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Clinical trial finds vitamin D does not ward off colds and flu

15 Jan, 2021 | 08:33h | UTC

Clinical trial finds vitamin D does not ward off colds and flu – QIMR Berghofer Medical Research Institute

Original study: The effect of vitamin D supplementation on acute respiratory tract infection in older Australian adults: an analysis of data from the D-Health Trial – The Lancet Diabetes & Endocrinology

 

Study: Pulmonary embolism detected in 6% of patients with COPD admitted to the hospital with acute worsening of respiratory symptoms

15 Jan, 2021 | 08:37h | UTC

Prevalence of Pulmonary Embolism Among Patients With COPD Hospitalized With Acutely Worsening Respiratory Symptoms – JAMA (link to abstract – $ for full-text)

 

Study: Seizure frequency does not increase during Pregnancy

15 Jan, 2021 | 08:28h | UTC

Changes in Seizure Frequency and Antiepileptic Therapy during Pregnancy – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: MONEAD Study: Does Pregnancy Lead to Increased Seizure Frequency in Women with Epilepsy? – Physician’s Weekly AND Pregnancy Does Not Increase Seizures in Women With Epilepsy – Medscape

 

Consequences to patients, clinicians, and manufacturers when very serious adverse drug reactions are identified (1997–2019)

15 Jan, 2021 | 08:26h | UTC

Consequences to patients, clinicians, and manufacturers when very serious adverse drug reactions are identified (1997–2019): A qualitative analysis from the Southern Network on Adverse Reactions (SONAR) – EClinicalMedicine

 

Commentary on Twitter

 

Cohort study: Piperacillin/tazobactam linked to increased risk of acute kidney injury when compared to cefepime or meropenem

15 Jan, 2021 | 08:24h | UTC

Risk of acute kidney injury and Clostridioides difficile infection with piperacillin/tazobactam, cefepime and meropenem with or without vancomycin – Clinical Infectious Diseases

 

Commentary on Twitter

 

Randomized trial: Biological mesh results in significantly more complications compared to synthetic mesh in noncomplex ventral hernia repair

15 Jan, 2021 | 08:17h | UTC

Synthetic Versus Biological Mesh in Laparoscopic and Open Ventral Hernia Repair (LAPSIS): Results of a Multinational, Randomized, Controlled, and Double-blind Trial – Annals of Surgery (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Randomized trial: Surgical and drug treatment options lead to similar outcomes for diabetic eye disease

15 Jan, 2021 | 08:22h | UTC

Surgical and drug treatment options lead to similar outcomes for diabetic eye disease – NIH News Release

Original Study: Effect of Intravitreous Aflibercept vs Vitrectomy With Panretinal Photocoagulation on Visual Acuity in Patients With Vitreous Hemorrhage From Proliferative Diabetic Retinopathy: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

 

Commentary on Twitter

 

[Abstract Only] A randomized clinical trial of low dose warfarin therapy for improving the longevity of permanent arteriovenous catheters

15 Jan, 2021 | 08:18h | UTC

A randomized clinical trial of low dose warfarin therapy for improving the longevity of permanent arteriovenous catheters – Annals of Vascular Surgery (link to abstract – $ for full-text)

 

CSCO and ASCO Guideline: Chemotherapy in combination with radiotherapy for definitive-intent treatment of stage II-IVA nasopharyngeal carcinoma

15 Jan, 2021 | 08:14h | UTC

Chemotherapy in Combination With Radiotherapy for Definitive-Intent Treatment of Stage II-IVA Nasopharyngeal Carcinoma: CSCO and ASCO Guideline – Journal of Clinical Oncology

 

Randomized trial: Cannula with long and narrow tubing noninferior to short binasal prongs for noninvasive ventilation in preterm infants

15 Jan, 2021 | 08:15h | UTC

Cannula With Long and Narrow Tubing vs Short Binasal Prongs for Noninvasive Ventilation in Preterm Infants: Noninferiority Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text)

Commentary: Israeli study finds effective, less invasive way to treat preterm babies – The Jerusalem Post

 

Commentary on Twitter

 

Randomized trial: Once-per-week selinexor, bortezomib, and dexamethasone versus twice-per-week bortezomib and dexamethasone in patients with multiple myeloma

15 Jan, 2021 | 08:12h | UTC

Once-per-week selinexor, bortezomib, and dexamethasone versus twice-per-week bortezomib and dexamethasone in patients with multiple myeloma (BOSTON): a randomised, open-label, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Triplet therapy slows refractory multiple myeloma – MedicalXpress

 

Systematic review: Prostatic arterial embolization for men with symptomatic benign prostatic hyperplasia provides similar short term (up to 12 months) improvement in urologic symptom scores and quality of life, but with an increase in re-treatment rates

15 Jan, 2021 | 08:11h | UTC

Prostatic arterial embolization for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia – Cochrane Library

Summary: Prostatic arterial embolization for treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia – Cochrane Library

 

Systematic review: Adding abiraterone acetate to androgen deprivation therapy for the treatment of metastatic hormone-sensitive prostate cancer

15 Jan, 2021 | 08:10h | UTC

Abiraterone acetate in combination with androgen deprivation therapy compared to androgen deprivation therapy only for metastatic hormone‐sensitive prostate cancer – Cochrane Library

Summary: Adding abiraterone acetate to androgen deprivation therapy for the treatment of metastatic hormone-sensitive prostate cancer – Cochrane Library

 

CoronaVac study in Brazil: Is the vaccine 50%, 78%, or 100% effective?

14 Jan, 2021 | 02:11h | UTC

Third time’s the charm? Brazil scales back efficacy claims for COVID-19 vaccine from China – Science

See also: CoronaVac’s Overall Efficacy in Brazil Measured at 50.4% – Bloomberg

 

Systematic review: Oral hygiene care with chlorhexidine mouthwash or gel in critically ill patients probably reduces the incidence of developing ventilator-associated pneumonia

15 Jan, 2021 | 08:09h | UTC

Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia – Cochrane Library

Summary: Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia – Cochrane Library

 

Meta-analysis: Saliva vs. nasopharyngeal swabs equally sensitive for Covid-19 diagnosis

14 Jan, 2021 | 02:13h | UTC

The Sensitivity and Costs of Testing for SARS-CoV-2 Infection With Saliva Versus Nasopharyngeal Swabs: A Systematic Review and Meta-analysis – Annals of Internal Medicine

Commentary: Saliva, Nasopharyngeal Samples Equally Sensitive for SARS-CoV-2 – Physician’s Weekly

 

Commentary on Twitter

https://twitter.com/EricTopol/status/1348758183846703104

 

A guide to vaccinology: from basic principles to new developments

14 Jan, 2021 | 02:09h | UTC

A guide to vaccinology: from basic principles to new developments – Nature Reviews Immunology

 

Pragmatic Recommendations for the Management of COVID-19 in Low- and Middle-Income Countries

14 Jan, 2021 | 02:04h | UTC

 

How COVID unlocked the power of RNA vaccines

14 Jan, 2021 | 02:09h | UTC

How COVID unlocked the power of RNA vaccines – Nature

Commentary: RNA Vaccines: A Suitable Platform for Tackling Emerging Pandemics? – Frontiers in Immunology

 

Three studies highlight low COVID risk of in-person school

14 Jan, 2021 | 02:06h | UTC

Three studies highlight low COVID risk of in-person school – CIDRAP

Study 1: Open Schools, Covid-19, and Child and Teacher Morbidity in Sweden – New England Journal of Medicine

Study 2: Incidence and Secondary Transmission of SARS-CoV-2 Infections in Schools – Pediatrics

Study 3: Minimal transmission of SARS-CoV-2 from paediatric COVID-19 cases in primary schools, Norway, August to November 2020 – Eurosurveillance

 

No ICU beds? Expect double the number of Covid-19 deaths

14 Jan, 2021 | 02:05h | UTC

No ICU beds? Expect double the number of Covid-19 deaths. – Vox

 

Study estimates 50% of new SARS-CoV-2 infections have originated from exposure to asymptomatic or pre-symptomatic individuals

14 Jan, 2021 | 02:08h | UTC

SARS-CoV-2 Transmission From People Without COVID-19 Symptoms – JAMA Network Open

Commentary: At least 50% of COVID-19 cases spread from people without symptoms, a new study found – Business Insider AND More than half of Covid-19 infections acquired from asymptomatic carriers – MedicalResearch

 

Commentary on Twitter

https://twitter.com/TennantRuth/status/1348208811039985665

 

Perspective: For people with OCD — and fearful of germs — the pandemic is upending years of therapy

14 Jan, 2021 | 02:00h | UTC

For people with OCD — and fearful of germs — the pandemic is upending years of therapy – STAT

 

Preparing previously COVID-19-positive patients for elective surgery: A framework for preoperative evaluation

14 Jan, 2021 | 02:02h | UTC

Preparing previously COVID-19-positive patients for elective surgery: a framework for preoperative evaluation – Perioperative Medicine

Commentary: New process evaluates patients for elective surgeries following COVID-19 – Oregon Health & Science University

Related: ASA and APSF Joint Statement on Elective Surgery and Anesthesia for Patients after COVID-19 Infection – American Society of Anesthesiology

 

Study: Despite recommendations, less than 2 percent of patients with treatment-resistant hypertension were tested for primary aldosteronism in a large U.S. cohort

14 Jan, 2021 | 01:55h | UTC

Testing for Primary Aldosteronism and Mineralocorticoid Receptor Antagonist Use Among U.S. Veterans: A Retrospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Primary Aldosteronism Testing Rare in Treatment-Resistant HTN – HealthDay AND Primary Aldosteronism Testing Rare for Patients with Resistant Hypertension – NEJM Journal Watch

 

Commentary from the author on Twitter (thread – click for more)

 

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