Chest Medicine
Delta’s rise is fuelled by rampant spread from people who feel fine.
20 Aug, 2021 | 09:54h | UTCDelta’s rise is fuelled by rampant spread from people who feel fine – Nature
Original study: Transmission dynamics and epidemiological characteristics of Delta variant infections in China – medRxiv
Post-Covid-19 Tachycardia Syndrome: A distinct phenotype of Post-acute Covid-19 Syndrome.
20 Aug, 2021 | 09:51h | UTC
Commentary on Twitter
Post-COVID19 tachycardia syndrome(s): nice proposal for phenotypeshttps://t.co/XI75HCGYUH pic.twitter.com/yg303QXd1E
— Otavio Ranzani (@otavio_ranzani) August 18, 2021
Long COVID-19: A Primer for Cardiovascular Health Professionals, on Behalf of the CCS Rapid Response Team.
20 Aug, 2021 | 09:49h | UTC
M-A: Prevalence, management and impact of chronic obstructive pulmonary disease in atrial fibrillation.
20 Aug, 2021 | 09:01h | UTCPrevalence, management and impact of chronic obstructive pulmonary disease in atrial fibrillation: a systematic review and meta-analysis of 4,200,000 patients – European Heart Journal (link to abstract – $ for full-text)
Commentary on Twitter
AF-COMET Meta-analysis showed #COPD is common in #AF, being found in 13% of patients
📌⬆️ burden of comorbidities & worse outcomes
📌More than a two-fold ⬆️ risk of all-cause death
📌⬆️ Risk of CV death and major bleedinghttps://t.co/fLAuGkQAX1 @ESC_Journals @SchakrabartiEP pic.twitter.com/50OSfACH84— Henry Han (@HanCardiomd) August 2, 2021
Review: Viral respiratory pathogens and lung injury.
20 Aug, 2021 | 08:43h | UTCViral Respiratory Pathogens and Lung Injury – Clinical Microbiology Reviews
IDSA response to plan for supplemental vaccine doses for vaccinated individuals.
19 Aug, 2021 | 09:02h | UTC
Viewpoint: Confronting the Delta variant of SARS-CoV-2.
19 Aug, 2021 | 09:03h | UTCConfronting the Delta Variant of SARS-CoV-2, Summer 2021 – JAMA
Studies: COVID vaccine protection waning against infection but not hospitalization.
19 Aug, 2021 | 09:05h | UTCStudies: COVID vaccine protection waning against infection but not hospitalization – CIDRAP
Commentary on Twitter (thread – click for more)
Very excited to share our most recent publication about #CovidVaccine effectiveness, just published today by the IVY network. Especially relevant in light of today’s news about #boosters (spoiler – I’m skeptical about the need for boosters for all). 🧵https://t.co/GbAxgzpo7R
— Nida Qadir, MD (@NidaQadirMD) August 18, 2021
NIH study shows no significant benefit of convalescent plasma for COVID-19 outpatients with early symptoms.
19 Aug, 2021 | 09:06h | UTCOriginal study: Early Convalescent Plasma for High-Risk Outpatients with Covid-19 – New England Journal of Medicine
Commentary on Twitter
Convalescent plasma did not prevent disease progression in patients seen in EDs within 7 days after the onset #COVID19 symptoms. https://t.co/9gmIK3ntKH #IDTwitter pic.twitter.com/sirzn1uGL0
— NEJM (@NEJM) August 18, 2021
U.S. officials’ decision on Covid-19 booster shots baffles — and upsets — some scientists.
19 Aug, 2021 | 09:00h | UTCU.S. officials’ decision on Covid-19 booster shots baffles — and upsets — some scientists – STAT
Commentary on Twitter
Scientists I spoke to today had a lot of questions about the administration's decision to start giving Americans 3rd doses of the mRNA vaccines next month. “I’m not sure we had enough [data] to pull the trigger right now," one said. https://t.co/eHUndOrQL4
— Helen Branswell 🇨🇦 (@HelenBranswell) August 18, 2021
Review: CT of postacute lung complications of COVID-19.
19 Aug, 2021 | 08:55h | UTCCT of Postacute Lung Complications of COVID-19 – Radiology
Related:
Fibrotic interstitial lung abnormalities at 1-year follow-up CT after severe COVID-19.
Postacute Sequelae of COVID-19 Pneumonia: 6-month Chest CT Follow-up.
COVID-19 Imaging: What we know now and what remains unknown.
Post severe COVID-19, CT reveals potentially lifetime lung damage in one-thirds of patients
COVID-19 mimics on chest CT: a pictorial review and radiologic guide
Review: Interstitial Lung Abnormalities.
19 Aug, 2021 | 08:37h | UTCInterstitial Lung Abnormalities: State of the Art – Radiology
Surgery for lung cancer: postoperative changes and complications—what the Radiologist needs to know.
19 Aug, 2021 | 08:36h | UTC
Lab study shows heterologous AstraZeneca/Pfizer vaccination produces strong immune response against SARS-CoV-2 Delta variant.
18 Aug, 2021 | 09:04h | UTCRelated:
Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination (several articles on the subject)
Commentary on Twitter (thread – click for more)
Mix and match vaccines, AZ then mRNA (@BioNTech_Group) achieves a very strong immune response against the Delta variant.
This is the 1st report to look at mix vs Delta, specifically.https://t.co/6N46cUh8HW @TheLancet pic.twitter.com/cvlHp2XtXJ— Eric Topol (@EricTopol) August 17, 2021
U.S. to recommend COVID vaccine boosters at 8 months.
18 Aug, 2021 | 09:02h | UTCSources: US to recommend COVID vaccine boosters at 8 months – Associated Press
See also: Biden administration expected to advise Covid booster shots for most Americans – CNN AND US experts expected to recommend Covid booster shots for all – The Guardian
Commentary on Twitter (thread – click for more)
This decision seems to reflect a common fallacy; trying to reason about whether we "need X" just based on what things are like without X, rather than how much X will do to help.
It's surprising to see it at play in a decision of such consequence.
— Wes Pegden (@WesPegden) August 17, 2021
Global, regional, and national burden of respiratory tract cancers and associated risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study.
18 Aug, 2021 | 08:44h | UTC
Commentary on Twitter (thread – click for more)
https://twitter.com/simonihay/status/1427465401303142417
Systematic review: Systemic corticosteroids for the treatment of COVID‐19.
17 Aug, 2021 | 09:11h | UTCSystemic corticosteroids for the treatment of COVID‐19 – Cochrane Library
Commentary on Twitter (thread – click for more)
JUST PUBLISHED – Systemic #corticosteroids for the treatment of #COVID19 from @CochraneHaem – https://t.co/l4V993gLzj 1/5 pic.twitter.com/Vjk4aHXKFV
— The Cochrane Library (@CochraneLibrary) August 16, 2021
Cohort study: Younger children may be more likely to transmit SARS-CoV-2 infection in households compared with older children, the risk being higher for contacts of children aged 0 to 3 years.
17 Aug, 2021 | 09:05h | UTCAssociation of Age and Pediatric Household Transmission of SARS-CoV-2 Infection – JAMA Pediatrics
Editorial: Yes, Children Can Transmit COVID, but We Need Not Fear
Commentary on Twitter (thread – click for more)
A new, large Ontario study of >6000 households (>1700 w/ secondary attacks) concludes that younger children (0-3 years) may transmit covid more than older (14-17); odds ratio 1.4https://t.co/TosD0Hc1Ve @JAMAPediatrics pic.twitter.com/LLHpTXOckt
— Eric Topol (@EricTopol) August 16, 2021
Anti-SARS-CoV-2 Antibodies Testing in Recipients of COVID-19 Vaccination: Why, When, and How?
17 Aug, 2021 | 09:03h | UTC
Commentary on Twitter
A nice read on and increasingly debated issue.
Anti-SARS-CoV-2 Antibodies Testing in Recipients of COVID-19 Vaccination: Why, When, and How? https://t.co/yllJVUEct0 via @MDPIOpenAccess— Adam Cifu (@adamcifu) August 16, 2021
[Preprint] Full vaccination suppresses SARS-CoV-2 delta variant mutation frequency.
17 Aug, 2021 | 08:59h | UTCFull vaccination suppresses SARS-CoV-2 delta variant mutation frequency – medRxiv
Commentary: Research debunks myth that COVID vaccination promotes mutations – News Medical
Commentary on Twitter
Evidence that vaccinations successfully suppress viral mutations and that the unvaccinated are the source of the variants. https://t.co/U80T4JLO7A
"No one is safe until everyone is safe." pic.twitter.com/B2pVeMm96r— Daniel Griffin MD PhD (@DanielGriffinMD) August 15, 2021
Accuracy of novel antigen rapid diagnostics for SARS-CoV-2: A living systematic review and meta-analysis.
17 Aug, 2021 | 09:02h | UTC
P/FP ratio: incorporation of PEEP into the PaO2/FiO2 ratio for prognostication and classification of acute respiratory distress syndrome.
17 Aug, 2021 | 08:46h | UTC
Commentary on Twitter
P/FP ratio – This multifactorial P/FP ratio has a greater predictive validity for hospital mortality in ARDS than the P/F ratio. Changes in severity classification with the P/FP ratio reflect both true illness severity and the applied PEEP strategy.https://t.co/bsCm7ZFjIv pic.twitter.com/wwZZ0hhnlF
— Sunitha Palanidurai (@PFPratio) August 12, 2021
FDA authorizes additional Covid-19 vaccine dose for certain immunocompromised individuals – Other fully vaccinated individuals do not need an additional vaccine dose right now.
16 Aug, 2021 | 01:22h | UTCCommentaries:
CDC, FDA recommend COVID booster for immune-compromised – CIDRAP
FDA authorizes additional dose of Covid-19 vaccine for the immunocompromised – STAT
Covid booster: US approves third jab for the immunocompromised – BBC
CDC Panel Recommends 3rd Vaccine Dose For Immunocompromised People – NPR
6 Things To Know If You’re Immunocompromised And Considering A 3rd Shot – NPR
CDC recommends third Covid-19 vaccine dose for certain immunocompromised people – CNN
Commentary on Twitter
The Infectious Diseases Society of America (IDSA) supports the @FDA and @CDCgov's decision to authorize a supplemental vaccine dose for immunocompromised patients.
Read our statement: https://t.co/odzzSgIxnY pic.twitter.com/4PZfUwpjhM
— IDSA (@IDSAInfo) August 13, 2021
Perspective | Don’t panic, but breakthrough cases may be a bigger problem than you’ve been told.
16 Aug, 2021 | 01:17h | UTCDon’t Panic, But Breakthrough Cases May Be a Bigger Problem Than You’ve Been Told – Intelligencer
Commentary on Twitter (thread – click for more)
The vaccines are still performing quite well in preventing severe disease. But with Delta they are doing much worse in stopping transmission. Breakthroughs are probably now 10-20% of new infections, and perhaps as much as 5% of new deaths. A thread. (1/x) https://t.co/NvGends1ZP
— David Wallace-Wells (@dwallacewells) August 12, 2021
Antibody responses after a single dose of AstraZeneca Covid-19 vaccine in previously infected individuals were similar or higher compared to antibody responses in SARS-CoV-2 naïve participants who received two doses of Pfizer mRNA vaccine.
16 Aug, 2021 | 01:15h | UTCCommentary (on the preprint): Single dose of Oxford-AstraZeneca vaccine protective in previously infected recipients, suggests study – News Medical
Related: More data showing one dose of Pfizer vaccine may be enough for individuals who’ve had COVID. (studies on the subject)