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RCT | Prophylactic tranexamic acid in cesarean delivery did not significantly reduce maternal death or transfusion risk

19 Apr, 2023 | 13:22h | UTC

Tranexamic Acid to Prevent Obstetrical Hemorrhage after Cesarean Delivery – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Tranexamic acid does not appear to prevent maternal hemorrhage after cesarean delivery – National Institutes of Health

 

Commentary on Twitter

 

RCT | Blood donor’s sex does not impact transfusion recipients’ survival

19 Apr, 2023 | 13:20h | UTC

Effect of Donor Sex on Recipient Mortality in Transfusion – New England Journal of Medicine (link to abstract – $ for full-text)

News release: Sex of blood donor has no effect on recipient survival – Ottawa Hospital

 

Commentary on Twitter

 

Perspective | Here’s a new data point for cancer patients to consider: ‘time toxicity’

19 Apr, 2023 | 13:18h | UTC

Here’s a new data point for cancer patients to consider: ‘time toxicity’ – STAT

 

Ischemia with nonobstructive coronary artery disease: concept, assessment, and management

19 Apr, 2023 | 13:17h | UTC

Ischemia With Nonobstructive Coronary Artery Disease: Concept, Assessment, and Management – JACC: Asia

Related:

Review: Myocardial infarction with non-obstructive coronary artery disease.

MINOCA from A to Z – American College of Cardiology

Guidelines for the Management of Myocardial Infarction/injury with Non-obstructive Coronary Arteries (MINOCA)

Prognosis and Predictors of Mortality in Patients Suffering Myocardial Infarction With Non‐Obstructive Coronary Arteries

Contemporary Diagnosis and Management of Patients With Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease: A Scientific Statement From the American Heart Association

The What, When, Who, Why, How and Where of Myocardial Infarction With Non-Obstructive Coronary Arteries (MINOCA) – Circulation Journal

Systematic Review of Patients Presenting With Suspected Myocardial Infarction and Nonobstructive Coronary Arteries – Circulation

Nonobstructive Versus Obstructive Coronary Artery Disease in Acute Coronary Syndrome: A Meta‐Analysis – Journal of the American Heart Association

 

M-A | Test characteristics of ultrasound for the diagnosis of peritonsillar abscess

19 Apr, 2023 | 13:15h | UTC

Test characteristics of ultrasound for the diagnosis of peritonsillar abscess: A systematic review and meta-analysis – Academic Emergency Medicine

Commentary: How Good is Ultrasound at Diagnosing PTA? – RebelEM

 

Global Survey | Incidence, management and prognosis of esophageal fistula after atrial fibrillation catheter ablation

19 Apr, 2023 | 13:14h | UTC

A worldwide survey on incidence, management and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: The POTTER-AF study – European Heart Journal

Commentary: Esophageal Fistula Still a Rare but Deadly Complication of AF Ablation: POTTER-AF – TCTMD

 

Commentary from the author on Twitter

 

SR | Opioids for procedural pain in neonates

19 Apr, 2023 | 13:11h | UTC

Opioids for procedural pain in neonates – Cochrane Library

Summary: Painkillers other than opioids to treat pain in babies undergoing painful procedures – Cochrane Library

 

Guideline | Management of psychiatric disorders in patients with hepatic and gastrointestinal diseases

19 Apr, 2023 | 13:07h | UTC

Management of Psychiatric Disorders in Patients with Hepatic and Gastrointestinal Diseases – Indian Journal of Psychiatry

 

RCT | Small benefit from pembrolizumab + gemcitabine/cisplatin vs. gemcitabine/cisplatin alone in advanced biliary tract cancer

19 Apr, 2023 | 13:10h | UTC

Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

News Release: First-line Pembrolizumab Plus Chemotherapy May Benefit Patients with Advanced Biliary Tract Cancers – American Association for Cancer Research

 

Commentary on Twitter

 

Study suggests that routine axillary scanning in diagnostic breast ultrasound has limited impact on cancer detection

19 Apr, 2023 | 13:06h | UTC

To scan or not to scan: effect of scanning the axilla of all patients undergoing diagnostic breast ultrasound – Clinical Imaging (link to abstract – $ for full-text)

Commentary: Is scanning the axilla during diagnostic breast ultrasound necessary? – Health Imaging

 

Opinion | Universal masking in health care settings: a pandemic strategy whose time has come and gone, for now

18 Apr, 2023 | 13:37h | UTC

Universal Masking in Health Care Settings: A Pandemic Strategy Whose Time Has Come and Gone, For Now – Annals of Internal Medicine

News Release: Healthcare epidemiologists and infectious diseases experts review changing context for masking in healthcare settings – Mass General Brigham

 

Opinion | In-person schooling is essential even during periods of high transmission of COVID-19

18 Apr, 2023 | 13:36h | UTC

In-person schooling is essential even during periods of high transmission of COVID-19 – BMJ Evidence-Based Medicine

 

Comprehensive clinical practice guidelines for the management of psychiatric emergencies

18 Apr, 2023 | 13:34h | UTC

Homepage: Clinical Practice Guidelines for Psychiatric Emergencies and Brain Stimulation Techniques – Indian Journal of Psychiatry

Editorial

Clinical Practice Guidelines for Management of Suicidal Behaviour

Clinical Practice Guidelines for Assessment and Management of Aggressive and Assaultive Behaviour

Clinical Practice Guidelines for the Assessment and Management of Elderly Presenting with Psychiatric Emergencies

Clinical Practice Guidelines for Assessment and Management of Children and Adolescents Presenting with Psychiatric Emergencies

Clinical Practice Guidelines for Assessment and Management of Psychiatric Emergencies in Victims of Sexual Violence

Clinical Practice Guidelines for Assessment and Management of Anxiety and Panic Disorders in Emergency Setting

Clinical Practice Guidelines for Assessment and Management of Dissociative Disorders Presenting as Psychiatric Emergencies

Clinical Practice Guidelines for Assessment and Management of Patients with Substance Intoxication Presenting to the Emergency Department

Clinical Practice Guidelines for Assessment and Management of Patients Presenting with Psychosocial Crisis

Clinical Practice Guidelines for Assessment and Management of Patients with Borderline Personality Disorder

Clinical Practice Guidelines on Breaking Bad News

Clinical Practice Guidelines for Assessment and Management of Psychiatric Morbidity in Medical Professionals

Clinical Practice Guidelines for the Use of Electroconvulsive Therapy

Clinical Practice Guidelines for the Therapeutic Use of Repetitive Transcranial Magnetic Stimulation in Neuropsychiatric Disorders

Clinical Practice Guidelines for the Use of Transcranial Direct Current Stimulation in Psychiatry

 

Cluster RCT | Salt substitute outperforms salt restriction in lowering blood pressure in older patients

18 Apr, 2023 | 13:30h | UTC

Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial – Nature Medicine (if the link is paywalled, try this one)

Commentary: Exploring effectiveness of salt substitutes in elderly care facilities – Medical Xpress

Related:

Salt substitutes vs. regular salt: a quick look.

Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis – Heart (link to abstract – $ for full-text)

Cluster RCT: A household salt substitution intervention is a cost-effective intervention for preventing stroke and improving quality of life.

#ESCCongress – Cluster RCT: Among patients at increased risk for stroke, salt substitution (75% sodium chloride and 25% potassium chloride by mass) reduced the rates of stroke, major cardiovascular events, and death from any cause.

RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients

Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths

Cluster Randomized Trial: Effect of Salt Substitution on Community-wide Blood Pressure and Hypertension Incidence

 

Commentary on Twitter

 

Study shows approximately half of infectious diseases guideline authors have conflicts of interest with pharmaceutical companies

18 Apr, 2023 | 13:28h | UTC

Conflicts of Interest Among Infectious Diseases Clinical Practice Guideline Authors and the Pharmaceutical Industry – JAMA Network Open

 

Review | Management of cardiogenic shock after acute coronary syndromes

18 Apr, 2023 | 13:27h | UTC

Management of cardiogenic shock after acute coronary syndromes – BJA Education

 

Large-scale study finds genetic causes for 41% of rare pediatric diseases

18 Apr, 2023 | 13:25h | UTC

Genomic Diagnosis of Rare Pediatric Disease in the United Kingdom and Ireland – New England Journal of Medicine (free for a limited period)

News Release: 5,500 people diagnosed with rare genetic diseases in major research study – University of Exeter

Commentary: Study endeavors to strengthen genomic diagnosis of rare pediatric diseases in the United Kingdom and Ireland – News Medical

 

Commentary on Twitter

 

Guideline | Intrahepatic cholestasis of pregnancy

18 Apr, 2023 | 13:24h | UTC

Intrahepatic cholestasis of pregnancy – BJOG

 

M-A | McDonald vs. Shirodkar cerclage technique in the prevention of preterm birth

18 Apr, 2023 | 13:22h | UTC

McDonald versus Shirodkar cerclage technique in the prevention of preterm birth: A systematic review and meta-analysis – BJOG

 

Review | Current practice in the perioperative management of patients with diabetes mellitus

18 Apr, 2023 | 13:19h | UTC

Current practice in the perioperative management of patients with diabetes mellitus: a narrative review – British Journal of Anaesthesia

Related:

Guideline Summary: New guidance on the perioperative management of diabetes.

Perioperative Evaluation and Management of Endocrine Disorders – Mayo Clinic Proceedings

Recent advances in diabetes treatments and their perioperative implications – Current Opinion in Anesthesiology

Perioperative Management of Oral Glucose-lowering Drugs in the Patient with Type 2 Diabetes – Anesthesiology

 

SR | Association between advanced care planning and emergency department visits

18 Apr, 2023 | 13:21h | UTC

Association between advanced care planning and emergency department visits: A systematic review – The American Journal of Emergency Medicine

 

Podcast | Resistant hypertension

18 Apr, 2023 | 13:16h | UTC

#390 Resistant Hypertension – The Curbsiders

 

Commonly encountered central nervous system infections in the intensive care unit

18 Apr, 2023 | 13:17h | UTC

Commonly encountered central nervous system infections in the intensive care unit – BJA Education

 

Review | Long-term outcomes following CAR T cell therapy: what we know so far

18 Apr, 2023 | 13:12h | UTC

Long-term outcomes following CAR T cell therapy: what we know so far – Nature Reviews Clinical Oncology (if the link is paywalled, try this one in PMC)

 

Commentary on Twitter

 

Podcast | Fungi fun! an in-depth look at tinea infections in children

18 Apr, 2023 | 13:14h | UTC

Fungi Fun! An In-Depth Look at Tinea Infections – The Cribsiders

 

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