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Patients are generally safe to drive *4 weeks* after hip arthroscopy and *6 weeks* after knee arthroscopy. Meta-Analysis from Palma et al in ASMAR this month gives us the evidence!

Is it time to revise your instructions for your patients? 🤔https://t.co/Bcg12tX0MM pic.twitter.com/wAhJx2vS8a

— Arthroscopy Journal (@ArthroscopyJ) October 20, 2021

RCT: Apatinib improves outcomes compared to placebo in patients with locally advanced or metastatic, radioactive iodine–refractory differentiated thyroid cancer.

10 Feb, 2022 | 09:56h | UTC

Apatinib vs Placebo in Patients With Locally Advanced or Metastatic, Radioactive Iodine–Refractory Differentiated Thyroid Cancer: The REALITY Randomized Clinical Trial – JAMA Oncology

Commentary on Twitter

Apatinib offered significant clinical benefits in terms of both prolonged progression-free survival and overall survival in patients with progressive locally advanced or metastatic radioactive iodine-refractory differentiated thyroid cancer. https://t.co/I14AyxKZNS

— JAMA Oncology (@JAMAOnc) December 16, 2021

RCT: Home phototherapy of term neonates improves parental bonding and stress.

10 Feb, 2022 | 08:25h | UTC

Home phototherapy of term neonates improves parental bonding and stress: Findings from a randomised controlled trial – Acta Paediatrica

Commentary on Twitter

Does treating Jaundice in babies at home, as compared to at hospital, improves parental bonding and reduces parental stress?

A new RCT published @ActaPaediatrica by Swedish researchers #EBNEOAlerts #neoEBM #FOAMNeo https://t.co/InjkdrC5JY pic.twitter.com/BaGs86Hf8t

— Evidence-Based Neo (@EBNEO) January 3, 2022

M-A: Pain management in acute pancreatitis.

10 Feb, 2022 | 08:29h | UTC

Pain Management in Acute Pancreatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials – Frontiers in Medicine

Opinion: Development of clinical practice guidelines ‘is a mess’.

9 Feb, 2022 | 10:16h | UTC

Development of clinical practice guidelines ‘is a mess’ – STAT

Recommendations for management of childhood psoriasis.

10 Feb, 2022 | 08:26h | UTC

Recommendations for management of childhood psoriasis – Indian Dermatology Online Journal

IDSA Updated Covid-19 Guideline now supports the use of convalescent plasma in ambulatory patients with mild to moderate COVID-19 at high risk for progression to severe disease.

9 Feb, 2022 | 10:15h | UTC

IDSA Guidelines on the Treatment and Management of Patients with COVID-19 – Infectious Diseases Society of America

Commentary on Twitter

Update Alert: Revised recommendation on the use of #convalescentplasma in ambulatory patients w/ COVID-19 at high risk of progression to severe disease w/ no other treatment options.

📄: https://t.co/YRCxtdilXT #COVID19Guidelines @JGPharmD @adarsh_bhimraj @RMKGandhi @ShohamTxID pic.twitter.com/KpXnywH362

— IDSA (@IDSAInfo) February 8, 2022

European guidelines for the treatment of infections caused by Multidrug-resistant Gram-negative bacilli.

9 Feb, 2022 | 10:18h | UTC

European Society of clinical microbiology and infectious diseases (ESCMID) guidelines for the treatment of infections caused by Multidrug-resistant Gram-negative bacilli (endorsed by ESICM –European Society of intensive care Medicine) – Clinical Microbiology and Infection

WHO: Two years into COVID pandemic, most countries still face significant health service disruptions.

9 Feb, 2022 | 10:13h | UTC

Two Years into COVID Pandemic, Most Countries Still Face Significant Health Service Disruptions – Health Policy Watch

Original Report: Third round of the global pulse survey on continuity of essential health services during the COVID-19 pandemic – World Health Organization

Cohort Study: Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England.

9 Feb, 2022 | 10:12h | UTC

Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study – The Lancet Child & Adolescent Health

Editorial: Assessing the impact of the pandemic in children and adolescents: SARS-CoV-2 infection and beyond – The Lancet Child & Adolescent Health

Commentary: Long COVID and kids: more research is urgently needed – Nature

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

E ditorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

M-A: Persistent symptoms following SARS-CoV-2 infection among children and young people – “Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Commentary on Twitter (thread – click for more)

NEW RESEARCH: free! Two studies on adolescent #LongCovid. Both found high symptom burden in COVID positive and negative participants; very heterogenous symptom profile. Pandemic has had profound impact on all adolescents. https://t.co/YzU3ogXZrw pic.twitter.com/ina0DgPxBf

— The Lancet Child & Adolescent Health (@LancetChildAdol) February 8, 2022

Though rare, Moderna Covid vaccine recipients have higher risk of heart inflammation than Pfizer.

9 Feb, 2022 | 10:06h | UTC

Though rare, Moderna Covid vaccine recipients have higher risk of heart inflammation than Pfizer – CNBC

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

[Preprint] Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy.

9 Feb, 2022 | 10:08h | UTC

Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy: a multi-database, self-controlled case series study -medRxiv

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

Commentary on Twitter

The incidence of mRNA vaccine myocarditis or pericarditis in Italy in ~3 million vaccinees age 12-39. Excess cases per 100,000; orange is 2nd dose, blue 1st dose. https://t.co/xvdV4qSdHw
Pfizer:~1/100,000 age 12-39, all 2nd dose
Moderna,: >5/100,000, age 12-39, and some 1st dose pic.twitter.com/Y1jfGrU53v

— Eric Topol (@EricTopol) February 9, 2022