Chest Medicine (all articles)
RCT | Oral fluvoxamine plus inhaled budesonide reduced hospitalizations in high-risk patients with early-onset COVID-19
24 Apr, 2023 | 13:51h | UTC
Commentary on Twitter
Treatment w/ oral fluvoxamine + inhaled budesonide among high-risk outpatients w/ early #COVID19 reduced incidence of severe disease requiring advanced care. The combined effect seems to offer benefits over individual use of each drug: https://t.co/wM2da5a5MD pic.twitter.com/Sl1qFzTOjD
— Annals of Int Med (@AnnalsofIM) April 19, 2023
RCT | Higher dose corticosteroids increase mortality in hypoxic COVID-19 patients on simple oxygen
24 Apr, 2023 | 13:55h | UTCEditorial: Higher-dose dexamethasone for patients with COVID-19 and hypoxaemia? – The Lancet
Commentary: Higher-dose corticosteroids tied to 60% more deaths in low-oxygen COVID patients – CIDRAP
Commentary on Twitter (thread – click for more)
Low-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support.
A new study evaluated the use of a higher dose of corticosteroids in this patient group. https://t.co/uJGSYSBQAO
— The Lancet (@TheLancet) April 13, 2023
Cold static preservation at 10°C shows promising results for safely extending lung transplantation timeframes
24 Apr, 2023 | 13:38h | UTCExtension of Cold Static Donor Lung Preservation at 10°C – NEJM Evidence
Commentary on Twitter
Donor lungs for transplantation are stored on ice and transplanted as rapidly as possible. In an advance that may ease transplant logistics, Ali et al. now report that prolonged storage of donor lungs at 10°C may lead to equivalent outcomes.
Read the Original Article:
— NEJM Evidence (@NEJMEvidence) April 22, 2023
Brief Review | The use of high-flow nasal oxygen
24 Apr, 2023 | 13:23h | UTCThe use of high-flow nasal oxygen – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
The use of high‑flow nasal oxygen:
? acute hypoxemic respiratory failure
? acute hypercapnic respiratory failure
? weaning from mechanical ventilation
? special populations: immunocompromised patients & tracheostomised patients
?️ https://t.co/3ZzGabkh0M pic.twitter.com/ieVCWjPDwE— Intensive Care Medicine (@yourICM) April 20, 2023
Brief Review | Aerosolized antibiotics in critical care
24 Apr, 2023 | 13:21h | UTCAerosolised antibiotics in critical care – Intensive Care Medicine
Related: How to Use Nebulized Antibiotics in Severe Respiratory Infections – Antibiotics
Commentary on Twitter
Aerosolised antibiotics in #ICU
? delivery to tracheobronchial tree? easy
? delivery to infected lung parenchyma? difficult
? clinical delivery of aerosolized ABTS
? how to address unmet clinical needs from a research standpoint
Free to read #FOAMcc
?️ https://t.co/tLjcvyUpY7 pic.twitter.com/brhTAGczRr— Intensive Care Medicine (@yourICM) April 22, 2023
Brief Review | Chronic cough and inflammatory bowel disease: an under-recognized association?
18 Apr, 2023 | 13:07h | UTCChronic cough and inflammatory bowel disease: an under-recognised association? – Breathe
Commentary on Twitter
Breathe: Respiratory complications of inflammatory bowel disease (IBD) are common and may be under-recognised. Chronic cough may present many years after a colectomy for IBD, is typically productive and can be very responsive to inhaled corticosteroids. https://t.co/9hw3bvMeGp pic.twitter.com/ZJURzidpMU
— ERS publications (@ERSpublications) April 15, 2023
SR | Oral direct thrombin inhibitors vs. conventional anticoagulants for the treatment of pulmonary embolism
17 Apr, 2023 | 13:02h | UTC
SR | Exercise‐based rehabilitation programs for pulmonary hypertension
17 Apr, 2023 | 12:44h | UTCExercise‐based rehabilitation programmes for pulmonary hypertension – Cochrane Library
Summary: Exercise-based rehabilitation in pulmonary hypertension – Cochrane Library
SR | Inhaled corticosteroids versus placebo for stable chronic obstructive pulmonary disease
17 Apr, 2023 | 12:40h | UTC
M-A | Association of inhaled corticosteroids with all-cause mortality risk in patients with COPD
12 Apr, 2023 | 13:25h | UTCAssociation of Inhaled Corticosteroids With All-Cause Mortality Risk in Patients With COPD: A Meta-analysis of 60 Randomized Controlled Trials – Chest (link to abstract – $ for full-text)
Commentary on Twitter
ICS-based inhaled therapy of longer than 6 months associated with reduction in all-cause mortality risk in patients with #COPD in a meta-analysis of 60 RCTs. Read the full original research in the January issue: https://t.co/p2CwSu8aqb#journalCHEST #MedEd pic.twitter.com/0j24enQmX3
— CHEST® Journal (@journal_CHEST) January 20, 2023
Review | Revised definition of pulmonary hypertension and approach to management
12 Apr, 2023 | 13:22h | UTCRelated:
#ESCCongress | 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension.
Pulmonary hypertension: An update of Dx and Tx guidelines – Journal of Family Practice
The physiological basis of pulmonary arterial hypertension – European Respiratory Journal
Topic-Based, Recent Literature Review on Pulmonary Hypertension – Mayo Clinic Proceedings
Review | Managing respiratory muscle weakness during weaning from invasive ventilation
11 Apr, 2023 | 14:12h | UTC
RCT | Targeted hypoglossal nerve stimulation may benefit patients with obstructive sleep apnea
11 Apr, 2023 | 14:07h | UTC
Commentary on Twitter
In this study, proximal targeted hypoglossal nerve responses proved safe and effective in treating sleep apnea and improving sleep architecture and quality of life, while comparing favorably with those in distal hypoglossal nerve stimulation trials. https://t.co/yorNGW9uoi
— JAMA Otolaryngology – Head & Neck Surgery (@JAMAOto) April 6, 2023
M-A | Noninvasive respiratory support after extubation
11 Apr, 2023 | 14:03h | UTC
Review | Pulmonary arterial hypertension in pregnancy
11 Apr, 2023 | 14:06h | UTCPulmonary arterial hypertension in pregnancy – Current Opinion in Cardiology
Review | Evaluation and management of chronic thromboembolic pulmonary hypertension
11 Apr, 2023 | 14:00h | UTCEvaluation and Management of Chronic Thromboembolic Pulmonary Hypertension – Chest
Perspective | ARDS complicating traumatic brain injury. Can opposite strategies converge?
10 Apr, 2023 | 13:39h | UTCAcute respiratory distress syndrome complicating traumatic brain injury. Can opposite strategies converge? – Intensive Care Medicine (free for a limited period)
M-A | High-flow nasal cannula vs. noninvasive positive pressure ventilation in acute hypoxic respiratory failure
10 Apr, 2023 | 13:37h | UTC
Review | Post-COVID syndrome
6 Apr, 2023 | 13:21h | UTCPost-COVID Syndrome – Deutsches Ärzteblatt International
Related:
Long COVID: major findings, mechanisms and recommendations – Nature Reviews Microbiology
ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia
5 Apr, 2023 | 13:45h | UTC
Commentary on Twitter
Management of severe community-acquired pneumonia: @EuroRespSoc @ESICM @ESCMID @ALATorax international guidelines
➡️ evidence-based recommendations for diagnosis, empirical treatment, ABTs
➡️ current knowledge gaps
➡️ recommendations for future research
?️ https://t.co/qhe1wlgN9t pic.twitter.com/LMNCbauYfs— Intensive Care Medicine (@yourICM) April 4, 2023
Contrary to prior studies, new research finds no heightened postoperative risk after a recent covid-19 infection
4 Apr, 2023 | 13:54h | UTCCommentaries:
COVID infection within 60 days not tied to adverse postsurgical outcomes – CIDRAP
Adverse Postoperative Outcomes Not Increased With Recent COVID-19 – HealthDay
Related:
ASA and APSF statement on perioperative testing for the COVID-19 virus.
Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery
BJS commission on surgery and perioperative care post-COVID-19.
ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.
Position statement: Perioperative management of post-COVID-19 surgical patients.
Bivalent Booster | Observational data suggests no increased cardiovascular risks compared to monovalent vaccine
4 Apr, 2023 | 13:55h | UTCCommentary: Similarly Low Risk of CV Events With Bivalent and Monovalent mRNA Boosters – TCTMD
Commentary on Twitter
In this French study, the risk of cardiovascular events was similar among recipients of the bivalent Pfizer–BioNTech vaccine and the original monovalent vaccine 21 days after the booster dose. https://t.co/FUZbbsn82I pic.twitter.com/ki0FPeutNm
— NEJM (@NEJM) March 29, 2023
M-A | Rapid antigen-based and rapid molecular tests for the detection of SARS-CoV-2
4 Apr, 2023 | 13:52h | UTCRelated:
Interpreting a lateral flow SARS-CoV-2 antigen test – The BMJ
Lateral flow devices maintain detection sensitivity across Alpha, Delta, and Omicron waves
3 Apr, 2023 | 13:53h | UTCSummary: The study assessed the performance of antigen lateral flow devices (LFDs) during the alpha, delta, and omicron waves of the SARS-CoV-2 pandemic in the UK. Researchers aimed to understand LFD performance concerning changes in variant infections, vaccination, viral load, and LFD use, as well as the devices’ ability to detect infectious individuals. Paired LFD and RT-PCR test results were collected from both asymptomatic and symptomatic participants between November 2020 and March 2022.
When compared to RT-PCR testing, the overall LFD sensitivity was 63.2%, and specificity was 99.71%. The sensitivity was higher in symptomatic participants (68.7%) than in asymptomatic participants (52.8%). The study found that increased viral load was independently associated with a higher likelihood of being LFD positive. There was no evidence of a significant difference in LFD sensitivity between the alpha and delta variants, but sensitivity increased during the omicron wave. Vaccination status did not show an independent association with LFD sensitivity.
The study concluded that LFDs can detect most SARS-CoV-2 infections across different viral variants and during vaccine roll-out, contributing to reduced transmission risk. However, LFD performance is lower in asymptomatic individuals, which should be taken into account when designing testing programs.
Invited Commentary: The performance of rapid antigen tests against SARS-CoV-2 variants – The Lancet Infectious Diseases
Related:
Interpreting a lateral flow SARS-CoV-2 antigen test – The BMJ
M-A | Incidence and prognostic role of pleural effusion in patients with pulmonary embolism
31 Mar, 2023 | 13:40h | UTC