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Chest Medicine

A population-based study in Qatar showed previous infection provided robust protection against reinfection with the alpha, beta, and delta variants of SARS-CoV-2 (approximately 90%). However, protection against reinfection with the omicron variant was lower (around 60%).

10 Feb, 2022 | 10:04h | UTC

Protection against the Omicron Variant from Previous SARS-CoV-2 Infection – New England Journal of Medicine

 

Commentary on Twitter

 

2021 Brazilian Thoracic Association recommendations for the management of severe asthma.

10 Feb, 2022 | 08:52h | UTC

2021 Brazilian Thoracic Association recommendations for the management of severe asthma – Jornal Brasileiro de Pneumologia

 

GOLD Report 2022: Global strategy for prevention, diagnosis and management of COPD.

10 Feb, 2022 | 08:53h | UTC

GOLD Report 2022: Global strategy for prevention, diagnosis and management of COPD

 

Perioperative approach to precapillary pulmonary hypertension in non-cardiac non-obstetric surgery.

10 Feb, 2022 | 08:34h | UTC

Perioperative approach to precapillary pulmonary hypertension in non-cardiac non-obstetric surgery – European Respiratory Review

 

Interstitial pneumonia with autoimmune features: challenges and controversies.

10 Feb, 2022 | 08:33h | UTC

Interstitial pneumonia with autoimmune features: challenges and controversies – European Respiratory Review

 

IDSA Updated Covid-19 Guideline now supports the use of convalescent plasma in ambulatory patients with mild to moderate COVID-19 at high risk for progression to severe disease.

9 Feb, 2022 | 10:15h | UTC

IDSA Guidelines on the Treatment and Management of Patients with COVID-19 – Infectious Diseases Society of America

Related: [Preprint] RCT: In symptomatic adults above 18 years positive for SARS-CoV-2, early outpatient treatment with high-titer convalescent plasma significantly reduced hospitalizations.

 

Commentary on Twitter

 

Expert Consensus: Treatment algorithm in cancer-associated thrombosis.

9 Feb, 2022 | 08:42h | UTC

Treatment Algorithm in Cancer-Associated Thrombosis: Updated Canadian Expert Consensus – Current Oncology

 

Systematic Review: Video-observed therapy vs. directly observed therapy in patients with tuberculosis.

9 Feb, 2022 | 08:35h | UTC

Video-Observed Therapy Versus Directly Observed Therapy in Patients With Tuberculosis – American Journal of Preventive Medicine (link to abstract – $ for full-text)

Related: RCT: Electronic directly observed therapy is noninferior to in-person observed therapy for ensuring adherence to tuberculosis treatment.

 

Commentary on Twitter

 

Malignant pleural effusions: a review of current guidelines and practices.

9 Feb, 2022 | 08:19h | UTC

Malignant Pleural Effusions—A Review of Current Guidelines and Practices – Journal of Clinical Medicine

Related: Meta-Analysis: Interventions for the Management of Malignant Pleural Effusions

 

ESCMID guidelines on testing for SARS-CoV-2 in asymptomatic individuals to prevent transmission in the healthcare setting.

8 Feb, 2022 | 10:18h | UTC

ESCMID guidelines on testing for SARS-CoV-2 in asymptomatic individuals to prevent transmission in the healthcare setting – Clinical Microbiology and Infection

 

In patients taking anticoagulants (DOAC or Warfarin), a respiratory tract infection not treated with antibiotics is associated with a greater than twofold increase in the risk of bleeding during the next 0-14 days.

8 Feb, 2022 | 08:46h | UTC

Respiratory tract infection and risk of bleeding in oral anticoagulant users: self-controlled case series – The BMJ

 

Commentary on Twitter

 

Cluster-Randomized Trial: A multicomponent diagnostic strategy (on-site molecular testing for tuberculosis, guided restructuring of clinic workflows, and monthly feedback of quality metrics) significantly improved the rates of a confirmed diagnosis of tuberculosis within 14 days after presentation.

8 Feb, 2022 | 08:43h | UTC

Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Clinical update on COVID-19 for the emergency clinician: Presentation and evaluation.

7 Feb, 2022 | 08:56h | UTC

Clinical update on COVID-19 for the emergency clinician: Presentation and evaluation – The American Journal of Emergency Medicine

 

[Preprint] Results from the first Covid-19 human challenge study (deliberately infecting individuals in a controlled environment).

3 Feb, 2022 | 09:48h | UTC

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge – Research Square

Commentaries:

Scientists deliberately gave people COVID — here’s what they learnt – Nature

Expert reaction to a preprint looking at the course of SARS-CoV-2 infection in a COVID-19 human challenge study – Science Media Centre

First COVID-19 human challenge study yields infection clues – CIDRAP

Exposure to one nasal droplet enough for Covid infection – study – The Guardian

Related:

Perspective | SARS-CoV-2 human challenge studies — establishing the model during an evolving pandemic.

World’s first coronavirus “Human Challenge” study receives ethics approval in the UK  (several texts on the subject) Are SARS-CoV-2 Human Challenge Trials Ethical? – “A clinical trial is underway in the UK in which young, healthy participants are exposed deliberately to SARS-CoV-2 to assess the viral inoculum needed to produce an infection and to test vaccine efficacy”.

 

Evaluation and management of traumatic pneumothorax: A Western Trauma Association critical decisions algorithm.

3 Feb, 2022 | 08:46h | UTC

Evaluation and management of traumatic pneumothorax: A Western Trauma Association critical decisions algorithm – Journal of Trauma and Acute Care Surgery

 

Outpatient Therapies for COVID-19: How do we choose?

2 Feb, 2022 | 08:53h | UTC

Outpatient Therapies for COVID-19: How do we choose? – Open Forum Infectious Diseases

 

Updated NIH COVID-19 Treatment Guidelines: Therapeutic management of nonhospitalized adults with COVID-19.

2 Feb, 2022 | 08:50h | UTC

Therapeutic Management of Nonhospitalized Adults With COVID-19 – NIH COVID-19 Treatment Guidelines

 

Commentary on Twitter

 

Review: Eosinophils and eosinophilic immune dysfunction in health and disease.

2 Feb, 2022 | 08:15h | UTC

Eosinophils and eosinophilic immune dysfunction in health and disease – European Respiratory Review

 

[Preprint] Study suggests SARS-CoV-2 Omicron subvariants BA.2 is even more transmissible than the original variant.

1 Feb, 2022 | 08:56h | UTC

Transmission of SARS-CoV-2 Omicron VOC subvariants BA.1 and BA.2: Evidence from Danish Households – medRxiv

Commentaries:

Study suggests BA.2 COVID-19 subvariant more contagious – CIDRAP

‘Stealth Omicron’ spreads more than original strain: study – MedicalXpress

The new Omicron subtype BA.2 could prolong the current wave of COVID-19 infection, scientists say- Business Insider

 

Commentary from the author on Twitter (thread – click for more)

 

Systematic Review: Self‐management interventions for people with chronic obstructive pulmonary disease.

1 Feb, 2022 | 08:21h | UTC

Self‐management interventions for people with chronic obstructive pulmonary disease – Cochrane Library

Summary: Self-management for people with chronic obstructive pulmonary disease – Cochrane Library

 

Commentary on Twitter

 

Registry study in Denmark found an increased bleeding risk with the association of systemic Fluconazole and Apixaban (OR 3.5; 95% CI, 1.4-10.6).

1 Feb, 2022 | 08:13h | UTC

Bleeding Risk Following Systemic Fluconazole or Topical Azoles in Patients with Atrial Fibrillation on Apixaban, Rivaroxaban, or Dabigatran – American Journal of Medicine

 

Review: Multidisciplinary management of tracheobronchial injury.

1 Feb, 2022 | 08:17h | UTC

Multidisciplinary management of tracheobronchial injury – European Respiratory Review

 

FDA halts use of antibody drugs that don’t work vs. Omicron.

30 Jan, 2022 | 14:35h | UTC

FDA halts use of antibody drugs that don’t work vs. omicron – Associated Press

Related: Lab study shows new antiviral pills maintain efficacy against Omicron, but antibody drugs are substantially less effective.

 

Despite the ongoing spread of Omicron, some European countries have decided to lift Covid-19 restrictions.

30 Jan, 2022 | 14:37h | UTC

England lifts COVID restrictions as omicron threat recedes – Associated Press

Denmark confirms plan to lift Covid-19 restrictions on February 1st – The Local dk

Netherlands lifts toughest Covid curbs with Denmark and France set to follow – The Guardian

Denmark will lift nearly ALL Covid restrictions within days and return to ‘life as we knew it before corona’ after vaccine programme proved a ‘super-weapon’ – despite soaring cases – Daily Mail

 

Commentary on Twitter

 

ELSO Guidelines for adult and pediatric extracorporeal membrane oxygenation circuits.

30 Jan, 2022 | 14:25h | UTC

ELSO Guidelines for Adult and Pediatric Extracorporeal Membrane Oxygenation Circuits – ASAIO Journal

Related: ELSO Guidelines for anticoagulation in adult and pediatric patients using extracorporeal membrane oxygenation (ECMO).

 

Commentary on Twitter

 

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