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Covid-19: European countries suspend use of Oxford-AstraZeneca vaccine after reports of blood clots

12 Mar, 2021 | 08:32h | UTC

Covid-19: European countries suspend use of Oxford-AstraZeneca vaccine after reports of blood clots – The BMJ

Commentary on Twitter

Denmark has temporarily suspended use of the Oxford-AstraZeneca covid-19 vaccine as a precautionary move after reports of blood clots. But the EMA and the UK’s regulatory body say there is no indication that vaccination is linked to thromboembolic events https://t.co/sW8GRqcnLg

— The BMJ (@bmj_latest) March 11, 2021

Update to living systematic review on covid-19 in pregnancy

12 Mar, 2021 | 08:28h | UTC

Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis – The BMJ

News release: Update to living systematic review on covid-19 in pregnancy – The BMJ

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

12 Mar, 2021 | 08:23h | UTC

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies – Nature

Perspective | Long Covid isn’t as unique as we thought

12 Mar, 2021 | 08:27h | UTC

Long Covid isn’t as unique as we thought – Vox

Perspective | Immunity to SARS-CoV-2 variants of concern

12 Mar, 2021 | 08:24h | UTC

Immunity to SARS-CoV-2 variants of concern – Science

Commentary on Twitter

https://twitter.com/EricTopol/status/1370094431668375552

Managing Patients with Failing Kidney Allograft: Many Questions Remain

12 Mar, 2021 | 08:06h | UTC

Managing Patients with Failing Kidney Allograft: Many Questions Remain – Clinical Journal of the American Society of Nephrology

M-A: Sequential combination of pharmacotherapy and psychotherapy in major depressive disorder

11 Mar, 2021 | 08:00h | UTC

Sequential Combination of Pharmacotherapy and Psychotherapy in Major Depressive Disorder: A Systematic Review and Meta-analysis – JAMA Psychiatry

Commentary: How To Prevent A Relapse Of Clinical Depression – Forbes

CDC Interim Recommendations for Fully Vaccinated People: An Important First Step

12 Mar, 2021 | 08:22h | UTC

CDC Interim Recommendations for Fully Vaccinated People: An Important First Step – JAMA

Original Guidance and Commentaries: New CDC Guideline for fully vaccinated individuals says people can get together indoors without masks. Precautions should continue in public.

M-A: Little benefit from antidepressants for low back pain

11 Mar, 2021 | 08:02h | UTC

Efficacy, acceptability, and safety of antidepressants for low back pain: a systematic review and meta-analysis – Systematic Reviews

Commentary: Antidepressants provide no important benefits for managing low back pain – News Medical

Related meta-analysis: Little benefit from antidepressants for the treatment of back pain and osteoarthritis (study and commentaries)

Comparison of palliative care delivery in the last year of life between adults with terminal noncancer illness or cancer

11 Mar, 2021 | 07:55h | UTC

Comparison of Palliative Care Delivery in the Last Year of Life Between Adults With Terminal Noncancer Illness or Cancer – JAMA Network Open

Commentary: People with dementia receive fewer palliative referrals than those with cancer: study – McNight’s

Commentary on Twitter

Cohort study finds differences in #PalliativeCare for cancer vs noncancer patients: Earlier initiation/Multiple settings/Shared care. Need to improve equitable access to care across all settings @CanadianHPCAssn @AAHPM @HQOntario @ICESOntario @SinaiHealth https://t.co/b7i4z8zokq

— JAMA Network Open (@JAMANetworkOpen) March 5, 2021

Cohort study: Association of Ibuprofen prescription with acute kidney injury among hospitalized children

11 Mar, 2021 | 07:57h | UTC

Association of Ibuprofen Prescription With Acute Kidney Injury Among Hospitalized Children in China – JAMA Network Open

Commentary on Twitter

Cohort study finds ibuprofen was widely used and associated with an increased risk of HA-AKI in hospitalized children. Rational prescribing of ibuprofen is an important strategy to reduce the burden of HA-AKI in children. https://t.co/jgQD4ELXxN

— JAMA Network Open (@JAMANetworkOpen) March 5, 2021

USPSTF Statement: begin screening for lung cancer at age 50 years instead of 55 years for patients at risk

10 Mar, 2021 | 08:28h | UTC

Recommendation Statement: Screening for Lung Cancer – US Preventive Services Task Force

Editorials: Broadened Eligibility for Lung Cancer Screening: Challenges and Uncertainty for Implementation and Equity – JAMA AND Expanded Access to Lung Cancer Screening—Implementing Wisely to Optimize Health – JAMA Network Open AND New USPSTF Guidelines for Lung Cancer Screening: Better but Not Enough – JAMA Surgery AND The 2021 US Preventive Services Task Force Recommendation on Lung Cancer Screening: The More Things Stay the Same… – JAMA Oncology

RCT: Effect of ventral vs. dorsal spinal surgery on patient-reported physical functioning in patients with cervical spondylotic myelopathy

10 Mar, 2021 | 08:26h | UTC

Effect of Ventral vs Dorsal Spinal Surgery on Patient-Reported Physical Functioning in Patients With Cervical Spondylotic Myelopathy: A Randomized Clinical Trial – JAMA (free for a limited period)

Commentary: First-of-its kind study compares two surgeries head-to-head for common neck condition – Beth Israel Lahey Health

Cohort study: Hypertensive disorders of pregnancy linked to subsequent risk of premature mortality

10 Mar, 2021 | 08:24h | UTC

Hypertensive Disorders of Pregnancy and Subsequent Risk of Premature Mortality – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Do Hypertension Disorders of Pregnancy Increase Risk of Premature Maternal Mortality? – American College of Cardiology AND Hypertension disorders of pregnancy increase risk of premature maternal mortality – American College of Cardiology

Position Statement: The Role of Pharmacogenomics in Contemporary Cardiovascular Therapy

11 Mar, 2021 | 07:53h | UTC

The Role of Pharmacogenomics in Contemporary Cardiovascular Therapy: A position statement from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

RCT: Secondary cytoreduction followed by chemotherapy vs. chemotherapy alone in platinum-sensitive relapsed ovarian cancer

10 Mar, 2021 | 08:18h | UTC

Secondary cytoreduction followed by chemotherapy versus chemotherapy alone in platinum-sensitive relapsed ovarian cancer (SOC-1): a multicentre, open-label, randomised, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentary on Twitter

NEW online: SOC-1 trial—Secondary #cytoreduction followed by #chemotherapy versus chemotherapy alone in platinum-sensitive relapsed #ovariancancer #surgery #gyncsm https://t.co/cFq41Ck9EW pic.twitter.com/5gFsIGLBDA

— The Lancet Oncology (@TheLancetOncol) March 9, 2021

WHO Report | Devastatingly pervasive: 1 in 3 women globally experience violence

10 Mar, 2021 | 08:21h | UTC

Devastatingly pervasive: 1 in 3 women globally experience violence – World Health Organization

Commentary: Violence Against Women Is “Unequivocally Pervasive”, Reveals Largest WHO Study Ever – Health Policy Watch

Global, regional, and national mortality trends in youth aged 15–24 years between 1990 and 2019: a systematic analysis

10 Mar, 2021 | 08:22h | UTC

Global, regional, and national mortality trends in youth aged 15–24 years between 1990 and 2019: a systematic analysis – The Lancet Global Health

Invited commentary: The pressing need for better statistics on youth mortality – The Lancet Global Health

https://twitter.com/BrunoMasquelier/status/1366707073715691523

[Press release – not published yet] Monoclonal antibodies reduced hospitalizations and death in Phase 3 trial for early COVID-19

11 Mar, 2021 | 08:41h | UTC

Press release: Lilly’s bamlanivimab and etesevimab together reduced hospitalizations and death in Phase 3 trial for early COVID-19

Commentary: Eli Lilly’s combo therapy for COVID-19 cuts serious illness and death in large study – Reuters

Death rate 64% higher with B117 COVID variant, study finds

11 Mar, 2021 | 08:38h | UTC

Death rate 64% higher with B117 COVID variant, study finds – CIDRAP

News release: Variant B.1.1.7 of COVID-19 associated with a significantly higher mortality rate, research shows – University of Bristol

Original Study: Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study – The BMJ

Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk

11 Mar, 2021 | 08:35h | UTC

Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk – Association of Anaesthetists of Great Britain and Ireland

Original study: Timing of surgery following SARS‐CoV‐2 infection: an international prospective cohort study – Anaesthesia

Commentary on Twitter

Reported by > 100 news organisations and > 200k Twitter impressions in just a few hours!

Here is the new @CovidSurg infographic! Time to establish timing of surgery guidelines?@aneelbhangu @dnepo @JoanaffSimoes #FOAMed

🔗https://t.co/mRnV7U6u1w pic.twitter.com/BmKlxf9ZIK

— 𝘈𝘯𝘢𝘦𝘴𝘵𝘩𝘦𝘴𝘪𝘢 (@Anaes_Journal) March 10, 2021

[Preprint] RECOVERY trial: Convalescent plasma does not improve outcomes in patients admitted to hospital with COVID-19

11 Mar, 2021 | 08:43h | UTC

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial – medRxiv

Commentary on Twitter (thread – click for more)

RECOVERY Pre-print:

Convalescent plasma does not improve survival in patients hospitalised with COVID-19 in this randomised controlled trial involving 11,558 patients:https://t.co/36YZwJNY3Q pic.twitter.com/sKR095n1PC

— Martin Landray (@MartinLandray) March 10, 2021