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#COVID19 vaccines—developed, trialled, manufactured & authorised in several countries within a year. @VictorDzau et al. on lessons from the pandemic to inform an end-to-end global research & development preparedness & response ecosystem. Read https://t.co/G9PA5JBuaJ pic.twitter.com/EtFORBxvTl

— The Lancet (@TheLancet) March 12, 2021

Cohort study: Effectiveness of three vs. six feet of physical distancing for controlling spread of COVID-19 among primary and secondary students and staff

14 Mar, 2021 | 20:48h | UTC

Effectiveness of three versus six feet of physical distancing for controlling spread of COVID-19 among primary and secondary students and staff: A retrospective, state-wide cohort study – Clinical Infectious Diseases

News release: With masks on, three feet is just as safe as six feet apart in Massachusetts schools, researchers find – Beth Israel Deaconess Medical Center

Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes

14 Mar, 2021 | 20:43h | UTC

Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes – Science

Commentary: Spacing COVID-19 vaccine doses has benefits, but longer-term outcomes depend on robust immunity – Princeton University

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

14 Mar, 2021 | 20:44h | UTC

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity – Cell

Commentary: Vaccine-induced antibodies may be less effective against several new SARS-CoV-2 variants

Commentary on Twitter (thread – click for more)

Our paper describing the potential for mRNA vaccines to induce antibodies capable of neutralizing many of the circulating variants is now available online at Cell!https://t.co/c8B87Tg55S pic.twitter.com/eRM8ABJrQY

— Balazs Lab (@BalazsLab) March 12, 2021

Cohort study: Association of ablative radiation therapy with survival among patients with inoperable pancreatic cancer

14 Mar, 2021 | 20:09h | UTC

Association of Ablative Radiation Therapy With Survival Among Patients With Inoperable Pancreatic Cancer – JAMA Oncology (free for a limited period)

Commentary on Twitter

Ablative RT to 98Gy biologically effective dose following multiagent induction therapy for locally advanced pancreatic cancer (LAPC) was safe & resulted in durable locoregional tumor control & favorable survival https://t.co/pLf52Tt6j0 #GICSM

— JAMA Oncology (@JAMAOnc) March 12, 2021

Guide to enhanced recovery for cancer patients undergoing breast surgery and reconstruction

14 Mar, 2021 | 20:01h | UTC

Guide to Enhanced Recovery for Cancer Patients Undergoing Breast Surgery and Reconstruction – Annals of Surgical Oncology

Study: Healthcare settings did not increase the risk for Covid-19 infection among health care workers in the US. Exposure outside the workplace was the strongest risk factor for SARSCoV2 seropositivity

14 Mar, 2021 | 20:41h | UTC

Risk Factors Associated With SARS-CoV-2 Seropositivity Among US Health Care Personnel – JAMA Network Open

Commentaries: Healthcare settings do not increase risk for Covid-19 infection spread – University of Maryland School of Medicine AND Did Healthcare Workers Catch Covid In Or Outside The Hospital? – MedicalResearch.com AND Community Covid-19 Risk Higher Than Workplace Risk for Health Care Personnel – Physician’s Weekly

Commentary on Twitter

Cross-sectional study finds #COVID19 exposure outside the workplace was the strongest risk factor for #SARSCoV2 seropositivity. No workplace factors were associated with seropositivity. @EmoryMedicine @UMMC @HopkinsMedicine @CDCgov https://t.co/DbdSxTEb8n

— JAMA Network Open (@JAMANetworkOpen) March 10, 2021

70-gene signature as an aid for treatment decisions in early breast cancer: updated results of the phase 3 randomised MINDACT trial with an exploratory analysis by age

14 Mar, 2021 | 20:07h | UTC

70-gene signature as an aid for treatment decisions in early breast cancer: updated results of the phase 3 randomised MINDACT trial with an exploratory analysis by age – The Lancet Oncology (link to abstract – $ for full-text)

Meta-analysis of observational studies suggests better long-term oncologic outcomes with propofol-based total intravenous anesthesia compared to any volatile anesthesia

14 Mar, 2021 | 19:59h | UTC

Anesthesia and Long-term Oncological Outcomes: A Systematic Review and Meta-analysis – Anesthesia & Analgesia

Commentary on Twitter

🔴 Patients who receive propofol-based TIVA for cancer surgery are associated with better overall survival than volatile anesthesia though there is no statistically significant difference in cancer-free survival between propofol-based TIVA https://t.co/lJHxmcqjtB pic.twitter.com/7gYmZYZRij

— Anesthesia&Analgesia (@IARS_Journals) March 3, 2021

Hearing loss prevalence and years lived with disability, 1990–2019: findings from the Global Burden of Disease Study 2019

12 Mar, 2021 | 08:16h | UTC

Hearing loss prevalence and years lived with disability, 1990–2019: findings from the Global Burden of Disease Study 2019 – The Lancet

Commentary: Addressing the global burden of hearing loss – The Lancet

Commentary on Twitter

https://twitter.com/IHME_UW/status/1370167273407705089

Study shows increased risk of all-cause mortality in STEMI patients without standard modifiable risk factors

12 Mar, 2021 | 08:13h | UTC

Mortality in STEMI patients without standard modifiable risk factors: a sex-disaggregated analysis of SWEDEHEART registry data – The Lancet

Commentary on Twitter

#Swedish study published in @TheLancet shows patients with myocardial infarction without standard risk factors suffer worse outcomes. Use of guideline-indicated treatments attenuated the risk, underscoring a therapeutic need for this lower-risk group.https://t.co/U49IXNtACK

— The Lancet Reg Health-Europe (@LancetRH_Europe) March 10, 2021

Drug dosing in the critically ill obese patient: a focus on medications for hemodynamic support and prophylaxis

12 Mar, 2021 | 08:08h | UTC

Drug dosing in the critically ill obese patient: a focus on medications for hemodynamic support and prophylaxis – Critical Care

M-A: Angiographic Patency of Coronary Artery Bypass Conduits

12 Mar, 2021 | 08:10h | UTC

Angiographic Patency of Coronary Artery Bypass Conduits: A Network Meta‐Analysis of Randomized Trials – Journal of the American Heart Association

Pragmatic RCT: No difference in outcomes from different gestational diabetes screening methods

11 Mar, 2021 | 08:12h | UTC

A Pragmatic, Randomized Clinical Trial of Gestational Diabetes Screening – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: One-Step Screening for Gestational Diabetes Increases Diagnoses — But Doesn’t Improve Outcomes – NEJM Journal Watch AND How Do Screening Methods for Gestational Diabetes Compare? – AJMC AND Different gestational diabetes screening methods cause no difference for complications – 2 Minute Medicine

Consensus Statement: Preoperative management of endocrine, hormonal, and urologic medications

11 Mar, 2021 | 08:04h | UTC

Preoperative Management of Endocrine, Hormonal, and Urologic Medications: Society for Perioperative Assessment and Quality Improvement (SPAQI) Consensus Statement – Mayo Clinic Proceedings

M-A: Early tracheostomy may lower the rates of ventilator-associated pneumonia and ventilator duration in critically ill patients

12 Mar, 2021 | 08:09h | UTC

Association of Early vs Late Tracheostomy Placement With Pneumonia and Ventilator Days in Critically Ill Patients: A Meta-analysis – JAMA Otolaryngology-Head & Neck Surgery

Author interview: Early vs Late Tracheotomy for Pneumonia and Ventilator Days

#Tracheostomy placement no more than 7 days after ventilator support may lower the rates of ventilator-associated pneumonia and ventilator duration https://t.co/gVPXoMEorN @Penn_ENT @UTHealthSA

— JAMA Otolaryngology – Head & Neck Surgery (@JAMAOto) March 11, 2021