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RCT | In patients with acute pancreatitis, early aggressive hydration resulted in a higher incidence of fluid overload without improvement in clinical outcomes.

15 Sep, 2022 | 13:15h | UTC

Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis – New England Journal of Medicine (link to abstract – $ for full-text)

 

RCT | Effects of cocoa extract and a multivitamin on cognitive function.

15 Sep, 2022 | 13:14h | UTC

Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial – Alzheimer’s & Dementia

Commentary: Daily multivitamins improved the brain function of seniors in a trial — but plenty of questions remain – STAT

 

Cohort Study | Patients diagnosed with diabetes by oral glucose tolerance test without elevated HbA1c had similar cardiovascular and renal disease risks as those without diabetes.

15 Sep, 2022 | 13:12h | UTC

Risk of Macrovascular and Microvascular Disease in Diabetes Diagnosed Using Oral Glucose Tolerance Test With and Without Confirmation by Hemoglobin A1c: The Whitehall II Cohort Study – Circulation

Commentary: Patients diagnosed by OGTT without elevated HbA1c had similar CV, renal disease risks as those without diabetes – ACP Diabetes

 

Commentary on Twitter

 

New research estimates the overall disease burden of genetic risk factors.

15 Sep, 2022 | 13:13h | UTC

News Release: New research estimates the overall disease burden of genetic risk factors – University of Helsinki

Original Study: Genetic risk factors have a substantial impact on healthy life years – Nature Medicine

 

Commentaries on Twitter

 

RCT | Effect of different itraconazole dosing regimens on cure rates, treatment duration, safety, and relapse rates in adult patients with tinea corporis/cruris.

15 Sep, 2022 | 13:10h | UTC

Effect of Different Itraconazole Dosing Regimens on Cure Rates, Treatment Duration, Safety, and Relapse Rates in Adult Patients With Tinea Corporis/Cruris: A Randomized Clinical Trial – JAMA Dermatology (free for a limited period)

 

Commentary on Twitter

 

Cohort Study | Long-term outcomes among men undergoing active surveillance for prostate cancer.

15 Sep, 2022 | 13:11h | UTC

Long-term Outcomes Among Men Undergoing Active Surveillance for Prostate Cancer in Sweden – JAMA Network Open

Invited Commentary: Exploring the Long-term Outcomes of Active Surveillance Among Men With Prostate Cancer—Best for Whom? – JAMA Network Open

 

RCT | Robotic vs. laparoscopic surgery for middle and low rectal cancer.

15 Sep, 2022 | 13:09h | UTC

Robotic versus laparoscopic surgery for middle and low rectal cancer (REAL): short-term outcomes of a multicentre randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentaries:

Robotic Surgery Tops Laparoscopic Surgery for Middle and Low Rectal Cancer — Randomized trial shows fewer positive circumferential resection margins with robotic technique – MedPage Today (free registration required)

 

Commentaries on Twitter

 

M-A | Role of pessaries in the treatment of pelvic organ prolapse.

15 Sep, 2022 | 13:08h | UTC

Role of Pessaries in the Treatment of Pelvic Organ Prolapse: A Systematic Review and Meta-analysis – Obstetrics & Gynecology (free for a limited period)

 

Consensus recommendations for the use of Automated Insulin Delivery (AID) technologies in clinical practice.

15 Sep, 2022 | 13:06h | UTC

Consensus Recommendations for the Use of Automated Insulin Delivery (AID) Technologies in Clinical Practice – Endocrine Reviews

 

German guidelines on non-alcoholic fatty liver disease.

15 Sep, 2022 | 13:07h | UTC

Updated S2k Clinical Practice Guideline on Non-alcoholic Fatty Liver Disease (NAFLD) issued by the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS) – Zeitschrift für Gastroenterologie

Related:

AGA Clinical Practice Update | Diagnosis and management of nonalcoholic fatty liver disease in lean individuals.

Quality standards for the management of non-alcoholic fatty liver disease (NAFLD): consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology NAFLD Special Interest Group – The Lancet Gastroenterology & Hepatology (free registration required)

Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: A Scientific Statement From the American Heart Association – Arteriosclerosis, Thrombosis, and Vascular Biology

Advancing the global public health agenda for NAFLD: a consensus statement – Nature Reviews Gastroenterology & Hepatology

Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease – Gastroenterology

Non-alcoholic fatty liver disease: A patient guideline – JHEP Reports

 

RCT | Minocycline added to standard antidepressant treatment did not improve symptoms in patients with treatment-resistant depression.

15 Sep, 2022 | 13:04h | UTC

Effect of Minocycline on Depressive Symptoms in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

 

NCCN Guideline | Myeloproliferative neoplasms.

15 Sep, 2022 | 13:05h | UTC

Myeloproliferative Neoplasms, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology – National Comprehensive Cancer Network

 

Systematic Review | Association of HIV infection with cardiovascular pathology based on advanced cardiovascular imaging.

15 Sep, 2022 | 13:02h | UTC

Association of HIV Infection With Cardiovascular Pathology Based on Advanced Cardiovascular Imaging: A Systematic Review – JAMA (free for a limited period)

Editorial: HIV, Subclinical Cardiovascular Disease, and Clinical Progression: Insights From Immunologic Heterogeneity – JAMA (free for a limited period)

 

Cohort Study | A 7-year study of the durability of improvements in pain, physical function, and work productivity after Roux-en-Y gastric bypass and sleeve gastrectomy.

15 Sep, 2022 | 13:03h | UTC

A 7-Year Study of the Durability of Improvements in Pain, Physical Function, and Work Productivity After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy – JAMA Network Open

News Release: Beyond weight loss: Improvements in pain, mobility persist long after bariatric surgery – University of Pittsburgh

Author Interview: Long-term Changes in Pain, Physical Function, and Work Productivity After Bariatric Surgery – JAMA

 

Study reveals the risk factors associated with infection following operative vaginal birth.

15 Sep, 2022 | 13:02h | UTC

Factors associated with infection following operative vaginal birth – a secondary analysis of the ANODE randomized controlled trial – American Journal of Obstetrics and Gynecology

 

Study finds a higher complication rate after acute coronary syndrome in patients with rheumatic immune‐mediated inflammatory diseases.

15 Sep, 2022 | 13:01h | UTC

Outcomes Following Acute Coronary Syndrome in Patients With and Without Rheumatic Immune‐Mediated Inflammatory Diseases – Journal of the American Heart Association

News Release: Study finds higher complication rate after heart attack in people with autoimmune disease – American Heart Association

 

Review | Postoperative acute kidney injury.

15 Sep, 2022 | 13:00h | UTC

Postoperative AKI – Clinical Journal of the American Society of Nephrology

 

Pregnancy-related acute myocardial infarction: a review of the recent literature.

15 Sep, 2022 | 12:59h | UTC

Pregnancy-related acute myocardial infarction: a review of the recent literature – Clinical Research in Cardiology

 

Head CT for the intensivist: 10 tips and pearls.

15 Sep, 2022 | 12:58h | UTC

Head CT for the intensivist: 10 tips and pearls – Minerva Anestesiologica

 

Traumatic cardiac arrest: scoping review of utilization of resuscitative endovascular balloon occlusion of the aorta.

15 Sep, 2022 | 12:57h | UTC

Traumatic Cardiac Arrest: Scoping Review of Utilization of Resuscitative Endovascular Balloon Occlusion of the Aorta – Frontiers in Medicine

 

USPSTF Statement | The current evidence is insufficient to recommend routine screening for prediabetes and type 2 diabetes in children and adolescents.

14 Sep, 2022 | 13:23h | UTC

Screening for Prediabetes and Type 2 Diabetes in Children and Adolescents: US Preventive Services Task Force Recommendation Statement – JAMA

Editorials:

Recommendations for Screening Children and Adolescents for Prediabetes and Type 2 Diabetes – JAMA

Broader Screening for Youth-Onset Type 2 Diabetes—We Just Are Not There Yet – JAMA Network Open

Evidence Report: Screening for Prediabetes and Type 2 Diabetes in Children and Adolescents: Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Patient Page: Screening for Type 2 Diabetes in Children and Adolescents – JAMA

Author Interview: USPSTF Recommendation: Screening for Prediabetes and Diabetes in Children and Adolescents – JAMA

 

Study | Vitamin D3 and omega-3 fatty acids not helpful in reducing the risk of frailty.

14 Sep, 2022 | 13:20h | UTC

News Release: Vitamin D3 and omega-3 fatty acids not helpful in reducing risk of frailty – Brigham and Women’s Hospital

Original Study: Effect of Vitamin D3 and Omega-3 Fatty Acid Supplementation on Risk of Frailty: An Ancillary Study of a Randomized Clinical Trial – JAMA Network Open

Invited Commentary: There Is No Magic Pill to Prevent Frailty—You Still Have to Eat Your Vegetables – JAMA Network Open

 

Commentary on Twitter

 

Cohort Study | Risk factors for heart disease and stroke are largely similar in men and women globally.

14 Sep, 2022 | 13:18h | UTC

News Release: Risk factors for heart disease and stroke are largely similar in men and women globally, finds study – McMaster University

Original Study: Metabolic, behavioural, and psychosocial risk factors and cardiovascular disease in women compared with men in 21 high-income, middle-income, and low-income countries: an analysis of the PURE study – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

https://twitter.com/TheLancet/status/1569636002762817536

 

RCT | Extended duration thromboprophylaxis (continued for 56 days postoperatively) is not beneficial after surgical resection of colorectal cancer.

14 Sep, 2022 | 13:22h | UTC

Efficacy and safety of extended duration to perioperative thromboprophylaxis with low molecular weight heparin on disease-free survival after surgical resection of colorectal cancer (PERIOP-01): multicentre, open label, randomised controlled trial – The BMJ

 

Cohort Study | Prospective associations of daily step counts and intensity with cancer and cardiovascular disease incidence and mortality and all-cause mortality.

14 Sep, 2022 | 13:17h | UTC

Prospective Associations of Daily Step Counts and Intensity With Cancer and Cardiovascular Disease Incidence and Mortality and All-Cause Mortality – JAMA Internal Medicine

Commentaries:

Higher Step Counts Equal Better CV Health: UK Biobank – TCTMD

Pace as important as 10,000 steps for health, finds new research – University of Sidney

How Many Steps a Day (and How Fast) to Lengthen Your Life? – HealthDay

 

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