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Expert Consensus | Imaging standardization in metastatic colorectal cancer.

26 Oct, 2022 | 14:36h | UTC

Imaging standardisation in metastatic colorectal cancer: A joint EORTC-ESOI-ESGAR expert consensus recommendation – European Journal of Cancer

 


Optimizing medication use in older adults with rheumatic diseases: deprescribing as an approach when less may be more.

26 Oct, 2022 | 14:33h | UTC

Optimizing Medication Use in Older Adults With Rheumatic Musculoskeletal Diseases: Deprescribing as an Approach When Less May Be More – ACP Open Rheumatology

Related:

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease. A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

Deprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis – Health Technology Assessment

Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports

How-to guide for medication reviews in older adults with cancer: A Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative – Journal of Geriatric Oncology

Deprescribing in Palliative Cancer Care – Life

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review – Research in Social and Administrative Pharmacy

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

Development of a Metric to Detect and Decrease Low-Value Prescribing in Older Adults – JAMA Network Open

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial – JAMA Internal Medicine

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines – Supportive Care in Cancer

Prescribing practices, patterns, and potential harms in patients receiving palliative care: A systematic scoping review – Exploratory Research in Clinical and Social Pharmacy

A narrative review of evidence to guide deprescribing among older adults – Journal of General and Family Medicine

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens – The Lancet Health Longevity

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt international

Eliminating Medication Overload: A National Action Plan – Lown Institute

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging

Common ED Medication Errors: Polypharmacy – emDocs

Current and future perspectives on the management of polypharmacy – BMC Family Practice

Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety

Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international

Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety

 


RCT | Intraoperative electrocorticography using high-frequency oscillations or spikes to tailor epilepsy surgery.

26 Oct, 2022 | 14:34h | UTC

Intraoperative electrocorticography using high-frequency oscillations or spikes to tailor epilepsy surgery in the Netherlands (the HFO trial): a randomised, single-blind, adaptive non-inferiority trial – The Lancet Neurology

 


Review | Smartphone apps in stroke management.

26 Oct, 2022 | 14:31h | UTC

Smartphone App in Stroke Management: A Narrative Updated Review – Journal of Stroke

Commentary: Stroke Management: There’s an App for That – Medscape (free registration required)

 


M-A | Age, sex, race, BMI, and duration of type 2 DM differences in cardiovascular outcomes with glucose lowering drugs.

26 Oct, 2022 | 14:32h | UTC

Age, sex, race, BMI, and duration of diabetes differences in cardiovascular outcomes with glucose lowering drugs in type 2 diabetes: A systematic review and meta-analysis – eClinicalMedicine

Commentary: Meta-analysis may guide optimal type 2 diabetes glucose-lowering agent for MACE protection – medwire News

 


The bleeding cervical cancer patient: systematic approach and management.

26 Oct, 2022 | 14:30h | UTC

The Bleeding Cervical Cancer Patient: Systematic Approach and Management – emDocs

 


M-A of RCT | Sleep deprivation is not effective as a treatment for major depressive episodes.

26 Oct, 2022 | 14:29h | UTC

Sleep deprivation as a treatment for major depressive episodes: A systematic review and meta-analysis – Sleep Medicine Reviews

 


M-A | Non-affective psychotic disorders and risk of dementia.

26 Oct, 2022 | 14:30h | UTC

Non-affective psychotic disorders and risk of dementia: a systematic review and meta-analysis – Psychological Medicine

Commentaries:

People with schizophrenia are 2.5 times more likely to develop dementia – News Medical/University College London

Psychotic Disorders May Raise Risk for Later Dementia – HealthDay

 


Single-arm P2 study | Toxic effects of stereotactic ablative radiotherapy for up to 5 oligometastases in patients with cancer.

26 Oct, 2022 | 14:28h | UTC

Treatment With Stereotactic Ablative Radiotherapy for Up to 5 Oligometastases in Patients With Cancer: Primary Toxic Effect Results of the Nonrandomized Phase 2 SABR-5 Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)

Commentary: Stereotactic Ablative Body Radiotherapy Produces Acceptable Toxic Effects in Patients With Cancer and Oligometastses – Cancer Network

 

Commentary on Twitter

 


New horizons in Type 2 myocardial infarction: pathogenesis, assessment and management of an emerging geriatric disease.

26 Oct, 2022 | 14:27h | UTC

New horizons in Type 2 myocardial infarction: pathogenesis, assessment and management of an emerging geriatric disease – Age and Ageing

 


M-A | Non-pharmacologic and pharmacologic treatments for anxiety in long-term care.

26 Oct, 2022 | 14:26h | UTC

Non-pharmacologic and pharmacologic treatments for anxiety in long-term care: a systematic review and meta-analysis – Age and Ageing

 


Phase 2 RCT | Immunoglobulin has no corticosteroid-sparing effects in Myasthenia Gravis.

26 Oct, 2022 | 14:25h | UTC

A Randomized, Double-Blind, Placebo-Controlled Trial of the Corticosteroid-Sparing Effects of Immunoglobulin in Myasthenia Gravis – Neurology

 


Differentiating multiple sclerosis from AQP4-neuromyelitis optica spectrum disorder and MOG-antibody disease with imaging.

26 Oct, 2022 | 14:24h | UTC

Differentiating Multiple Sclerosis From AQP4-Neuromyelitis Optica Spectrum Disorder and MOG-Antibody Disease With Imaging – Neurology (PDF)

 

Commentary on Twitter

 


RCT | In critically ill patients receiving MV, there was no difference in outcomes between different O2 saturation targets.

25 Oct, 2022 | 13:23h | UTC

Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Study finds that the most common oxygen saturation targets for hospitalized patients appear equally safe and effective – Vanderbilt University Medical Center

Related:

Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial – JAMA

Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure – New England Journal of Medicine

Oxygen targets – Intensive Care Medicine (if the link is paywalled, try this one)

Thoracic Society of Australia and New Zealand Position Statement on Acute Oxygen Use in Adults: ‘Swimming between the flags’ – Respirology

Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia – Intensive Care Medicine

Oxygen Targets During Mechanical Ventilation in the ICU: A Systematic Review and Meta-Analysis – Critical Care Explorations

Higher versus lower oxygenation strategies in the general intensive care unit population: A systematic review, meta-analysis and meta-regression of randomized controlled trials – Journal of Critical Care

 

Commentary on Twitter

 


Recommendations for laboratory testing of patients with acute myeloid leukemia.

25 Oct, 2022 | 13:21h | UTC

A British Society for Haematology good practice paper: Recommendations for laboratory testing of UK patients with acute myeloid leukaemia – British Journal of Haematology

 


Diaphragmatic function in cardiovascular disease: JACC review topic of the week.

25 Oct, 2022 | 13:22h | UTC

Diaphragmatic Function in Cardiovascular Disease: JACC Review Topic of the Week – Journal of the American College of Cardiology

 


Guideline | Reporting of surgically removed lymph nodes for breast tumors.

25 Oct, 2022 | 13:20h | UTC

Reporting of Surgically Removed Lymph Nodes for Breast Tumors: Recommendations From the International Collaboration on Cancer Reporting – Archives of Pathology & Laboratory Medicine

 


ESGE Position Statement | Expected value of artificial intelligence in gastrointestinal endoscopy.

25 Oct, 2022 | 13:20h | UTC

Expected value of artificial intelligence in gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement – Endoscopy

 


RCT | Recapture and retreatment rates with ixekizumab after withdrawal of therapy in patients with axial spondyloarthritis.

25 Oct, 2022 | 13:19h | UTC

Recapture and retreatment rates with ixekizumab after withdrawal of therapy in patients with axial spondyloarthritis: results at week 104 from a randomised placebo-controlled withdrawal study – Annals of Rheumatic Diseases

Commentary: Successful retreatment of axSpA flare feasible following ixekizumab withdrawal – medwire News

 


RCT | Effect of a novel brief motivational intervention for alcohol-intoxicated young adults in the emergency department.

25 Oct, 2022 | 13:18h | UTC

Effect of a Novel Brief Motivational Intervention for Alcohol-Intoxicated Young Adults in the Emergency Department: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

 


Post-trial follow-up | IV calcium does not improve long-term outcomes in patients with out-of-hospital cardiac arrest.

25 Oct, 2022 | 13:17h | UTC

Effect of calcium vs. placebo on long-term outcomes in patients with out-of-hospital cardiac arrest – Resuscitation

Original Study: RCT: Intravenous or intraosseous calcium does not improve the return of spontaneous circulation in adults with out-of-hospital cardiac arrest.

 

Commentary on Twitter

 


Post-hoc analysis | Two-year visual field outcomes of the Treatment for Advanced Glaucoma Study (TAGS).

25 Oct, 2022 | 13:15h | UTC

Two-year visual field outcomes of the Treatment for Advanced Glaucoma Study (TAGS) – American Journal of Ophthalmology

Original study and commentary: Study Commentary | Advanced glaucoma: surgery lowers pressure in the eye more effectively than eye drops.

 


Systematic Review | Point-of-care ultrasound in dyspnea, nontraumatic hypotension, and shock.

25 Oct, 2022 | 13:16h | UTC

POCUS in dyspnea, nontraumatic hypotension, and shock; a systematic review of existing evidence – European Journal of Internal Medicine

 


Post-trial follow-up | Long-term treatment with Ponesimod in relapsing-remitting multiple sclerosis.

25 Oct, 2022 | 13:14h | UTC

Long-term Treatment With Ponesimod in Relapsing-Remitting Multiple Sclerosis: Results From Randomized Phase 2b Core and Extension Studies – Neurology

Commentary: Optimal Dose of Ponesimod for Control of Relapsing-Remitting Multiple Sclerosis – Neurology Advisor

Original Study: Oral ponesimod in relapsing–remitting multiple sclerosis: a randomised phase II trial – Journal of Neurology, Neurosurgery & Psychiatry

 


RCT | Transcutaneous Electrical Acustimulation (TEA) vs. sham-TEA for irritable bowel syndrome with constipation.

25 Oct, 2022 | 13:12h | UTC

Transcutaneous Electrical Acustimulation Improves Irritable Bowel Syndrome With Constipation by Accelerating Colon Transit and Reducing Rectal Sensation Using Autonomic Mechanisms – American Journal of Gastroenterology

 


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