.
— NEJM (@NEJM) January 14, 2021
Meta-analysis: Safety and efficacy of dexmedetomidine in acutely ill adults requiring non-invasive ventilation
17 Jan, 2021 | 21:42h | UTCSafety and efficacy of dexmedetomidine in acutely ill adults requiring non-invasive ventilation: a systematic review and meta-analysis of randomized trials – CHEST (link to abstract – $ for full-text)
Observational study: Among patients hospitalized with Covid-19 not receiving mechanical ventilation, transfusion of plasma with higher anti–SARS-CoV-2 IgG antibody levels is linked to lower risk of death than transfusion of plasma with lower antibody levels
15 Jan, 2021 | 08:59h | UTCEditorial: (A Little) Clarity on Convalescent Plasma for Covid-19 – New England Journal of Medicine
Commentaries: Expert reaction to study looking at convalescent plasma antibody levels and risk of death from COVID-19 – Science Media Centre AND Antibody-rich convalescent plasma may lower risk of COVID death – CIDRAP
Opinion: RCTs don’t justify using convalescent plasma or antibody cocktails
15 Jan, 2021 | 08:58h | UTCRCTs don’t justify using convalescent plasma or antibody cocktails – PulmCrit
[Preprint] Past COVID-19 infection provides some immunity but people may still carry and transmit virus
15 Jan, 2021 | 09:02h | UTCSee also: Covid-19: Past infection provides 83% protection for five months but may not stop transmission, study finds – The BMJ AND COVID reinfections are unusual — but could still help the virus to spread – Nature AND COVID-19 infection gives some immunity, but virus can still be spread, study finds – Reuters AND Expert reaction to a preprint from the SIREN study looking at SARS-CoV-2 infection rates in antibody positive healthcare workers – Science Media Centre