All Posts

Opinion | The FDA really did have to take this long – “If vaccine approval feels maddeningly scrupulous, that’s because the alternative is worse”.

24 Aug, 2021 | 10:01h | UTC

The FDA Really Did Have to Take This Long – The Atlantic

 

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Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience – “Despite negligible fatality, complications including hospitalization, hypoxemia, and pneumonia were more frequent in children and adolescents with COVID-19 than with influenza”.

24 Aug, 2021 | 09:51h | UTC

Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience – Pediatrics

Related:

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

AAP Guidance: Post-COVID-19 conditions in children and adolescents.

Cohort study: Risk factors for long covid in previously hospitalized children.

Cohort study: Neurological manifestations of SARS-CoV-2 infection in hospitalized children and adolescents in the UK – “around 1 in 20 of children hospitalized with COVID-19 develop brain or nerve complications linked to the viral infection”.

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Deaths from COVID ‘incredibly rare’ among children.

[Preprint] Study confirms children’s extremely low risk of death from Covid-19 – “99·995% of children and young people with a positive SARS-CoV-2 test survived”.

 

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Perspective | How should schools and daycare treat colds in the covid age? It’s complicated. – “Will every sniffle and cough be treated as potential Covid until proven otherwise?”.

24 Aug, 2021 | 09:53h | UTC

How Should Schools And Daycare Treat Colds In The Covid Age? It’s Complicated. – Romper

 

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How I Do It: Considering lung transplantation for patients with COVID-19.

24 Aug, 2021 | 09:55h | UTC

How I Do It: Considering lung transplantation for patients with COVID-19 – CHEST

 

Related:

Early outcomes after lung transplantation for severe COVID-19: a series of the first consecutive cases from four countries

Report: Lung transplantation for 3 patients with severe COVID-19

 

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COVID vaccines protect against Delta, but their effectiveness wanes.

24 Aug, 2021 | 09:57h | UTC

COVID vaccines protect against Delta, but their effectiveness wanes – Nature

Original study: [Preprint] Pfizer vaccine effectiveness against Delta declines faster than AstraZeneca, both offering the same protection after 4 months.

 

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AGA clinical practice update on evaluation and management of early complications after bariatric/metabolic surgery.

24 Aug, 2021 | 09:02h | UTC

AGA Clinical Practice Update on Evaluation and Management of Early Complications After Bariatric/Metabolic Surgery: Expert Review – Clinical Gastroenterology and Hepatology

 

Commentary on Twitter

August's Essential Reading article is a Clinical Practice Update on evaluation and management of early complications after bariatric/metabolic surgery @AmerGastroAssn https://t.co/mm8qSkR95y pic.twitter.com/6vsI3qGv2I

— CGH (@AGA_CGH) July 28, 2021

 

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Editorial | Enhanced recovery after surgery: The road to improve peri-operative care globally.

24 Aug, 2021 | 08:54h | UTC

Enhanced recovery after surgery: The road to improve peri-operative care globally – European Journal of Anaesthesiology

See also: Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines

 

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Guideline for immunizations in patients with inflammatory bowel disease.

24 Aug, 2021 | 09:00h | UTC

Canadian Association of Gastroenterology Clinical Practice Guideline for Immunizations in Patients With Inflammatory Bowel Disease (IBD)—Part 1: Live Vaccines – Gastroenterology

Canadian Association of Gastroenterology Clinical Practice Guideline for Immunizations in Patients With Inflammatory Bowel Disease (IBD)—Part 2: Inactivated Vaccine – Gastroenterology

 

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European guidelines on microscopic colitis.

24 Aug, 2021 | 08:58h | UTC

European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations – UEG Journal

 

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RCT: SGLT2 inhibition reduces the risk of hyperkalemia in patients with diabetes and chronic kidney disease.

24 Aug, 2021 | 08:57h | UTC

Effects of canagliflozin on serum potassium in people with diabetes and chronic kidney disease: the CREDENCE trial – European Heart Journal (link to abstract – $ for full-text)

 

Commentary on Twitter

SGLT2 inhibition reduces the risk of serious hyperkalemia in people with diabetic kidney disease, which may enable greater use of RAAS inhibitors in CKD and/or heart failure

New CREDENCE data presented this week at #ESCCongress, now in @ESC_Journals:https://t.co/OEqnXTdBDi pic.twitter.com/zsanEFZVCy

— Brendon Neuen (@brendonneuen) August 23, 2021

 

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M-A: Patient–ventilator asynchrony, impact on clinical outcomes and effectiveness of interventions.

24 Aug, 2021 | 08:51h | UTC

Patient–ventilator asynchrony, impact on clinical outcomes and effectiveness of interventions: a systematic review and meta-analysis – Journal of Intensive Care

 

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Guide to statistics and methods: estimands, estimators, and estimates.

24 Aug, 2021 | 08:52h | UTC

Estimands, Estimators, and Estimates – JAMA (free for a limited period)

 

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Systematic review: Pain management after complex spine surgery.

24 Aug, 2021 | 08:50h | UTC

Pain management after complex spine surgery – European Journal of Anaesthesiology

 

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Study commentary: How risky for developing psychosis are ‘At Risk Mental States’ in youths?

24 Aug, 2021 | 08:45h | UTC

How risky for developing psychosis are ‘At Risk Mental States’ in youths? – The Mental Elf

Original study: Systematic Review and Meta-analysis: Psychosis Risk in Children and Adolescents With an At-Risk Mental State – Journal of the American Academy of Child & Adolescent Psychiatry (link to abstract – $ for full-text)

 

Commentary on Twitter

Wouldn't it be great if we could identify teens at risk for psychosis & then prevent it?

Trouble is we can't- lit review shows that most "at risk" teens aren't really at risk/predictive tools don't predict accurately.

And the "At Risk" label can burden teens with stigma & meds. https://t.co/1SiBH5tQRz

— Allen Frances (@AllenFrancesMD) August 23, 2021

 

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Review: Managing diabetic ketoacidosis in children.

24 Aug, 2021 | 08:46h | UTC

Managing Diabetic Ketoacidosis in Children – Annals of Emergency Medicine

 

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Review: A pragmatic approach to weaning temporary mechanical circulatory support.

24 Aug, 2021 | 08:47h | UTC

A Pragmatic Approach to Weaning Temporary Mechanical Circulatory Support: A State-of-the-Art Review – JACC: Heart Failure

 

Commentary on Twitter

⚠️ A Pragmatic Approach to Weaning Temporary Mechanical Circulatory Support

📌 A State-of-the-Art Review ‼️ in @JACCJournals @secardiologia @AgudosSEC @SACardiologia @JuanFDelgado1 @Dr_Manito @MartaCoboMarcos @MartaFarrero https://t.co/R2vqHwBcfi pic.twitter.com/AraH7AUMu5

— Javier Torres (@JTLLERGO) August 11, 2021

 

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Adult ADHD is linked to numerous physical conditions.

24 Aug, 2021 | 08:41h | UTC

Adult ADHD is linked to numerous physical conditions – Karolinska Institutet

Original study: Mapping phenotypic and aetiological associations between ADHD and physical conditions in adulthood in Sweden: a genetically informed register study – The Lancet Psychiatry

 

Commentaries on Twitter

Our new study in the Swedish population shows that ADHD leads to small by significant increases in the risk for many somatic disorders: https://t.co/SYTCntG9FD https://t.co/tLQ9qSxWWF

— Stephen Faraone (he/him/his) (@StephenFaraone) July 7, 2021

Important paper in @TheLancetPsych led by @EbbaDuRietz and @LarssonPsychEpi. We found that #ADHD in adults was associated with 34 out of 35 medical conditionshttps://t.co/K8xbokzZYx pic.twitter.com/Spw0ww98X0

— Samuele Cortese (@CorteseSamuele) July 6, 2021

 

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Cluster RCT: Effects of a large-scale social media advertising campaign on holiday travel and COVID-19 infections.

23 Aug, 2021 | 00:01h | UTC

Effects of a large-scale social media advertising campaign on holiday travel and COVID-19 infections: a cluster randomized controlled trial – Nature Medicine

 

Commentary on Twitter

Even though we are tired, we should continue trying to educate the public through social media – “Social media messages recorded by health professionals before the winter holidays in the US led to a significant reduction in holiday travel and subsequent COVID-19 infections” https://t.co/kyeKTe4sJn

— gilberto lopes (@GlopesMd) August 22, 2021

 

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M-A of randomized trials: Effectiveness of psychological interventions in prison to reduce recidivism.

24 Aug, 2021 | 08:42h | UTC

Effectiveness of psychological interventions in prison to reduce recidivism: a systematic review and meta-analysis of randomised controlled trials – The Lancet Psychiatry

 

Commentary on Twitter

“Interventions that ensure continuity of care in community settings should be prioritised for future research.” https://t.co/FDIz1pbx7y

— ROBERTO COLOM (@ROBERTO_COLOM) August 20, 2021

 

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Among patients receiving mRNA vaccines, clinically significant symptoms were more frequent following dose 2, following dose 1 in patients with previous SARS-CoV-2 infection, and in those who received the Moderna vaccine.

22 Aug, 2021 | 23:54h | UTC

Association of Vaccine Type and Prior SARS-CoV-2 Infection With Symptoms and Antibody Measurements Following Vaccination Among Health Care Workers – JAMA Internal Medicine

 

Commentary on Twitter

New @JAMA_current paper says @moderna_Tx caused 2.3x the number of "significant" symptoms compared to @pfizer in a sample of 950 people.

Moderna also produced more antibodies. Raising the question of what a third dose, which produces still MORE, will do.https://t.co/drvhhsnpHo

— Alex Berenson (@AlexBerenson) August 16, 2021

 

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RCT: A single-session of pain management skills intervention was noninferior to 8 sessions of cognitive behavioral therapy in adults with chronic low back pain.

24 Aug, 2021 | 08:39h | UTC

Comparison of a Single-Session Pain Management Skills Intervention With a Single-Session Health Education Intervention and 8 Sessions of Cognitive Behavioral Therapy in Adults With Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Network Open

Commentaries:

Single two-hour session of pain management skills could offer as much benefit as longer-course of CBT – News Medical

New approach effectively relieves chronic low back pain – Stanford Medicine

 

Commentary on Twitter

NEW STUDY: Our Empowered Relief trial just published!

A *single-session* pain relief skills class was non-inferior to 8-session CBT for pain & symptom reduction at 3 months post-treatmenthttps://t.co/HYmWNkxUoR via @JAMANetworkOpen part of @JAMANetwork

funded by @NIH_NCCIH

— Beth Darnall, PhD (@BethDarnall) August 16, 2021

 

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[Preprint] Study shows symptomatic breakthrough infections are probably less transmissible than SARS-CoV-2 infections in unvaccinated individuals.

22 Aug, 2021 | 23:59h | UTC

Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine-breakthrough infections: a multi-center cohort study – medRxiv

 

Commentary on Twitter (thread – click for more)

Did you hear vaccinated people with Delta “have just as much virus in their nose so are just as infectious as unvaccinated”?

Turns out vaccinated people have significantly less culturable virus present at the same Ct count

They are LESS INFECTIOUS 💥 https://t.co/OX0Ul0ntWc pic.twitter.com/3vDQSJ6j84

— Alasdair Munro (@apsmunro) August 22, 2021

 

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RCT: Awake prone positioning reduces the need for intubation in patients with COVID-19.

23 Aug, 2021 | 00:03h | UTC

Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial – The Lancet Respiratory Medicine

Invited commentary: Awake prone positioning in COVID-19: is tummy time ready for prime time?

Related:

RCT: Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19 – no difference in intubation rates compared to standard care.

M-A: Prone positioning of nonintubated patients with Covid-19 improve oxygenation variables without any reported serious adverse events – randomized trials with patient-relevant outcomes such as the need for intubation or mortality rates are required

 

Commentary on Twitter

Awake prone positioning of pts w/ hypoxaemic respiratory failure due to #COVID19 reduces incidence of treatment failure & need for intubation w/o any signal of harm

Meta-trial from the Awake Prone Positioning Meta-Trial Group https://t.co/GuDdjPnVps pic.twitter.com/ZS08uQN1gE

— The Lancet Respiratory Medicine (@LancetRespirMed) August 21, 2021

 

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Evidence mounts that people with breakthrough infections can spread Delta easily.

22 Aug, 2021 | 23:57h | UTC

Evidence mounts that people with breakthrough infections can spread Delta easily – National Geographic

Original study: Shedding of Infectious SARS-CoV-2 Despite Vaccination when the Delta Variant is Prevalent – Wisconsin, July 2021 – medRxiv

 

Commentary on Twitter

The evidence that supports Delta breakthrough infections ability to spread (and why fully vaccinated people need to 😷 up)https://t.co/27NOf6mYCM @NatGeo by @Ecquis w/ studies and input by @GuptaR_lab and @KasenRiemersma

— Eric Topol (@EricTopol) August 20, 2021

 

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Lab study shows a heterologous AstraZeneca + Pfizer immunization strategy provides stronger immunogenicity against Covid compared to homologous AZ + AZ or Pfizer + Pfizer strategies.

22 Aug, 2021 | 23:51h | UTC

Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study – The Lancet Respiratory Medicine

Invited Commentary: Heterologous ChAdOx1-nCoV19–BNT162b2 vaccination provides superior immunogenicity against COVID-19

Related:

Lab study shows heterologous AstraZeneca/Pfizer vaccination produces strong immune response against SARS-CoV-2 Delta variant.

RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.

Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination (several articles on the subject)

 

Commentary on Twitter

NEW Research—Heterologous ChAdOx1 nCov-19–BNT162b2 immunisation w/ 10–12-week interval is well tolerated & improves immunogenicity vs homologous ChAdOx1 nCov-19 vax w/ 10–12-week interval & BNT162b2 vax w/ 3-week interval

Study from Prof Sander & co https://t.co/VAB54NokSi pic.twitter.com/wfeBsvoKhO

— The Lancet Respiratory Medicine (@LancetRespirMed) August 13, 2021

 

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