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WHO says it is monitoring a new Covid variant called ‘mu’.

3 Sep, 2021 | 10:21h | UTC

WHO says it is monitoring a new Covid variant called ‘mu’ – CNBC

See also:

What’s the Mu variant? And will we keep seeing more concerning variants? – The Conversation

WHO monitoring new coronavirus variant named ‘Mu’ – France 24

New ‘mu’ coronavirus variant could escape vaccine-induced immunity, WHO says – LiveScience

WHO monitoring new coronavirus variant named Mu – The Guardian

 

[Preprint] Largest study of masks yet details their importance in fighting Covid-19.

3 Sep, 2021 | 10:30h | UTC

Largest study of masks yet details their importance in fighting Covid-19 – NBC News

Original study: The Impact of Community Masking on COVID-19: A Cluster-Randomized Trial in Bangladesh – Innovations for Poverty Action

See also: A Study In Bangladesh Tripled The Rate Of Mask-Wearing. Can It Help In The U.S.? – NPR

 

Commentaries on Twitter (thread – click for more)

(thread from the author – click for more)

 

EU agency says to focus on vaccines first not booster shots.

3 Sep, 2021 | 10:34h | UTC

EU agency says to focus on vaccines first not booster shots – Associated Press

See also: European officials say COVID-19 booster isn’t urgent – CIDRAP

 

Opinion | “The downsides of masking young students are real”.

3 Sep, 2021 | 10:24h | UTC

The Downsides of Masking Young Students Are Real – The Atlantic

 

Commentary with a rebuttal on Twitter (thread – click for more)

 

Review: Cardiovascular care of older adults.

3 Sep, 2021 | 10:13h | UTC

Cardiovascular care of older adults – The BMJ

 

AAP Guideline: Long-term follow-up care for childhood, adolescent, and young adult cancer survivors.

3 Sep, 2021 | 10:17h | UTC

Long-term Follow-up Care for Childhood, Adolescent, and Young Adult Cancer Survivors – Pediatrics

News release: American Academy of Pediatrics Offers Guidance for Caring and Treatment of Long-Term Cancer Survivors – American Academy of Pediatrics

 

Musculoskeletal complications following critical illness: A scoping review.

3 Sep, 2021 | 10:07h | UTC

Musculoskeletal complications following critical illness: A scoping review – Journal of Critical Care

 

Commentary on Twitter

 

Reimagining construction and renovation of health care facilities during emergence from a pandemic.

3 Sep, 2021 | 10:19h | UTC

Reimagining Construction and Renovation of Health Care Facilities During Emergence from a Pandemic – Infectious Disease Clinics of North America

 

RCT: In patients with Immune Thrombocytopenia, the addition of Mycophenolate Mofetil to a standard glucocorticoid regimen reduced refractory or relapsed disease but was associated with decreased quality of life outcomes regarding physical function and fatigue.

3 Sep, 2021 | 10:15h | UTC

Mycophenolate Mofetil for First-Line Treatment of Immune Thrombocytopenia – New England Journal of Medicine

 

Role of diagnostic imaging in psoriatic arthritis: how, when, and why.

3 Sep, 2021 | 10:05h | UTC

Role of diagnostic imaging in psoriatic arthritis: how, when, and why – Insights into Imaging

 

Position Paper: Diagnosis and management of heart failure in elderly patients from hospital admission to discharge.

3 Sep, 2021 | 10:11h | UTC

Diagnosis and Management of Heart Failure in Elderly Patients from Hospital Admission to Discharge: Position Paper – Journal of Clinical Medicine

 

Study casts doubt on WHO guidance on antibiotics for neonatal sepsis.

3 Sep, 2021 | 09:57h | UTC

Study casts doubt on WHO guidance on antibiotics for neonatal sepsis – CIDRAP

Original study: Effects of antibiotic resistance, drug target attainment, bacterial pathogenicity and virulence, and antibiotic access and affordability on outcomes in neonatal sepsis: an international microbiology and drug evaluation prospective substudy (BARNARDS) – The Lancet Infectious Diseases

Invited commentary: Antibiotics for neonatal sepsis in low-income and middle-income countries—where to go from here? (free registration required)

 

Commentary on Twitter

 

The Role of Lung Ultrasound in the Management of the Critically Ill Neonate—A Narrative Review and Practical Guide.

3 Sep, 2021 | 10:00h | UTC

The Role of Lung Ultrasound in the Management of the Critically Ill Neonate—A Narrative Review and Practical Guide – Children

 

Drowning in the literature? These smart software tools can help.

3 Sep, 2021 | 10:09h | UTC

Drowning in the literature? These smart software tools can help – Nature

 

RCT: Baricitinib reduced mortality in hospitalized adults with COVID-19.

2 Sep, 2021 | 10:17h | UTC

Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial – The Lancet Respiratory Medicine

Commentaries:

Baricitinib: the first immunomodulatory treatment to reduce COVID-19 mortality in a placebo-controlled trial – The Lancet Respiratory Medicine

Rheumatoid Arthritis Drug Combined with Standard of Care May Help Reduce Mortality for Hospitalized COVID-19 Patients – Vanderbilt University Medical Center

 

Commentaries on Twitter

(thread – click for more)

 

Pro-Con Debate: 1- vs 2-Hour Fast for Clear Liquids Before Anesthesia in Children.

3 Sep, 2021 | 09:55h | UTC

Pro-Con Debate: 1- vs 2-Hour Fast for Clear Liquids Before Anesthesia in Children – Anesthesia & Analgesia

Related: ESPEN practical guideline: Clinical nutrition in surgery – “Preoperative fasting from midnight is unnecessary in most patients. Patients undergoing surgery, who are considered to have no specific risk of aspiration, shall drink clear fluids until 2 h before anesthesia. Solids shall be allowed until 6 h before anesthesia.”

 

Review | COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses.

2 Sep, 2021 | 10:06h | UTC

COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses – The Lancet Rheumatology

 

Commentary on Twitter

 

Long COVID: the physical and mental health of children and non-hospitalized young people after SARS-CoV-2 infection – one in seven children may still have symptoms 15 weeks after infection.

2 Sep, 2021 | 10:10h | UTC

Long COVID – the physical and mental health of children and non-hospitalised young people 3 months after SARS-CoV-2 infection; a national matched cohort study (The CLoCk) Study.

Commentaries:

Long Covid in children ‘nowhere near scale feared’ – BBC

Long covid: One in seven children may still have symptoms 15 weeks after infection, data show – The BMJ

Related:

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Cohort study: Risk factors for long covid in previously hospitalized children.

M-A: More than 50 long-term effects of COVID-19.

 

Commentary on Twitter (thread – click for more)

 

Another study shows Pfizer mRNA vaccine immunity is reduced over time.

2 Sep, 2021 | 10:05h | UTC

Waning of BNT162b2 vaccine protection against SARS-CoV-2 infection in Qatar – medRxiv

Related:

[Press release – not published yet] Study shows vaccine protection wanes over time, but vaccines still offer good protection against severe disease.

Studies: COVID vaccine protection waning against infection but not hospitalization.

Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.

 

Commentary on Twitter (thread – click for more)

 

Scientific Statement: Coronavirus Disease-2019 and Heart Failure.

2 Sep, 2021 | 10:08h | UTC

Coronavirus Disease-2019 and Heart Failure: A Scientific Statement From the Heart Failure Society of America – Journal of Cardiac Failure

 

Commentary on Twitter

 

Recommendations for ventilation of indoor spaces to reduce COVID-19 transmission.

2 Sep, 2021 | 10:02h | UTC

Recommendations for ventilation of indoor spaces to reduce COVID-19 transmission – Journal of the Formosan Medical Association

Related:

We studied how to reduce airborne COVID spread in hospitals. Here’s what we learnt.

Report: Improved ventilation essential to safe use of buildings and public spaces, say leading engineers.

WHO: Roadmap to improve and ensure good indoor ventilation in the context of COVID-19

CDC releases new ventilation guidelines for indoor environments to reduce Covid-19 risk

Guidance: Using Ventilation and filtration to reduce aerosol transmission of COVID-19 in long-term care homes

 

RCT: Among critically ill patients, targeting oxygenation to a low-normal range vs. high-normal range did not result in a reduction in organ dysfunction.

2 Sep, 2021 | 08:23h | UTC

Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial – JAMA (free for a limited period)

Related:

M-A of randomized trials: Conservative oxygen therapy for critically ill patients.

Oxygen administration for patients with ARDS – Journal of Intensive Care

Randomized trial: Similar outcomes with lower vs. higher oxygenation targets for acute hypoxemic respiratory failure

Systematic Review: Higher vs. Lower Fraction of Inspired Oxygen or Targets of Arterial Oxygenation for Adults Admitted to the Intensive Care Unit

 

Commentary on Twitter

 

EBM Learning | How to create PICO questions about diagnostic test. In this paper, the author presents an example of a PICO for a question about test accuracy and an example of a PICO for a question about the effects of care with a test.

2 Sep, 2021 | 08:18h | UTC

How to create PICO questions about diagnostic test – BMJ Evidence-Based Medicine

 

RCT: In patients with acute hypoxemic respiratory failure, a strategy of lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal was not associated with improved outcomes.

2 Sep, 2021 | 08:21h | UTC

Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial – JAMA (free for a limited period)

Related: Randomized Trial: Low vs Intermediate Tidal Volume Strategy in ICU Patients Without ARDS

 

Commentary on Twitter

 

Treatment of urinary tract infections in infants <2 Months: A Living Systematic Review - short and long duration of parenteral antibiotics were associated with a similar risk of UTI recurrence.

2 Sep, 2021 | 08:19h | UTC

Treatment of UTIs in Infants <2 Months: A Living Systematic Review – Hospital Pediatrics

 

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