All Posts
Podcast | Myositis and myopathy.
24 Aug, 2022 | 14:04h | UTC#348 Myositis and Myopathy, LIVE! – The Curbsiders
Cluster RCT | Effect of antiseptic bathing with chlorhexidine or octenidine on central line–associated bloodstream infections in intensive care patients.
24 Aug, 2022 | 14:02h | UTCEffect of antiseptic bathing with chlorhexidine or octenidine on central line–associated bloodstream infections in intensive care patients: a cluster-randomized controlled trial – Clinical Microbiology and Infection (link to abstract – $ for full-text)
Commentary on Twitter
Antiseptic bathing for CLABSI prevention:
SW-RCT incl 72 ICUs with 76,815 showed no significant differences between daily bathing with a) 2% chlorhexidine-impregnated cloths vs b) 0.08% octenidine vs c) water & soap in CLAPSI
Thanks to @CritCareReviews https://t.co/Ou3g3ptMLp— Peter Nydahl (@NydahlPeter) May 30, 2022
Evaluating how clear the questions being investigated in randomized trials are: systematic review of estimands.
24 Aug, 2022 | 13:59h | UTC
Commentary from the author Twitter (thread – click for more)
Are randomised trials answering clear & useful questions? We conducted this review of published trials to find out https://t.co/ZO2GacCZ90 @bmj_latest pic.twitter.com/r9VXYvpHRX
— Suzie Cro (@Suzie_cro) August 23, 2022
Using individual participant data to improve network meta-analysis projects.
24 Aug, 2022 | 14:00h | UTC
Commentary on Twitter
Using individual participant data to improve network meta-analysis projects
All the details are explained by @Richard_D_Riley and colleagues.#OpenAccess
📰 https://t.co/r0wdeK6jmd pic.twitter.com/jKp4Z2VklK
— BMJ Evidence-Based Medicine (@BMJ_EBM) August 19, 2022
M-A | Androgen receptor signaling inhibitors in addition to Docetaxel with androgen deprivation therapy for metastatic hormone-sensitive prostate cancer.
24 Aug, 2022 | 13:58h | UTC
Cohort analysis of the relationship between intraoperative complications of cataract surgery and axial length.
24 Aug, 2022 | 13:57h | UTC
Cluster RCT | Effect of biannual mass azithromycin distributions to preschool-aged children on trachoma prevalence.
24 Aug, 2022 | 13:55h | UTC
Commentary on Twitter
Cluster-randomized trial in trachoma-hypoendemic region of Niger mass azithromycin distributions targeted to pre-school children did not reduce trachoma. #OAResearch https://t.co/G7rfZShdz7 pic.twitter.com/UGUlc0x8G8
— JAMA Network Open (@JAMANetworkOpen) August 23, 2022
Review | New concepts in the treatment of hepatocellular carcinoma.
24 Aug, 2022 | 13:56h | UTCNew concepts in the treatment of hepatocellular carcinoma – UEG Journal
Long-term follow up of a RCT | Precancerous cervical lesions caused by non-vaccine-preventable HPV types after vaccination with the bivalent AS04-adjuvanted HPV vaccine.
24 Aug, 2022 | 13:53h | UTCPrecancerous cervical lesions caused by non-vaccine-preventable HPV types after vaccination with the bivalent AS04-adjuvanted HPV vaccine: an analysis of the long-term follow-up study from the randomised Costa Rica HPV Vaccine Trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary on Twitter
Virological replacement & clinical unmasking are two phenomena of interest following #HPVvaccination. We show that clinical unmasking might attenuate long-term reductions in cervical precancer following successful implementation of HPV vax programs in highly screened populations https://t.co/Z7dGQNG1kG
— Monica Sierra (@MonicaSSierra) June 14, 2022
Systematic Review | Interventions to reduce computed tomography usage in the emergency department.
24 Aug, 2022 | 13:54h | UTC
RCT | Efficacy of Ubrogepant in the acute treatment of migraine with mild pain versus moderate or severe pain.
24 Aug, 2022 | 13:52h | UTC
Updated systematic review and critical appraisal: prediction models for diagnosis and prognosis of covid-19.
23 Aug, 2022 | 13:31h | UTCCommentary: Update to living systematic review on prediction models for diagnosis and prognosis of covid-19 – The BMJ
Commentary on Twitter
NEW update in @bmj_latest
606 prognostic models for #COVID19 identified – 29 had low risk of bias, 32 had unclear risk of bias, AND 545 HAD HIGH RISK OF BIAS!
+Poorly reported – use TRIPOD please https://t.co/tVA0xHXdRu#epitwitter #statstwitter pic.twitter.com/n71vdgY8wM
— Gary Collins 🇪🇺 (@GSCollins) August 22, 2022
Update on applications and limitations of perioperative tranexamic acid.
23 Aug, 2022 | 13:30h | UTCUpdate on Applications and Limitations of Perioperative Tranexamic Acid – Anesthesia & Analgesia (free for a limited period)
Infographic: Tranexamic Acid: Current Knowns and Unknowns – Anesthesia & Analgesia (free for a limited period)
Much anticipated Alzheimer Disease prevention trial finds no clinical benefit from drug targeting amyloid; highlights need to consider other approaches.
23 Aug, 2022 | 13:29h | UTCMuch Anticipated Alzheimer Disease Prevention Trial Finds No Clinical Benefit From Drug Targeting Amyloid; Highlights Need to Consider Other Approaches – JAMA (free for a limited period)
Commentary on Twitter
The hypothesis that amyloid deposits in the brain cause Alzheimer disease has gotten many hits over the years, as one antiamyloid treatment after another failed to show a clinical benefit. Time to move on? @RitaRubin writes about the debate. https://t.co/913A0WWcR7
— JAMA (@JAMA_current) August 17, 2022
A cohort study of patients with mild traumatic brain injury found that 56% of patients had incomplete recovery after 6 months.
23 Aug, 2022 | 13:27h | UTCCommentary: Incomplete Recovery Common 6 Months After Mild TBI – Medscape (free registration required)
Commentary on Twitter (thread – click for more)
1/🧵Mild Traumatic Brain Injury (TBI) isn’t “Mild” 🧠
Our daughter fell off a high diving board headfirst to cement years ago. Though she had 2 cracks through her foramen magnum, her GCS was 15 & CT had no bleeding.
“She’s OK,” they said.
Wrong answer 😔#TrackTBI Data… pic.twitter.com/1FZuRnt4so— WesElyMD (@WesElyMD) August 22, 2022
Study Commentary | Non-sterile gloves for suturing traumatic lacerations?
23 Aug, 2022 | 13:29h | UTCNon-Sterile Gloves for Suturing Traumatic Lacerations? – RebelEM
Original Study: Non-sterile gloves and dressing versus sterile gloves, dressings and drapes for suturing of traumatic wounds in the emergency department: a non-inferiority multicentre randomised controlled trial – Emergency Medicine Journal (link to abstract – $ for full-text)
Risk of myocarditis after sequential doses of COVID-19 vaccine vs. after SARS-CoV-2 infection by age and sex.
23 Aug, 2022 | 13:25h | UTCNews Release: Myocarditis risk significantly higher after COVID-19 infection vs. after a COVID-19 vaccine – Circulation
M-A | Incidence and mortality of non-AIDS-defining cancers among people living with HIV.
23 Aug, 2022 | 13:26h | UTCRelated: Study: Cancer Patients with HIV Infection Have Worse Outcomes
M-A | Incubation period of COVID-19 caused by unique SARS-CoV-2 strains.
23 Aug, 2022 | 13:24h | UTC
Guideline | Management of adults with diabetes on dialysis.
23 Aug, 2022 | 13:16h | UTCManagement of adults with diabetes on dialysis – Joint British Diabetes Societies for Inpatient Care (PDF)
News Release: Latest JBDS dialysis guideline published – Diabetes Times
Evidence-based clinical practice guidelines for chronic pancreatitis.
23 Aug, 2022 | 13:15h | UTCRelated:
ACG Clinical Guideline: Chronic Pancreatitis – American Journal of Gastroenterology
Pancreatitis – National Institute for Health and Care Excellence
Guidelines for the understanding and management of pain in chronic pancreatitis – Pancreatology
Guideline | Application of anti-seizure medications in the perioperative period of supratentorial craniocerebral surgery.
23 Aug, 2022 | 13:13h | UTC
Review | Dangerous causes of nausea/vomiting beyond the GI system.
23 Aug, 2022 | 13:13h | UTCDangerous Causes of Nausea/Vomiting Beyond the GI System – emDocs
Observational analysis shows chronic kidney disease is associated with increased risk of intracerebral hemorrhage.
23 Aug, 2022 | 13:12h | UTCAssociation of Chronic Kidney Disease With Risk of Intracerebral Hemorrhage – JAMA Neurology (link to abstract – $ for full-text)
Case-control study | Assessment of outcomes from 1-year surveillance after detection of early gastric cancer among patients at high risk.
23 Aug, 2022 | 13:11h | UTCCommentary: Intensive Endoscopy Might Not Be One-and-Done for Gastric Cancer Surveillance — High-risk group had similar new lesion detection rates initially and at 15 months – MedPage Today (free registration required)
Commentary on Twitter
Among patients with a high risk of gastric cancer, 1-year surveillance was warranted even after intensive endoscopic examination using both white light and narrow-band imaging. https://t.co/3KIghTavjb
— JAMA Network Open (@JAMANetworkOpen) August 19, 2022