All Posts
Systematic Review | Therapeutic drug monitoring of biopharmaceuticals in inflammatory rheumatic and musculoskeletal disease.
25 Aug, 2022 | 11:55h | UTC
Vasospastic angina: a contemporary review of its pathophysiology, diagnosis and management.
25 Aug, 2022 | 11:53h | UTC
Commentary on Twitter
Almost 50% of angina pts have non obstructive CAD on cath: 3 types of ANOCA & each has its’ own Rx:
🫀Coronary micro vascular dz B blockers
🫀Coronary endothelial dysfunction (? Rx)
🫀Coronary vasospasm (Ca channel blockers/nitrates) @minissianm https://t.co/zJjhEDAs0K pic.twitter.com/zxDjDoM6ru— Ritu Thamman MD (@iamritu) August 20, 2022
Review | Prevention of first decompensation in advanced chronic liver disease.
25 Aug, 2022 | 11:52h | UTCPrevention of First Decompensation in Advanced Chronic Liver Disease – Clinics in Liver Disease
Commentary on Twitter
Presentations and drivers of decompensated liver disease #LiverTwitter #MedEdhttps://t.co/3h5eJ0tWVM pic.twitter.com/k6A00EGM8L
— Keith Siau (@drkeithsiau) August 20, 2022
Cohort Study | Analysis of neonatal neurobehavior and developmental outcomes among preterm infants.
25 Aug, 2022 | 11:51h | UTCInvited commentary: Neurobehavior in the Neonatal Intensive Care Unit—Window to the Future? – JAMA Network Open
Commentary on Twitter
A new study in @JAMANetworkOpen examines the association between medical and neurobehavioral risk at discharge and neurodevelopmental outcomes at 2 years https://t.co/1hAJwIpLQp #EBNEOalerts #neoEBM #neotwitter pic.twitter.com/a0F01LqUcd
— Evidence-Based Neo (@EBNEO) July 27, 2022
Study Commentary | Is the evidence strong for spinal cord stimulation for diabetic neuropathy? Not all experts agree.
25 Aug, 2022 | 11:52h | UTCOriginal Study: RCT: Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy
Study Commentary | Digital youth mental health interventions: will the evidence ever catch up?
25 Aug, 2022 | 11:54h | UTCDigital youth mental health interventions: will the evidence ever catch up? – The Mental Elf
Original Study: Evidence on Digital Mental Health Interventions for Adolescents and Young People: Systematic Overview – JMIR Mental Health
Review | Subphenotypes in acute kidney injury.
25 Aug, 2022 | 11:50h | UTCSubphenotypes in acute kidney injury: a narrative review – Critical Care
Observational study suggests frequent aspirin use may reduce the risk of ovarian cancer.
25 Aug, 2022 | 11:49h | UTCModification of the Association Between Frequent Aspirin Use and Ovarian Cancer Risk: A Meta-Analysis Using Individual-Level Data From Two Ovarian Cancer Consortia – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentaries:
Frequent Aspirin Use Tied to Lower Ovarian Cancer Risk – HealthDay
Commentary on Twitter
💊 Frequent aspirin use ⬇️ #OvarianCancer risk among women with other risk factors for ovarian cancer
Read more in #JCO: https://t.co/QV4bK0lB5M #prevention #gyncsm #ovca @LaurenMHurwitz @b_trabert pic.twitter.com/xvU1yb60mi
— Journal of Clinical Oncology (@JCO_ASCO) August 18, 2022
RCT | Nivolumab vs. nivolumab plus docetaxel for previously treated advanced or recurrent immune checkpoint inhibitor-naïve non-small-cell lung cancer.
25 Aug, 2022 | 11:48h | UTC
USPSTF Recommendation Statement | Statin use for the primary prevention of cardiovascular disease in adults.
24 Aug, 2022 | 14:21h | UTCEditorials:
Author Interview: USPSTF Recommendation: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults – JAMA
Patient Page: Statins for the Prevention of Cardiovascular Disease – JAMA
Commentary: Latest statins guidance keeps more conservative approach to preventing first stroke or heart attack – CNN
RCT | In women at risk of preterm delivery, half dose antenatal Dexamethasone was NOT noninferior compared to full dose Dexamethasone on neonatal outcomes.
24 Aug, 2022 | 14:20h | UTCNeonatal outcomes for women at risk of preterm delivery given half dose versus full dose of antenatal betamethasone: a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
On 50th anniversary of Liggins & Howie's discovery of benefits of antenatal steroids for preterm birth, new study in @TheLancet confirms full dose (11.4 mg x 2) of betamethasone is necessary for optimum benefit. https://t.co/VgjtprM0W8#neoTwitter #obstetrics @EBNEO @ESPR_EBN pic.twitter.com/Cl1GbzWoRl
— Atul Malhotra (@Atul_Monash) August 19, 2022
Non-nutritive sweeteners affect human microbiomes and can alter glycemic responses.
24 Aug, 2022 | 14:17h | UTCNews Release: Non-nutritive sweeteners affect human microbiomes and can alter glycemic responses – Cell Press
Original Study: Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance – Cell
Commentary on Twitter
The skinny on non-nutritive sweeteners (they are not inert) via a randomized trial & gut #microbiome assessment: impact is individualized and can impair glycemic responsehttps://t.co/B7CUPy7tMf @CellCellPress @SuezLab @EranElinav @segal_eran @WeizmannScience @Yot_Coh @Elinav_Lab pic.twitter.com/Jz7lUkWlNr
— Eric Topol (@EricTopol) August 19, 2022
Retrospective Cohort Study | Clinical and genetic risk factors for acute incident venous thromboembolism in ambulatory patients with COVID-19.
24 Aug, 2022 | 14:17h | UTC
Commentary on Twitter
Ambulatory #COVID19 was associated with a substantially increased risk of incident venous thromboembolism, but this risk was greatly reduced in fully vaccinated people with breakthrough infection. https://t.co/98zKNfEWaU #Research
— JAMA Internal Medicine (@JAMAInternalMed) August 18, 2022
Monkeypox: a clinical update for pediatricians.
24 Aug, 2022 | 14:19h | UTCMonkeypox: A clinical update for paediatricians – Journal of Pediatrics and Child Health
Related:
CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US.
Update on the Monkeypox Outbreak – JAMA
WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch
Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases
Long-term results of a RCT | Vasopressin and methylprednisolone did not improve outcomes in patients with in-hospital cardiac arrest.
24 Aug, 2022 | 14:15h | UTC
Retrospective Cohort Study | Association of COVID-19 vs. Influenza with risk of arterial and venous thrombotic events among hospitalized patients.
24 Aug, 2022 | 14:16h | UTCCommentary: Higher risk of vein blood clots in COVID vs flu patients – CIDRAP
News Release: People with Severe COVID-19 Face Increased Risk of Life-Threatening Blood Clots – Penn Medicine News
Commentary on Twitter
The risk of blood clots in hospitalized patients with Covid vs influenza was increased 60-90% within 90 days, for venous but not arterial thrombosishttps://t.co/wPHf18NYYB @JAMA_current
Retrospective, much smaller influenza cohort from 2018-2019 pic.twitter.com/sClYHF0J6U— Eric Topol (@EricTopol) August 16, 2022
Guidelines for clinical assessment and management of adult cochlear implantation for single-sided deafness.
24 Aug, 2022 | 14:13h | UTC
Position Statement | Chronic kidney disease as cardiovascular risk factor in routine clinical practice.
24 Aug, 2022 | 14:14h | UTC
M-A of randomized trials | Risk of cutaneous adverse events in cancer patients treated with phosphatidylinositol-3-kinase inhibitors.
24 Aug, 2022 | 14:12h | UTC
Clinical practice guidelines for the management of atopic dermatitis.
24 Aug, 2022 | 14:13h | UTC
Secondary analysis of a RCT | Early rhythm control in patients with atrial fibrillation and high comorbidity burden.
24 Aug, 2022 | 14:11h | UTCEarly Rhythm Control in Patients With Atrial Fibrillation and High Comorbidity Burden – Circulation
Commentary on Twitter
#OriginalResearch: In #EAST_AFNET4, substudy of patients w/ CHA2DS2VASC4 >=4 had decreased composite efficacy outcome of lower CV death, CVA or HF/ACS hospitalization w/ rhythm control, but not in patients with lower como… @AndreasRillig @AndreasMetzner7 https://t.co/izES0WodVQ pic.twitter.com/DVyfWsUsOx
— Circulation (@CircAHA) August 17, 2022
Systematic Review | Anticholinergic burden for prediction of cognitive decline or neuropsychiatric symptoms in older adults with mild cognitive impairment or dementia.
24 Aug, 2022 | 14:10h | UTCRelated:
Commonly-prescribed drugs and dementia: should we be worried? – Evidently Cochrane
How well do you know your anticholinergic (antimuscarinic) drugs? – Therapeutics Initiative
Anticholinergic drugs and risk of dementia: case-control study – The BMJ
Management of hand osteoarthritis: from an US evidence-based medicine guideline to a European patient-centric approach.
24 Aug, 2022 | 14:09h | UTCRelated:
Erosive hand osteoarthritis: latest findings and outlook – Nature Reviews Rheumatology
ACR Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee
Research: Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis
Podcast | USPSTF Update: aspirin for primary prevention of cardiovascular disease.
24 Aug, 2022 | 14:05h | UTC#347 USPSTF Update: Aspirin for Primary Prevention of CVD – The Curbsiders
Related Guideline: USPSTF Recommendation Statement: Aspirin Use to Prevent Cardiovascular Disease.
Related Randomized Trials:
Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease
Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes
Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly
Related Meta-Analysis:
Meta-Analysis: Efficacy and Safety of Aspirin for Primary Prevention of Cardiovascular Events
Related Opinions:
Aspirin for Primary Prevention: Is This the End of the Road?
Evidence evolving on aspirin as prevention – ACP Internist
RCT | Rib fixation is not beneficial for non–ventilator-dependent chest wall injuries.
24 Aug, 2022 | 14:03h | UTCRib fixation in non–ventilator-dependent chest wall injuries: A prospective randomized trial – Journal of Trauma and Acute Care Surgery (link to abstract – $ for full-text)
Commentary on Twitter
Prospective randomized trial assessing #RibFixation in non ventilator dependent rib fracture patients compared to non operative management. Outcomes assessed were pain early, & at 3 & 6 months & quality of life. No benefit of rib fixation was demonstrated. https://t.co/0D9GbJ9Oye pic.twitter.com/b7G3wEPkxx
— Journal of Trauma and Acute Care Surgery (@JTraumAcuteSurg) June 7, 2022