Chest Medicine
AstraZeneca COVID vaccine 70% effective vs. B117 variant
1 Apr, 2021 | 03:55h | UTCAstraZeneca COVID vaccine 70% effective vs B117 variant – CIDRAP
Commentary on Twitter (thread – Click for more)
ASYMPTOMATIC & SYMPTOMATIC Efficacy of Oxford-AstraZeneca #COVID19 vaccine versus #B117 & non-B117 variants via 200k swabs in ~8500:🧵
Symptomatic #B117➡️ 70%
Asymptomatic #B117➡️ 29%
Other variants symptomatic➡️ 81.5%
Other variants asymptomatic➡️ 70%https://t.co/qSWYlHKP0g pic.twitter.com/gS7P9MCpyz
— Eric Feigl-Ding (@DrEricDing) March 31, 2021
[Press release – not published yet] Pfizer-BioNTech vaccine 100% effective against Covid-19 in adolescents
1 Apr, 2021 | 03:52h | UTCPress release: Pfizer-BioNTech Announce Positive Topline Results Of Pivotal Covid-19 Vaccine Study In Adolescents
Commentaries: The Pfizer-BioNTech Vaccine Is Said to Be Powerfully Protective in Adolescents – The New York Times AND Covid: Children ‘well protected by Pfizer vaccine’ – BBC AND Pfizer Says COVID-19 Vaccine Shows ‘100% Efficacy’ In Adolescents – NPR AND Pfizer says its COVID-19 vaccine protects younger teens – Associated Press AND Pfizer and BioNTech say vaccine prevents Covid-19 in adolescents – STAT
Commentaries on Twitter
https://twitter.com/hildabast/status/1377376427239075840
This is really terrific
In trial of 2260 adolescents 12-15 year of age, Pfizer vaccine highly effective at preventing infections
18 infections in placebo group
0 infections in vaccine group
Robust antibody response
No serious side-effects
Looking forward to @US_FDA review https://t.co/VymGXOVb5E
— Ashish K. Jha, MD, MPH (@ashishkjha) March 31, 2021
Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study
1 Apr, 2021 | 03:43h | UTC
Commentary on Twitter
Follow-up of nearly 48,000 hospitalized patients with covid-19 shows a high rate of readmission, death, and multi-organ disease (heart, diabetes, kidney, lung) compared with matched controls https://t.co/dzxVYdugz2 @bmj_latest pic.twitter.com/hWBn5w2XQf
— Eric Topol (@EricTopol) April 1, 2021
Bill Gates: 5 things you should know about variants
1 Apr, 2021 | 03:49h | UTC5 things you should know about variants – GatesNotes
Commentary on Twitter
Here are five things you should know if you want to understand how variants are (and aren’t) complicating the pandemic. https://t.co/rANiDcZynJ
— Bill Gates (@BillGates) March 31, 2021
Opinion | “Vaccine Passport” Certification — Policy and Ethical Considerations
1 Apr, 2021 | 03:40h | UTCRelated: Covid-19 vaccine passports will harm sustainable development – The BMJ Opinion AND Covid-19 vaccine passports and vaccine hesitancy: freedom or control? – The BMJ Opinion AND Vaccine certificates: does the end justify the means? – The Lancet Microbe AND Interim position paper: considerations regarding proof of COVID-19 vaccination for international travellers – World Health Organization
Antibody evasion by the P.1 strain of SARS-CoV-2
31 Mar, 2021 | 03:36h | UTCAntibody evasion by the P.1 strain of SARS-CoV-2 – Cell
Commentary on Twitter (thread – Click for more)
An in-depth assessment of the P.1 (Brazil) variant
—less immune evasion than B.1.351 (South Africa) variant despite similar receptor binding domain mutations
—very good neutralization by mRNA vaccine via sera from vaccineshttps://t.co/2m0A1Pjs9O @CellCellPress today pic.twitter.com/uyV2eZdLQ9— Eric Topol (@EricTopol) March 30, 2021
Why indoor spaces are still prime COVID hotspots
31 Mar, 2021 | 03:35h | UTCWhy indoor spaces are still prime COVID hotspots – Nature
[Preprint] Single dose of AstraZeneca and Pfizer vaccines shows 62% efficacy for preventing disease and reduces viral load/transmissibility of SARS-CoV-2 in residents of Long-Term Care Facilities
31 Mar, 2021 | 03:38h | UTCCommentaries: Single dose of Pfizer and Oxford vaccines shows 60% efficacy in elderly care home residents – NewsMedical AND Care home residents gain 62% protection from single dose of COVID-19 vaccine – University College London
Commentary on Twitter (thread – click for more)
https://twitter.com/sailorrooscout/status/1376512132318121990
Transmissibility and transmission of respiratory viruses
31 Mar, 2021 | 03:33h | UTCTransmissibility and transmission of respiratory viruses – Nature Reviews Microbiology
Opinion | Covid-19 vaccine passports will harm sustainable development
31 Mar, 2021 | 03:31h | UTCCovid-19 vaccine passports will harm sustainable development – The BMJ Opinion
“Where you are born can predict how freely you will be able to travel for opportunity, education, and leisure. Being a citizen of certain countries grants people access to nearly the entire globe, whereas others face challenges just to legally leave the borders of the country they live in”
Opinion | Covid-19 vaccine passports and vaccine hesitancy: freedom or control?
31 Mar, 2021 | 03:29h | UTCCovid-19 vaccine passports and vaccine hesitancy: freedom or control? – The BMJ Opinion
“Recent debates around “vaccine passports,” or formal/mandatory certification of vaccination, point towards a potential widening societal divide between those who are vaccinated and those who are not.”
The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis
31 Mar, 2021 | 03:27h | UTC
M-A: Decreased mortality in acute respiratory distress syndrome patients treated with corticosteroids
30 Mar, 2021 | 03:01h | UTC
‘Real world’ study by CDC shows Pfizer and Moderna vaccines were 90% effective
30 Mar, 2021 | 03:27h | UTC‘Real world’ study by CDC shows Pfizer and Moderna vaccines were 90% effective – STAT
Commentary on Twitter (thread – Click for more)
https://twitter.com/hildabast/status/1376648088878608386
COVID-19, Personal Protective Equipment, and Human Performance
30 Mar, 2021 | 03:14h | UTCCOVID-19, Personal Protective Equipment, and Human Performance – Anesthesiology
Study: mRNA vaccine is associated with decreased SARS-CoV-2 viral load in individuals with breakthrough infection, suggesting a role in suppressing onward transmission
30 Mar, 2021 | 03:25h | UTC
Commentaries on Twitter
https://twitter.com/nresearchnews/status/1376667763914240000
(Thread – Click for more)
New @NatureMedicine: The concern about asymptomatic transmission addressed in nearly 5,000 people after 1st dose of mRNA vaccine (~2 -5 wks). Viral load markedly reduced (high Ct). Supports vaccine effect for blocking or strongly reducing chance of spreadhttps://t.co/mmJmZPZfHK pic.twitter.com/0TTf4cFZed
— Eric Topol (@EricTopol) March 29, 2021
COVID associated with hearing loss, tinnitus and vertigo – new study confirms link
30 Mar, 2021 | 03:19h | UTCOriginal study: One year on: an updated systematic review of SARS-CoV-2, COVID-19 and audio-vestibular symptoms – International Journal of Audiology
Cochrane Library Editorial: Contested effects and chaotic policies: the 2020 story of (hydroxy) chloroquine for treating COVID‐19
28 Mar, 2021 | 22:55h | UTCCommentary and Infographic: Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus? – Cochrane Library
Original review: Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19 – Cochrane Library
Commentary on Twitter
New #VisualAbstract for the @Cochrane_IDG systematic review on #Chloroquine or #hydroxychloroquine for prevention and treatment of #COVID19 https://t.co/U7TnMzQTil Many thanks to @tylerdau & @cg_coleman from @EmoryMedicine pic.twitter.com/tlFKKa31E8
— The Cochrane Library (@CochraneLibrary) March 25, 2021
Effect of timing of intubation on clinical outcomes of critically ill patients with COVID-19: a systematic review and meta-analysis of non-randomized cohort studies
30 Mar, 2021 | 03:12h | UTC
Commentary on Twitter
https://twitter.com/VGiannakoulis/status/1375795854301392896
RCT: Discontinuing betalactam treatment after 3 days as good as 8 days of treatment for stable patients with community-acquired pneumonia in non-critical care wards
28 Mar, 2021 | 22:25h | UTC
Commentary on Twitter
Less can be more for pneumonia. In 50% CAP patients was possible stop Abx at 3 days and outcomes were the same @TheLancet https://t.co/Hc1AxyndWS pic.twitter.com/Ypk2uXeDQV
— Michael Marks (@dr_michaelmarks) March 26, 2021
Another study indicates SARS-CoV-2 variant B.1.351, but not variant B.1.1.7, has partial resistance to neutralizing antibodies generated by natural infection or mRNA vaccination
28 Mar, 2021 | 22:53h | UTC
Commentaries on Twitter
Now a peer-reviewed pub in a top journal, this elegant study clearly shows that variant B.1.351 isn't stopped by antibodies from prior infection or the Pfizer vax. We'll have revised vaccines, but we don't yet. Please behave accordingly. https://t.co/w8GHPDB7aL
— EQV Analytics 🇺🇦😷🔬🪷 (@AnalyticsEqv) March 27, 2021
New @NatureMedicine, further data on immune response after vaccination to 2 variants, B.1.1.7 (UK) and B.1.351 (SA). Reinforcing recent reports, the latter is more of an immune evader, and may pose vulnerability for reinfection post-vaccinehttps://t.co/w8xFc3fkh5 pic.twitter.com/i7DAnjSZwE
— Eric Topol (@EricTopol) March 26, 2021
Covid-19: Middle aged women face greater risk of debilitating long term symptoms
28 Mar, 2021 | 22:49h | UTCCovid-19: Middle aged women face greater risk of debilitating long term symptoms – The BMJ
Linked Opinion: The stigma is real for people living with long covid – The BMJ Opinion
How COVID-19 Affects the Brain
28 Mar, 2021 | 22:51h | UTCHow COVID-19 Affects the Brain – JAMA Psychiatry
Commentary on Twitter
#COVID19 brain symptoms are a rising concern. Mechanisms of brain damage by the virus include lasting neuroinflammation, thrombotic events and alteration of neurotransmitters release. Consequently, people suffer cognitive, emotional and behavioral symptoms https://t.co/pTzJo6DLV8
— JAMA Psychiatry (@JAMAPsych) March 26, 2021
Opinion | The Coronavirus Variants Don’t Seem to Be Highly Variable So Far
28 Mar, 2021 | 22:46h | UTCThe Coronavirus Variants Don’t Seem to Be Highly Variable So Far – Scientific American
Persistent neurologic symptoms and cognitive dysfunction in non‐hospitalized Covid‐19 “long haulers”
28 Mar, 2021 | 22:48h | UTCCommentary: 85% of COVID-19 long-haulers have multiple brain-related symptoms – LiveScience AND ‘Brain fog’ and other neurologic symptoms can last for months after Covid – NBC News AND Neurologic Symptoms Persistent for Many COVID-19 ‘Long-Haulers’ – Health Day