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"As SARS-CoV-2 remains predominantly a mild infection in the paediatric population, the incidence of long covid is a critical factor in the risk-benefit equation for policy and parental decisions on covid-19 vaccines for children," says Editorialhttps://t.co/POidCyS2RZ

— The BMJ (@bmj_latest) January 20, 2022

Perioperative guidelines on antiplatelet and anticoagulant agents: 2022 Update.

21 Jan, 2022 | 09:53h | UTC

Perioperative Guidelines on Antiplatelet and Anticoagulant Agents: 2022 Update – Current Anesthesiology Reports

RCT: Metal pins no better than traditional plaster cast for a broken wrist.

21 Jan, 2022 | 09:51h | UTC

News Release: Metal pins no better than traditional plaster cast for a broken wrist – BMJ

Original Study: Surgical fixation with K-wires versus casting in adults with fracture of distal radius: DRAFFT2 multicentre randomised clinical trial – The BMJ

Commentary: Wrist fractures: study compares casting to surgical fixation – MedicalResearch.com

Commentary on Twitter

Fascinating to read the results of #DRAFFT2 in the BMJ. Lots to think about: No difference in wrist function at 12 months but higher reoperation rate for loss of position in cast-only group (13% v 0.4%) #orthotwitter https://t.co/QJO43XBdB6 pic.twitter.com/IMCpcsoiSh

— Tom Lewis (@thomasllewis) January 20, 2022

ATS Guideline: Outpatient respiratory management of infants, children, and adolescents with post-prematurity respiratory disease.

21 Jan, 2022 | 09:55h | UTC

Outpatient Respiratory Management of Infants, Children, and Adolescents with Post-Prematurity Respiratory Disease: An Official American Thoracic Society Clinical Practice Guideline – American Journal of Respiratory and Critical Care Medicine

News Release: Outpatient Management of Patients with Post-Prematurity Respiratory Disease: American Thoracic Society Publishes New Clinical Practice Guideline

RCT: Lenvatinib plus pembrolizumab improve outcomes compared to chemotherapy in patients with advanced endometrial cancer.

21 Jan, 2022 | 09:46h | UTC

Lenvatinib plus Pembrolizumab for Advanced Endometrial Cancer – New England Journal of Medicine

Commentary on Twitter

In women with advanced endometrial cancer, the median progression-free survival was 7.2 months with lenvatinib plus pembrolizumab and 3.8 months with chemotherapy; the median overall survival was 18.3 months and 11.4 months, respectively. https://t.co/lzqFDnhAQn pic.twitter.com/Tm2BJZuh1D

— NEJM (@NEJM) January 19, 2022

Review: Diagnostic evaluation of gastric motor and sensory disorders.

21 Jan, 2022 | 09:42h | UTC

Diagnostic Evaluation of Gastric Motor and Sensory Disorders – American Journal of Gastroenterology

Cohort Study: Among patients with resolved Hepatitis B infections and concomitant autoimmune disease, exposure to prednisone doses greater than 20 mg/day were associated with a high risk for HBV reactivation or hepatitis flare.

21 Jan, 2022 | 09:39h | UTC

Average corticosteroid dose and risk for HBV reactivation and hepatitis flare in patients with resolved hepatitis B infection – Annals of Rheumatic Disease (link to abstract – $ for full-text)

Commentary on Twitter

Patients with time-weighted average prednisone dose greater than 20 mg/day would be classified as the high risk for HBV reactivation or hepatitis flare. Prophylactic Anti-HBV therapy may be needed for these high-risk patientshttps://t.co/qLuirdyXDK pic.twitter.com/yDJ4c072qm

— Annals of the Rheumatic Diseases (@eular_ARD) December 23, 2021

Systematic Review: In people with Alzheimer’s disease and vascular dementia with agitation and psychosis, atypical antipsychotics probably reduce agitation slightly (moderate‐certainty evidence) but probably have a negligible effect on psychosis or risk of any adverse event.

21 Jan, 2022 | 09:50h | UTC

Antipsychotics for agitation and psychosis in people with Alzheimer’s disease and vascular dementia – Cochrane Library

Summary: Do antipsychotic medicines reduce agitated behaviour and psychotic symptoms in people with Alzheimer’s disease and vascular dementia? – Cochrane Library

Sleeping on the LEFT side seems to be associated with reduced nocturnal acid exposure compared with supine and right lateral decubitus positions.

21 Jan, 2022 | 09:45h | UTC

Associations Between Sleep Position and Nocturnal Gastroesophageal Reflux: A Study Using Concurrent Monitoring of Sleep Position and Esophageal pH and Impedance – American Journal of Gastroenterology (link to abstract – $ for full-text)

Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.

21 Jan, 2022 | 09:36h | UTC

Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline – Journal of Clinical Oncology

15th Report on Carcinogens now includes 256 listings of substances that are known or reasonably anticipated to cause cancer in humans.

21 Jan, 2022 | 09:34h | UTC

15th Report on Carcinogens – National Toxicology Program

Commentary on Twitter

8 substances have been added to the 15th report on Carcinogens, bringing the total list to 256 substances that are known, or reasonably anticipated, to cause cancer in humanshttps://t.co/r1e9Bv8hIU pic.twitter.com/BVGt809g2T

— K Pavithran (@drkpavithran) December 23, 2021

Is precision public health the future — or a contradiction?

21 Jan, 2022 | 09:31h | UTC

Is precision public health the future — or a contradiction? – Nature

M-A: No difference in outcomes with Beta-lactam monotherapy vs. combination therapy for bloodstream infections or pneumonia due to P. aeruginosa.

21 Jan, 2022 | 09:37h | UTC

Beta-lactam monotherapy or combination therapy for bloodstream infections or pneumonia due to P. aeruginosa: a meta-analysis – International Journal of Antimicrobial Agents (link to abstract – $ for full-text)

The validity of progression-free survival 2 as a surrogate trial end point for overall survival.

21 Jan, 2022 | 09:31h | UTC

The validity of progression-free survival 2 as a surrogate trial end point for overall survival – Cancer (link to abstract – $ for full-text)

M-A: In patients with acute coronary syndrome, a guided approach (i.e., platelet function or genetic testing) to P2Y12 inhibiting therapy may reduce major adverse cardiovascular events without increased risk of bleeding.

21 Jan, 2022 | 09:33h | UTC

Comparative effects of guided vs. potent P2Y₁₂ inhibitor therapy in acute coronary syndrome: a network meta-analysis of 61 898 patients from 15 randomized trials – European Heart Journal (link to abstract – $ for full-text)

Commentary: Another Win for Guided P2Y12 Therapy in ACS: Meta-analysis – TCTMD

Commentary on Twitter

Comparative effects of guided vs. potent P2Y12 inhibitor therapy in acute coronary syndrome: a network meta-analysis of 61 898 patients from 15 randomized trials: read more in EHJ!https://t.co/oAehSfPVdt #cardiotwitter @ESC_Journals @escardio pic.twitter.com/AEuH7V6IkR

— EHJ Editor-in-Chief (@ehj_ed) December 23, 2021

RCT: In patients with previously untreated Diffuse Large B-Cell Lymphoma, a modified regimen of R-CHOP (pola-R-CHP), in which vincristine was replaced with polatuzumab, was associated with improved outcomes compared to standard R-CHOP treatment.

21 Jan, 2022 | 09:28h | UTC

Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma – New England Journal of Medicine (link to abstract – $ for full-text)

M-A: In comatose survivors of cardiac arrest, targeted hypothermia is not associated with improved survival or better neurological outcomes vs. targeted normothermia.

21 Jan, 2022 | 09:29h | UTC

Targeted Hypothermia Versus Targeted Normothermia In Survivors of Cardiac Arrest: A Systematic Review and Meta-Analysis of Randomized Trials – American Journal of Medicine

RCT: In comatose survivors of out-of-hospital cardiac arrest, there was no difference in mortality and neurologic outcomes with mild (target temperature of 34 °C) vs. moderate therapeutic hypothermia (target temperature of 31 °C).

M-A: Targeted temperature management following out-of-hospital cardiac arrest – “Routine use of moderate or deep hypothermia in comatose survivors of OHCA may potentially be associated with more harm than benefit”.

RCT: In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not improve outcomes.

Systematic Review: Comparison of clinical manifestations in rheumatoid arthritis vs. spondyloarthritis.

21 Jan, 2022 | 09:24h | UTC

Comparison of Clinical Manifestations in Rheumatoid Arthritis vs. Spondyloarthritis: A Systematic Literature Review – Rheumatology and Therapy

Consensus statements for the assessment and management of non-radiographic axial spondyloarthritis.

21 Jan, 2022 | 09:26h | UTC

Australian Consensus Statements for the Assessment and Management of Non-radiographic Axial Spondyloarthritis – Rheumatology and Therapy

Cluster Randomized Trial: A multifactorial falls prevention program in UK care homes reduced fall rates among older people and was cost effective.

21 Jan, 2022 | 09:21h | UTC

Multifactorial falls prevention programme compared with usual care in UK care homes for older people: multicentre cluster randomised controlled trial with economic evaluation – The BMJ

News Release: Falls in care homes can be significantly reduced with intervention, says new study – University of Nottingham

Commentary on Twitter

NEW RESEARCH: A falls prevention programme for older people in care homes, co-designed with care home staff & residents, that involved awareness raising, education, screening, decision & implementation support was associated with a reduction in falls rate https://t.co/wupI0LeAxj

— The BMJ (@bmj_latest) December 11, 2021