Cardiology (all articles)
RCT | Indobufen vs. aspirin on top of clopidogrel after coronary drug-eluting stent implantation.
11 Nov, 2022 | 14:03h | UTC
Commentary on Twitter
#OriginalResearch simpub #AHA2022 #CIRCAHA22: In this #RCT, indobufen + clopidogrel DAPT compared with aspirin + clopidogrel DAPT significantly reduced the risk of 1-year net clinical outcomes, mainly driven by a reduction in bleeding events without an ….https://t.co/ctk1fwhXt2 pic.twitter.com/vFPS6gvpjN
— Circulation (@CircAHA) November 6, 2022
RCT | Early routine use of ECMO fails to improve outcomes in patients with cardiogenic shock.
11 Nov, 2022 | 14:01h | UTCCommentaries:
Early ECMO No Better Than Watch-and-Wait Approach in Cardiogenic Shock – TCTMD
Immediate Use of ECMO Did Not Improve Outcomes in Patients with Cardiogenic Shock – HCP Live
Commentary on Twitter
#OriginalResearch simpub #AHA2022: In this #RCT immediate implementation of VA-ECMO in patients with cardiogenic shock did not improve clinical outcomes compared with an early conservative strategy which allowed downstream use of… #CIRCAHA22 #AHAJournals https://t.co/03qVyC0Vgl pic.twitter.com/WRNDsAZfpD
— Circulation (@CircAHA) November 6, 2022
RCT | Helicobacter pylori eradication may prevent peptic ulcer bleeding in older patients prescribed aspirin in primary care.
11 Nov, 2022 | 14:00h | UTCNews Release: Cutting the risk of stomach bleeding, occasionally caused by regular aspirin use – University of Nottingham
Commentary on Twitter
New @TheLancet – the HEAT trial of H pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (1/4)https://t.co/9SlP3y6DGf #gitwitter #medtwitter
— Rob Brierley (@Rob__Brierley) November 4, 2022
RCT | Dual endothelin antagonist Aprocitentan is effective for resistant hypertension.
11 Nov, 2022 | 13:59h | UTCDual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentaries:
Endothelin Receptor Antagonist Effective in Resistant Hypertension: PRECISION – TCTMD
Phase 2RCT | Baxdrostat reduces BP in patients with treatment-resistant hypertension.
11 Nov, 2022 | 13:57h | UTCPhase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Big Drops in Blood Pressure With Baxdrostat: BrigHTN Phase II Study – TCTMD
New Drug Helps Tame Uncontrolled High Blood Pressure – HealthDay
RCT | A small study tested Apixaban’s efficacy and safety versus a Vitamin K-antagonist in patients on chronic hemodialysis.
11 Nov, 2022 | 13:52h | UTCRelated Study: Apixaban for Patients with Atrial Fibrillation on Hemodialysis: A Multicenter Randomized Controlled Trial – Circulation
Matched cohort study | Long-term clinical and radiographic outcomes in patients with clinically isolated aortitis.
11 Nov, 2022 | 13:43h | UTC
M-A | Cardiovascular safety of febuxostat and allopurinol in patients with gout.
11 Nov, 2022 | 13:41h | UTC
On the natural history of coronary artery disease: a longitudinal nationwide serial angiography study.
10 Nov, 2022 | 14:03h | UTC
M-A | Bioresorbable vascular scaffolds are inferior compared to conventional drug-eluting stents across time.
10 Nov, 2022 | 13:57h | UTC
Commentary on Twitter
Bioresorbable vascular scaffolds #BVS vs. conventional drug-eluting stents #DES across time:
A #metaanalysis of RCTs@banerjeep https://t.co/XyDVI7XNMi pic.twitter.com/AjEPC6Zv3E— Open Heart (@Open_HeartBMJ) October 27, 2022
RCT | Effects of a narrative-based psychoeducational intervention to prepare patients for responding to acute MI.
10 Nov, 2022 | 13:51h | UTC
Review | New horizons in the ageing autonomic nervous system: orthostatic hypotension and supine hypertension.
10 Nov, 2022 | 13:37h | UTC
Retrospective Cohort Study | Trends, predictors, and outcomes of CV complications at delivery associated with gestational diabetes.
10 Nov, 2022 | 13:34h | UTC
Commentary on Twitter
https://twitter.com/ErinMichos/status/1586008508331266048
AHA Scientific Statement | Arrhythmias in repaired Tetralogy of Fallot.
9 Nov, 2022 | 12:33h | UTCSummary: Arrhythmias in Repaired Tetralogy of Fallot – American Heart Association
Top Things to Know: Arrhythmias in Repaired Tetralogy of Fallot – American Heart Association
Commentary: Challenges in Managing Arrhythmias in Adult Tetralogy of Fallot – American Heart Association
Review | Diagnosis of cardiac surgery-associated acute kidney injury.
10 Nov, 2022 | 13:27h | UTCRelated:
Clinical practice update for management of acute kidney injury associated with cardiac surgery.
RCT | Using an algorithm to stratify the risk of patients with acute heart failure may improve outcomes.
9 Nov, 2022 | 12:30h | UTCTrial of an Intervention to Improve Acute Heart Failure Outcomes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: New Tool Assesses Risk in Acute HF Then Suggests Next Steps, Cutting Later Events – TCTMD
Commentary on Twitter
The use of a validated tool for risk assessment, combined with rapid follow-up, led to a lower risk of death or hospitalization for cardiovascular causes at 30 days among patients with acute heart failure. #AHA22 https://t.co/0cbvcHl3US pic.twitter.com/kpWbRGpOJX
— NEJM (@NEJM) November 5, 2022
RCT | In infants undergoing heart surgery, prophylactic methylprednisolone did not significantly improve outcomes.
9 Nov, 2022 | 12:31h | UTCMethylprednisolone for Heart Surgery in Infants — A Randomized, Controlled Trial – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Steroids during surgery may not be helpful for infants having heart bypass – American Heart Association
Commentary on Twitter
In this randomized, controlled trial involving infants undergoing surgery with cardiopulmonary bypass, prophylactic use of methylprednisolone did not significantly reduce the likelihood of a worse outcome. #AHA22 https://t.co/jaza6JCAuk pic.twitter.com/lLrxci7SaE
— NEJM (@NEJM) November 6, 2022
Study Commentary | Radial artery beats both right internal thoracic artery and vein grafting at 15 years.
9 Nov, 2022 | 12:28h | UTC(Not published yet, presented at the American Heart Association Scientific Sessions, November 6, 2022)
RAPCO: Radial Artery Beats Both RITA and Vein Grafting at 15 Years – TCTMD
See also:
Related:
Meta-Analysis: Radial-Artery vs Saphenous-Vein Grafts in CABG
M-A | DOACs increase the risk of arterial thrombosis vs. Vitamin-K antagonists in antiphospholipid syndrome.
9 Nov, 2022 | 12:28h | UTCDirect Oral Anticoagulants vs Vitamin-K Antagonists in Thrombotic Antiphospholipid Syndrome: Meta-analysis of Randomized Controlled Trials – Journal of the American College of Cardiology (link to abstract – $ for full-text)
M-A | Comparative efficacy of antiplatelet or anticoagulant therapy in patients with chronic coronary syndromes after PCI.
9 Nov, 2022 | 12:20h | UTC
Canadian guideline for the prevention and management of cardiovascular disease in primary care.
8 Nov, 2022 | 12:37h | UTCNews Release: New one-stop guideline for cardiovascular health in Canada – Canadian Medical Association Journal
Follow-up of the ISCHEMIA trial | Similar survival after invasive vs. conservative management of stable coronary disease.
8 Nov, 2022 | 12:32h | UTCSurvival After Invasive or Conservative Management of Stable Coronary Disease – Circulation (free for a limited period)
Original Articles:
ISCHEMIA Trial: Initial Invasive vs. Conservative Strategy for Stable Coronary Disease
ISCHEMIA Trial: Management of Coronary Disease in Patients with Advanced Kidney Disease
See also:
Commentary on Twitter
#OriginalResearch simpub #AHA2022 #CIRCAHA22: From the #ISCHEMIA-EXTEND study – No difference in all-cause mortality between initial invasive vs conservative strategy but ⬇️ risk of CV mortality and ⬆️ risk of non-CV mortality w/ initial invasive strat… https://t.co/XwFS1KO02z pic.twitter.com/SG2z4D3lzY
— Circulation (@CircAHA) November 6, 2022
RCT | In patients with paroxysmal, untreated AF, cryoballoon ablation reduced recurrence compared to drug therapy.
8 Nov, 2022 | 12:29h | UTCProgression of Atrial Fibrillation after Cryoablation or Drug Therapy – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Initial treatment of paroxysmal atrial fibrillation with cryoballoon ablation was associated with a lower incidence of persistent atrial tachyarrhythmias over 3 years than rhythm-control medications. #AHA22 https://t.co/ZjLkt9L2xr pic.twitter.com/tzRiDPBSdx
— NEJM (@NEJM) November 7, 2022
RCT | Surgery reduced major adverse limb events vs. endovascular therapy in patients with chronic limb-threatening ischemia.
8 Nov, 2022 | 12:34h | UTCSurgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Bypass surgery favorable for initial treatment of chronic limb-threatening ischemia – National Institutes of Health
Commentary on Twitter
https://twitter.com/NEJM/status/1589621195632439296
Phase 2 RCT | Small interfering RNA to reduce Lipoprotein(a) in cardiovascular disease.
8 Nov, 2022 | 12:30h | UTCSmall Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Lipoprotein(a) is similar to LDL cholesterol but contains apolipoprotein(a). A trial tested the effects of an oligonucleotide drug targeting apo(a) mRNA on lipoprotein(a) concentrations in patients with CVD. #AHA22 https://t.co/eLgnrnTm5D pic.twitter.com/QmNUcxeJwX
— NEJM (@NEJM) November 6, 2022