All Posts
RCT | Rezvilutamide vs. Bicalutamide in combination with androgen-deprivation therapy in patients with high-volume, metastatic, hormone-sensitive prostate cancer.
11 Sep, 2022 | 22:52h | UTCCommentaries:
Treatment options for metastatic hormone-sensitive prostate cancer – The Lancet Oncology
Rezvilutamide benefits shown in metastatic hormone-sensitive prostate cancer – medwire News
Commentary on Twitter
In a preplanned interim analysis of the phase III CHART trial in pts with high-volume mHSPC, rezvilutamide +ADT improve PFS (HR 0.44, 95% CI 0.33–0·.8; P<0.0001) & OS (HR 0.58, 95% CI 0.44–0.77]; P=0.0001) compared with bicalutamide + ADT: https://t.co/42IVnDUxfH #PCSM #uroonc
— NatureRevClinOncol (@NatRevClinOncol) September 7, 2022
Guidelines for cancer treatment during pregnancy: ethics-related content evolution and implications for clinicians.
11 Sep, 2022 | 22:47h | UTC
Five-year outcomes in patients with fully magnetically levitated vs. axial-flow left ventricular assist devices in the MOMENTUM 3 randomized trial.
11 Sep, 2022 | 22:43h | UTCFive-Year Outcomes in Patients With Fully Magnetically Levitated vs Axial-Flow Left Ventricular Assist Devices in the MOMENTUM 3 Randomized Trial – JAMA (free for a limited period)
Commentary on Twitter
Among patients with advanced #heartfailure, receipt of a fully magnetically levitated centrifugal-flow LVAD vs axial-flow LVAD was associated with a better composite outcome and higher likelihood of overall survival at 5 years. #Research https://t.co/S0KdHp0tAO
— JAMA (@JAMA_current) September 8, 2022
A randomized crossover trial with 12 patients showed that a bihormonal “artificial pancreas” with closed-loop glucose control increases patients’ time on euglycemia after total pancreatectomy.
11 Sep, 2022 | 22:45h | UTCBihormonal Artificial Pancreas With Closed-Loop Glucose Control vs Current Diabetes Care After Total Pancreatectomy: A Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Commentary: Novel Bihormonal Artificial Pancreas Beneficial After Pancreatectomy – HealthDay
Survey | Medical counseling on sexual enrichment aids: women’s preferences and medical practitioner expertise.
11 Sep, 2022 | 22:42h | UTC
Screening for high-risk human papillomavirus using passive, self-collected menstrual blood.
11 Sep, 2022 | 22:41h | UTCCommentary: Pap smears, be gone? Using menstrual blood to detect HPV – Stanford Medicine
Commentary on Twitter
FREE: Screening for High-Risk Human Papillomavirus Using Passive, Self-Collected Menstrual Blood #obgyn #HPV #GYN https://t.co/zLno2ab605 pic.twitter.com/mfPGjlTLdD
— The Green Journal (@greenjrnl) September 1, 2022
Network M-A | Comparative efficacy of lipid‐lowering therapies added to maximally tolerated statins for the reduction of LDL cholesterol.
11 Sep, 2022 | 22:38h | UTC
Study shows vaginal birth is feasible in some patients with low-lying placenta.
11 Sep, 2022 | 22:39h | UTCCommentary: Vaginal birth possible in 50% of women with low-lying placenta – MDedge
RCT | Effects of Nicorandil administration on infarct size in patients with ST‐Segment–Elevation Myocardial Infarction undergoing primary percutaneous coronary intervention.
11 Sep, 2022 | 22:37h | UTC
Nonadherence was revealed through measurements of serum concentrations of antihypertensive drugs in one-third of patients with resistant hypertension previously evaluated as adherent.
11 Sep, 2022 | 22:35h | UTC
M-A | Performance of single serum progesterone in the evaluation of symptomatic first-trimester pregnant patients.
11 Sep, 2022 | 22:32h | UTCPerformance of single serum progesterone in the evaluation of symptomatic first-trimester pregnant patients: a systematic review and meta-analysis – Canadian Journal of Emergency Medicine (if the link is paywalled, try this one)
M-A | Combination therapy with rifaximin and lactulose in hepatic encephalopathy.
11 Sep, 2022 | 22:33h | UTCCommentary: Rifaximin Plus Lactulose Linked to Greater Effectiveness, Decreased Mortality in HE – AJMC
Systematic Review | Long-term outcomes after non-traumatic out-of-hospital cardiac arrest in pediatric patients.
11 Sep, 2022 | 22:30h | UTC
Systematic Review | Surgery for the treatment of obesity in children and adolescents.
11 Sep, 2022 | 22:29h | UTCSurgery for the treatment of obesity in children and adolescents – Cochrane Library
Summary: Surgery for the treatment of obesity in children and adolescents – Cochrane Library
RCT | Adjuvant atezolizumab fails to improve outcomes in patients with renal cell carcinoma at increased risk of recurrence following resection.
11 Sep, 2022 | 22:28h | UTCAdjuvant atezolizumab versus placebo for patients with renal cell carcinoma at increased risk of recurrence following resection (IMmotion010): a multicentre, randomised, double-blind, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentaries:
Adjuvant atezolizumab falls short in renal cell carcinoma – Urology Times
IMmotion010 does not support adjuvant atezolizumab in intermediate-, high-risk RCC – medwire News
Commentary from the author on Twitter (thread – click for more)
Grateful to @TheLancet for allowing us to publish our experience with #adjuvant #atezolizumab (#IMmotion010) simultaneous w the presentation by #AxelBex at #ESMO22. It's interesting to envision how this data impacts current landscape (link below): (1/10) https://t.co/F5Y5HyNaxY pic.twitter.com/klAYWAQVwV
— Sumanta K. Pal, MD, FASCO (@montypal) September 10, 2022
Phase 2 RCT | Adjuvant nivolumab plus ipilimumab or nivolumab alone versus placebo in patients with resected stage IV melanoma with no evidence of disease.
11 Sep, 2022 | 22:25h | UTC
RCT | Overall survival with maintenance Olaparib at a 7-year follow-up in patients with newly diagnosed advanced ovarian cancer and a BRCA mutation.
11 Sep, 2022 | 22:21h | UTC
RCT | Busulfan plus Cyclophosphamide is noninferior to total body irradiation plus Cyclophosphamide for adults Acute B Lymphoblastic Leukemia.
11 Sep, 2022 | 22:24h | UTC
Large study unravels the risk factors for heart failure among childhood cancer survivors.
11 Sep, 2022 | 22:22h | UTC
Cluster RCT | Umbilical cord milking may improve health in non-vigorous term and near-term infants.
8 Sep, 2022 | 14:47h | UTCNews Release: Umbilical cord milking may improve health in non-vigorous term and near-term infants – NIH News Releases
Original Study: Umbilical cord milking in non-vigorous infants: A cluster-randomized crossover trial – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)
Commentary on Twitter
Does milking the umbilical cord benefit infants non-vigorous at birth?
A new RCT by @NeoAnup published in @AJOG_thegray evaluates this https://t.co/M5RRAzdEHz#neoEBM #neoTwitter #EBNEOAlerts pic.twitter.com/mZnSKjcGNt
— Evidence-Based Neo (@EBNEO) August 20, 2022
Study suggests many stable patients with ST-Elevation Myocardial Infarction may not require routine admission to a cardiac intensive care unit following PCI reperfusion.
8 Sep, 2022 | 14:45h | UTC
Early versus delayed non–vitamin k antagonist oral anticoagulant therapy after acute ischemic stroke in atrial fibrillation: a registry-based randomized controlled noninferiority study.
8 Sep, 2022 | 14:46h | UTCEarly Versus Delayed Non–Vitamin K Antagonist Oral Anticoagulant Therapy After Acute Ischemic Stroke in Atrial Fibrillation (TIMING): A Registry-Based Randomized Controlled Noninferiority Study – Circulation (free for a limited period)
Commentary on Twitter
Congrats to my good friend/colleague @BoNorrving for the TIMING study! Starting NOAC after stroke d/t AF <4 d is safe (no ICH) and = or better than 5-10 d. Registry-based, pragmatic, investigator led, PROBE design. High value = science first approach.
https://t.co/35qiZ5Ivoa— Dr. Lee Schwamm (@Braindoc_MGH) September 7, 2022
Cohort Study | Long-term cardiac pathology in individuals with mild initial COVID-19 illness.
8 Sep, 2022 | 14:44h | UTCLong-term cardiac pathology in individuals with mild initial COVID-19 illness – Nature Medicine
Review | COVID-19 in children.
8 Sep, 2022 | 14:43h | UTCCOVID-19 in Children – Pediatric Clinics of North America
Guideline Summary | Management of patients with suspected or confirmed antibiotic allergy.
8 Sep, 2022 | 14:42h | UTCRelated:
M-A: Most patients with allergy to Penicillin can be given Cefazolin
Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy
Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule
NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk