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Opinion | “Doctors have been blamed for the rise in black fungus in India, but the COVID treatment guidelines could be contributing” – improper use of antibiotics and higher than usual doses of corticosteroids may be contributing to the emergence of mucormycosis and other fungal co-infections.
6 Jun, 2021 | 23:48h | UTCRelated: The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries – The Lancet AND What Is ‘Black Fungus’? And Why Is It Spreading Among India’s COVID Patients? – NPR AND Mucormycosis: The ‘black fungus’ maiming Covid patients in India AND What is mucormycosis, the fungal infection affecting COVID patients in India? – The Conversation
RCT: Early, intensive mobilization poststroke may harm patients.
6 Jun, 2021 | 23:45h | UTCFatal and Nonfatal Events Within 14 days After Early, Intensive Mobilization Poststroke – Neurology
Moving from bytes to bedside: a systematic review on the use of artificial intelligence in the intensive care unit.
6 Jun, 2021 | 23:42h | UTC
Commentary on Twitter
Overview of current maturity of using #ArtificialIntelligence in #ICU, research methodologies, risk of bias: SR including 494 studies. To date, vast majority of published ICU #AI models remain in prototyping/development environment, not tested at bedside. https://t.co/kTpSy2Is7J https://t.co/oU11J3XYjA pic.twitter.com/tKIwQYqgRH
— Intensive Care Medicine (@yourICM) June 5, 2021
M-A: Direct comparison of preoperative imaging modalities for localization of primary hyperparathyroidism – “choline PET-CT would be the best preoperative imaging modality for localization of primary hyperparathyroidism”.
6 Jun, 2021 | 23:40h | UTCJAMA Otolaryngology – Head & Neck Surgery (free for a limited period)
Invited commentary: Localization Studies for Parathyroid Surgery (free for a limited period)
Investigation | Covid 19: How harm reduction advocates and the tobacco industry capitalized on the pandemic to promote nicotine.
6 Jun, 2021 | 23:51h | UTCCommentaries: Researchers report how the tobacco and e-cigarette industry capitalized on COVID-19 to promote smoking – News Medical AND Investigation discredits studies suggesting lower COVID-19 risk for smokers
M-A: The benefit of dysphagia screening in adult patients with stroke.
6 Jun, 2021 | 23:43h | UTC
Update on the diagnosis and treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome.
6 Jun, 2021 | 23:37h | UTCUpdate on the Diagnosis and Treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome: A Review – JAMA Oncology (free for a limited period)
Viewpoint | A national goal to advance health equity through value-based payment.
6 Jun, 2021 | 23:39h | UTCA National Goal to Advance Health Equity Through Value-Based Payment – JAMA
Another study shows a high frequency of antibiotic use among patients hospitalized with Covid-19 (85.2%), despite low rates of confirmed secondary bacterial infections.
4 Jun, 2021 | 10:43h | UTCCommentaries: Very high use of antibiotics in COVID-19 treatment could be reduced – University of Glasgow AND More evidence of frequent antibiotic use noted in COVID patients – CIDRAP AND Covid-19: Antimicrobial use was high during first wave despite bacterial co-infections being rare, study finds – The BMJ
Related: Many hospitalized Covid-19 patients are given antibiotics. That’s a problem – STAT
Commentary on Twitter (thread – click for more)
Our paper on co-infections, secondary infections & antimicrobial use in patients hospitalised with #COVID19 in UK during the 1st wave is out in @LancetMicrobe!@ISARIC1 @CCPUKstudy @CVRinfo @UofGlasgow @EdinburghUni @LivUni @imperialcollege https://t.co/QYU1B2Eyup
A🧵
— Antonia Ho (@DrToniHo) June 3, 2021
M-A: Prehospital Tranexamic Acid reduces mortality among bleeding trauma patients without increasing the risk of venous thromboembolism.
6 Jun, 2021 | 23:34h | UTCThe impact of prehospital TXA on mortality among bleeding trauma patients: A systematic review and meta-analysis – Journal of Trauma and Acute Care Surgery (link to abstract – $ for full-text)
Commentary: Prehospital TXA for Trauma – Meta-analysis – JournalFeed
RCT: No benefit from posterior quadratus lumborum block in total hip arthroplasty.
6 Jun, 2021 | 23:35h | UTC
Commentary on Twitter
In the context of a multimodal postoperative analgesic strategy, providing a quadratus lumborum block using ropivacaine resulted in no less morphine consumption or pain in the first 24 postoperative hours compared to saline injection #visualabstract https://t.co/cvxuQ9AQPQ pic.twitter.com/HP5EwrKagx
— Anesthesiology (@_Anesthesiology) April 20, 2021
Cohort study: long working hours (more than 55 h/week) linked to increased risk of recurrent coronary events.
6 Jun, 2021 | 23:32h | UTCLong Working Hours and Risk of Recurrent Coronary Events – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Working long hours may increase odds of second heart attack – American College of Cardiology AND Recurrent CHD Risk Up With Long Working Hours After First MI – HealthDay AND Longer Work Hours After MI Tied to Higher Risk of Recurrent Events – TCTMD
In a Mendelian randomization study, researchers found no genetic evidence to support an association between Vitamin D levels and COVID-19 susceptibility, severity, or hospitalization.
4 Jun, 2021 | 10:35h | UTCCommentary: Vitamin D may not provide protection from COVID-19 susceptibility or disease severity, study suggests – PLOS
Related: Living systematic review: The evidence is insufficient to determine the benefits and harms of vitamin D supplementation as a treatment of COVID‐19. AND RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19
RCT: Prophylactic post-exposure prophylaxis with Bamlanivimab reduced the incidence of Covid-19 among residents and staff of skilled nursing and assisted living facilities.
4 Jun, 2021 | 10:40h | UTCEditorial: Bamlanivimab for Prevention of COVID-19
[Preprint] Covid-19 B.1.617.2 variant of concern (Delta) is associated with increased transmissibility compared to B.1.1.7 (Alpha) that will rapidly lead to B.1.617.2 becoming the prevailing variant in the UK.
4 Jun, 2021 | 10:36h | UTCRelated: Covid: Indian variant ‘now dominant’ in the UK – BBC
United States Unveils Global Vaccine Sharing Scheme for 80 Million Doses by End June
4 Jun, 2021 | 10:32h | UTCSee also: Statement by President Joe Biden on Global Vaccine Distribution – The White House
Target arterial PO2 according to the underlying pathology: a mini-review of the available data in mechanically ventilated patients.
4 Jun, 2021 | 10:26h | UTC
RCT: No benefit from passive leg raising during cardiopulmonary resuscitation in out-of-hospital cardiac arrest.
4 Jun, 2021 | 10:28h | UTC
Commentary on Twitter
Recently released in @Crit_Care our passive leg raising out-of-hospital cardiac arrest randomized controlled trial
Neutral results in survival and no evidence of adverse effects @eneko70 @alfredobardaji @mjimenezherrera https://t.co/dyxCJAB4bG— Youcef Azeli (@YoucefAzeli) May 25, 2021
WHO: Vaccinating kids ‘not a high priority’ amid shortage
4 Jun, 2021 | 10:31h | UTCWHO: Vaccinating kids ‘not a high priority’ amid shortage – Associated Press
Related: WHO: Wealthy nations urged to delay youth Covid vaccines, donate to solidarity scheme AND Editorial: Vaccinating children against SARS-CoV-2 – “Hard to justify right now for most children in most countries”. AND Opinion | American Kids Can Wait – “The U.S. should delay shots for children until global vaccine-manufacturing capacity significantly expands and the crisis in India subsides”. AND Vaccinating children before poor morally wrong, Oxford scientist says – BBC
M-A: In hypoxemic non-hypercapnic patients, early extubation followed by noninvasive ventilation can reduce the total number of days of invasive mechanical ventilation (mean difference, − 2.04 days), without effects in ICU mortality.
4 Jun, 2021 | 10:27h | UTC
ANCA-Associated Vasculitis: An Update.
4 Jun, 2021 | 10:23h | UTCANCA-Associated Vasculitis: An Update – Journal of Clinical Medicine
RCT: Among patients with ANCA-associated vasculitis without severe glomerulonephritis or alveolar hemorrhage treated with Rituximab, a reduced-dose glucocorticoids regimen (prednisolone 0.5 mg/kg/d) was noninferior to a high-dose glucocorticoid regimen (prednisolone 1 mg/kg/d) for the induction of disease remission.
4 Jun, 2021 | 10:25h | UTC
Countries hit hardest by COVID-19 – estimated mortality countries will have on September 1, 2021.
3 Jun, 2021 | 11:09h | UTCCountries Hit Hardest by COVID-19 – Think Global Health
Commentary on Twitter (thread – click for more)
❓🌎🌍🌏 Which countries will have the highest mortality from COVID-19 come September 1, 2021? IHME researchers ran the numbers for a new article in @ThinkGlobalHlth ⤵️🧵https://t.co/d2CFHVzCYX
— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) June 2, 2021
Cohort study showed good recovery for most children 6 months after Pediatric Inflammatory Multisystem Syndrome (PIMS-TS) associated with SARS-CoV-2.
3 Jun, 2021 | 11:06h | UTCCommentary: Most severe effects of MIS-C in children typically resolve within six months, new research suggests – CNN AND Children who developed a rare inflammation disease after COVID-19 are mostly better after 6 months, but some still suffer fatigue and anxiety, a small UK study found – Insider AND Most severe effects of PIMS-TS resolved at six months – HealthDay
Commentary on Twitter
New Research—A study of 46 patients with #PIMSTS found that most symptoms were resolved after 6 months, but fatigue, difficulty exercising, and emotional difficulties persisted in some childrenhttps://t.co/mHz3D8a11d #COVID19 @GreatOrmondSt @KarynMoshal pic.twitter.com/PJCxGGmJNo
— The Lancet Child & Adolescent Health (@LancetChildAdol) May 24, 2021
Diagnosis and management of diabetes insipidus for the internist: an update
4 Jun, 2021 | 10:22h | UTC