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RCT | Among patients with symptomatic intracranial stenosis, the addition of stenting to medical therapy is not better at reducing the risk of stroke or death compared to medical therapy alone.
10 Aug, 2022 | 15:36h | UTCEditorial: Therapeutic Strategies for Intracranial Atherosclerosis – JAMA (free for a limited period)
Commentary: Stenting Hits Another Wall in Intracranial Stenosis Stroke – MedPage Today (free registration required)
Commentary on Twitter
Findings of this #RandomizedClinicalTrial do not support the addition of percutaneous transluminal angioplasty and stenting to medical therapy for the treatment of patients with symptomatic severe intracranial atherosclerotic stenosis. https://t.co/X9qi3WQ0JC pic.twitter.com/rH6aDo4GjV
— JAMA (@JAMA_current) August 9, 2022
RCT | In patients with large vessel occlusion stroke, intravenous Tirofiban before endovascular thrombectomy does not improve functional outcomes.
10 Aug, 2022 | 15:34h | UTCEffect of Intravenous Tirofiban vs Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke: The RESCUE BT Randomized Clinical Trial – JAMA (free for a limited period)
See also: Visual Abstract
Commentary: RESCUE BT: IV Tirofiban No Help During Stroke Thrombectomy – TCTMD
M-A | Association of dual antiplatelet therapy with ticagrelor with vein graft failure after coronary artery bypass graft surgery.
10 Aug, 2022 | 15:32h | UTCAssociation of Dual Antiplatelet Therapy With Ticagrelor With Vein Graft Failure After Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-analysis – JAMA (free for a limited period)
Editorial: Balancing the Risks and Benefits of Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery – JAMA (free for a limited period)
Author Interview: Coronary Artery Bypass Surgery in 2022 – JAMA
News Release: Two-medication strategy offers both benefit and risk after coronary artery bypass surgery – Weill Cornell Medicine
Viewpoint | Making electronic health records both SAFER and SMARTER.
10 Aug, 2022 | 15:28h | UTCMaking Electronic Health Records Both SAFER and SMARTER – JAMA (free for a limited period)
Author Interview: Making Electronic Health Records More Supportive for Clinicians – JAMA
Commentary: Opinion: physicians need to use smarter, safer EHRS – healthleaders
Related:
The EMR has changed the doctor-patient duet into a ménage-à-trois – STAT
The future of electronic health records – Nature
Systematic Review | Catheter‐directed therapies for the treatment of high risk (massive) and intermediate risk (submassive) acute pulmonary embolism.
10 Aug, 2022 | 12:32h | UTC
Cohort Study | Association of younger vs. older ages with changes in incidence of stroke and other vascular events, 2002-2018.
10 Aug, 2022 | 15:30h | UTCAssociation of Younger vs Older Ages With Changes in Incidence of Stroke and Other Vascular Events, 2002-2018 – JAMA (free for a limited period)
See also: Diverging Temporal Trends in Stroke Incidence in Younger vs Older People: A Systematic Review and Meta-analysis – JAMA Neurology (free for a limited period)
Commentaries on Twitter
Data from Oxford area in @JAMA_current show worrisome incr. in stroke rate in adults <55 yrs comparing two time periods. 67% incr seen in younger adults, 15% decr in older adults. Need further study of why young stroke rates are on the rise#MYStrokeCenterhttps://t.co/MG4MgUGAA4
— Seemant Chaturvedi (@ChaturvediNeuro) August 9, 2022
The consistently divergent temporal trend in stroke incidence at younger vs older ages highlights the urgent need to better understand etiology and prevention of stroke at younger ages. https://t.co/phhRcpWwRw
— JAMA Neurology (@JAMANeuro) August 9, 2022
Systematic Review | Patch angioplasty versus primary closure for carotid endarterectomy.
10 Aug, 2022 | 12:30h | UTCPatch angioplasty versus primary closure for carotid endarterectomy – Cochrane Library
Summary: Patch angioplasty versus primary closure for carotid endarterectomy – Cochrane Library
Systematic Review | Laser trabeculoplasty for open‐angle glaucoma and ocular hypertension.
10 Aug, 2022 | 12:28h | UTCLaser trabeculoplasty for open‐angle glaucoma and ocular hypertension – Cochrane Library
Summary: Laser trabeculoplasty for open-angle glaucoma – Cochrane Library
Related Study: Randomized Trial: Selective Laser Trabeculoplasty vs. Eye Drops for First-line Treatment of Ocular Hypertension and Glaucoma
Systematic Review | Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth.
10 Aug, 2022 | 12:26h | UTC
RCT | Thoracic epidural analgesia vs. rectus sheath catheter analgesia after open midline major abdominal surgery.
10 Aug, 2022 | 12:24h | UTC
Non-parenteral Ketamine for depression: a practical discussion on addiction potential and recommendations for judicious prescribing.
10 Aug, 2022 | 12:19h | UTC
Bicuspid aortic valve stenosis: from pathophysiological mechanism, imaging diagnosis, to clinical treatment methods.
10 Aug, 2022 | 12:22h | UTC
Multiple Sclerosis in children: differential diagnosis, prognosis, and disease-modifying treatment
10 Aug, 2022 | 12:18h | UTC
Retrospective cohort study | In patients with recurrent prosthetic joint infection after attempted surgical eradication, chronic antibiotic suppression may be a reasonable strategy in patients who lack or refuse further surgical treatment options.
10 Aug, 2022 | 12:17h | UTCPredictors of Success with Chronic Antibiotic Suppression for Prosthetic Joint Infections – The Journal of Arthroplasty (link to abstract – $ for full-text)
Commentary: Chronic antibiotic suppression may successfully treat periprosthetic joint infections – Healio (free registration required)
Review | Chronic post-surgical pain – update on incidence, risk factors and preventive treatment options.
10 Aug, 2022 | 12:12h | UTC
Advancing digital health applications: priorities for innovation in real-world evidence generation.
10 Aug, 2022 | 12:15h | UTC
Review | Developments in procedural sedation for adults.
10 Aug, 2022 | 12:14h | UTCDevelopments in procedural sedation for adults – BJA Education
RCT | Effectiveness of early time-restricted eating for weight loss, fat loss, and cardiometabolic health in adults with obesity.
9 Aug, 2022 | 12:59h | UTCAuthor Interview: Effectiveness of Early Time-Restricted Eating for Weight Loss and Fat Loss in Adults With Obesity – JAMA
Commentaries:
Time-Restricted Eating to Improve Health—A Promising Idea in Need of Stronger Clinical Trial Evidence – JAMA Internal Medicine (free for a limited period)
Related:
Time-Restricted Eating: Integrating The What With The When – Advances in Nutrition
Calorie Restriction with or without Time-Restricted Eating in Weight Loss- New England Journal of Medicine (link to abstract – $ for full-text)
Review | Anesthesia for bariatric surgery.
10 Aug, 2022 | 12:11h | UTCAnaesthesia for bariatric surgery – BJA Education
AAP Guideline Update | Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation.
9 Aug, 2022 | 13:00h | UTC
RCT | Hughes abdominal closure vs. standard mass closure to reduce incisional hernias following surgery for colorectal cancer.
9 Aug, 2022 | 12:56h | UTC
M-A | Global prevalence and incidence of tinnitus.
9 Aug, 2022 | 12:57h | UTCGlobal Prevalence and Incidence of Tinnitus: A Systematic Review and Meta-analysis – JAMA Neurology (free for a limited period)
Commentary: Review: Global Pooled Prevalence of Tinnitus 14.4 Percent – HealthDay
Commentary on Twitter
The global burden of #tinnitus is large, similar to #migraine and pain, and the lack of effective treatment options justifies a major investment in research in this area. https://t.co/9uVJmnYh9c
— JAMA Neurology (@JAMANeuro) August 8, 2022
Guideline Synopsis | Treatment of Clostridioides difficile infection.
9 Aug, 2022 | 12:54h | UTCTreatment of Clostridioides difficile Infection – JAMA (free for a limited period)
Original Guideline: ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections – American Journal of Gastroenterology
Related Guidelines:
Commentary on Twitter
A summary of @AmCollegeGastro’s 2021 guidelines on treatment of Clostridioides difficile infection. https://t.co/QzrMa71ttu
— JAMA (@JAMA_current) August 8, 2022
Diagnostic Test Interpretation | Serum Cystatin C for estimation of glomerular filtration rate.
9 Aug, 2022 | 12:52h | UTCSerum Cystatin C for Estimation of GFR – JAMA (free for a limited period)
Commentary on Twitter
An 80-year-old man with #type2diabetes and #hypertension was referred to the nephrology clinic for assessment of persistent hyperkalemia despite discontinuation of his ACE inhibitor. #JAMADiagnosticTestInterpretation https://t.co/kxg0yHeGUr
— JAMA (@JAMA_current) August 8, 2022
Changes to the European Resuscitation Council guidelines for adult resuscitation.
9 Aug, 2022 | 12:50h | UTCChanges to the European Resuscitation Council guidelines for adult resuscitation – BJA Education
Related:
2021 Resuscitation Guidelines – Resuscitation Council UK