All Posts
RCT | Methotrexate may increase response rates in patients with uncontrolled gout receiving Pegloticase.
19 Sep, 2022 | 12:38h | UTCCommentary: Data Now Out for Pegloticase-MTX Combo Gout Treatment – MedPage Today (free registration required)
Systematic Review | Debulking hysterectomy followed by chemoradiotherapy vs. chemoradiotherapy alone for women with locally advanced cancer of the cervix – not enough evidence to guide recommendations.
19 Sep, 2022 | 12:39h | UTC
M-A of randomized trials | Transanal tube vs. defunctioning stoma after low anterior resection for rectal cancer.
19 Sep, 2022 | 12:37h | UTC
M-A | Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide.
19 Sep, 2022 | 12:36h | UTC
RCT | Olokizumab, a monoclonal antibody against interleukin-6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by tumor necrosis factor inhibitor therapy.
19 Sep, 2022 | 12:35h | UTC
M-A of randomized trials | Ondansetron vs. Metoclopramide for managing hyperemesis gravidarum.
19 Sep, 2022 | 12:34h | UTCCommentary: Ondansetron or metoclopramide, which is better for managing hyperemesis gravidarum? – Medical Dialogues
The risk of subsequent surgery following bowel resection for Crohn’s disease in a national cohort of 19,207 patients.
19 Sep, 2022 | 12:33h | UTCThe risk of subsequent surgery following bowel resection for Crohn’s disease in a national cohort of 19,207 patients – Colorectal Disease (link to abstract – $ for full-text)
Commentary: Investigators Assess Risk of Further Surgery for Crohn’s Disease Patients – HCPLive
RCT | Intensity-modulated radiotherapy vs. stereotactic body radiotherapy for prostate cancer.
19 Sep, 2022 | 12:31h | UTCIntensity-modulated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): 2-year toxicity results from an open-label, randomised, phase 3, non-inferiority trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary from the author on Twitter (thread – click for more)
My first Tweetorial 🧵 2 year toxicity results of PACE B published here. Big thanks to the 🇬🇧🇨🇦 and🇮🇪collaborators and the 874 men with prostate cancer who made this trial possible https://t.co/mERz2ox8TM
— Alison Tree 💙 (@alison_tree) September 14, 2022
Phase 2 RCT | Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma.
19 Sep, 2022 | 12:32h | UTCCombined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial – The Lancet (free registration required for full-text)
ASCO Rapid Recommendation | Systemic therapy update on 177Lutetium-PSMA-617 for metastatic castration-resistant prostate cancer.
19 Sep, 2022 | 12:31h | UTC
Review | Aerosol delivery of lung surfactant and nasal CPAP in the treatment of neonatal respiratory distress syndrome.
19 Sep, 2022 | 12:29h | UTC
Nutrition assessment and management in patients with cirrhosis and cognitive impairment: a comprehensive review of literature.
19 Sep, 2022 | 12:29h | UTCCommentary: Review Outlines Nutrition Assessment, Management in Patients With Cirrhosis – AJMC
The Lancet Commission on lessons for the future from the COVID-19 pandemic – “a massive global failure.”
16 Sep, 2022 | 13:03h | UTCHomepage: The Lancet COVID-19 Commission
The Lancet Commission on lessons for the future from the COVID-19 pandemic
Editorial: COVID-19: the case for prosociality
Infographic: COVID-19 response: a massive global failure
Commentaries:
WHO responds to The Lancet COVID-19 Commission – World Health Organization
Covid-19: Commission describes “massive global failures” of pandemic response – The BMJ
Lancet Commission on COVID-19 response: ‘Massive global failure’ – CIDRAP
Update | Management of hepatorenal syndrome in liver cirrhosis.
19 Sep, 2022 | 12:27h | UTC
Guideline Synopsis | AHA/ACC Guideline for the management of heart failure.
16 Sep, 2022 | 13:01h | UTCManagement of Heart Failure – JAMA (free for a limited period)
Original Article: #ACC22 – 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure.
The Lancet Commission | Towards the elimination of chronic obstructive pulmonary disease.
16 Sep, 2022 | 13:02h | UTCHomepage: Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission – The Lancet
Commission: Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission
Editorial: COPD: from an end-stage disease to lifelong lung health
Invited Commentary: Classification of COPD: fostering prevention and precision medicine in the Lancet Commission on COPD
Commentary: Proposed classification of COPD according to major risk factors – News Medical
AHA Scientific Statement | Management of patients at risk for and with left ventricular thrombus.
16 Sep, 2022 | 13:00h | UTC
RCT | Among neonates with probable bacterial infection, switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) was noninferior to a full course of intravenous antibiotics and resulted in shorter hospitalization (median duration of 3.4 vs. 6.8 days).
16 Sep, 2022 | 12:59h | UTCEfficacy and safety of switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) versus a full course of intravenous antibiotics in neonates with probable bacterial infection (RAIN): a multicentre, randomised, open-label, non-inferiority trial – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)
Commentary: Dutch team devise less painful ‘drip and drink’ antibiotics treatment for babies – Dutch News
Commentaries on Twitter
*New trial*—early switch to #OralAntibiotics is not inferior to full-course IV antibiotics in #neonates with probable bacterial infection; & adverse events were not increased with use of oral antibiotics
By @IKMReiss @karelallegaert & colleagues
https://t.co/2yzeh3ptuc pic.twitter.com/BgBosxfECC
— The Lancet Child & Adolescent Health (@LancetChildAdol) September 12, 2022
In term and near-term infants <28 days with probable bacterial infection, how safe is it to switch to oral Amox-Clav as opposed to completing a course of intravenous antibiotics? A new RCT in @Lancet tries to answer this question.https://t.co/M2Za54cfxF#EBNeoAlerts#NeoEBM pic.twitter.com/zKpIiW1Whx
— Evidence-Based Neo (@EBNEO) September 12, 2022
(Thread – click for more)
Efficacy & safety of switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) vs full course of IV antibiotics in neonates with probable bacterial infection (RAIN):multicentre, randomised,open-label,non-inferiority trial -The Lancet https://t.co/mcyr9bILRq
— Prof. Dr. Sanjeev Bagai (@BagaiDr) September 13, 2022
Study | The specificity and positive predictive value of high-sensitivity cardiac troponin I for the diagnosis of myocardial infarction are reduced in older individuals.
16 Sep, 2022 | 12:57h | UTCInfluence of Age on the Diagnosis of Myocardial Infarction – Circulation
RCT | Short-term outcomes of laparoscopy-assisted vs. open surgery for patients with low rectal cancer.
16 Sep, 2022 | 12:58h | UTC
Commentary on Twitter
https://twitter.com/JAMAOnc/status/1570532915393744896
Consensus Statement | How to optimize the adherence to a guideline-directed medical therapy in the secondary prevention of cardiovascular diseases.
16 Sep, 2022 | 12:56h | UTC
Transesophageal echocardiography in the emergency department: a comprehensive guide for acquisition, implementation, and quality assurance.
16 Sep, 2022 | 12:54h | UTC
Review | Obesity and contraceptive use: impact on cardiovascular risk.
16 Sep, 2022 | 12:53h | UTCObesity and contraceptive use: impact on cardiovascular risk – ESC Heart Failure
News Release: Combined birth control pill linked with increased risk of blood clots in obese women – European Society of Cardiology
Systematic Review | The effects of water compared with other solutions for wound cleansing – not enough evidence to guide recommendations.
16 Sep, 2022 | 12:52h | UTCWater for wound cleansing – Cochrane Library
Summary: The effects of water compared with other solutions for wound cleansing – Cochrane Library
Global, regional, and national burdens of HIV and other sexually transmitted infections in adolescents and young adults aged 10–24 years from 1990 to 2019: a trend analysis based on the Global Burden of Disease Study 2019.
16 Sep, 2022 | 12:50h | UTCGlobal, regional, and national burdens of HIV and other sexually transmitted infections in adolescents and young adults aged 10–24 years from 1990 to 2019: a trend analysis based on the Global Burden of Disease Study 2019 – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)
Commentary on Twitter
New analysis of #GBD data reports the global incidence of #HIV and other #STIs in adolescents and young adults https://t.co/hSjgHMGg4R pic.twitter.com/JBd7Goa9Sa
— The Lancet Child & Adolescent Health (@LancetChildAdol) September 13, 2022