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RCT: Time to functional recovery after laser tonsillotomy performed under local anesthesia vs. conventional tonsillectomy with general anesthesia among adults.

22 Feb, 2022 | 08:22h | UTC

Time to Functional Recovery After Laser Tonsillotomy Performed Under Local Anesthesia vs Conventional Tonsillectomy With General Anesthesia Among Adults: A Randomized Clinical Trial – JAMA Network Open

Commentary on Twitter

RCT found laser tonsillotomy under local anesthesia had faster functional recovery but lower resolution of the chief complaint leading to surgery vs conventional tonsillectomy under general anesthesia; it may offer a feasible alternative. https://t.co/yfaWeFJeEl pic.twitter.com/DDYxlEhZEp

— JAMA Network Open (@JAMANetworkOpen) February 21, 2022

Monoclonal antibodies against rabies: current uses in prophylaxis and in therapy.

22 Feb, 2022 | 08:15h | UTC

Monoclonal antibodies against rabies: current uses in prophylaxis and in therapy – Current Opinion in Virology

Expert Analysis | Asymptomatic ventricular preexcitation (Wolff-Parkinson-White Pattern): when to be concerned.

22 Feb, 2022 | 08:18h | UTC

Asymptomatic Ventricular Preexcitation (Wolff-Parkinson-White Pattern): When to Be Concerned – American College of Cardiology

Personal View | Effective, disease-modifying, clinical approaches to patients with mild-to-moderate hypertriglyceridemia.

22 Feb, 2022 | 08:17h | UTC

Effective, disease-modifying, clinical approaches to patients with mild-to-moderate hypertriglyceridaemia – The Lancet Diabetes & Endocrinology (free for a limited period)

Dietary carbohydrate and the risk of type 2 diabetes: an updated systematic review and dose–response meta-analysis of prospective cohort studies.

22 Feb, 2022 | 08:16h | UTC

Dietary carbohydrate and the risk of type 2 diabetes: an updated systematic review and dose–response meta-analysis of prospective cohort studies – Scientific Reports

ESCMID rapid guidelines for assessment and management of long COVID.

21 Feb, 2022 | 09:31h | UTC

ESCMID rapid guidelines for assessment and management of long COVID – Clinical Microbiology and Infection

ERS statement on Long COVID-19 follow-up.

Proposed subtypes of long-Covid and their respective potential therapies.

EuGMS Guidance: Management of post-acute COVID-19 patients in geriatric rehabilitation.

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

RCT: In patients with mild to moderate Covid-19 and comorbidities, treatment with Ivermectin did not reduce the risk of disease progression.

21 Feb, 2022 | 09:34h | UTC

Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and Comorbidities: The I-TECH Randomized Clinical Trial – JAMA Internal Medicine

Commentaries:

Ivermectin doesn’t prevent severe disease from Covid-19, new study finds – CNN

Ivermectin futile for mild to moderate COVID-19, study finds – CIDRAP

Case Series: Toxic effects from ivermectin use associated with prevention and treatment of Covid-19.

Long-term consequences of the misuse of ivermectin data.

Ivermectin: How false science created a Covid ‘miracle’ drug.

Fraudulent ivermectin studies open up new battleground between science and misinformation.

The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable.

Ivermectin: Cochrane’s most talked about review so far, ever. Why?

Flawed ivermectin preprint highlights challenges of COVID drug studies.

Systematic review: no evidence to support the use of Ivermectin for treating or preventing COVID-19.

Why was a major study on ivermectin for covid-19 just retracted?

RCT: Ivermectin does not prevent hospitalizations in patients with COVID-19.

Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials – “IVM did not reduce all-cause mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease”.

Ivermectin is the new hydroxychloroquine, take 2 – “Ivermectin shouldn’t be used to treat COVID-19 outside of the context of a well-designed clinical trial”.

Therapeutics and COVID-19 | WHO guideline update advises Ivermectin should only be used to treat COVID-19 within clinical trials

RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19

RCT: Advising overweight patients to increase sleep duration may reduce caloric intake.

21 Feb, 2022 | 09:27h | UTC

Effect of Sleep Extension on Objectively Assessed Energy Intake Among Adults With Overweight in Real-life Settings: A Randomized Clinical Trial – JAMA Internal Medicine

News Release: Getting more sleep reduces caloric intake, a game changer for weight loss programs – University of Chicago Medical Center

Commentaries:

Cut nearly 300 calories a day by doing something you already do – CNN

Individualized Sleep Counseling Can Aid Weight Loss in Overweight – HealthDay

Commentary on Twitter

In this randomized clinical trial of overweight adults who habitually sleep <6.5 hours per night, sleep extension reduced daily energy intake by ~270 kcal. Maintaining adequate sleep duration could be a viable intervention to prevent or reverse obesity. https://t.co/4nURTFSMO0 pic.twitter.com/jXaRx7wOdG

— JAMA Internal Medicine (@JAMAInternalMed) February 7, 2022

Review | Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus.

21 Feb, 2022 | 09:30h | UTC

Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus – European Heart Journal

News Release: Review highlights impact of Long COVID on cardiovascular system – University of Oxford

The pathogenesis and long-term consequences of Covid-19 cardiac injury: state-of-the-art review.

COVID-19 infections increase risk of heart conditions up to a year later, study finds.

Perspective | Is it time to live with COVID-19? Some scientists warn of ‘endemic delusion’.

21 Feb, 2022 | 09:28h | UTC

Is it time to live with COVID-19? Some scientists warn of ‘endemic delusion’ – Science

Real-world effectiveness of COVID-19 vaccines: a literature review and meta-analysis.

21 Feb, 2022 | 09:33h | UTC

Real-world effectiveness of COVID-19 vaccines: a literature review and meta-analysis – International Journal of Infectious Diseases

Surgery students ‘losing dexterity to stitch patients’.

21 Feb, 2022 | 09:24h | UTC

Surgery students ‘losing dexterity to stitch patients’ – BBC

ESGE Guideline: Endoscopic management of subepithelial lesions, including neuroendocrine neoplasms.

21 Feb, 2022 | 08:49h | UTC

Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Endoscopy

Somatic Genomic Testing in Patients with Metastatic or Advanced Cancer: ASCO Provisional Clinical Opinion.

21 Feb, 2022 | 08:47h | UTC

Somatic Genomic Testing in Patients With Metastatic or Advanced Cancer: ASCO Provisional Clinical Opinion – Journal of Clinical Oncology

News Release: ASCO Provisional Clinical Opinion Offers Guidance for Using and Interpreting Genomic Testing in Patients With Advanced Cancer – ASCO Daily News

IPSO Pediatric Surgical Oncology Surgical Practice Guidelines.

21 Feb, 2022 | 08:44h | UTC

International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines – eCancer

ERAS/SVS Consensus Statement on perioperative care in open aortic vascular surgery.

21 Feb, 2022 | 09:21h | UTC

Perioperative care in open aortic vascular surgery: A Consensus Statement by the Enhanced Recovery after Surgery (ERAS®) Society and Society for Vascular Surgery – Journal of Vascular Surgery

Expert Review | The importance of nutrition in pregnancy and lactation: lifelong consequences.

21 Feb, 2022 | 08:38h | UTC

The importance of nutrition in pregnancy and lactation: lifelong consequences – The American Journal of Obstetrics & Gynecology

Review: Cancer-associated venous thromboembolism.

21 Feb, 2022 | 08:42h | UTC

Cancer-associated venous thromboembolism – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Cancer-associated venous thromboembolism – Nature Reviews Disease Primers (if the link is paywalled, try this one)

NCCN Guideline: Cancer-Associated Venous Thromboembolic Disease.

ASH 2021 guidelines for prevention and treatment of venous thromboembolism in patients with cancer

Review: venous and arterial thromboembolism in patients with cancer.

Systematic Review: Does testing for cancer in people with unprovoked blood clots in the legs and lungs reduce cancer- and blood clot-related death and illness?

M-A: Extended thromboprophylaxis after hospital discharge for medically ill patients with cancer – Extended thromboprophylaxis is not associated with a reduced rate of venous thromboembolic events and is associated with increased risk of hemorrhage

Systematic review: Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy

AAAAI Practical Guidance for the Diagnosis and Management of Secondary Hypogammaglobulinemia.

21 Feb, 2022 | 08:45h | UTC

Practical Guidance for the Diagnosis and Management of Secondary Hypogammaglobulinemia: A Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees – The Journal of Allergy and Clinical Immunology

RCT: Sub dissociative dose of ketamine with haloperidol vs. fentanyl on pain reduction in patients with acute pain in the emergency department.

21 Feb, 2022 | 08:37h | UTC

Sub dissociative dose of ketamine with haloperidol versus fentanyl on pain reduction in patients with acute pain in the emergency department; a randomized clinical trial – The American Journal of Emergency Medicine (link to abstract – $ for full-text)

Free Supplement: Preeclampsia and Eclampsia.

21 Feb, 2022 | 08:40h | UTC

Preeclampsia and Eclampsia – The American Journal of Obstetrics & Gynecology

Analysis of 567,758 randomized controlled trials published over 30 years reveals trends in phrases used to discuss results that do not reach statistical significance.

21 Feb, 2022 | 08:34h | UTC

Analysis of 567,758 randomized controlled trials published over 30 years reveals trends in phrases used to discuss results that do not reach statistical significance – PLOS Biology

Commentary on Twitter

Spinning p-values in randomized controlled trials:

"Analysis of 567,758 randomized controlled trials published over 30 years reveals trends in phrases used to discuss results that do not reach statistical significance" (https://t.co/2MXZeCShWU)#statstwitter pic.twitter.com/uu8RiRR63J

— Gary Collins 🇪🇺 (@GSCollins) February 19, 2022