All Posts
State of the art review: Management of non-alcoholic fatty liver disease
21 Jan, 2021 | 01:13h | UTCManagement of non-alcoholic fatty liver disease – The BMJ
Thrombolytic strategies versus standard anticoagulation for acute deep vein thrombosis of the lower limb
21 Jan, 2021 | 01:10h | UTCSummary: Thrombolysis for treatment of acute deep vein thrombosis – Cochrane Library
Randomized trial: Oral Rimegepant for preventive treatment of migraine
21 Jan, 2021 | 01:04h | UTCOral rimegepant for preventive treatment of migraine: a phase 2/3, randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary: Rimegepant bests placebo for preventing migraine – MedicalXpress
Against placebo? It would be interesting to know how this new drug works against other established treatments.
Randomized trial: In pediatric acute CNS infections, 3% Hypertonic saline is superior to 20% Mannitol for reducing intracranial pressure
21 Jan, 2021 | 01:08h | UTCRandomized Clinical Trial of 20% Mannitol Versus 3% Hypertonic Saline in Children With Raised Intracranial Pressure Due to Acute CNS Infections – Pediatric Critical Care Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Feature w/#VisualAbstract
RCT of 20% mannitol vs. 3% hypertonic saline in children w/raised ICP due to acute CNS infections: Which is superior?
Rameshkumar, @drarunbansal, Jayashree 🇮🇳: https://t.co/ZGWaPMhPvr
Editorial by Argent 🇿🇦: https://t.co/BsbZKsEG03#PedsICU @WFPICCS pic.twitter.com/5asM9HNQaN
— Pediatric Critical Care Medicine (@PedCritCareMed) December 21, 2020
Randomized trial: Repeated Ketamine administration for chronic posttraumatic stress disorder
21 Jan, 2021 | 01:03h | UTCA Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder – The American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Repeated Ketamine Infusions Reduce Symptom Severity in Individuals With Chronic Post-Traumatic Stress Disorder – Mount Sinai AND Repeated Ketamine Infusions May Rapidly Reduce Chronic PTSD Symptoms – Psychiatry News Alert
Commentary on Twitter
Patients with chronic PTSD given repeated infusions of ketamine over 2 weeks showed significantly greater symptom improvement than those given a psychoactive placebo control infusion, the first evidence of efficacy.
Learn More: https://t.co/qqcIsNfCHC pic.twitter.com/r7Bggz4cIj— Journals of The American Psychiatric Association (@APAPubJournals) January 5, 2021
Meta-analysis: Perioperative systemic dexamethasone reduces length of stay in total joint arthroplasty
21 Jan, 2021 | 01:52h | UTCPerioperative Systemic Dexamethasone Reduces Length of Stay in Total Joint Arthroplasty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials – The Journal of Arthroplasty (link to abstract – $ for full-text)
Acute flaccid myelitis: Cause, diagnosis, and management
21 Jan, 2021 | 00:58h | UTCAcute flaccid myelitis: cause, diagnosis, and management – The Lancet (free registration required)
Randomized non-inferiority study: Long-acting cabotegravir and rilpivirine dosed every 2 months in adults with HIV-1 infection
21 Jan, 2021 | 01:01h | UTCLong-acting cabotegravir and rilpivirine dosed every 2 months in adults with HIV-1 infection (ATLAS-2M), 48-week results: a randomised, multicentre, open-label, phase 3b, non-inferiority study – The Lancet (link to abstract – $ for full-text)
Commentary (thread – click for more)
Long-acting cabotegravir and rilpivirine dosed every 2 months in adults with #HIV-1 infection (ATLAS-2M), 48-week results: a randomised, multicentre, open-label, phase 3b, non-inferiority study: https://t.co/4SdfnRRCje
— The Lancet (@TheLancet) December 21, 2020
Podcast: MGUS, Myeloma, and Immunology
21 Jan, 2021 | 00:53h | UTCMGUS, Myeloma, and Immunology – The Curbsiders Internal Medicine Podcast
Antenatal interventions for preventing stillbirth, fetal loss and perinatal death: an overview of Cochrane systematic reviews
21 Jan, 2021 | 00:59h | UTCCommentary: What are the most effective interventions during pregnancy for preventing stillbirth? – Cochrane Library
Commentary on Twitter
@CochranePCG overview of Cochrane systematic reviews included 43 Cochrane reviews that assessed 61 different ways of preventing stillbirth during pregnancy, or infant deaths around the time of birth. Read the feature https://t.co/ijf9Id8jjO & full review https://t.co/tMZsCVhs3m
— Cochrane Neonatal (@CochraneNeonate) January 7, 2021
Managing code status conversations for seriously ill older adults in respiratory failure
21 Jan, 2021 | 00:55h | UTC
Meta-Analysis: Low-intensity warfarin may be an option for patients under 65 years of age with non-valvular atrial fibrillation
21 Jan, 2021 | 00:57h | UTCMeta-Analysis Evaluating the Efficacy and Safety of Low-Intensity Warfarin for Patients >65 Years of Age With Non-Valvular Atrial Fibrillation – The American Journal of Cardiology (link to abstract – $ for full-text)
Case series: Portable Magnetic Resonance Imaging for ICU Patients
21 Jan, 2021 | 00:54h | UTCPortable Magnetic Resonance Imaging for ICU Patients – Critical Explorations
[Abstract Only] Meta-analysis: Ablation of aldosterone producing adenoma is associated with a reduced operative duration, decreased intraoperative blood loss, and faster postoperative recovery compared to laparoscopic adrenalectomy
21 Jan, 2021 | 00:50h | UTCAblation versus laparoscopic adrenalectomy for the treatment of aldosterone‑producing adenoma: a meta-analysis – Abdominal Radiology (link to abstract – $ for full-text)
Critical analysis of a randomized controlled trial
21 Jan, 2021 | 00:52h | UTCCritical Analysis of a Randomized Controlled Trial – Indian Journal of Critical Care Medicine
[Abstract Only] Meta-analysis: Myelodysplastic syndrome and acute myeloid leukemia in patients treated with PARP inhibitors
21 Jan, 2021 | 00:37h | UTCMyelodysplastic syndrome and acute myeloid leukaemia in patients treated with PARP inhibitors: a safety meta-analysis of randomised controlled trials and a retrospective study of the WHO pharmacovigilance database – The Lancet Haematology (link to abstract – $ for full-text)
Commentary on Twitter
NEW research: a safety meta-analysis of RCTs and a retrospective study of the WHO pharmacovigilance database shows an increased risk of myelodysplastic syndrome and acute myeloid leukaemia in patients treated w/ PARP inhibitors #MDSsm #leusm https://t.co/evYF1ozg6c
— The Lancet Haematology (@TheLancetHaem) December 21, 2020
Consensus statement: Electrodiagnostic assessment of the autonomic nervous system
21 Jan, 2021 | 00:34h | UTC
EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris – Part 1: treatment and monitoring recommendations
21 Jan, 2021 | 00:48h | UTC
Randomized trial: No benefit from discontinuing ACE Inhibitors and ARBs in patients admitted with COVID-19
20 Jan, 2021 | 01:55h | UTCCommentary: Discontinuing vs. Continuing ACEIs, ARBs in Patients Admitted With COVID-19 – American College of Cardiology
Related study (study and commentary): Randomized trial: Renin–angiotensin system inhibitors can be safely continued in patients admitted to hospital with COVID-19
Randomized trial: Dabigatran non-inferior to standard of care for children with acute venous thromboembolism
21 Jan, 2021 | 00:35h | UTCDabigatran etexilate for the treatment of acute venous thromboembolism in children (DIVERSITY): a randomised, controlled, open-label, phase 2b/3, non-inferiority trial – The Lancet Haematology (link to abstract – $ for full-text)
Study: Crowded ICUs linked to increased mortality from COVID-19
20 Jan, 2021 | 01:53h | UTCCommentaries: Intensive Care Unit Strain and Mortality Risk Among Critically Ill Patients With COVID-19—There Is No “Me” in COVID – JAMA Network Open AND Crowded ICUs tied to higher risk of COVID-19 death – CIDRAP
What we know about Covid-19 reinfection so far
20 Jan, 2021 | 01:52h | UTCWhat we know about covid-19 reinfection so far – The BMJ
Commentary on Twitter
https://twitter.com/bmj_latest/status/1351493503675748352
Study: Immune system ‘remembers’ coronavirus for at least 6 months
20 Jan, 2021 | 01:44h | UTCImmune system ‘remembers’ coronavirus for at least 6 months: study – MedicalXpress
Original study: Evolution of antibody immunity to SARS-CoV-2 – Nature
Commentary on Twitter
Just published @nature: Memory B cells to #SARSCoV2 from 87 infectees persist >6 months, evolve, more potent than original antibodies, likely more resistant to "escape" spike mutations, antigen persistence in gut in 7/14 biopsied https://t.co/ImuoZdfzJO
@c_gaebler @NussenzweigL pic.twitter.com/P1wahDOuiI— Eric Topol (@EricTopol) January 18, 2021
Study: Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity
20 Jan, 2021 | 01:49h | UTC
Commentary on Twitter
A new, very large #SARSCoV2 household transmission study (27K households, 30K cases, 58K contacts)https://t.co/a89uAw3Ohg
—age ≥ 60 and infants most likely to get infected
—<age 20 most likely to infect others (1.6X)@TheLancetInfDis pic.twitter.com/nM044rVEdo— Eric Topol (@EricTopol) January 18, 2021
How effective is a single vaccine dose against Covid-19?
20 Jan, 2021 | 01:42h | UTCHow effective is a single vaccine dose against Covid-19? – BBC