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Study Commentaries: Non-invasive ventilation for COVID 19 patients. The Recovery RS trial.

22 Aug, 2021 | 23:52h | UTC

Commentary 1: JC: Non-invasive ventilation for COVID 19 patients. The Recovery RS trial – St Emlyn’s

Commentary 2: An adaptive randomized controlled trial of non-invasive respiratory strategies in acute respiratory failure patients with COVID-19 – The Bottom Line

Original study: [Preprint] RCT: non-invasive respiratory strategies in acute respiratory failure in patients with COVID-19 – CPAP reduced the composite outcome of intubation or death within 30 days; high-flow nasal oxygenation was not associated with better outcomes.

 

CoronaVac vaccine in older adults during a gamma variant associated epidemic of covid-19 in Brazil – Effectiveness against symptomatic disease was 46.8%, 55.5% against hospitalization, and 61.2% against deaths.

22 Aug, 2021 | 23:48h | UTC

Effectiveness of the CoronaVac vaccine in older adults during a gamma variant associated epidemic of covid-19 in Brazil: test negative case-control study – The BMJ

Editorial: Real world effectiveness of covid-19 vaccines

Related: CoronaVac vaccine: its results are patchy, but the world can’t ignore its usefulness. (several texts on the subject)

 

[Preprint] SARS-CoV-2 aerosol transmission in schools: theoretical effectiveness of different interventions – “Combined interventions (i.e., natural ventilation, masks, and HEPA filtration) were the most effective (≥ 30-fold decrease)”.

22 Aug, 2021 | 23:50h | UTC

SARS-CoV-2 aerosol transmission in schools: the effectiveness of different interventions – medRxiv

Related: The right way to protect our children and return to in-person learning – CNN

 

Commentaries on Twitter

 

The Lancet Series: Heat and health.

22 Aug, 2021 | 23:04h | UTC

Homepage: Heat and health

Commentary: Study finds ‘very concerning’ 74% increase in deaths associated with extreme heat brought on by the climate crisis – CNN

Editorial: Health in a world of extreme heat

Ollie Jay: managing heat, improving health

Hot weather and heat extremes: health risks

Reducing the health effects of hot weather and heat extremes: from personal cooling strategies to green cities

Observational data from Canada: Effectiveness of mRNA covid-19 vaccines was 91% against symptomatic disease and 98% against hospitalization and deaths.

22 Aug, 2021 | 23:47h | UTC

Effectiveness of BNT162b2 and mRNA-1273 covid-19 vaccines against symptomatic SARS-CoV-2 infection and severe covid-19 outcomes in Ontario, Canada: test negative design study – The BMJ

Editorial: Real world effectiveness of covid-19 vaccines

 

ACOG Guideline: Osteoporosis prevention, screening, and diagnosis.

22 Aug, 2021 | 23:08h | UTC

Osteoporosis Prevention, Screening, and Diagnosis: ACOG Clinical Practice Guideline No. 1 – Obstetrics & Gynecology

 

NICE Guideline: Obstructive sleep apnea/hypopnea syndrome and obesity hypoventilation syndrome in over 16s.

22 Aug, 2021 | 23:10h | UTC

Obstructive sleep apnoea/hypopnoea syndrome and obesity hypoventilation syndrome in over 16s – National Institute for Health and Care Excellence

 

M-A: GLP-1 receptor agonists reduce major adverse cardiovascular events, all-cause mortality, hospital admission for heart failure, and worsening kidney function in patients with type 2 diabetes.

22 Aug, 2021 | 22:50h | UTC

Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Related: Guideline: SGLT-2 inhibitors or GLP-1 receptor agonists for adults with type 2 diabetes – This guidance recommends a risk-based approach, advising against starting SGLT-2 inhibitors or GLP-1 receptor agonists in patients with three or fewer cardiovascular risk factors and without established CVD or CKD.

 

Hot, Cold, and Deadly – Extreme temperature is a threat to global health.

22 Aug, 2021 | 23:01h | UTC

Hot, Cold, and Deadly – Think Global Health

 

Estimating the cause-specific relative risks of non-optimal temperature on daily mortality: a two-part modeling approach applied to the Global Burden of Disease Study.

22 Aug, 2021 | 23:02h | UTC

Estimating the cause-specific relative risks of non-optimal temperature on daily mortality: a two-part modelling approach applied to the Global Burden of Disease Study – The Lancet

Related article: Mortality risk attributable to high and low ambient temperature: a multicountry observational study – The Lancet

 

Commentary on Twitter

 

M-A: The role of SGLT2 inhibitors in heart failure.

22 Aug, 2021 | 22:46h | UTC

The Role of SGLT2 Inhibitors in Heart Failure: A Systematic Review and Meta-Analysis – Cardiology Research and Practice

Related:

ESC Position Paper: Cardiac, renal, and metabolic effects of SGLT2 inhibitors.

Guideline: SGLT-2 inhibitors or GLP-1 receptor agonists for adults with type 2 diabetes – This guidance recommends a risk-based approach, advising against starting SGLT-2 inhibitors or GLP-1 receptor agonists in patients with three or fewer cardiovascular risk factors and without established CVD or CKD.

Summary: SGLT2 inhibitors and GLP-1 receptor agonists established and emerging indications.

M-A: SGLT2 inhibitors decrease cardiovascular death and heart failure hospitalizations in patients with heart failure.

Meta-analysis: Association of SGLT2 inhibitors with cardiovascular and kidney outcomes in patients with Type 2 diabetes

#ESCCongress – [Abstract Only] SGLT2 inhibitors in patients with heart failure with reduced ejection fraction: A meta-analysis of the EMPEROR-Reduced and DAPA-HF trials

[Abstract Only] Randomized Trial: SGLT2 Inhibitor Improves Outcomes in Patients with Heart Failure Even in the Absence of Diabetes

 

Why remote consultation with a doctor is difficult – and how it can be improved.

22 Aug, 2021 | 23:00h | UTC

Why remote consultation with a doctor is difficult – and how it can be improved – The Conversation

Original article: Planning and Evaluating Remote Consultation Services: A New Conceptual Framework Incorporating Complexity and Practical Ethics – Frontiers in Digital Health

 

Commentary on Twitter

https://twitter.com/trishgreenhalgh/status/1428664245357584390

 

Health researchers report funder pressure to suppress results – “Small study hints that interference from bodies funding research into public-health issues such as nutrition and exercise might be more common than realized”.

22 Aug, 2021 | 22:41h | UTC

Health researchers report funder pressure to suppress results – Nature

Original study: “He who pays the piper calls the tune”: Researcher experiences of funder suppression of health behaviour intervention trial findings – PLOS One

 

The assessment of blood pressure in pregnant women: pitfalls and novel approaches.

22 Aug, 2021 | 22:12h | UTC

The assessment of blood pressure in pregnant women: pitfalls and novel approaches – American Journal of Obstetrics & Gynecology

 

Commentary on Twitter

 

Survey: Workplace mistreatment reported frequently by emergency medicine residents.

22 Aug, 2021 | 22:18h | UTC

Workplace Mistreatment Reported Frequently by Emergency Medicine Residents – HealthDay

Original study: Prevalence of Discrimination, Abuse, and Harassment in Emergency Medicine Residency Training in the US – JAMA Network Open

 

Commentary on Twitter

 

Study: Macrolide use significantly associated with both prevalent and incident tinnitus.

22 Aug, 2021 | 22:11h | UTC

Macrolide-associated ototoxicity: a cross-sectional and longitudinal study to assess the association of macrolide use with tinnitus and hearing loss – Journal of Antimicrobial Chemotherapy

Commentary: Macrolide Use and Tinnitus: A New Safety Ringtone? – NEJM Journal Watch (free for a limited period)

 

Viewpoint: Sentinel lymph node biopsy in cutaneous melanoma—where do we stand?

22 Aug, 2021 | 22:16h | UTC

Sentinel Lymph Node Biopsy in Cutaneous Melanoma—Where Do We Stand? – JAMA Dermatology (free for a limited period)

 

[Preprint] Pfizer vaccine effectiveness against Delta declines faster than AstraZeneca, both offering the same protection after 4 months.

20 Aug, 2021 | 10:03h | UTC

Impact of Delta on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK – University of Oxford

Commentaries:

Vaccines Are Less Effective Against Delta—And Pfizer’s Protection Wanes Rapidly—But Are The Best Way To Protect Against Covid, Large Study Finds – Forbes

Expert reaction to preprint looking at the impact of the delta variant on vaccine effectiveness – Science Media Centre

Pfizer vaccine effectiveness declines faster than AstraZeneca – study – Evening Standard

 

Commentary on Twitter

 

Covid-19: How many variants are there, and what do we know about them?

20 Aug, 2021 | 10:00h | UTC

Covid-19: How many variants are there, and what do we know about them? – The BMJ

 

Commentary on Twitter

 

New SARS-CoV-2 variants have changed the pandemic. What will the virus do next?

20 Aug, 2021 | 09:58h | UTC

New SARS-CoV-2 variants have changed the pandemic. What will the virus do next? – Science

 

Commentary on Twitter

 

Treatment escalation vs. immediate initiation of highly effective treatment for patients with relapsing-remitting multiple sclerosis: data from 2 different national strategies.

22 Aug, 2021 | 22:06h | UTC

Treatment Escalation vs Immediate Initiation of Highly Effective Treatment for Patients With Relapsing-Remitting Multiple Sclerosis: Data From 2 Different National Strategies – JAMA Neurology (free for a limited period)

 

Commentary on Twitter

 

The Origins of SARS-CoV-2: A Critical Review.

20 Aug, 2021 | 09:52h | UTC

The Origins of SARS-CoV-2: A Critical Review – Cell

Related:

The animal origin of SARS-CoV-2 – “Trading of animals susceptible to bat coronaviruses is the likely cause of the COVID-19 pandemic”.

Fauci says natural origins theory of coronavirus is still the most likely.

 

A grim warning from Israel: Vaccination blunts, but does not defeat Delta.

20 Aug, 2021 | 09:56h | UTC

A grim warning from Israel: Vaccination blunts, but does not defeat Delta – Science

 

Delta’s rise is fuelled by rampant spread from people who feel fine.

20 Aug, 2021 | 09:54h | UTC

Delta’s rise is fuelled by rampant spread from people who feel fine – Nature

Original study: Transmission dynamics and epidemiological characteristics of Delta variant infections in China – medRxiv

 

Post-Covid-19 Tachycardia Syndrome: A distinct phenotype of Post-acute Covid-19 Syndrome.

20 Aug, 2021 | 09:51h | UTC

Post-Covid-19 Tachycardia Syndrome: A distinct phenotype of Post-acute Covid-19 Syndrome – The American Journal of Medicine

 

Commentary on Twitter

 

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