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Single Arm Trial | Low-carbohydrate diet improves glycemic control in type 1 diabetes

13 Jul, 2023 | 13:04h | UTC

Effects of a low-carbohydrate diet in adults with type 1 diabetes management: A single arm non-randomised clinical trial – PLOS One

Related:

Management of Type 1 Diabetes With a Very Low–Carbohydrate Diet – Pediatrics (link to abstract – $ for full-text)

Meta-analysis of randomized trials: patients adhering to a low carbohydrate diet for six months may experience remission of diabetes without adverse consequences

RCT | A calorie-unrestricted low-carbohydrate, high-fat diet resulted in short-term weight loss and better glycemic control.

Comparison of the Effectiveness of Low Carbohydrate Versus Low Fat Diets, in Type 2 Diabetes: Systematic Review and Meta-Analysis of Randomized Controlled Trials – Nutrients

Consensus Statement: Effect of carbohydrate-restricted diets and intermittent fasting on obesity, type 2 diabetes mellitus, and hypertension management.

Effects of a 6-month, low-carbohydrate diet on glycaemic control, body composition, and cardiovascular risk factors in patients with type 2 diabetes: An open-label randomized controlled trial – Diabetes, Obesity and Metabolism

Lower carbohydrate diets for adults with type 2 diabetes – British Journal of Nutrition

Low carbohydrate diet: Insights from a general practice service in patients with type 2 diabetes

Diabetes Canada Position Statement on Low-Carbohydrate Diets for Adults With Diabetes: A Rapid Review – Canadian Journal of Diabetes

Low Carbohydrate Diets for Diabetes: A Review of the Clinical Effectiveness and Guidelines – Canadian Agency for Drugs and Technologies in Health

Adapting diabetes medication for low carbohydrate management of type 2 diabetes: a practical guide – British Journal of General Practice

 

Phase 2 Study | BRAF-MEK inhibition in BRAF-mutated papillary craniopharyngiomas leads to tumor volume reduction

13 Jul, 2023 | 13:02h | UTC

BRAF–MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Rare Brain Tumor Responds to Targeted Tumor Treatment with ‘Unprecedented’ Success – Mass General Brigham

 

Commentary on Twitter

 

RCT| Exercise during hemodialysis improves physical function in chronic kidney failure patients

13 Jul, 2023 | 13:01h | UTC

Exercise during Hemodialysis in Patients with Chronic Kidney Failure – NEJM Evidence

 

RCT | Cytisinicline shows significant efficacy in smoking cessation over placebo

13 Jul, 2023 | 12:58h | UTC

Cytisinicline for Smoking Cessation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

See also: Visual Abstract

News Release: First large US clinical trial of cytisinicline finds the smoking cessation medication effective and well tolerated – Massachusetts General Hospital

 

Practice Guidance | Six steps to better care for older people in acute hospitals

12 Jul, 2023 | 14:00h | UTC

Six steps to better care for older people in acute hospitals – British Geriatrics Society

News Release: New guidance outlines ‘Six steps to better care for older people in hospital’ – British Geriatrics Society

 

Clinical practice guideline for deprescribing opioid analgesics

12 Jul, 2023 | 13:58h | UTC

Clinical practice guideline for deprescribing opioid analgesics: summary of recommendations – Medical Journal of Australia

Related:

RCT | Opioids not more effective than placebo for acute low back and neck pain

Deprescribing considerations for older people in general practice – Australian Journal of General Practice

Deprescribing Strategies for Opioids and Benzodiazepines with Emphasis on Concurrent Use: A Scoping Review – Journal of Clinical Medicine

An Overview of Systematic Reviews and Meta-Analyses on the Effect of Medication Interventions Targeting Polypharmacy for Frail Older Adults – Journal of Clinical Medicine

Physician-led medication reviews in polypharmacy patients treated with at least 12 medications in a type 2 diabetes outpatient clinic: a randomised trial – Diabetic Medicine

RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care

Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence – Cochrane Library

Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis – Health Technology Assessment

Barriers and facilitators to deprescribing of cardiovascular medications: a systematic review – BMJ Open

A National Modified Delphi Consensus Process to Prioritize Experiences and Interventions for Antipsychotic Medication Deprescribing Among Adult Patients With Critical Illness – Critical Care Explorations

Deprescribing proton pump inhibitors – Australian Journal of General Practice

Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis – Age and Ageing

Optimizing Medication Use in Older Adults With Rheumatic Musculoskeletal Diseases: Deprescribing as an Approach When Less May Be More – ACP Open Rheumatology

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease. A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

Deprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports

How-to guide for medication reviews in older adults with cancer: A Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative – Journal of Geriatric Oncology

Deprescribing in Palliative Cancer Care – Life

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review – Research in Social and Administrative Pharmacy

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

Development of a Metric to Detect and Decrease Low-Value Prescribing in Older Adults – JAMA Network Open

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial – JAMA Internal Medicine

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines – Supportive Care in Cancer

Prescribing practices, patterns, and potential harms in patients receiving palliative care: A systematic scoping review – Exploratory Research in Clinical and Social Pharmacy

A narrative review of evidence to guide deprescribing among older adults – Journal of General and Family Medicine

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens – The Lancet Health Longevity

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt international

Eliminating Medication Overload: A National Action Plan – Lown Institute

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging

Common ED Medication Errors: Polypharmacy – emDocs

Current and future perspectives on the management of polypharmacy – BMC Family Practice

Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety

Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international

Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety

 

RCT | Self-administered intranasal etripamil superior to placebo for acute supraventricular tachycardia conversion

12 Jul, 2023 | 13:54h | UTC

Self-administered intranasal etripamil using a symptom-prompted, repeat-dose regimen for atrioventricular-nodal-dependent supraventricular tachycardia (RAPID): a multicentre, randomised trial – The Lancet

 

WHO Guideline | Policies to protect children from the harmful impact of food marketing

12 Jul, 2023 | 13:52h | UTC

Policies to protect children from the harmful impact of food marketing: WHO guideline – World Health Organization

News Release: WHO recommends stronger policies to protect children from the harmful impact of food marketing – World Health Organization

Commentary: WHO Launches New Guideline for Protecting Children from Unhealthy Food Marketing – Health Policy Watch

 

M-A | The effect of blood pressure lowering medications on the prevention of episodic migraine

12 Jul, 2023 | 13:50h | UTC

The effect of blood pressure lowering medications on the prevention of episodic migraine: A systematic review and meta-analysis – Cephalalgia

News Release: New study shows common blood pressure meds underused for migraine – George Institute for Global Health

 

2023 ETA clinical practice guidelines for thyroid nodule management

12 Jul, 2023 | 13:48h | UTC

2023 European Thyroid Association clinical practice guidelines for thyroid nodule management – European Thyroid Journal

 

The 2023 Bethesda System for reporting thyroid cytopathology

12 Jul, 2023 | 13:46h | UTC

The 2023 Bethesda System for Reporting Thyroid Cytopathology – Thyroid

 

A guide and pragmatic considerations for applying GRADE to network meta-analysis

12 Jul, 2023 | 13:44h | UTC

A guide and pragmatic considerations for applying GRADE to network meta-analysis – The BMJ

 

Commentary on Twitter

 

Myocarditis: a primer for intensivists

12 Jul, 2023 | 13:42h | UTC

Myocarditis: a primer for intensivists – Intensive Care Medicine

 

Commentary on Twitter

 

Retrospective Analysis | 18% of ICU patients develop sepsis-associated AKI, mostly stage 1, diagnosed by low urine output

12 Jul, 2023 | 13:39h | UTC

Sepsis-associated acute kidney injury in the intensive care unit: incidence, patient characteristics, timing, trajectory, treatment, and associated outcomes. A multicenter, observational study – Intensive Care Medicine

 

Commentary on Twitter

 

Intervention Study | Pharmacist review may reduce antibiotic overuse at discharge

12 Jul, 2023 | 13:37h | UTC

Improving antibiotic utilization through an outpatient stewardship initiative – Antimicrobial Stewardship & Healthcare Epidemiology

Commentary: Pharmacist review identifies improper antibiotic prescriptions – CIDRAP

 

M-A | Cognitive rehabilitation may improve everyday activities in mild to moderate dementia

12 Jul, 2023 | 13:34h | UTC

Cognitive rehabilitation for people with mild to moderate dementia – Cochrane Library

 

RCT | Supplementing CPVI with low-voltage-area ablation lowers atrial arrhythmia recurrence in elderly with paroxysmal AF

12 Jul, 2023 | 13:31h | UTC

Circumferential Pulmonary Vein Isolation With vs Without Additional Low-Voltage-Area Ablation in Older Patients With Paroxysmal Atrial Fibrillation: A Randomized Clinical Trial – JAMA Cardiology (link to abstract – $ for full-text)

See also: Visual Abstract

 

Review | Head to toe ultrasound: a narrative review of experts’ recommendations of methodological approaches

12 Jul, 2023 | 13:32h | UTC

Head to toe ultrasound: a narrative review of experts’ recommendations of methodological approaches – Journal of Anesthesia, Analgesia and Critical Care

 

USPSTF | Routine depression screening recommended for adults including pregnant and postpartum women

11 Jul, 2023 | 14:09h | UTC

Screening for Depression and Suicide Risk in Adults: US Preventive Services Task Force Recommendation Statement – JAMA

Evidence Report: Depression and Suicide Risk Screening: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Patient Page: Screening for Depression and Suicide Risk in Adults – JAMA

Editorials:

Reframing the Key Questions Regarding Screening for Suicide Risk – JAMA

Suicidality Screening Guidelines Highlight the Need for Intervention Studies – JAMA Network Open

Related:

USPSTF Recommendations | Screen for anxiety disorders in adults, including pregnant and postpartum women

USPSTF Statement | Screening for anxiety is recommended in children and adolescents aged 8 to 18 years.

USPSTF Statement | Screening for depression and suicide risk is recommended in children and adolescents aged 12 to 18 years.

 

M-A | P2Y12 inhibitors show superior efficacy over aspirin for secondary prevention in CAD

11 Jul, 2023 | 14:06h | UTC

P2Y12 Inhibitor or Aspirin Monotherapy for Secondary Prevention of Coronary Events – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Related:

Monotherapy with a P2Y12 inhibitor or aspirin for secondary prevention in patients with established atherosclerosis: a systematic review and meta-analysis – The Lancet (link to abstract – $ for full-text)

RCT | Clopidogrel is better than Aspirin for chronic maintenance monotherapy after percutaneous coronary intervention.

Meta-analysis of randomized trials: Clopidogrel is better than aspirin for the secondary prevention of cardiovascular events.

#ACC21 – RCT: Clopidogrel better than aspirin for chronic maintenance monotherapy after percutaneous coronary intervention.

 

Commentary on Twitter

 

Cohort Study | Long-term use of menopausal hormone therapy linked to heightened dementia risk

11 Jul, 2023 | 14:04h | UTC

Menopausal hormone therapy and dementia: nationwide, nested case-control study – The BMJ

Editorial: Menopausal hormone therapy and dementia – The BMJ

News Release: Menopausal hormone therapy linked to increased rate of dementia – BMJ Newsroom

Commentaries: Expert reaction to observational study on HRT and dementia – Science Media Centre

 

Health advisory on social media use in adolescence

11 Jul, 2023 | 14:03h | UTC

Health advisory on social media use in adolescence – American Psychological Association

News Release: APA panel issues recommendations for adolescent social media use – American Psychological Association

 

Cohort Study | Fewer than half of new drugs add substantial therapeutic value over existing treatments

11 Jul, 2023 | 14:01h | UTC

News Release: Fewer than half of new drugs add substantial therapeutic value over existing treatments – BMJ Newsroom

Article: Therapeutic value of first versus supplemental indications of drugs in US and Europe (2011-20): retrospective cohort study – The BMJ

Editorial: Patients need better treatments, not just more of the same – The BMJ

 

AASLD Guidance | Use of TIPS, variceal embolization, and retrograde transvenous obliteration in variceal hemorrhage

11 Jul, 2023 | 13:59h | UTC

AASLD Practice Guidance on the Use of TIPS, Variceal Embolization, and Retrograde Transvenous Obliteration in the Management of Variceal Hemorrhage – Hepatology

 

AHA Scientific Statement | Pulmonary hypertension in congenital heart disease

11 Jul, 2023 | 13:57h | UTC

Pulmonary Hypertension in Congenital Heart Disease: A Scientific Statement From the American Heart Association – Circulation: Heart Failure

Commentary: It’s Classified: The Complexity of Pulmonary Hypertension Associated with Congenital Heart Disease – American Heart Association

 

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