Chest Medicine
Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil – “we estimate that P.1 may be 1.7–2.4-fold more transmissible”
15 Apr, 2021 | 07:09h | UTCGenomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil – Science
Commentary: The P.1 coronavirus variant is twice as transmissible as earlier strains – ScienceNews
Pandemic Boosts an Old Idea—Bringing Acute Care to the Patient
15 Apr, 2021 | 06:51h | UTCPandemic Boosts an Old Idea—Bringing Acute Care to the Patient – JAMA
Related studies: Cohort Study: Selected patients with Covid-19 can be safely discharged on home oxygen, with low mortality and readmission rates AND Association of a Bundled Hospital-at-Home and 30-Day Postacute Transitional Care Program With Clinical Outcomes and Patient Experiences – JAMA Internal Medicine
Case Report: Thrombotic Thrombocytopenia after Johnson & Johnson Vaccine
15 Apr, 2021 | 07:02h | UTCThrombotic Thrombocytopenia after Ad26.COV2.S Vaccination – New England Journal of Medicine
Related: U.S. regulators pause Johnson & Johnson vaccine rollout over rare (1 in a million) cases of blood clots AND 4 Things to Know About the J&J Covid Vaccine Pause – Kaiser Health News AND Why Johnson & Johnson shots were paused — and why that’s so confusing – Vox AND Is it the adenovirus vaccine technology, used by AstraZeneca and Johnson & Johnson, causing blood clots? There’s no evidence yet – The Conversation
Opinion | Deep Cleaning Isn’t a Victimless Crime
15 Apr, 2021 | 06:56h | UTCDeep Cleaning Isn’t a Victimless Crime – The Atlantic
Related: CDC Updated Guidance: “It is possible for people to be infected through contact with contaminated surfaces or objects, but the risk is generally considered to be low” (CDC Guidance and more)
Observational study: Impact of the influenza vaccine on COVID-19 infection rates and severity
15 Apr, 2021 | 06:47h | UTCCommentary: Flu shot associated with fewer, less severe COVID cases – University of Michigan
Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: a study in 48 440 adult patients
15 Apr, 2021 | 06:49h | UTCCommentaries: Exercise may strongly protect against poor COVID-19 outcomes – CIDRAP AND One Good Way to Help Beat COVID: Exercise – HealthDay
New studies suggest SARS-CoV-2 variant B.1.1.7 is not more deadly, just more transmissible
14 Apr, 2021 | 02:12h | UTCCommentaries: Expert reaction to two papers looking at the transmissibility and severity of the B.1.1.7 variant – Science Media Centre AND UK coronavirus variant not more deadly, just spreads more easily, studies find – LiveScience
Why would a Covid vaccine cause rare blood clots? Researchers have found clues
14 Apr, 2021 | 02:14h | UTCWhy would a Covid vaccine cause rare blood clots? Researchers have found clues – STAT
Related: How could a COVID vaccine cause blood clots? Scientists race to investigate – Nature
U.S. regulators pause Johnson & Johnson vaccine rollout over rare (1 in a million) cases of blood clots
14 Apr, 2021 | 02:16h | UTCJoint CDC and FDA Statement on Johnson & Johnson COVID-19 Vaccine – U.S. Food & Drug Administration
Commentaries: Covid-19: US suspends Johnson and Johnson vaccine rollout over blood clots – BMJ AND CDC and FDA recommend US pause use of Johnson & Johnson’s Covid-19 vaccine over blood clot concerns – CNN AND US halts J&J COVID vaccine after reports of blood clots – CIDRAP AND U.S. urges pause on use of Johnson & Johnson Covid-19 vaccine after rare blood clotting cases – CIDRAP
RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19
13 Apr, 2021 | 05:30h | UTCOriginal study (preprint): Inhaled budesonide for COVID-19 in people at higher risk of adverse outcomes in the community: interim analyses from the PRINCIPLE trial – medRxiv
Commentary: Covid: Asthma drug ‘speeds up recovery at home’ – BBC
Related study: Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19 (study and commentaries)
Tobacco Taxes Are Most Effective Yet Least Implemented Tactics, Says WHO
13 Apr, 2021 | 05:06h | UTCTobacco Taxes Are Most Effective Yet Least Implemented Tactics, Says WHO – Health Policy Watch
Guidance: WHO technical manual on tobacco tax administration – World Health Organization
Infectivity of severe acute respiratory syndrome coronavirus 2 in children compared with adults
13 Apr, 2021 | 05:27h | UTCCommentary: Children may be less infectious in spreading SARS-CoV-2 to others – News Medical
M-A: Post-extubation oxygenation strategies in acute respiratory failure – NPPV or HFNC may reduce the risk of endotracheal reintubation but not mortality
12 Apr, 2021 | 00:42h | UTC
China considers mixing COVID-19 vaccines to boost protection rate
13 Apr, 2021 | 05:24h | UTCChina considers mixing COVID-19 vaccines to boost protection rate – Reuters
Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19
13 Apr, 2021 | 05:21h | UTCRelated: Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery AND Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk
[Press release – not published yet] Phase 3 prevention trial showed 81% reduced risk of symptomatic SARS-CoV-2 infections with subcutaneous administration of monoclonal antibodies
13 Apr, 2021 | 05:26h | UTCCommentaries: Regeneron says antibody cocktail prevented Covid when given as simple injection, not an IV – STAT AND Regeneron’s Covid mAb as a prophylactic injection: Reduced risk of symptomatic infection by 81% – Endpoint News
Cohort study: SARS-CoV-2 infection rates of antibody-positive vs. antibody-negative health-care workers – previous infection was associated with 84% lower risk of (re)infection
12 Apr, 2021 | 01:30h | UTCCommentary: Correlates of protection from SARS-CoV-2 infection – The Lancet
Commentary on Twitter
💥SIREN STUDY💥 @TheLancet
Previous SARS-CoV-2 infection
provides protection similar to or even better than currently used vaccines
📌84% risk reduction(RR) for reinfection
📌93% RR for those w symptomatic infections
📌B.1.1.7 circulate during the studyhttps://t.co/uQ3M9yahAv pic.twitter.com/leQCNbmHQO— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) April 10, 2021
Perspective | They Tested Negative for Covid. Still, They Have Long Covid Symptoms.
13 Apr, 2021 | 05:23h | UTCThey Tested Negative for Covid. Still, They Have Long Covid Symptoms. – Kaiser Health News
Commentary on Twitter
Scary: Many people have tested negative for SARSCoV2, yet they developed Long Covid. What's to blame? Haphazard testing protocols, delays & difficulties accessing tests & poor quality of many of the tests on the market. All have have left people without proof of infection. https://t.co/KH3QYkbbKW pic.twitter.com/MVuRhWoHle
— delthia ricks 🔬 (@DelthiaRicks) April 12, 2021
Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients
12 Apr, 2021 | 01:23h | UTC
Commentary on Twitter
Prone position in #COVID19, use & effect:
➡️PP widely adopted, the more severe the respiratory failure, the more frequent the use
➡️PP improved oxygenation in most (better V/Q matching?)
➡️mortality of O2-Non-Responders significantly higher@Crit_Care https://t.co/Q2Z15a8Pvr pic.twitter.com/CZqshIfJrg— M Velia Antonini (@FOAMecmo) April 7, 2021
[Preprint] Pfizer vaccine less effective for SARS-CoV-2 variant B.1.351
12 Apr, 2021 | 01:26h | UTCCommentaries: South African variant may evade protection from Pfizer vaccine, Israeli study says – Reuters AND Israeli data shows South African variant able to ‘break through’ Pfizer vaccine – The Times of Israel
Related: Another study indicates SARS-CoV-2 variant B.1.351, but not variant B.1.1.7, has partial resistance to neutralizing antibodies generated by natural infection or mRNA vaccination AND SARS-CoV-2 variants B.1.351 and P.1 can escape from therapeutic antibodies and evade antibodies induced by infection or mRNA vaccination AND B.1.351 strain of SARS-CoV-2 neutralization titer reduced 8- to 9-fold for Pfizer and AstraZeneca vaccinees. Convalescent plasma and therapeutic antibodies were less effective against this variant as well.
[Preprint] Efficacy and safety of CoronaVac in healthcare professionals in Brazil
12 Apr, 2021 | 01:17h | UTC
Commentary on Twitter (thread – click for more)
https://twitter.com/hildabast/status/1381366467665391619
Papers Confirm Rare Thrombocytopenia Link to AstraZeneca Vaccine
12 Apr, 2021 | 01:20h | UTCPapers Confirm Rare Thrombocytopenia Link to AstraZeneca Vaccine – TCTMD
Study 1: Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination – New England Journal of Medicine
Study 2: Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination – New England Journal of Medicine
Japanese doctors perform world’s first living donor lung transplant to a Covid-19 patient
12 Apr, 2021 | 01:12h | UTCJapanese doctors perform world’s first living donor lung transplant to a Covid-19 patient – CNN
EMA Reviews Link Between Blood Clots and Johnson & Johnson Vaccine
12 Apr, 2021 | 01:18h | UTCEMA Reviews Link Between Blood Clots and Johnson & Johnson Vaccine – Health Policy Watch
See also: Johnson & Johnson’s COVID-19 vaccine under scrutiny at EMA after 4 ‘serious cases’ of unusual blood clots – Fierce Pharma AND J&J COVID-19 vaccine under EU review over blood clots, AstraZeneca probe grows – Reuters
Chinese COVID-19 vaccine maintains protection in variant-plagued Brazil
12 Apr, 2021 | 01:14h | UTCChinese COVID-19 vaccine maintains protection in variant-plagued Brazil – Science
Original study: [Preprint] CoronaVac is 50% effective for reducing symptomatic SARS-CoV-2 infection after the first dose in the setting of high P.1 variant transmission in Brazil (study and commentary on Twitter)