All Posts
Preliminary results of a RCT | Once-only colonoscopy vs. two rounds of fecal immunochemical testing 2 years apart for colorectal cancer screening.
20 Sep, 2022 | 13:29h | UTCOnce-only colonoscopy or two rounds of faecal immunochemical testing 2 years apart for colorectal cancer screening (SCREESCO): preliminary report of a randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Commentary: Two Rounds of FIT vs Single Colonoscopy as a One-time CRC Screening – Medscape (free registration required)
Network M-A | Associations between statins and adverse events in secondary prevention of cardiovascular disease.
20 Sep, 2022 | 13:30h | UTC
Consensus Paper | Pediatric robotic surgery: issues in management.
20 Sep, 2022 | 13:28h | UTC
Guideline on pharmacological interventions for long-term secondary prevention after ischemic stroke or transient ischemic attack.
20 Sep, 2022 | 13:27h | UTCEuropean Stroke Organisation (ESO) guideline on pharmacological interventions for long-term secondary prevention after ischaemic stroke or transient ischaemic attack – European Stroke Journal (free for a limited period)
Guidelines on treatment of patients with intracranial atherosclerotic disease.
20 Sep, 2022 | 13:26h | UTCEuropean Stroke Organisation guidelines on treatment of patients with intracranial atherosclerotic disease – European Stroke Journal (free for a limited period)
Guidelines on management of unruptured intracranial aneurysms.
20 Sep, 2022 | 13:25h | UTCEuropean Stroke Organisation (ESO) guidelines on management of unruptured intracranial aneurysms – European Stroke Journal (free for a limited period)
Guideline on screening for subclinical atrial fibrillation after stroke or transient ischemic attack of undetermined origin.
20 Sep, 2022 | 13:25h | UTCEuropean Stroke Organisation (ESO) guideline on screening for subclinical atrial fibrillation after stroke or transient ischaemic attack of undetermined origin – European Stroke Journal (free for a limited period)
M-A of randomized trials | Hyperthermic intraperitoneal chemotherapy (HIPEC) for the management of primary advanced and recurrent ovarian cancer.
20 Sep, 2022 | 13:23h | UTCRelated:
Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer – New England Journal of Medicine
M-A of randomized trials | Effectiveness and cost-effectiveness of oral nutritional supplements in frail older people who are malnourished or at risk of malnutrition.
20 Sep, 2022 | 13:24h | UTCInvited Commentary: Do oral nutritional supplements effectively reduce malnutrition or its adverse outcomes in older people with frailty? – The Lancet Health Longevity
RCT | Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis.
20 Sep, 2022 | 13:20h | UTCCommentary: Dupilumab Eases Atopic Dermatitis in Children Younger Than 6 Years – HealthDay
Single-arm phase 1/2 study | Tumor-agnostic efficacy and safety of Selpercatinib in patients with RET fusion-positive solid tumors other than lung or thyroid tumors.
20 Sep, 2022 | 13:18h | UTCInvited Commentary: Tissue-agnostic RET inhibition: can you trust your target? – The Lancet Oncology
Commentary from the author on Twitter (thread – click for more)
🥁🚨Hot off the press in Lancet Oncology 👉So honored to share A MAJOR milestone in #PrecisionMedicine
👉Tumour-agnostic efficacy + safety of Selpercatinib in RET fusion-positive solid tumours -LIBRETTO-001 @TheLancetOncol @myESMO #ESMO22 @MDAndersonNews https://t.co/xriueGKju0 pic.twitter.com/e0fkih6Aov— Vivek Subbiah, MD (@VivekSubbiah) September 12, 2022
RCTs | Linzagolix with and without hormonal add-back therapy for the treatment of symptomatic uterine fibroids.
20 Sep, 2022 | 13:19h | UTC
Case report and brief review | Severe thrombotic complications secondary to antiphospholipid syndrome and undiagnosed systemic lupus erythematosus.
20 Sep, 2022 | 13:17h | UTC
RCT | Deucravacitinib vs. placebo and Apremilast in moderate to severe plaque psoriasis.
20 Sep, 2022 | 13:16h | UTC
A simple score to identify increased risk of transthyretin amyloid cardiomyopathy in heart failure with preserved ejection fraction.
20 Sep, 2022 | 13:16h | UTCA Simple Score to Identify Increased Risk of Transthyretin Amyloid Cardiomyopathy in Heart Failure With Preserved Ejection Fraction – JAMA Cardiology (link to abstract – $ for full-text)
Commentary on Twitter
This cohort study found that a simple 6 variable clinical score may be used to guide use of PYP and increase recognition of cardiomyopathy (ATTR-CM) among patients with HFpEF in the community. https://t.co/2fzCZf97Mp #Research
— JAMA Cardiology (@JAMACardio) September 7, 2022
Evaluation of an ambulatory ECG analysis platform using deep neural networks in routine clinical practice.
20 Sep, 2022 | 13:14h | UTC
Commentary on Twitter
An AI-based Holter ECG analysis strategy saves time and performs similarly compared with a conventional approach @EloiMarijon #AHAJournals https://t.co/lK7h0po4xj
— JAHA (@JAHA_AHA) September 15, 2022
RCT | Cerebral embolic protection during transcatheter aortic-valve replacement did not significantly reduce the incidence of periprocedural stroke.
19 Sep, 2022 | 12:49h | UTCCerebral Embolic Protection during Transcatheter Aortic-Valve Replacement – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
PROTECTED TAVR: No Less Stroke With Embolic Protection, but Some See Hope – TCTMD
Presumed Clinical Benefits of TAVR Cerebral Protection Remain Unproven — Large trial comes up short in proving a definitive benefit to debris filters – MedPage Today (free registration required)
News Release: Cerebral Embolic Protection During Transcatheter Aortic-Valve Replacement – Cedars-Sinai
Commentary on Twitter
In a randomized trial involving patients with aortic stenosis, the use of a cerebral protection device during TAVR did not decrease the risk of periprocedural stroke, but there were fewer disabling strokes. #TCT2022 https://t.co/wBgNlgmIty pic.twitter.com/EViLG19shX
— NEJM (@NEJM) September 17, 2022
RCT | Multiple doses of prophylactic intravenous antibiotics are no better than a single dose in implant-based breast reconstruction.
19 Sep, 2022 | 12:48h | UTC
Commentary on Twitter
Multiple-dose antibiotic prophylaxis was not superior to a single-dose regimen in preventing surgical site infection and implant removal after implant-based breast reconstruction in this RCT. https://t.co/p7GbNRMPfW #OAResarch
— JAMA Network Open (@JAMANetworkOpen) September 16, 2022
Cohort Study | Seven healthy lifestyle habits linked to reduced risk of dementia in people with diabetes.
19 Sep, 2022 | 12:45h | UTCAssociation of Combined Healthy Lifestyle Factors With Incident Dementia in Patients With Type 2 Diabetes – Neurology (link to abstract – $ for full-text)
News Release: Seven healthy lifestyle habits may reduce dementia risk for people with diabetes – American Academy of Neurology
Commentary: Lifestyle Factors May Cut Dementia Risk in Patients With Diabetes – HealthDay
Cluster RCT | Effects of real-time prescription benefit recommendations on patient out-of-pocket costs.
19 Sep, 2022 | 12:47h | UTCEffects of Real-time Prescription Benefit Recommendations on Patient Out-of-Pocket Costs: A Cluster Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Invited Commentary: Real-time Prescription Benefit Tools—The Promise and Peril – JAMA Internal Medicine (free for a limited period)
Commentary on Twitter
Real-time Prescription Benefits (RTPB) uses patient out-of-pocket (OOP) cost to recommend lower-cost med alternatives to prescribers. In a RCT, RTPB reduced med OOP costs by 11%, though recommendations were only made for a small proportion of orders. https://t.co/xXviGvnbKw pic.twitter.com/naeciB3CDg
— JAMA Internal Medicine (@JAMAInternalMed) September 12, 2022
M-A | Nonpharmacological interventions to lengthen sleep duration in healthy children.
19 Sep, 2022 | 12:44h | UTCNonpharmacological Interventions to Lengthen Sleep Duration in Healthy Children: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a limited period)
Editorial: Children’s Sleep and Our Power to Improve It – JAMA Pediatrics (free for a limited period)
Commentary: Data Demonstrates the Best Intervention for Pediatric Sleep Health is Earlier Bedtime – HCP Live
Commentary on Twitter
Supporting children to go to bed earlier can increase sleep duration in healthy children, and interventions to encourage earlier bedtimes should be included. https://t.co/i8BzSKwlQX #Research
— JAMA Pediatrics (@JAMAPediatrics) September 14, 2022
Guideline | Procedural sedation in the emergency department.
19 Sep, 2022 | 12:43h | UTCProcedural Sedation in the Emergency Department – Royal College of Emergency Medicine (PDF)
Diet and irritable bowel syndrome: an update from a UK consensus meeting.
19 Sep, 2022 | 12:42h | UTCDiet and irritable bowel syndrome: an update from a UK consensus meeting – BMC Medicine
Related:
M-A | Efficacy of a restrictive diet in irritable bowel syndrome.
10 mistakes in dietary management of irritable bowel syndrome and how to avoid them.
Supplement: Irritable bowel syndrome and related conditions.
RCT: FODMAPs, but not gluten, elicit modest symptoms of irritable bowel syndrome.
British Society of Gastroenterology guidelines on the management of irritable bowel syndrome
Guidelines for the treatment of irritable bowel syndrome
ACG Clinical Guideline: Management of irritable bowel syndrome
M-A: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome
AAP Policy Statement | Helmet use in preventing head injuries in bicycling, snow sports, and other recreational activities and sports.
19 Sep, 2022 | 12:43h | UTCTechnical Report: Helmet Use in Preventing Head Injuries in Bicycling, Snow Sports, and Other Recreational Activities and Sports – Pediatrics
Commentary: Multifaceted Approach Urged for Promoting Helmet Use for Children – HealthDay
RCT | Open-source automated insulin delivery in Type 1 Diabetes.
19 Sep, 2022 | 12:41h | UTCOpen-Source Automated Insulin Delivery in Type 1 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
Video summary: Open-Source Automated Insulin Delivery in Type 1 Diabetes – NEJM
Commentaries:
Automated Insulin Delivery Ups Time in Target Glucose Range in T1D – HealthDay