All Posts | Links Medicus - Free Medical News & Perspective

RCT: Referral for early, supported exercise after breast cancer surgery improves shoulder function and health-related quality of life.

1 Mar, 2022 | 08:50h | UTC

Abstract: Exercise to prevent shoulder problems after breast cancer surgery: the PROSPER RCT – Health Technology Assessment

Full Report: Exercise to prevent shoulder problems after breast cancer surgery: the PROSPER RCT – Health Technology Assessment

RCT: Prophylactic melatonin does not reduce the incidence of delirium in intensive care patients.

1 Mar, 2022 | 08:45h | UTC

Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial – Intensive Care Medicine (link to abstract – $ for full-text)

Commentaries on Twitter

Enteral prophylactic melatonin initiated early (within 48h of admission) & continued throughout #ICU (MAX 14 consecutive days) do not ⬇️#delirium prevalence vs placebo, Pro-MEDIC multicentre RCT
➡️12🇦🇺ICUs
➡️841 pts
➡️delirium-free assessments 79.2% vs 80%https://t.co/Gt5o1VuRo7 pic.twitter.com/gPRWxxmhHS

— Intensive Care Medicine (@yourICM) February 28, 2022

In 841 ICU patients with expected stay >72h, 4 mg melatonin within 48h after admission for 14 days vs placebo made no sign. differences in delirium-free assessments, LoS, 90d mortality, nor quality & quantity of sleep
Good bye Melatonin, we had a good timehttps://t.co/d0dayil99W

— Peter Nydahl (@NydahlPeter) February 28, 2022

RCT: A mindfulness-oriented intervention may reduce opioid misuse and chronic pain in primary care.

1 Mar, 2022 | 08:32h | UTC

Mindfulness-Oriented Recovery Enhancement vs Supportive Group Therapy for Co-occurring Opioid Misuse and Chronic Pain in Primary Care: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Mindfulness-Based Intervention Found to Reduce Chronic Pain and Opioid Misuse – Psychiatric News Alert

Commentary on Twitter

A randomized clinical trial showed that #Mindfulness-Oriented Recovery Enhancement delivered in the primary care setting reduces opioid misuse by as much as 46%, while simultaneously reducing chronic pain and emotional distress. https://t.co/eNj42RBCRA @DrEricGarland pic.twitter.com/tBatMT9lkQ

— JAMA Internal Medicine (@JAMAInternalMed) February 28, 2022

Review: New generation psychological treatments in chronic pain.

1 Mar, 2022 | 08:41h | UTC

New generation psychological treatments in chronic pain – The BMJ (free for a limited period)

HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.

1 Mar, 2022 | 08:30h | UTC

HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management – Nature Reviews Clinical Oncology (if the link is paywalled, try this one)

New CDC interim guidance recommends a 4-month Rifapentine-Moxifloxacin regimen to treat drug-susceptible pulmonary tuberculosis.

27 Feb, 2022 | 22:49h | UTC

Interim Guidance: 4-Month Rifapentine-Moxifloxacin Regimen for the Treatment of Drug-Susceptible Pulmonary Tuberculosis — United States, 2022 – CDC Morbidity and Mortality Weekly Report

Summary | WHO recommendations on the treatment of drug-resistant tuberculosis, 2020 update.

WHO Guideline: Screening for Tuberculosis Disease

New WHO Recommendations to Prevent Tuberculosis

CDC Guidelines for the Treatment of Latent Tuberculosis Infection

Guideline: Treatment of Drug-Resistant Tuberculosis

NICE Guideline: Tuberculosis

The Lancet Commission: Management of Multidrug-resistant and Incurable Tuberculosis

Regimens to Treat Multidrug-resistant Tuberculosis: Past, Present and Future Perspectives

Guidelines for the Management of TB in Adults Living with HIV

Commentary on Twitter

Clinicians: @CDC_TB released interim guidance on a new regimen to treat #TB disease. Learn more about the 4-month regimen containing rifapentine, moxifloxacin, isoniazid, and pyrazinamide for people with drug-susceptible pulmonary TB disease in the U.S.: https://t.co/eOcR34tYJu pic.twitter.com/EFGMwAwN7c

— MMWR (@CDCMMWR) February 25, 2022

CDC issues long-awaited new guidance on when to wear masks.

27 Feb, 2022 | 22:45h | UTC

CDC issues long-awaited new guidance on when to wear masks – STAT

ESCMID COVID-19 guidelines: diagnostic testing for SARS-CoV-2.

27 Feb, 2022 | 22:47h | UTC

ESCMID COVID-19 guidelines: diagnostic testing for SARS-CoV-2 – Clinical Microbiology and Infection

Guideline: Plasma exchange and glucocorticoid dosing for patients with ANCA-associated vasculitis.

27 Feb, 2022 | 22:40h | UTC

Plasma exchange and glucocorticoid dosing for patients with ANCA-associated vasculitis: a clinical practice guideline – The BMJ

Commentary on Twitter

New rapid recommendation makes a weak recommendation against plasma exchange in patients with low risk of end stage kidney disease, and a weak recommendation in favour of plasma exchange in patients with moderate-high risk of ESKD https://t.co/PeEjSuRIxI #BMJInfographic pic.twitter.com/YR55t6XYhS

— The BMJ (@bmj_latest) February 25, 2022

Cohort Study: A polygenic risk score may improve risk stratification of coronary artery disease.

27 Feb, 2022 | 22:31h | UTC

A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study – European Heart Journal

Editorial: Polygenic risk score: a tool ready for clinical use?

Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps.

Studies: Little Benefit from Polygenic Risk Score vs. Clinical Risk Score for Predicting Cardiovascular Risk

Perspective: The Approach to Predictive Medicine that is Taking Genomics Research by Storm

Meta-analysis suggests there is low risk of delayed intracranial hemorrhage (after a negative initial head CT) following low energy blunt head trauma while on direct oral anticoagulants.

27 Feb, 2022 | 22:30h | UTC

Delayed Intracranial Hemorrhage Following Blunt Head Trauma While on Direct Oral Anticoagulants: A Systematic Review and Meta-analysis – Journal of the American College of Surgeons

4 lessons from the life of global health visionary Paul Farmer.

27 Feb, 2022 | 22:42h | UTC

4 lessons from the life of global health visionary Paul Farmer – Vox

Consensus on intraoperative technical/surgical aspects to prevent surgical site infection after colorectal surgery.

27 Feb, 2022 | 22:32h | UTC

Delphi Consensus on Intraoperative Technical/Surgical Aspects to Prevent Surgical Site Infection after Colorectal Surgery – Journal of the American College of Surgeons

Review: CRISPR in cancer biology and therapy.

27 Feb, 2022 | 22:27h | UTC

CRISPR in cancer biology and therapy – Nature Reviews Cancer (if the link is paywalled, try this one)

New treatment strategies for advanced-stage gastrointestinal stromal tumors.

27 Feb, 2022 | 22:28h | UTC

New treatment strategies for advanced-stage gastrointestinal stromal tumours – Nature Reviews Clinical Oncology (if the link is paywalled, try this one)

Commentary on Twitter

In a Review now live online, @LRberyllium, @HKhosroyani, Jason D. Kent & Michael Heinrich from the @GistLab at @OHSUKnight discuss 'New treatment strategies for advanced-stage gastrointestinal stromal tumours: https://t.co/pJ0cMuvUMG #scmsm #stcsm #esocsm #CRCSM pic.twitter.com/lMtjkAcJUZ

— NatureRevClinOncol (@NatRevClinOncol) February 25, 2022

Consensus Statement: Successfully implementing digital health to ensure future global health security during pandemics.

25 Feb, 2022 | 11:34h | UTC

Successfully Implementing Digital Health to Ensure Future Global Health Security During Pandemics: A Consensus Statement – JAMA Network Open

At least 5 million children have lost a parent or caregiver due to COVID-19 since March 2020, updated figures suggest.

25 Feb, 2022 | 11:32h | UTC

News Release: At least 5 million children have lost a parent or caregiver due to COVID-19 since March 2020, updated figures suggest – The Lancet

Original Study: Global, regional, and national minimum estimates of children affected by COVID-19-associated orphanhood and caregiver death, by age and family circumstance up to Oct 31, 2021: an updated modelling study – The Lancet Child & Adolescent Health

Commentaries:

Integrative approaches required to support children affected by COVID-19 – The Lancet Child & Adolescent Health

Millions of children worldwide have lost a parent or caregiver to COVID-19: “The hidden pandemic” – CBS News

More than 1.5 million children lost a primary or secondary caregiver due to the COVID-19 pandemic.

Covid-19 Has Created Thousands Of Newly Single Parents And Orphans

Commentary on Twitter (thread – click for more)

At least 5 million children have lost a parent or caregiver due to #COVID19 since March 2020, updated figures suggest.

Authors urge actions to prioritise affected children, incl. economic strengthening, enhanced community & family support, & education. https://t.co/1slpFhjDJd pic.twitter.com/AvEncg4Yx1

— The Lancet (@TheLancet) February 24, 2022

Meta-analysis of randomized trials: Effectiveness of physical activity interventions delivered or prompted by health professionals in primary care settings.

25 Feb, 2022 | 11:27h | UTC

Effectiveness of physical activity interventions delivered or prompted by health professionals in primary care settings: systematic review and meta-analysis of randomised controlled trials – The BMJ

Editorial: Lack of physical activity is a global problem

News Release: Primary care exercise interventions help boost physical activity levels and reduce weight in adults – BMJ

Risk of cancer in regular and low meat-eaters, fish-eaters, and vegetarians: a prospective analysis of UK Biobank participants.

25 Feb, 2022 | 11:24h | UTC

Risk of cancer in regular and low meat-eaters, fish-eaters, and vegetarians: a prospective analysis of UK Biobank participants – BMC Medicine

Commentaries:

Expert reaction to study looking at eating meat and risk of cancer – Science Media Centre

Low-meat and meat-free diets associated with lower overall cancer risk – Biomed Central

Commentary on Twitter

Study suggests being #vegetarian may be associated w/lower risk of #cancer

⬇️risk of #colorectalcancer in low meat 🥩 eaters consistent w/evidence of impact of meat

⬇️risk of postmenopausal #breastcancer in #vegetarian 🌱women may be explained by🔽BMIhttps://t.co/1uQfEFgoRT pic.twitter.com/VHhh9NbFSL

— Gil Morgan, MD (@weoncologists) February 25, 2022

Study suggests multisystem inflammatory syndrome in children (MIS-C) is rare among vaccinated teens.

25 Feb, 2022 | 11:29h | UTC

Reported cases of multisystem inflammatory syndrome in children aged 12–20 years in the USA who received a COVID-19 vaccine, December, 2020, through August, 2021: a surveillance investigation – The Lancet Child & Adolescent Health

Commentaries:

When vaccine adverse event reporting generates hope, not fear – The Lancet Child & Adolescent Health

MIS-C rare in COVID-vaccinated teens, study finds – CIDRAP

Vaccination Greatly Reduces Odds of MIS-C in Teens Who Get COVID – HealthDay

Commentary on Twitter

New study from @CDCgov finds that multi-system inflammatory syndrome in children (#MISC) is rare among 12 to 20-year-olds who have received #COVID19 vaccination (1.0 case per million individuals receiving one or more doses)https://t.co/BpsXSpMMcH

— The Lancet Child & Adolescent Health (@LancetChildAdol) February 23, 2022