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RCT: Vaginal administration of misoprostol is superior to buccal administration of misoprostol along with a Foley catheter for induction of labor.
9 Jun, 2021 | 08:11h | UTCBuccal vs vaginal misoprostol combined with Foley catheter for cervical ripening at term (the BEGIN trial): a randomized controlled trial – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)
Commentary on Twitter
https://twitter.com/AJOG_thegray/status/1393529144395374592
Short review: Neurological complications of COVID-19.
8 Jun, 2021 | 09:36h | UTCNeurological complications of COVID-19 – Intensive Care Medicine
Commentary on Twitter
NeuroCOVID potential mechanism(s)?
🧠 #COVID19 neuro-complications
🧠 direct neuroinvasion
🧠 inflammatory/autoimmune
🧠 vascular
+
🧠 #ICU complications
🧠 drugs toxicity/side effects
🧠 PICS/PACS & PTSD
Challenging to identify/diagnose: strictly monitor! https://t.co/0YlAoanUFo pic.twitter.com/unM0SWFR7L— Intensive Care Medicine (@yourICM) June 7, 2021
Difficult airway management in neonates and infants: knowledge of devices and a device-oriented strategy.
9 Jun, 2021 | 08:08h | UTC
Underlying medical conditions associated with severe COVID-19 illness among children – the strongest risk factors for hospitalization were chronic and complex chronic diseases, type 1 diabetes, and obesity.
8 Jun, 2021 | 09:37h | UTCCommentaries: Underlying illness, respiratory infection raise risk for severe COVID in kids – CIDRAP AND COVID-19 in Children—Not Just Little Adults – JAMA Network Open
Commentary on Twitter
This cross-sectional study found a higher risk of severe #COVID19 illness among children with medical complexity and certain underlying conditions, such as type 1 diabetes, cardiac and circulatory congenital anomalies, and obesity. https://t.co/ifq1Ao0HKS
— JAMA Network Open (@JAMANetworkOpen) June 7, 2021
Are SARS-CoV-2 Human Challenge Trials Ethical? – “A clinical trial is underway in the UK in which young, healthy participants are exposed deliberately to SARS-CoV-2 to assess the viral inoculum needed to produce an infection and to test vaccine efficacy”.
8 Jun, 2021 | 09:29h | UTCAre SARS-CoV-2 Human Challenge Trials Ethical? – JAMA Internal Medicine
Related: World’s first coronavirus “Human Challenge” study receives ethics approval in the UK (several texts on the subject)
Commentary on Twitter
I am not convinced of #SARSCoV2 #ChallengeTrials. You should not pay volunteers. If things go wrong, there is no effective treatment. What will be learnt from mild disease, when you are interested in severe disease? #COVID19 #Covid #Corona #coronavirushttps://t.co/JjXDJDfOl2
— Martin Michaelis (@MartMichaelis) June 8, 2021
The “Black Fungus” in India: The Emerging Syndemic of COVID-19–Associated Mucormycosis – careful use of antibiotics and corticosteroids and closely monitoring blood glucose levels are some of the strategies suggested by the authors.
8 Jun, 2021 | 09:34h | UTC
Multicenter Epidemiologic Study of Coronavirus Disease–Associated Mucormycosis, India – Uncontrolled diabetes mellitus was the most common underlying disease; improper glucocorticoid use was independently associated with the disease.
8 Jun, 2021 | 09:33h | UTCCommentary: COVID19: Secondary Infections Still a Big Challenge in India – News Click
Commentary on Twitter
New study from India on mucormycosis
– COVID-19 has led to increases in mucormycosis, partly from inappropriate steroid use
– Uncontrolled diabetes was the most common underlying disease
Better diabetes care & rational steroid use are key!https://t.co/Wv8kCyTDtK pic.twitter.com/KK78BKg2Xf
— Madhu Pai, MD, PhD (@paimadhu) June 7, 2021
Report: 376,000 people in UK have had long Covid symptoms for at least a year.
8 Jun, 2021 | 09:27h | UTC376,000 people in UK have had long Covid symptoms for at least a year – ONS – The Guardian
Original report: Prevalence of ongoing symptoms following coronavirus (COVID-19) infection in the UK: 4 June 2021 – Office for National Statistics
Practice Pointer | Mask related acne (“maskne”) and other facial dermatoses.
8 Jun, 2021 | 09:24h | UTCMask related acne (“maskne”) and other facial dermatoses – The BMJ
Commentary on Twitter
The term “maskne” has become increasingly popular during the pandemic, particularly in the media.
This #BMJInfographic presents common distributions that can be used as a starting point for assessment @will_s_t https://t.co/mKQUaN3PYY pic.twitter.com/OCBuFxiY9s
— The BMJ (@bmj_latest) June 7, 2021
Synopsis | Updates to the Pediatrics Asthma Management Guidelines.
8 Jun, 2021 | 09:22h | UTCUpdates to the Pediatrics Asthma Management Guidelines – JAMA Pediatrics (free for a limited period)
Original Guideline: 2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group
RCT: Low tidal volume ventilation is not superior to no ventilation during cardiopulmonary bypass in heart surgery.
8 Jun, 2021 | 09:16h | UTCLow Tidal Volume Mechanical Ventilation Against No Ventilation During Cardiopulmonary Bypass in Heart Surgery (MECANO): A Randomized Controlled Trial – CHEST (link to abstract – $ for full-text)
Diagnostic value of cutaneous manifestation of SARS-CoV-2 infection – there was a significant association between skin rashes and a positive swab test result (odds ratio 1.67).
8 Jun, 2021 | 09:26h | UTCDiagnostic value of cutaneous manifestation of SARS-CoV-2 infection – British Journal of Dermatology
Time-to-positivity in bloodstream infection is not a prognostic marker for mortality: analysis of a prospective multicenter randomized control trial.
8 Jun, 2021 | 09:21h | UTC
Commentary on Twitter
🆕💥Analysis Data from RAPIDO RCT
Time to positivity is not associated with mortality, except in Candida spp (longer times associated with worse outcomes), and possibly in Streptococci (shorter times associated with worse outcomes) #IDTwitter #medtwitter https://t.co/v17uT8j7u9— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) June 7, 2021
More data suggests no cardiovascular benefit from Omega-3 supplementation – secondary analysis of STRENGHT trial did not show an association between achieved Omega-3 fatty acid levels and major adverse cardiovascular outcomes in patients with high cardiovascular risk.
8 Jun, 2021 | 09:19h | UTCOriginal study: #AHA20 – Randomized trial: High-dose Omega-3 fatty acids did not reduce the risk of cardiac events in patients at high cardiovascular risk
RCT: Heart-protecting drugs likely unnecessary for most breast cancer patients undergoing adjuvant treatment.
8 Jun, 2021 | 09:15h | UTCCommentaries: Heart-protecting drugs likely unnecessary for many breast cancer patients – American College of Cardiology
RCT: In patients hospitalized with Covid-19 with elevated D-Dimer, a full-dose anticoagulation strategy based on rivaroxaban (full-dose heparins in unstable patients) + rivaroxaban to day 30 was not better than prophylactic anticoagulation and increased bleeding risk.
7 Jun, 2021 | 00:01h | UTC
Commentary on Twitter
https://twitter.com/RenatoDLopes1/status/1400962037610582026
Six months of COVID vaccines: what 1.7 billion doses have taught scientists.
6 Jun, 2021 | 23:57h | UTCSix months of COVID vaccines: what 1.7 billion doses have taught scientists – Nature
See also: Coronavirus (COVID-19) Vaccinations – Our World in Data
Related commentary on Twitter
• To administer the first half a billion vaccines took 113 days
• The second half a billion 30 days
• The third half a billion 23 days
• And the fourth half a billion were administered in the last 16 daysWe keep on counting on @OurWorldInData here: https://t.co/7lOyDamxxx pic.twitter.com/Pg7OPJxliI
— Max Roser (@MaxCRoser) June 4, 2021
Review: Management of patients with venous thromboembolism after the initial treatment period.
8 Jun, 2021 | 09:13h | UTC
WHO approval of Chinese CoronaVac COVID vaccine will be crucial to curbing pandemic.
6 Jun, 2021 | 23:56h | UTCWHO approval of Chinese CoronaVac COVID vaccine will be crucial to curbing pandemic – Nature
Related: WHO validates Sinovac-CoronaVac COVID-19 vaccine for emergency use and issues interim policy recommendations. AND Brazilian town experiment shows mass vaccination can wipe out COVID-19.
Study shows reduced neutralizing antibody activity induced by Pfizer–BioNTech vaccine against SARS-CoV-2 variants of concern B.1.617.2 (Delta) and B.1.351 (Beta).
6 Jun, 2021 | 23:59h | UTC
Commentary on Twitter (thread – click for more)
“Immune escape” in #DeltaVariant. That’s the latest finding – that #B16172 is as bad for antibody neutralization as the Beta variant #B1351 from South Africa 🇿🇦. 1st dose alone very small effect— 2 doses needed, but weakest against Delta. Let’s walk through evidence 🧵 #COVID19 https://t.co/GurgkNVgiY pic.twitter.com/o0s9WIudCW
— Eric Feigl-Ding (@DrEricDing) June 5, 2021
Case report: Successful treatment of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT).
6 Jun, 2021 | 23:55h | UTC
More data on the harmful effects of the COVID-19 pandemic on the mental health of adolescents.
6 Jun, 2021 | 23:52h | UTCCommentaries: A lost generation? COVID-19 and adolescent mental health – The Lancet Psychiatry AND COVID-19 pandemic has had significant impact on the mental health of adolescents – Columbia University Mailman School of Public Health
Commentary on Twitter (thread – click for more)
https://twitter.com/TheLancetPsych/status/1400783180937011202
2 new meta-analysis detail neurologic and psychiatric conditions in COVID-19.
6 Jun, 2021 | 23:54h | UTCNeurologic, psychiatric conditions common in COVID-19 – CIDRAP
Challenges and solutions for physician mothers: a critical review of the literature.
6 Jun, 2021 | 23:46h | UTC
Commentary on Twitter
Challenges and Solutions for Physician Mothers: A Critical Review of the Literature in @MayoProceedings
By @sherry_chesak @anjalibhagramd et al.#WomenInMedicine @AMWADoctors https://t.co/RXvXt739PN pic.twitter.com/7aNuA9JVJQ— Mayo Clinic GRIT (@MayoGRIT) April 9, 2021
Perspective | Could statins do more than lower cholesterol in patients with COVID-19? – “Don’t Start, Don’t Stop”.
6 Jun, 2021 | 23:49h | UTCCould Statins Do More Than Lower Cholesterol in Patients With COVID-19? – JAMA