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Guideline | Management of pheochromocytoma and paraganglioma in patients harboring germline SDHD pathogenic variants

24 Apr, 2023 | 13:32h | UTC

Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants – The Lancet Diabetes & Endocrinology (free registration required)

 

Commentary on Twitter

https://twitter.com/TheLancetEndo/status/1647547884361981953

 

M-A | 5-alpha-reductase inhibitors are not associated with increased risk of mortality from prostate cancer

24 Apr, 2023 | 13:30h | UTC

Association Between 5α-Reductase Inhibitors and Prostate Cancer Mortality: A Systematic Review and Meta-analysis – JAMA Oncology (free for a limited period)

 

Commentary on Twitter

 

Perioperative opioids: a narrative review contextualizing new avenues to improve prescribing

24 Apr, 2023 | 13:26h | UTC

Perioperative opioids: a narrative review contextualising new avenues to improve prescribing – British Journal of Anaesthesia

 

Preliminary study show wireless pacemakers may be safe and effective for children with bradycardia

24 Apr, 2023 | 13:27h | UTC

Transcatheter Leadless Pacing in Children: A PACES Collaborative Study in the Real-World Setting – Circulation: Arrhythmia and Electrophysiology

News Release: Wireless pacemakers may be safe, effective for children with irregular heart rhythms – American Heart Association

Commentary: Leadless Pacemakers Could Prove Useful for Pediatric Patients with Arrhythmias – HCP Live

 

SR | Etiology, diagnosis, and modern management of chronic pancreatitis

24 Apr, 2023 | 13:29h | UTC

Etiology, Diagnosis, and Modern Management of Chronic Pancreatitis: A Systematic Review – JAMA Surgery (free for a limited period)

 

Brief Review | Acute kidney injury

24 Apr, 2023 | 13:24h | UTC

Acute kidney injury – Intensive Care Medicine (if the link is paywalled, try this one)

 

Commentary on Twitter

 

Brief Review | The use of high-flow nasal oxygen

24 Apr, 2023 | 13:23h | UTC

The use of high-flow nasal oxygen – Intensive Care Medicine (if the link is paywalled, try this one)

 

Commentary on Twitter

 

Brief Review | Aerosolized antibiotics in critical care

24 Apr, 2023 | 13:21h | UTC

Aerosolised antibiotics in critical care – Intensive Care Medicine

Related: How to Use Nebulized Antibiotics in Severe Respiratory Infections – Antibiotics

 

Commentary on Twitter

 

Cohort Study | Circulating tumor DNA methylation may enable early detection of recurrence in colorectal cancer

24 Apr, 2023 | 13:12h | UTC

Early Detection of Molecular Residual Disease and Risk Stratification for Stage I to III Colorectal Cancer via Circulating Tumor DNA Methylation – JAMA Oncology (free for a limited period)

Editorial: Liquid Biopsy Assessment of Molecular Residual Disease in Localized Colorectal Cancer: Is It Ready for Prime Time? – JAMA Oncology (free for a limited period)

Related: Study shows patients with circulating tumor DNA are at increased risk of relapse after surgery for resectable colorectal cancer

Using Circulating Tumor DNA in Colorectal Cancer: Current and Evolving Practices – Journal of Clinical Oncology

 

Commentary on Twitter

 

Cohort Study | Prenatal exposure to antiseizure medication and incidence of childhood-onset psychiatric disorders

24 Apr, 2023 | 13:10h | UTC

Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders – JAMA Neurology (link to abstract – $ for full-text)

Author Interview: Prenatal Exposure to Antiseizure Medication and Psychiatric Disorders – JAMA

 

Commentary on Twitter

 

RCT | Intermittent fasting plus early time-restricted eating vs. calorie restriction and standard care in adults at risk of type 2 DM

24 Apr, 2023 | 13:07h | UTC

Intermittent fasting plus early time-restricted eating versus calorie restriction and standard care in adults at risk of type 2 diabetes: a randomized controlled trial – Nature Medicine (if the link is paywalled, try this one)

News Release: Fasting diet reduces risk markers of type 2 diabetes – University of Adelaide

Related:

RCT | Time-restricted eating not more effective than daily calorie restriction for managing nonalcoholic fatty liver disease

Health effects of the time-restricted eating in adults with obesity: A systematic review and meta-analysis – Frontiers in Nutrition

Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial – Cell Metabolism

Effectiveness of Early Time-Restricted Eating for Weight Loss, Fat Loss, and Cardiometabolic Health in Adults With Obesity: A Randomized Clinical Trial – JAMA Internal Medicine

Effects of Intermittent Fasting in Human Compared to a Non-intervention Diet and Caloric Restriction: A Meta-Analysis of Randomized Controlled Trials – Frontiers in Nutrition

Time-Restricted Eating: Integrating The What With The When – Advances in Nutrition

Calorie Restriction with or without Time-Restricted Eating in Weight Loss- New England Journal of Medicine

Intermittent Fasting and Obesity-Related Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials – JAMA Network Open

 

Commentary on Twitter

 

RCT | Peri-intubation hypoxia after delayed vs. rapid sequence intubation in critically injured patients on arrival to trauma triage

24 Apr, 2023 | 13:04h | UTC

Peri-Intubation Hypoxia After Delayed Versus Rapid Sequence Intubation in Critically Injured Patients on Arrival to Trauma Triage: A Randomized Controlled Trial – Anesthesia & Analgesia (link to abstract – $ for full-text)

 

Review | The management of pregnant trauma patients

24 Apr, 2023 | 13:01h | UTC

The Management of Pregnant Trauma Patients: A Narrative Review – Anesthesia & Analgesia (free for a limited period)

See also: Infographic (free for a limited period)

 

2023 ACC expert consensus on management of heart failure with preserved ejection fraction

21 Apr, 2023 | 13:10h | UTC

2023 ACC Expert Consensus Decision Pathway on Management of Heart Failure With Preserved Ejection Fraction: A Report of the American College of Cardiology Solution Set Oversight Committee – Journal of the American College of Cardiology

Commentaries:

New Expert Consensus Papers Aim to Boost Management, Outcomes in HFpEF – TCTMD

HFpEF the Focus of New ACC Expert Consensus Decision Pathway and JACC Scientific Statement – American College of Cardiology

 

RCT | Piperacillin-tazobactam better than cefoxitin in antimicrobial prophylaxis for open pancreatoduodenectomy

21 Apr, 2023 | 13:08h | UTC

Piperacillin-Tazobactam Compared With Cefoxitin as Antimicrobial Prophylaxis for Pancreatoduodenectomy: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Informing a Rational Approach to Antimicrobial Prophylaxis in Open Pancreatoduodenectomy – JAMA (free for a limited period)

 

Commentary on Twitter

 

Study estimates poor diet causes 70% of diabetes cases globally

21 Apr, 2023 | 13:06h | UTC

Incident type 2 diabetes attributable to suboptimal diet in 184 countries – Nature Medicine

News Release: Study links poor diet to 14 million cases of type 2 diabetes globally – Tufts University

 

Commentary on Twitter

 

RCT | Pregnant individuals benefit from brief interpersonal psychotherapy for depression

21 Apr, 2023 | 13:05h | UTC

Effect of Brief Interpersonal Therapy on Depression During Pregnancy: A Randomized Clinical Trial – JAMA Psychiatry

Commentary: Interpersonal Psychotherapy Reduces Depression Symptoms of Pregnant Women – HCP Live

 

Commentary on Twitter

 

M-A | Electroconvulsive therapy may be superior to ketamine for patients with major depressive episode

21 Apr, 2023 | 13:03h | UTC

Ketamine vs Electroconvulsive Therapy for Major Depressive Episode: A Systematic Review and Meta-analysis – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries:

Expert reaction to systematic review and meta-analysis comparing ECT and ketamine for major depressive episodes – Science Media Centre

Electroconvulsive Therapy Bests Ketamine in Treating Major Depressive Episodes – HCP Live

ECT May Be Superior to Ketamine for Adults Experiencing Major Depressive Episode – Psychiatric News Alert

 

Review | The importance of using placebo controls in nonpharmacological randomized trials

21 Apr, 2023 | 13:02h | UTC

The importance of using placebo controls in nonpharmacological randomised trials – Pain

 

RCT | Efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata

21 Apr, 2023 | 13:00h | UTC

Efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata: a randomised, double-blind, multicentre, phase 2b–3 trial – The Lancet (link to abstract – $ for full-text)

News Release: Progress in search for alopecia areata treatment for adolescents  – Yale News

 

Commentary on Twitter

 

M-A | Adverse events related to tirzepatide (a dual GIP/GLP-1 receptor agonist)

21 Apr, 2023 | 12:59h | UTC

Adverse Events Related to Tirzepatide – Journal of the Endocrine Society

Related:

RCT | Safety and efficacy of Tirzepatide as an add-on to single oral antihyperglycaemic medication in patients with type 2 diabetes in Japan.

Tirzepatide Once Weekly for the Treatment of Obesity – New England Journal of Medicine

Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: a systematic review and meta-analysis – Diabetologia

Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis – Nature Medicine

Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

 

ACSM expert consensus statement on exertional heat illness: recognition, management, and return to activity

19 Apr, 2023 | 13:27h | UTC

ACSM Expert Consensus Statement on Exertional Heat Illness: Recognition, Management, and Return to Activity – Current Sports Medicine Reports

Related:

Exertional heat stroke: pathophysiology and risk factors – BMJ Medicine

Classic and exertional heatstroke – Nature Reviews Disease Primers

Heat-Related Illness in Emergency and Critical Care: Recommendations for Recognition and Management with Medico-Legal Considerations – Biomedicines

Treatment and Prevention of Heat-Related Illness – New England Journal of Medicine

Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Heat Illness: 2019 Update

 

Study shows that parathyroidectomy in adults with primary hyperparathyroidism probably has no effect on kidney function

21 Apr, 2023 | 12:57h | UTC

Estimated Effect of Parathyroidectomy on Long-Term Kidney Function in Adults With Primary Hyperparathyroidism – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: Study: Parathyroidectomy shows no effect on kidney function in older adults with hyperparathyroidism – American College of Physicians

Commentary: Parathyroidectomy for primary hyperparathyroidism didn’t affect kidney function in older patients – ACP Internist

 

Commentary on Twitter

 

Joint statement for assessing and managing high blood pressure in children and adolescents

19 Apr, 2023 | 13:26h | UTC

Chapter 1: How to correctly measure blood pressure in children and adolescents – Frontiers in Pediatrics

Chapter 2: How to manage high blood pressure in children and adolescents – Frontiers in Pediatrics

Related:

AHA Scientific Statement | Pediatric primary hypertension: An underrecognized condition

AHA Scientific Statement: Ambulatory blood pressure monitoring in children and adolescents.

Hypertension in Children and Adolescents: A Position Statement From a Panel of Multidisciplinary Experts Coordinated by the French Society of Hypertension – Frontiers in Pediatrics

USPSTF Statement: Insufficient evidence to recommend screening for high blood pressure in children and adolescents

 

M-A | Glucocorticoids may increase mortality for hospitalized Covid-19 patients not receiving oxygen

19 Apr, 2023 | 13:24h | UTC

Meta-Analysis of Glucocorticoids for Covid-19 Patients Not Receiving Oxygen – NEJM Evidence

 

Commentary on Twitter (thread – click for more)

 

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