All Posts | Links Medicus - Free Medical News & Perspective

RCT | Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast.

9 Aug, 2022 | 12:46h | UTC

Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3–07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study – The Lancet (link to abstract – $ for full-text)

RCT | Effect of a comprehensive telehealth intervention vs. telemonitoring and care coordination in patients with persistently poor type 2 diabetes control.

9 Aug, 2022 | 12:44h | UTC

Effect of a Comprehensive Telehealth Intervention vs Telemonitoring and Care Coordination in Patients With Persistently Poor Type 2 Diabetes Control: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Comprehensive telehealth intervention effective for reducing HbA1c in poorly controlled diabetes – Physician’s Weekly

Commentary on Twitter

A comprehensive telehealth intervention improved HbA1c in persistently poorly-controlled type 2 diabetes compared to a simpler telehealth intervention; the comprehensive telehealth approach may warrant implementation in systems with appropriate resources. https://t.co/qXnuclyipQ

— JAMA Internal Medicine (@JAMAInternalMed) July 29, 2022

Systematic Review | Smoking cessation for secondary prevention of cardiovascular disease.

9 Aug, 2022 | 12:42h | UTC

Smoking cessation for secondary prevention of cardiovascular disease – Cochrane Library

Summary: Does stopping smoking make people with heart disease less likely to have another heart attack? – Cochrane Library

M-A | Immunogenicity, safety, and efficacy of the HPV vaccines among people living with HIV.

9 Aug, 2022 | 12:41h | UTC

Immunogenicity, safety, and efficacy of the HPV vaccines among people living with HIV: A systematic review and meta-analysis – eClinicalMedicine

RCT | Efficacy and safety of intravenous acetaminophen (2 g/day) for reducing opioid consumption in Chinese adults after elective orthopedic surgery.

9 Aug, 2022 | 12:39h | UTC

Efficacy and safety of intravenous acetaminophen (2 g/day) for reducing opioid consumption in Chinese adults after elective orthopedic surgery: A multicenter randomized controlled trial – Frontiers in Pharmacology

M-A | Management of neovascular glaucoma.

9 Aug, 2022 | 12:37h | UTC

A systematic review and meta-analysis of randomised controlled trials in the management of neovascular glaucoma: absence of consensus and variability in practice – Graefe’s Archive for Clinical and Experimental Ophthalmology

Inhaled antibiotics in critical care: state of the art and future perspectives.

9 Aug, 2022 | 12:30h | UTC

Inhaled antibiotics in critical care: State of the art and future perspectives – Infectious Diseases Now

RCT | Effectiveness of Varenicline and Cytisine for alcohol use reduction among people with HIV and substance use.

9 Aug, 2022 | 12:35h | UTC

Effectiveness of Varenicline and Cytisine for Alcohol Use Reduction Among People With HIV and Substance Use: A Randomized Clinical Trial – JAMA Network Open

Commentary: Varenicline and cytisine not more efficacious than nicotine to treat risky drinking and smoking, study says – News Medical / Vanderbilt University Medical Center

Commentary on Twitter

In this RCT, varenicline and cytisine were not more efficacious than nicotine to treat risky drinking and smoking among individuals with HIV; rates of behavior change for alcohol consumption and smoking were high in all treatment groups. #OrigInvestigation https://t.co/h8M6e5nOkf

— JAMA Network Open (@JAMANetworkOpen) August 5, 2022

Review | Role of imaging in CNS infections.

9 Aug, 2022 | 12:26h | UTC

Role of imaging in CNS infections – Indian Journal of Pathology & Microbiology

Systematic Review | Diabetes mellitus and perioperative outcomes.

9 Aug, 2022 | 12:28h | UTC

Diabetes mellitus and perioperative outcomes: a scoping review of the literature – British Journal of Anaesthesia

RCT | Palliative radiation for advanced central lung tumors with intentional avoidance of the esophagus.

9 Aug, 2022 | 12:24h | UTC

Palliative Radiation for Advanced Central Lung Tumors With Intentional Avoidance of the Esophagus (PROACTIVE): A Phase 3 Randomized Clinical Trial – JAMA Oncology

Commentary: Esophagus-Sparing Radiation Fails QOL Test in Lung Cancer— Esophageal-specific quality of life no better, but treatment reduced symptomatic esophagitis – MedPage Today (free registration required)

Commentary on Twitter

PROACTIVE was a phase 3 RCT of 90 pts with incurable lung cancer treated with esophageal sparing IMRT vs. standard palliative RT. ES-IMRT did not improve FACT-E ECS quality of life scores at 2wks but reduced grade≥2 esophagitis (24% vs. 2%). https://t.co/ExIp22WBPe #RadOnc #LCSM pic.twitter.com/lX8lD4Duja

— JAMA Oncology (@JAMAOnc) February 24, 2022

Cohort Study | Impact of low versus negative estrogen/progesterone receptor status on clinico-pathologic characteristics and survival outcomes in HER2-negative breast cancer.

9 Aug, 2022 | 12:20h | UTC

Impact of low versus negative estrogen/progesterone receptor status on clinico-pathologic characteristics and survival outcomes in HER2-negative breast cancer – npj Breast Cancer

Commentary on Twitter

Out on NPJ Breast a new report on #ERlowtumors. No difference in characteristics, pCR rates, RFS os OS compared with #TNBC. Patients with ER-low tumors should be treated as for TNBC. Also, important confounder to remember in HER2-low prognostic analyses.https://t.co/M1GF8eyYbT pic.twitter.com/CrLyUgyhUV

— Paolo Tarantino (@PTarantinoMD) July 11, 2022

Single-arm phase 2 study | Long-term follow-up of combination of B-Cell maturation antigen and CD19 chimeric antigen receptor T cells in multiple myeloma.

9 Aug, 2022 | 12:22h | UTC

Long-Term Follow-Up of Combination of B-Cell Maturation Antigen and CD19 Chimeric Antigen Receptor T Cells in Multiple Myeloma – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentary: Durable Response Achieved With CAR-T Combination in Relapsed/Refractory Multiple Myeloma – Hematology Advisor

Commentary on Twitter

🙌 Combination of anti-BCMA and anti-CD19 CAR T cells induced durable response in patients with relapsed/refractory #MultipleMyeloma ➡️ https://t.co/TkPRcTKSxg #JCO #MMSM pic.twitter.com/0OZAJtTXF1

— Journal of Clinical Oncology (@JCO_ASCO) April 15, 2022

Position statement | Use of albumin in liver cirrhosis.

8 Aug, 2022 | 11:58h | UTC

Position statement on the use of albumin in liver cirrhosis – Annals of Hepatology

ACG Clinical Guideline | Gastroparesis.

8 Aug, 2022 | 12:00h | UTC

ACG Clinical Guideline: Gastroparesis – The American Journal of Gastroenterology

RCT | Effect of once-weekly semaglutide versus thrice-daily insulin aspart, both as add-on to metformin and optimized insulin glargine treatment in participants with type 2 diabetes.

8 Aug, 2022 | 11:56h | UTC

Effect of once-weekly semaglutide versus thrice-daily insulin aspart, both as add-on to metformin and optimized insulin glargine treatment in participants with type 2 diabetes (SUSTAIN 11): A randomized, open-label, multinational, phase 3b trial – Diabetes, Obesity and Metabolism

RCT | Antiseptic skin agents to prevent surgical site infection after incisional surgery.

8 Aug, 2022 | 11:54h | UTC

Antiseptic Skin Agents to Prevent Surgical Site Infection After Incisional Surgery: A Randomized, Three-armed Combined Non-inferiority and Superiority Clinical Trial (NEWSkin Prep Study) – Annals of Surgery (link to abstract – $ for full-text)

Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomised controlled trials – The Lancet Infectious Diseases

Reducing surgical site infections in low-income and middle-income countries (FALCON): a pragmatic, multicentre, stratified, randomised controlled trial – The Lancet

Two randomized trials found monoclonal antibodies are no better than placebo for Parkinson’s Disease.

8 Aug, 2022 | 11:53h | UTC

Study 1: Trial of Cinpanemab in Early Parkinson’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Study 2: Trial of Prasinezumab in Early-Stage Parkinson’s Diseas – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Monoclonal Antibodies No Better Than Placebo for Early Parkinson Disease – HealthDay

Cochrane Collection | Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence.

8 Aug, 2022 | 11:50h | UTC

Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence – Cochrane Library

Systematic Review | Impact of low‐dose computed tomography screening on lung cancer‐related mortality.

8 Aug, 2022 | 11:52h | UTC

Impact of low‐dose computed tomography (LDCT) screening on lung cancer‐related mortality – Cochrane Library

Summary: Impact of computed tomography (CT) on lung cancer screening – Cochrane Library

Association of computed tomography screening with lung cancer stage shift and survival in the United States: quasi-experimental study – The BMJ

Screening for Lung Cancer: CHEST Guideline and Expert Panel Report.

USPSTF Statement: begin screening for lung cancer at age 50 years instead of 55 years for patients at risk

Meta-analysis: Lung cancer screening using low-dose computed tomography reduces lung cancer–specific mortality, albeit with a tradeoff of likely overdiagnosis

Is the contemporary care of older persons with acute coronary syndrome evidence-based?

8 Aug, 2022 | 11:48h | UTC

Is the contemporary care of the older persons with acute coronary syndrome evidence-based? – European Heart Journal Open

Commentary from the author on Twitter

♦️Heart disease leading cause of death in older adults
♦️Less likely to receive guideline recommended treatment
♦️Frailty, multi-morbidity linked to worse outcomes
♦️We explore this in our manuscript led by @GregBMills1
💥Open access for free download😊https://t.co/l452O1QJTJ pic.twitter.com/HCRuwle3KK

— Professor Vijay Kunadian (@VijayKunadian) January 29, 2022

Guidelines for the choice of intravenous fluids for vascular filling in critically ill patients.

8 Aug, 2022 | 11:45h | UTC

Guidelines for the choice of intravenous fluids for vascular filling in critically ill patients, 2021 – Anaesthesia Critical Care & Pain Medicine

Commentary on Twitter

🚨GUIDELINES for THE CHOICE of INTRAVENOUS FLUIDS for VASCULAR FILLING in CRITICALLY ILL PATIENTS 🚨
🦠Sepsis/septic shock
🩸 Haemorrhagic shock
🧠Acute brain failure
🤰 Peri-partum
✨New #guidelines published in #OpenAccess

📄https://t.co/UJyr3tToKS #CriticalCare #Emergency https://t.co/OhcXGL19Au pic.twitter.com/G8QjKFKn9e

— Anaesthesia Critical Care & Pain Medicine (ACCPM) (@AccpmJ) May 31, 2022