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RCT: Organ preservation in patients with rectal adenocarcinoma treated with total neoadjuvant therapy.

1 May, 2022 | 23:20h | UTC

Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy – Journal of Clinical Oncology

 

RCT: Digital breast tomosynthesis plus synthesized mammography versus digital screening mammography for the detection of invasive breast cancer.

1 May, 2022 | 23:14h | UTC

Digital breast tomosynthesis plus synthesised mammography versus digital screening mammography for the detection of invasive breast cancer (TOSYMA): a multicentre, open-label, randomised, controlled, superiority trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Breast Cancer Screening With Digital Breast Tomosynthesis Plus Synthesized Mammography vs Digital Mammography – The ASCO Post

 

Review: Anti-tuberculosis treatment strategies and drug development: challenges and priorities.

1 May, 2022 | 23:23h | UTC

Anti-tuberculosis treatment strategies and drug development: challenges and priorities – Nature Reviews Microbiology (if the link is paywalled, try this one)

News Release: A major update on global tuberculosis fight – Hackensack Meridian Health

 

Commentary on Twitter

 

Collider bias in observational studies: consequences for medical research.

1 May, 2022 | 23:12h | UTC

Collider Bias in Observational Studies: Consequences for Medical Research – Deutsches Ärzteblatt International

 

M-A: Comparative safety and efficacy of cognitive enhancers for Alzheimer’s dementia.

1 May, 2022 | 23:10h | UTC

Comparative safety and efficacy of cognitive enhancers for Alzheimer’s dementia: a systematic review with individual patient data network meta-analysis – BMJ Open

 

Guideline: Clinical utility of multigene profiling assays in early-stage invasive breast cancer.

1 May, 2022 | 23:06h | UTC

Clinical Utility of Multigene Profiling Assays in Early-Stage Invasive Breast Cancer: An Ontario Health (Cancer Care Ontario) Clinical Practice Guideline – Current Oncology

 

M-A: Early neurodevelopment of HIV-exposed uninfected children in the era of antiretroviral therapy.

1 May, 2022 | 23:09h | UTC

Early neurodevelopment of HIV-exposed uninfected children in the era of antiretroviral therapy: a systematic review and meta-analysis – The Lancet Child & Adolescent Health

 

M-A: The effect of endogenous Cushing’s syndrome on all-cause and cause-specific mortality.

1 May, 2022 | 23:05h | UTC

The effect of endogenous Cushing’s syndrome on all-cause and cause-specific mortality: A systematic review and meta-analysis – The Journal of Clinical Endocrinology & Metabolism

 

Checklists to reduce diagnostic error: a systematic review of the literature using a human factors framework.

1 May, 2022 | 23:02h | UTC

Checklists to reduce diagnostic error: a systematic review of the literature using a human factors framework – BMJ Open

 

RCT: Extended vs. standard antibiotic course duration in children below 5 years of age hospitalized with community-acquired pneumonia in high-risk settings.

29 Apr, 2022 | 11:16h | UTC

Extended Versus Standard Antibiotic Course Duration in Children <5 Years of Age Hospitalized With Community-acquired Pneumonia in High-risk Settings: Four-week Outcomes of a Multicenter, Double-blind, Parallel, Superiority Randomized Controlled Trial – The Pediatric Infectious Disease Journal

Related:

Short- vs Standard-Course Outpatient Antibiotic Therapy for Community-Acquired Pneumonia in Children: The SCOUT-CAP Randomized Clinical Trial – JAMA Pediatrics

Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians – Annals of Internal Medicine

Short-Course Antimicrobial Therapy for Pediatric Community-Acquired Pneumonia: The SAFER Randomized Clinical Trial – JAMA Pediatrics

Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial – JAMA

Treatment of UTIs in Infants <2 Months: A Living Systematic Review – Hospital Pediatrics

Effect of 7 vs 14 Days of Antibiotic Therapy on Resolution of Symptoms Among Afebrile Men With Urinary Tract Infection: A Randomized Clinical Trial – JAMA

Seven versus fourteen Days of Antibiotic Therapy for uncomplicated Gram-negative Bacteremia: a Non-inferiority Randomized Controlled Trial – Clinical Infectious Diseases

Efficacy of short-course antibiotic treatments for community-acquired pneumonia in adults: A systematic review and meta-analysis – Antimicrobial Agents and Chemotherapy

 

Commentary on Twitter

 

Review: Nutrition, longevity and disease: From molecular mechanisms to interventions.

29 Apr, 2022 | 11:18h | UTC

Nutrition, longevity and disease: From molecular mechanisms to interventions – Cell

 

Commentary on Twitter

Under a CC BY-NC-ND 4.0 license

 

WHO reveals shocking extent of exploitative formula milk marketing.

29 Apr, 2022 | 10:58h | UTC

News Release: WHO reveals shocking extent of exploitative formula milk marketing – World Health Organization

Report: Scope and impact of digital marketing strategies for promoting breastmilk substitutes – World Health Organization

Related: More than half of parents and pregnant women exposed to aggressive formula milk marketing – WHO, UNICEF – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

Review: Understanding vaccine safety and the roles of the FDA and the CDC.

29 Apr, 2022 | 11:13h | UTC

Understanding Vaccine Safety and the Roles of the FDA and the CDC – New England Journal of Medicine

 

Commentary on Twitter

 

RCT: BCG vaccine is not effective in reducing healthcare worker absenteeism in COVID-19 pandemic.

29 Apr, 2022 | 11:05h | UTC

BCG vaccine to reduce healthcare worker absenteeism in COVID-19 pandemic, a randomized controlled trial – Clinical Microbiology and Infection

 

Commentary on Twitter

 

Hepatitis outbreak in children: explainer on adenovirus type 41, the possible culprit.

29 Apr, 2022 | 11:07h | UTC

Hepatitis outbreak in children: explainer on adenovirus type 41, the possible culprit – The Conversation

Related:

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing – UK Health Security Agency

Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization

WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT

CDC Alerts Providers to Hepatitis Cases of Unknown Origin – Centers for Disease Control and Prevention

Recommendations for Adenovirus Testing and Reporting of Children with Acute Hepatitis of Unknown Etiology – Centers for Disease Control and Prevention

Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch

Increase in hepatitis (liver inflammation) cases in children under investigation – UK Health Security Agency

U.S., U.K. investigating unusual cases of hepatitis in young children – STAT

Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland – World Health Organization

Increase in acute hepatitis of unknown origin among children – United Kingdom – European Centre for Disease Prevention and Control

Mysterious liver illness seen in kids in US, Europe – Associated Press

 

The Lancet Series: Optimizing child and adolescent health and development.

29 Apr, 2022 | 10:55h | UTC

Homepage: Optimising Child and Adolescent Health and Development – The Lancet (free registration required for all articles)

Health and development from preconception to 20 years of age and human capital

Effects of early-life poverty on health and human capital in children and adolescents: analyses of national surveys and birth cohort studies in LMICs

What can work and how? An overview of evidence-based interventions and delivery strategies to support health and human development from before conception to 20 years

Improving health and social systems for all children in LMICs: structural innovations to deliver high-quality services

Optimising child and adolescent health and development in the post-pandemic world

Opportunities in crisis for optimising child health and development

 

Review: The gut microbiome as a modulator of healthy ageing.

29 Apr, 2022 | 10:47h | UTC

The gut microbiome as a modulator of healthy ageing – Nature Reviews Gastroenterology & Hepatology (if the link is paywalled, try this one via PMC)

 

Bring it on: Top five antimicrobial stewardship challenges in transplant infectious diseases and practical strategies to address them.

29 Apr, 2022 | 10:51h | UTC

Bring it on: Top five antimicrobial stewardship challenges in transplant infectious diseases and practical strategies to address them – Antimicrobial Stewardship & Healthcare Epidemiology

 

Commentary on Twitter

Under a http://creativecommons.org/licenses/by/4.0/ license

 

M-A: Household secondary attack rates of SARS-CoV-2 by variant and vaccination status.

29 Apr, 2022 | 10:57h | UTC

Household Secondary Attack Rates of SARS-CoV-2 by Variant and Vaccination Status: An Updated Systematic Review and Meta-analysis – JAMA Network Open

 

Commentary on Twitter

 

M-A: Coronary flow reserve and cardiovascular outcomes.

29 Apr, 2022 | 10:43h | UTC

Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis – European Heart Journal

 

Commentary on Twitter

 

Varicose veins: what can be done to help?

29 Apr, 2022 | 10:49h | UTC

Varicose veins: what can be done to help? – Evidently Cochrane

Related:

Graduated compression stockings for the initial treatment of varicose veins in people without venous ulceration – Cochrane Library

Interventions for great saphenous vein incompetence – Cochrane Library

Surgery for deep venous insufficiency – Cochrane Library

CHIVA method for the treatment of chronic venous insufficiency – Cochrane Library

Injection sclerotherapy for varicose veins – Cochrane Library

 

Expert Consensus: Topical treatment of recurrent vulvovaginal candidiasis.

29 Apr, 2022 | 10:46h | UTC

Topical Treatment of Recurrent Vulvovaginal Candidiasis: An Expert Consensus – Women’s Health Reports

 

Systematic Review: Antiepileptic drugs for the primary and secondary prevention of seizures after stroke.

29 Apr, 2022 | 10:45h | UTC

Antiepileptic drugs for the primary and secondary prevention of seizures after stroke – Cochrane Library

Summary: Effects of antiepileptic drugs for the primary and secondary prevention of seizures after stroke – Cochrane Library

 

M-A: Dietary fiber in hypertension and cardiovascular disease management.

29 Apr, 2022 | 08:26h | UTC

Dietary fibre in hypertension and cardiovascular disease management: systematic review and meta-analyses – BMC Medicine

 

Perspective | Obesity – an unexplained epidemic.

29 Apr, 2022 | 08:23h | UTC

Obesity – an unexplained epidemic – American Journal of Clinical Nutrition

 

Commentary on Twitter

 

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