Chest Medicine (all articles) | Page 58 of 169 | Links Medicus Content Curation & Alerts in Medicine

Data on 1 year outcomes for patients with post-COVID lung fibrosis. Small study, very little clinical information, including on treatment, and I object to the use of the term ILA, but overall not suggestive of progressive fibrotic lung disease. Thoughts?https://t.co/Kdt1pmTREl pic.twitter.com/mu1Jd2G6sd

— Anna Podolanczuk (@AnnaPodolanczuk) August 4, 2021

International, multicenter observational study: Outcomes with percutaneous dilatational tracheotomy in high-risk ICU patients.

6 Aug, 2021 | 08:59h | UTC

Percutaneous dilatational tracheotomy in high-risk ICU patients – Annals of Intensive Care

SARS-CoV-2 Variants in Patients with Immunosuppression.

5 Aug, 2021 | 09:02h | UTC

SARS-CoV-2 Variants in Patients with Immunosuppression – New England Journal of Medicine

Commentary on Twitter

In the pandemic, immunocompromised people (~3% of Americans) are not getting adequate recognition for the potential of in-host evolution of the virus (highlighted studies) and the need for far better approaches to protect them https://t.co/XDT1VxC9ZK @NEJM pic.twitter.com/ciw1WD9EzC

— Eric Topol (@EricTopol) August 4, 2021

RCT: In noncritically ill patients hospitalized with Covid-19, therapeutic-dose anticoagulation with heparin increased the probability of survival to hospital discharge compared with usual-care thromboprophylaxis.

5 Aug, 2021 | 09:07h | UTC

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19 – New England Journal of Medicine

Editorial: Surviving Covid-19 with Heparin?

Commentaries:

Full-dose blood thinners reduce the need for organ support in moderately ill COVID-19 patients, but not in critically ill patients – National Institutes of Health

Therapeutic-Dose Heparin in COVID-19: Who Benefits, Who Doesn’t – TCTMD

Canadian-Led International Study: Full-Dose Blood Thinners Benefit Moderately Ill COVID-19 Patients – University of Manitoba

Commentary on Twitter

In noncritically ill patients with #COVID19, anticoagulation increased the probability of survival to hospital discharge without organ support. https://t.co/3JzKdmL3SB #IDTwitter pic.twitter.com/iDjSelp2HL

— NEJM (@NEJM) August 4, 2021

RCT: In critically ill patients with Covid-19, therapeutic anticoagulation with heparin did not result in improved outcomes compared to usual-care pharmacologic thromboprophylaxis.

5 Aug, 2021 | 09:04h | UTC

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19 – New England Journal of Medicine

Editorial: Surviving Covid-19 with Heparin?

Commentaries:

Full-dose blood thinners reduce the need for organ support in moderately ill COVID-19 patients, but not in critically ill patients – National Institutes of Health

Therapeutic-Dose Heparin in COVID-19: Who Benefits, Who Doesn’t – TCTMD

Commentary on Twitter

Anticoagulation did not improve hospital survival in critically Ill patients with #COVID19. https://t.co/E8RXE01jbF pic.twitter.com/9idGxgbUas

— NEJM (@NEJM) August 4, 2021

RCT: Subcutaneous REGEN-COV antibody combination prevented symptomatic Covid-19 infection in previously uninfected household contacts of infected persons.

5 Aug, 2021 | 09:01h | UTC

Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19 – New England Journal of Medicine

RCT: Bamlanivimab plus Etesevimab reduce mortality and hospitalization in ambulatory patients with early Covid-19 (within 3 days of a positive test) who are at risk for clinical deterioration (i.e., older people, obese, diabetics, immunocompromised, with CV disease).

[Preprint] RECOVERY trial finds Regeneron’s monoclonal antibody combination reduces deaths for hospitalized COVID-19 patients who have not mounted their own immune response.

Commentary on Twitter

Subcutaneous REGEN-COV prevented symptomatic #COVID19 and asymptomatic #SARSCoV2 infection in previously uninfected household contacts. https://t.co/rRNFTjS9hX pic.twitter.com/B7qXeyWKUb

— NEJM (@NEJM) August 4, 2021

Review: Lung transplantation for interstitial lung disease.

5 Aug, 2021 | 08:32h | UTC

Lung transplantation for interstitial lung disease – European Respiratory Review

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

4 Aug, 2021 | 10:06h | UTC

Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2 – The Lancet Child & Adolescent Health

Invited commentary: Citizen science and biomedical research (free registration required)

Commentaries:

Expert reaction to study looking at long-lasting symptoms from COVID-19 in children – Science Media Centre

Long Covid uncommon in children, analysis finds – King’s College London

Study finds long-term Covid symptoms rare in school-age children – The Guardian

Most children with Covid-19 recover within a week, but a small percentage have long-term symptoms, a study says. – The New York Times

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Cohort study: Risk factors for long covid in previously hospitalized children.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Commentary on Twitter

New @LancetChildAdol is a very reassuring prospective study of >250,000 children, >1700 with + covid test, age 5-17, that shows the risk for chronic Covid symptoms is quite low; 4.4% beyond 4 weekshttps://t.co/XVFs0UtHWC pic.twitter.com/XBVH5wmFve

— Eric Topol (@EricTopol) August 3, 2021

Review: Tuberous sclerosis complex for the pulmonologist.

5 Aug, 2021 | 08:30h | UTC

Tuberous sclerosis complex for the pulmonologist – European Respiratory Review

Opinion (video): “The Delta Surge May Collapse Faster Than You Think.”

4 Aug, 2021 | 09:53h | UTC

The Delta Surge May Collapse Faster Than You Think – ZDoggMD

The study behind new CDC’s mask guidance found vaccinated people can spread delta variant.

How the coronavirus infects cells — and why Delta is so dangerous.

COVID vaccines slash viral spread, but Delta is an unknown – “Studies show that vaccines reduce the spread of SARS-CoV-2 by more than 80%, but the Delta variant is creating fresh uncertainty”.

CDC changes mask guidance in response to threat of Delta variant of Covid-19.

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

4 Aug, 2021 | 09:55h | UTC

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset – eLlife

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

Commentary on Twitter (thread – click for more)

Excess mortality across the world with the World Mortality Dataset – officially published at @eLife!https://t.co/bCudrKhZ6d

A thread on data, findings, and more.

1

(Illustration by Gal Kabiri) pic.twitter.com/oqtXRqUQH9

— Ariel Karlinsky (@ArielKarlinsky) August 3, 2021

Antimicrobial stewardship in the ICU in COVID times: the known unknowns.

4 Aug, 2021 | 09:16h | UTC

Antimicrobial stewardship in the ICU in COVID times: the known unknowns – International Journal of Antimicrobial Agents

IDSA Updated Covid-19 Guidance: Co-Infection and Antimicrobial Stewardship – “bacterial coinfections with SARS-CoV-2 infection are relatively infrequent (likely occurring in less than 10% of hospitalized COVID-19 patients)”.

Antimicrobial stewardship in ICUs during the COVID-19 pandemic: back to the 90s?

Another study shows a high frequency of antibiotic use among patients hospitalized with Covid-19 (85.2%), despite low rates of confirmed secondary bacterial infections.

Too many COVID-19 patients get unneeded ‘just in case’ antibiotics

RCT: Text-message reminders can increase COVID-19 vaccinations.

4 Aug, 2021 | 09:12h | UTC

Behavioral Nudges Increase COVID-19 Vaccinations – Nature

Commentaries:

Text-message ‘nudges’ can encourage holdouts to get COVID vaccination, study finds – UCLA

Text reminders boost vaccine appointments – Carnegie Mellon University

Commentary on Twitter

Sometimes the tools that actually work in public health are profoundly boring. Here, a text message reminder system is shown in a randomized trial to increase vaccine uptake. Years of HIV adherence research has shown the value of simple nudges like this.https://t.co/1ndpnQ6Ha6 https://t.co/Gltll8DTJ4

— Natalie E. Dean, PhD (@nataliexdean) August 3, 2021

Spontaneous pneumomediastinum in patients diagnosed with covid-19: a case series with review of literature.

4 Aug, 2021 | 09:13h | UTC

Spontaneous Pneumomediastinum in Patients Diagnosed with COVID-19: a Case Series with Review of Literature – Academic Radiology

M-A: Noninvasive respiratory support outside the intensive care unit for acute respiratory failure related to coronavirus-19 disease.

3 Aug, 2021 | 09:09h | UTC

Noninvasive respiratory support outside the intensive care unit for acute respiratory failure related to coronavirus-19 disease: a systematic review and meta-analysis – Critical Care

A blood marker predicts who gets ‘breakthrough’ COVID (neutralizing antibodies).

3 Aug, 2021 | 09:01h | UTC

A blood marker predicts who gets ‘breakthrough’ COVID – Nature

A correlate of protection for SARS-CoV-2 vaccines is urgently needed – “Recent studies suggest that neutralizing antibodies could serve as a correlate of protection for vaccines against SARS-CoV-2 in humans”.

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection.

Covid-19 breakthrough infections in vaccinated health care workers.

Postacute Sequelae of COVID-19 Pneumonia: 6-month Chest CT Follow-up.

3 Aug, 2021 | 09:02h | UTC

Postacute Sequelae of COVID-19 Pneumonia: 6-month Chest CT Follow-up – Radiology

Covid: Pulse oxygen monitors work less well on darker skin, experts say.

3 Aug, 2021 | 09:00h | UTC

Covid: Pulse oxygen monitors work less well on darker skin, experts say – BBC

FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias

“Racial Bias in Pulse Oximetry Measurement”. In two large cohorts, Black patients had nearly three times the frequency of occult hypoxemia that was not detected by pulse oximetry as White patients

Opinion | Should pregnant women have a COVID vaccine? The evidence says it’s safe and effective.

2 Aug, 2021 | 00:28h | UTC

Should pregnant women have a COVID vaccine? The evidence says it’s safe and effective – The Conversation

The study behind new CDC’s mask guidance found vaccinated people can spread delta variant.

2 Aug, 2021 | 00:33h | UTC

CDC Report: Outbreak of SARS-CoV-2 Infections, Including COVID-19 Vaccine Breakthrough Infections, Associated with Large Public Gatherings — Barnstable County, Massachusetts, July 2021 – Centers for Disease Control and Prevention

Commentaries:

The Study Behind CDC’s Mask Guidance Found Vaccinated People Can Spread Delta Variant – NPR

What Delta has changed in the Covid pandemic — and what it hasn’t – STAT

Commentary on Twitter (thread – click for more)

New @CDCMMWR on the Delta variant public gathering outbreak (incl "densely packed indoor events") in Barnstable Co involving 469 people, 74% among vaccinated, w/ similar viral load (Ct) as non-vaccinated. https://t.co/67sPljvaSQ pic.twitter.com/JNpfGD9qkB

— Eric Topol (@EricTopol) July 30, 2021

Guideline: Clinical management of adult patients with COVID-19 Outside Intensive Care Units.

2 Aug, 2021 | 00:26h | UTC

Clinical Management of Adult Patients with COVID-19 Outside Intensive Care Units: Guidelines from the Italian Society of Anti-Infective Therapy (SITA) and the Italian Society of Pulmonology (SIP) – Infectious Diseases and Therapy

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”

2 Aug, 2021 | 00:31h | UTC

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – American College of Obstetricians and Gynecologists (ACOG) and the Society for Maternal-Fetal Medicine (SMFM)

Additional reading:

Practice Advisory: COVID-19 Vaccination Considerations for Obstetric-Gynecologic Care

COVID-19 Vaccines and Pregnancy: Conversation Guide for Clinicians

Commentaries:

Obstetrician groups recommend COVID vaccine during pregnancy – Associated Press

Statements By Obstetrics Societies Strongly Advise Covid-19 Vaccinations For Pregnant Women – Forbes

Commentary on Twitter

Pregnant? ACOG and @MySMFM now recommend #COVID19 vaccination of pregnant individuals and urge our members to recommend that pregnant patients #GetVaccinated. The #covidvaccine is the best tool we have to save lives and end the pandemic: https://t.co/pUbLqqkKym #VaccinesWork pic.twitter.com/Ef2MOPv27L

— ACOG (@acog) July 30, 2021