All Posts
RCT: Tislelizumab vs. chemotherapy as second-line treatment for advanced or metastatic esophageal squamous cell carcinoma.
3 May, 2022 | 10:36h | UTC
Commentary on Twitter
In the phase III RATIONALE-302 trial of tislelizumab vs chemotherapy as 2nd-line therapy for advanced-stage ESCC, mOS was 8.6 vs 6.3 months (HR 0.70; P=0.0001), rising to 10.3 vs 6.8 months for those with a PD-L1 tumour area positivity score >10%: https://t.co/CNxads2Kn2 #esocsm
— NatureRevClinOncol (@NatRevClinOncol) April 27, 2022
M-A: Risk factors for contracting invasive meningococcal disease and related mortality.
3 May, 2022 | 10:29h | UTC
M-A: Endoscopic spinal surgery vs. microscopic surgery in lumbar spinal stenosis.
3 May, 2022 | 10:28h | UTC
Contemporary antiplatelet therapy for secondary stroke prevention: a narrative review of current literature and guidelines.
3 May, 2022 | 10:26h | UTC
Position Paper: Diagnosis and management of rare cardiomyopathies in adult and pediatric patients.
3 May, 2022 | 10:24h | UTC
M-A: Adverse events relating to prolonged hard collar immobilization.
3 May, 2022 | 10:27h | UTC
AAP Guidance for pediatric end-of-life care.
2 May, 2022 | 00:51h | UTCGuidance for Pediatric End-of-Life Care – Pediatrics
Related Guidance: End of life care for infants, children and young people with life-limiting conditions: planning and management – National Institute for Health and Care Excellence
CDC Report: Acute hepatitis and adenovirus infection among children.
2 May, 2022 | 00:46h | UTCCommentaries:
CDC releases new clinical details in cases of unusual hepatitis in children – CNN
CDC report finds no Covid link in children’s hepatitis cases in Alabama – NBC News
Related:
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentaries on Twitter
Report from Alabama of acute hepatitis & adenovirus infection in young kids, Oct 21-Feb 22. 9 cases, all had adenovirus, 5/5 tested +ve for Adenovirus type 41. No epi links found. All under 6 yrs of age, immunocompetent, & no significant comorbidities. https://t.co/DcgcfN3KHo
— Andrew Lee is heading to @andrewleedr.bsky.social (@andrewleedr) April 29, 2022
New report from @CDCMMWR on the 9 episodes of severe acute hepatitis in children from Alabama
All 9 positive for Adenovirus on whole blood PCR (all 5 samples sequences were type 41)
None PCR positive for #SARSCoV2
HT @tonisoriano66 https://t.co/h9LmHeVHEf
— Alasdair Munro (@apsmunro) April 29, 2022
ATS/ERS/JRS/ALAT Guideline: Idiopathic pulmonary fibrosis and progressive pulmonary fibrosis in adults.
2 May, 2022 | 00:53h | UTC
Commentary on Twitter (thread – click for more)
🔥Finally out online: the latest multisocietal guidance defining progression in fibrotic lung disease🫁 has arrived!
These long-awaited guidelines help better clarify disease definition and guide treatmenthttps://t.co/LVuoVdZRj2
What does this mean? Hang on to your hats! 🧵1/n pic.twitter.com/3jvFGSfSuI
— Deji Adegunsoye, MD, PhD (@drdayjee) April 29, 2022
ECDC publishes Rapid Risk Assessment – Increase in severe acute hepatitis cases of unknown etiology in children.
2 May, 2022 | 00:44h | UTCRelated:
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Pfizer says COVID treatment Paxlovid fails to prevent infection of household members.
2 May, 2022 | 00:43h | UTCPfizer says COVID treatment Paxlovid fails to prevent infection of household members – Reuters
Commentary on Twitter
Pfizer Inc on Friday said a large trial found that its COVID-19 oral antiviral treatment Paxlovid was not effective at preventing coronavirus infection in people living with someone who had been exposed to the virus. https://t.co/95zphEYaxc
— Reuters Health (@Reuters_Health) April 29, 2022
RCT: Phentermine/Topiramate for the treatment of adolescent obesity.
2 May, 2022 | 00:41h | UTCPhentermine/Topiramate for the Treatment of Adolescent Obesity – NEJM Evidence
Commentary on Twitter
This RCT evaluated phentermine/topiramate in adolescents ages 12 to <17 yrs with high BMIs over a 56 week period. At both mid- and top-doses, treatment significantly reduced BMI and waist circumference compared to placebo. https://t.co/HbCZOAlZPf@PedsEndoSociety #PedsEndo2022 pic.twitter.com/nB5juqxyA0
— NEJM Evidence (@NEJMEvidence) April 30, 2022
RCT: Digital remote monitoring plus usual care vs. usual care in patients treated with oral anticancer agents.
2 May, 2022 | 00:37h | UTCDigital remote monitoring plus usual care versus usual care in patients treated with oral anticancer agents: the randomized phase 3 CAPRI trial – Nature Medicine (if the link is paywalled, try this one)
Commentary on Twitter
A phase 3 clinical trial evaluating the impact of a digital nurse navigator-led system in patients receiving oral #cancer treatment shows that remote monitoring with a smartphone results in improved patient experience & optimizes resources @GustaveRoussy https://t.co/N8fEXb00r7
— Nature Medicine (@NatureMedicine) April 26, 2022
RCT: Efficiency of electronic health record assessment of patient-reported outcomes after cancer immunotherapy.
2 May, 2022 | 00:36h | UTCInvited Commentary: An Assistive Electronic Patient-Reported Outcome Monitoring Intervention for Management of Immune-Related Toxic Effects—Moving Toward Efficiency and Scale – JAMA Network Open
Commentary on Twitter
This RCT aimed to compare the efficiency between ePRO and traditional follow up models in cancer immunotherapy among 278 patients from 28 hospitals, finding that an ePRO model can improve safety & QOL, and is less time consuming. https://t.co/KtpcNz0keb pic.twitter.com/EsmNyTkdfB
— JAMA Network Open (@JAMANetworkOpen) March 31, 2022
Consensus Recommendations: Quality standards for the management of non-alcoholic fatty liver disease.
2 May, 2022 | 00:21h | UTCRelated Guidelines:
Non-alcoholic fatty liver disease: A patient guideline – JHEP Reports
NICE chronic primary pain guidelines: what the busy GP needs to know.
2 May, 2022 | 00:25h | UTCOriginal Guideline: Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain – National Institute for Health and Care Excellence
Guideline: Management of alcohol-related liver disease.
1 May, 2022 | 23:34h | UTC
Non-Inferiority Trials: Understanding the concepts.
1 May, 2022 | 23:33h | UTCNon-Inferiority Trials: Understanding the Concepts – Students 4 Best Evidence
Related:
Non-inferiority trials in cardiology: what clinicians need to know – Heart
M-A: Transradial vs. transfemoral approach for percutaneous coronary intervention in patients with ST-elevation myocardial infarction.
1 May, 2022 | 23:29h | UTC
Commentary on Twitter
Radial first, even for PCI in #STEMI patients with #CardiogenicShock? A meta-analysis of the available data in https://t.co/saeRZFAsqg #EHJQCCO #CathLab #ACS @cpgale3 @diogoasantosfer pic.twitter.com/RSvb2injLM
— European Society of Cardiology Journals (@ESC_Journals) May 1, 2022
Systematic Review: Negative pressure wound therapy for surgical wounds healing by primary closure.
1 May, 2022 | 23:32h | UTCNegative pressure wound therapy for surgical wounds healing by primary closure – Cochrane Library
Summary: Dressings that use negative pressure for closed surgical wounds – Cochrane Library
Commentary on Twitter
https://twitter.com/CochraneUK/status/1520732015972208647
RCT: Hybrid vs. open surgical reconstruction for iliofemoral occlusive disease.
1 May, 2022 | 23:28h | UTC
Clinical management of metastatic colorectal cancer in the era of precision medicine.
1 May, 2022 | 23:27h | UTC
Controversies in enhanced recovery after cardiac surgery.
1 May, 2022 | 23:25h | UTCControversies in enhanced recovery after cardiac surgery – Perioperative Medicine
Related:
See also: Enhanced Recovery After Surgery (ERAS) Society Guidelines
Review: Novel approaches to imaging the pulmonary vasculature and right heart.
2 May, 2022 | 00:29h | UTCNovel Approaches to Imaging the Pulmonary Vasculature and Right Heart – Circulation Research (free for a limited period)
10-year results of a RCT: Effects of parathyroidectomy vs. observation on morbidity and mortality in patients with mild primary hyperparathyroidism.
1 May, 2022 | 23:22h | UTCMortality and Morbidity in Mild Primary Hyperparathyroidism: Results From a 10-Year Prospective Randomized Controlled Trial of Parathyroidectomy Versus Observation – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Parathyroidectomy No Better for Mild Primary Hyperparathyroidism – HealthDay
Commentary on Twitter
#ICYMI: new RCT from @UniOslo found early surgery does not appear to reduce negative outcomes for healthy patients with primary #hyperparathyroidism: https://t.co/RnWadklja2 pic.twitter.com/vuS4xSt128
— Annals of Int Med (@AnnalsofIM) April 25, 2022