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Study: Among kidney transplant recipients who did not respond after 2 doses, a third dose of an mRNA-1273 vaccine induced a serologic response in 49% of patients.
26 Jul, 2021 | 02:54h | UTCCommentary: Case Mounts for COVID Vaccine Boosters in Kidney Transplant Recipients – MedPage Today (free registration required)
Related:
[Preprint] 3rd AstraZeneca shot gives strong immunity.
Commentary on Twitter
JUST PUBLISHED @JAMANetwork
✔️N=159 kidney #transplant recipients
✔️3rd dose of #mRNA #Moderna #vaccine induced a #serologic response in 49% of kidney transplant recipients who did not respond after 2 doseshttps://t.co/NCDyraI98x#RealTimeCOVID19 @IDSAInfo @HIV_TID @AST_info— COVID-19 Real-Time Learning Network (RTLN) (@RealTimeCOVID19) July 24, 2021
Case report: Kawasaki-like multisystem inflammatory syndrome associated with SARS-CoV-2 infection in an adult.
26 Jul, 2021 | 02:52h | UTCRelated:
Case report: Multisystem inflammatory syndrome in an adult after SARS-CoV-2 infection.
Case series of multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection
Case Reports: 2 Adults with Kawasaki-like Multisystem Inflammatory Syndrome Associated with COVID-19
Position paper: Advancing precision medicine for acute respiratory distress syndrome.
26 Jul, 2021 | 02:28h | UTCRelated:
Review: Personalized mechanical ventilation in acute respiratory distress syndrome.
Seminar | Acute respiratory distress syndrome.
ARDS: Contemporary management and novel approaches during COVID-19
COVID vaccines to reach poorest countries in 2023 — “Amid a COVID surge in Africa, vaccine promises from richer nations are not enough to bring an early end to the pandemic, experts say”.
26 Jul, 2021 | 02:51h | UTCCOVID vaccines to reach poorest countries in 2023 — despite recent pledges – Nature
International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes.
26 Jul, 2021 | 02:27h | UTC
Commentary on Twitter
Consensus Statement on Nomenclature and Classification of the Congenital Bicuspid Aortic Valve https://t.co/Uux9d40kkj pic.twitter.com/LA8dfuWv90
— CM Otto (@ottoecho) July 22, 2021
M-A: Low-molecular-weight heparin for prevention of preeclampsia and other placenta-mediated complications.
26 Jul, 2021 | 02:24h | UTC
WHO Guideline on the prevention of drowning through provision of day-care and basic swimming and water safety skills.
26 Jul, 2021 | 02:30h | UTCSee also: World Drowning Prevention Day 2021 (25 July)
News release: Drowning is a leading cause of accidental death – United Nations
Related:
AAP Technical Report | Prevention of Drowning.
Preventing drowning: an implementation guide – World Health Organization
Global report on drowning: preventing a leading killer – World Health Organization
Report: Open Water Drowning and Risks for Children
Commentary on Twitter (thread – click for more)
It's the first-ever World #DrowningPrevention Day
Every year, drowning claims the lives of at least 236,000 people. It's 1 of the 🔝10 causes of death for people aged 1-24 years
We can all take action to end drowning
Anyone can drown, no one should 🏊
👉https://t.co/9viCLzCx6e pic.twitter.com/ozB4P10z36— World Health Organization (WHO) (@WHO) July 25, 2021
Review: Dietary carbohydrates and fats in nonalcoholic fatty liver disease.
26 Jul, 2021 | 02:22h | UTCDietary carbohydrates and fats in nonalcoholic fatty liver disease – Nature Reviews Gastroenterology & Hepatology (free for a limited period)
Commentary on Twitter
A Review published in @NatRevGastroHep discusses the role of dietary fats and carbohydrates in the pathogenesis of nonalcoholic fatty liver disease. https://t.co/QSYLruuXGt pic.twitter.com/3FoQjZoNOO
— Nature Portfolio (@NaturePortfolio) July 22, 2021
Clinical practice guidelines for the medical management of Graves’ orbitopathy.
26 Jul, 2021 | 02:26h | UTC
Editorial | Antibiotic overuse: managing uncertainty and mitigating against overtreatment.
26 Jul, 2021 | 02:16h | UTCAntibiotic overuse: managing uncertainty and mitigating against overtreatment – BMJ Quality & Safety
Commentary on Twitter
Our editorial in @BMJ_Qual_Saf discusses uncertainty and antibiotic overuse, and identifies 4 strategies to address the tendency to prescribe 'just in case'. @EM_Krockow https://t.co/kvIG5uxxOL pic.twitter.com/eTIuqGOj1o
— Prof Carolyn Tarrant (@carolynctarrant) July 21, 2021
Review: Timing and completeness of revascularization in acute coronary syndromes.
26 Jul, 2021 | 02:21h | UTCTiming and completeness of revascularisation in acute coronary syndromes – Heart
Commentary on Twitter
Education: Timing and completeness of revascularisation in acute coronary syndromes https://t.co/VBQ76c3545 pic.twitter.com/tpNaZfhrxI
— Heart_BMJ (@Heart_BMJ) July 22, 2021
Cohort study: Higher intake of ultra-processed food linked to increased risk of inflammatory bowel disease.
26 Jul, 2021 | 02:13h | UTCCommentaries:
Ultra-processed food linked to higher risk of IBD – BMJ
International study links ultra-processed foods with IBD risk – Medical News Today
RCT: Real time remote symptom monitoring during chemotherapy for cancer may reduce symptom burden and improve quality of life.
26 Jul, 2021 | 02:18h | UTCCommentaries:
Remote 24-hour monitoring shows sizable, positive effect on cancer patients – BMJ
Remote Monitoring System Reduces Chemotherapy Symptom Burden – HealthDay
eSMART trial adds support for remote symptom monitoring in people with cancer – medwire News
Related:
Study: Cancer patients benefit from using automated device to manage their symptoms
Study: Web-Based Symptom Monitoring Increases Overall Survival in Lung Cancer
Commentary on Twitter
👇🏼 Results from an RCT, conducted at multiple centres across Europe, showing the benefits of remote patient monitoring and highlighting the vital role it will play in services going forward – congratulations @roma_maguire @Lisa_McCann_ and colleagues https://t.co/8zWrykJEjS
— Katie McMillan (@KathrynMc91) July 22, 2021
WHO: Vaccine inequity undermining global economic recovery.
23 Jul, 2021 | 10:53h | UTCNews release: Vaccine inequity undermining global economic recovery – World Health Organization
Dashboard: Global Dashboard for Vaccine Equity
Commentaries: Urgent need for COVID-19 vaccine equity – University of Oxford AND COVID-19 Vaccine Inequity Undermines Global Economic Recovery – Health Policy Watch
Commentary on Twitter (thread – click for more)
COVID-19 vaccine inequity is undermining 🌍 economic recovery. 🆕WHO, @UNDP and @BlavatnikSchool Dashboard on #VaccinEquity finds that low-income countries would add $38B to their GDP forecast if they had the same vaccination rate as high-income countrieshttps://t.co/BsYF2eYL1G
— World Health Organization (WHO) (@WHO) July 22, 2021
Sodium-glucose cotransporter-2 inhibitors for type 2 diabetes mellitus in adults: An overview of 46 systematic reviews.
26 Jul, 2021 | 02:14h | UTC
M-A of cohort studies: Meat consumption and risk of ischemic heart disease.
26 Jul, 2021 | 02:09h | UTCCommentary: Red and processed meat linked to increased risk of heart disease, Oxford study shows – Oxford University
Opinion | Tocilizumab in COVID-19 therapy: who benefits, and how? – the researchers suggest that maybe IL-6 inhibitors should be given only to patients with high IL-6.
23 Jul, 2021 | 10:51h | UTCTocilizumab in COVID-19 therapy: who benefits, and how? – The Lancet
Related: A living WHO guideline on drugs for covid-19 – interleukin-6 receptor blockers are now recommended for patients with severe or critical covid-19. AND M-A: Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 – “The 4% absolute risk reduction in mortality from 25% to 21% with IL-6 inhibition added to glucocorticoids may not translate to patients with a lower baseline mortality risk and likely do not justify the additional expense and risk for toxicities for patients hospitalized with modest oxygen requirements and a stable clinical course (from editorial)”. AND RECOVERY trial: In hospitalized COVID-19 patients with hypoxia and systemic inflammation (C-reactive protein ≥75 mg/L), tocilizumab improved survival and other clinical outcomes AND Secondary analysis of RCT finds Tocilizumab was beneficial to patients hospitalized with Covid-19 if CRP levels were greater than 15.0 mg/dL, but not if CRP levels were 15.0 mg/dL or less. AND M-A: Tocilizumab in COVID-19 – “For hospitalized COVID-19 patients, there is some evidence that tocilizumab use may be associated with a short-term mortality benefit, but further high-quality data are required”.
Perspective | SARS-CoV-2 human challenge studies — establishing the model during an evolving pandemic.
23 Jul, 2021 | 10:49h | UTCRelated: World’s first coronavirus “Human Challenge” study receives ethics approval in the UK (several texts on the subject) AND Are SARS-CoV-2 Human Challenge Trials Ethical? – “A clinical trial is underway in the UK in which young, healthy participants are exposed deliberately to SARS-CoV-2 to assess the viral inoculum needed to produce an infection and to test vaccine efficacy”.
What are the Delta, Gamma, Beta and Alpha Covid variants?
23 Jul, 2021 | 10:45h | UTCWhat are the Delta, Gamma, Beta and Alpha Covid variants? – BBC
Related: Increased transmissibility and global spread of SARS-CoV-2 variants of concern – “Estimated transmissibility increases of alpha 29% (95% CI: 24–33), beta 25% (95% CI: 20–30), gamma 38% (95% CI: 29–48) & delta 97% (95% CI: 76–117)”. AND WHO renames COVID-19 variants with the Greek alphabet (i.e., Alpha, Beta, Gamma, etc), making them simple, easy to say and remember. The naming system aims to prevent calling COVID-19 variants by the places where they are detected, which is stigmatizing & discriminatory.
Secondary sclerosing cholangitis: an emerging complication in critically ill COVID-19 patients.
23 Jul, 2021 | 10:47h | UTC
New series from The Lancet: Physical Activity 2021.
23 Jul, 2021 | 10:37h | UTCHomepage: Physical Activity 2021 – The Lancet (free registration required for all articles)
Summary and commentary: Experts call for immediate action to ensure physical activity is built into everyday lives – News Medical
Commentary on Twitter (thread – click for more)
🆕 In the early stages of the #pandemic, #PhysicalActivity was considered *essential* for health by many governments—but inactivity remains a major issue.
Ahead of #Tokyo2020, we launch @TheLancet #PhysicalActivity21 Series 🤸♀️👨🦽
Access here: https://t.co/j0GhLGKAAD pic.twitter.com/mrcOnRPyR6
— The Lancet (@TheLancet) July 22, 2021
How the Delta variant achieves its ultrafast spread – “Viral load is roughly 1,000 times higher in people infected with the Delta variant than those infected with the original coronavirus strain, according to a study in China”.
23 Jul, 2021 | 10:46h | UTCHow the Delta variant achieves its ultrafast spread – Nature
The Lambda variant: is it more infectious, and can it escape vaccines? A virologist explains.
23 Jul, 2021 | 10:43h | UTCRelated: Lambda, the Newest WHO Variant of Interest, is Now in 29 Countries – Health Policy Watch
CDC releases new guidelines for the treatment of sexually transmitted infections.
23 Jul, 2021 | 10:41h | UTCTable of Contents: Sexually Transmitted Infections Treatment Guidelines, 2021
Related (just released): WHO Guidelines for the management of symptomatic sexually transmitted infections.
Commentary on Twitter (thread – click for more)
Here's my greatest hits from today’s new @CDCSTD #STI Treatment Guidelines: a 🧵
1)#STI guidelines instead of #STD!
2)Expedited Partner Therapy: not just for “heterosexuals” 👏
3)#HepatitisC: screen all pregnant people
4)Rectal/throat GC/CT: consider for non-MSM like teens 👏 pic.twitter.com/gfEhrWpMKA— Ina Park (@InaParkMD) July 22, 2021
Review: Treatment strategies for new onset atrial fibrillation in patients treated on an intensive care unit.
23 Jul, 2021 | 10:30h | UTC