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Oxford/AstraZeneca study supports UK decision to delay second doses
3 Feb, 2021 | 01:47h | UTCOxford/AstraZeneca study supports UK decision to delay second doses – Financial Times
Original study (preprint): Single Dose Administration, And The Influence Of The Timing Of The Booster Dose On Immunogenicity and Efficacy Of ChAdOx1 nCoV-19 (AZD1222) Vaccine
See also: Single dose of AstraZeneca vaccine could cut transmission by 67% – The Guardian AND Oxford vaccine could substantially cut spread – BBC
Commentary on Twitter (thread – click for more)
NEW: fresh data from trials in Brazil, South Africa and the UK shows the Oxford/AstraZeneca vaccine is highly effective with a 12 week gap between doses.
Efficacy is in fact much higher with a 12 week interval than a shorter gap
Story by @donatopmancini: https://t.co/PK4NHhGHeH pic.twitter.com/W3urxSECKL
— John Burn-Murdoch (@jburnmurdoch) February 2, 2021
Russia’s Sputnik V COVID-19 vaccine candidate appears safe and is 91.6% effective
3 Feb, 2021 | 01:49h | UTCCommentaries: Sputnik V COVID-19 vaccine candidate appears safe and effective – The Lancet AND Russia’s “Sputnik V” COVID Vaccine Makes Strong 91.6 % Efficacy Showing In Peer-Reviewed Trial Results – Health Policy Watch AND Russia’s COVID vaccine 92% effective, even in those over 60 – CIDRAP AND Russia’s Sputnik V vaccine has 92% efficacy in trial – BBC AND Expert reaction to study looking at preliminary efficacy and safety results from interim analysis of Russian COVID-19 phase 3 vaccine (Sputnik) trial – Science Media Centre
Commentary on Twitter
NEW—Interim analysis of Russian #COVID19 #vaccine phase 3 trial involving nearly 20,000 participants suggests a two-dose regimen has an efficacy of 91.6% against symptomatic #COVID19. No serious adverse events were deemed to be associated with vaccination. https://t.co/40sM7f2nbS pic.twitter.com/Hzrs34uCWr
— The Lancet (@TheLancet) February 2, 2021
Editorial: Coronavirus is in the air — there’s too much focus on surfaces
3 Feb, 2021 | 01:40h | UTCCoronavirus is in the air — there’s too much focus on surfaces – Nature
Related: COVID-19 rarely spreads through surfaces. So why are we still deep cleaning? – Nature
Covid-19: People who have had infection might only need one dose of mRNA vaccine
3 Feb, 2021 | 01:44h | UTCCovid-19: People who have had infection might only need one dose of mRNA vaccine – The BMJ
Original preprint studies: Robust spike antibody responses and increased reactogenicity in seropositive individuals after a single dose of SARS-CoV-2 mRNA vaccine – medRxiv AND Single Dose Vaccination in Healthcare Workers Previously Infected with SARS-CoV-2 – medRxiv
Coronapod: Fixing the world’s pandemic alarm – A year ago the WHO’s coronavirus emergency alarm was largely ignored. Why?
3 Feb, 2021 | 01:43h | UTCCoronapod: Fixing the world’s pandemic alarm – Nature
Observational study: The combination of Immunoglobulins + Methylprednisolone was associated with a better course of fever compared to Immunoglobulins alone in Multisystem Inflammatory Syndrome in children
3 Feb, 2021 | 01:39h | UTC
Commentaries on Twitter
In this cohort study, treatment w IVIG + methylprednisolone was associated w lower risk of treatment failure (defined as fever persistence 2d after start of therapy or fever recrudescence within 7 days) vs IVIG alone among children w MIS-C https://t.co/LjEBFuf33q
— JAMA (@JAMA_current) February 1, 2021
Yes, retrospective, but I find these data interesting as I expect the combined treatment group to be the sicker of the 2
Association of IVIG Plus Methylprednisolone With Persistent or Recurrent Fever in Children With MIS-C https://t.co/Oio8t05zQ1 via @JAMA_current @JAMANetwork
— Joshua Denson MD (@jdensonMD) February 2, 2021
Perspective: We may never get to herd immunity
3 Feb, 2021 | 01:37h | UTCWe May Never Get to Herd Immunity – Think Global Health
Opinion: The Brazil variant is exposing the world’s vulnerability
3 Feb, 2021 | 01:38h | UTCThe Brazil Variant Is Exposing the World’s Vulnerability – The Atlantic
WHO SCORE Global Report highlights urgent need for better data to strengthen pandemic response and improve health outcomes
2 Feb, 2021 | 01:12h | UTCReport: Global report on health data systems and capacity, 2020 – World Health Organization
Commentary on Twitter
🆕 SCORE 🌐 global report on health data systems & capacity helps countries to:
✅ address gaps & inequalities in health information systems
✅ invest in areas having the greatest impact on quality, availability, analysis, accessibility & use of data📊👉 https://t.co/QjPZ4I4Z9k pic.twitter.com/fKwHuUB400
— World Health Organization (WHO) (@WHO) February 1, 2021
One in three adults report anxiety, depression related to COVID-19
3 Feb, 2021 | 01:35h | UTCOne in three adults report anxiety, depression related to COVID-19 – Duke-NUS Medical School
Podcast: Hypertension Update
2 Feb, 2021 | 01:07h | UTC#254 Hypertension Update with Dr. Wanpen Vongpatanasin – The Curbsiders Internal Medicine Podcast
Ambulatory management of pulmonary embolism: A comparison of two risk-stratification scores
2 Feb, 2021 | 01:11h | UTC
Resumption of cardiac activity after withdrawal of life-sustaining measures
2 Feb, 2021 | 01:09h | UTCResumption of Cardiac Activity after Withdrawal of Life-Sustaining Measures – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: When is ‘dead’ really dead? What happens after a person ‘flatlines’ – The Conversation
Disorders of the enteric nervous system — a holistic view
2 Feb, 2021 | 01:04h | UTC
Safety and effectiveness of bronchial thermoplasty after 10 years in patients with persistent asthma
2 Feb, 2021 | 01:06h | UTCSafety and effectiveness of bronchial thermoplasty after 10 years in patients with persistent asthma (BT10+): a follow-up of three randomised controlled trials – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Coccidioidomycosis: a review
2 Feb, 2021 | 01:04h | UTCCoccidioidomycosis: a review – Journal of Investigative Medicine
Living systematic review on Cannabis and other plant-based treatments for chronic pain
2 Feb, 2021 | 01:01h | UTC
AAP urges continuing obesity management
2 Feb, 2021 | 01:03h | UTCAAP urges continuing obesity management – Contemporary Pediatrics
Original Guideline: Obesity Management and Treatment During COVID-19 – American Academy of Pediatrics
Meta-analysis of longitudinal studies: Frequent or dependent cannabis use in youth linked to decline IQ
2 Feb, 2021 | 01:02h | UTC
SARS-CoV-2 evolution and vaccines: cause for concern?
2 Feb, 2021 | 01:27h | UTCSARS-CoV-2 evolution and vaccines: cause for concern? – The Lancet
Commentaries on Twitter
Just to show how fast things are moving
On the same day this was published
"#SARSCoV2 evolution and vaccines: cause for concern?"@LancetRespirMed https://t.co/YE3J6tSMRV
The ? was answered, w/ a drop-off in vaccine efficacy (89%->49%) for B.1.351, (96%->86%) for B.1.1.7— Eric Topol (@EricTopol) January 31, 2021
✨✨The overall effectiveness of immunisation will correlate with rates of vaccine uptake
The ⬆️ the proportion of a population vaccinated,the ⬇️ the number of susceptible individuals, and the fewer opportunities SARS-CoV-2 will have to spread & mutate✨✨ https://t.co/hxOCkTXyB6— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) January 31, 2021
Covid-19: WHO warns against “vaccine nationalism” or face further virus mutations
2 Feb, 2021 | 01:30h | UTCCovid-19: WHO warns against “vaccine nationalism” or face further virus mutations – The BMJ
Perspective: Are we expecting too much from our COVID-19 vaccines?
2 Feb, 2021 | 01:26h | UTCAre We Expecting Too Much from Our COVID-19 Vaccines? – HIV and ID Observations
Covid-19: Novavax vaccine efficacy is 86% against UK variant and 60% against South African variant
2 Feb, 2021 | 01:29h | UTC
Commentary on Twitter
The SARS-CoV-2 vaccine produced by Novavax is 95.6% effective against the original variant of SARS-CoV-2 but also provides protection against the newer variants B.1.1.7 (85.6%) and B.1.351 (60%), preliminary data from clinical trials show https://t.co/lhsB2UzD08
— The BMJ (@bmj_latest) February 1, 2021
Variants, 3 new Covid vaccines, and contested efficacy claims: A month of seismic shifts and confusion
2 Feb, 2021 | 01:25h | UTC
Covid: The devastating toll of the pandemic on children
2 Feb, 2021 | 01:22h | UTCCovid: The devastating toll of the pandemic on children – BBC
Commentary on Twitter (thread – click for more)
Longtime school closures cause major psychological harm to children. School closures also affect their education, future prospects in life and cause further inequality in society. The long-term economic harm of school closures will be felt by all.
1/https://t.co/n7yhUEfXmL— Prof Francois Balloux (@BallouxFrancois) January 30, 2021